Principaux thèmes de recherche

  • Application de l'échantillonnage par microdialyse dans les études pharmacocinétiques chez l'homme et chez le rat.
  • Développement de modèles expérimentaux d'obésité et de syndrome métabolique chez l'animal.
  • Effets fonctionnels des céréales.
  • Influence des nutriments côliques/prébiotiques sur le métabolisme glucidique et lipidique.
  • Mécanismes moléculaires impliqués dans la mort cellulaire induite par l'association des vitamines C et K3
  • Rôle des cellules de Kupffer dans la régulation du métabolisme hépatique.
  • Utilisation de la pharmacocinétique de population pour l'ajustement posologique individuel des immunosuppresseurs, antiviraux, et antibiotiques.

 

Publications représentatives dans la recherche en Pharmacocinétique

Verbeeck RK, Kanfer I and Walker RB: Generic substitution: the use of medicinal products containing different salts and implications for safety and efficacy. Eur. J. Pharm. Sci. 28: 1-6, 2006.

Eeckhoudt SL, Horsmans Y and Verbeeck RK: Differential induction of midazolam metabolism in small intestine and liver by p.o. and i.v. dexamethasone pretreatment in the rat. Xenobiotica 32: 975-984, 2002.

Mathy F-X, Préat V and Verbeeck RK: Validation of subcutaneous microdialysis sampling for pharmacokinetic studies of flurbiprofen in the rat. J. Pharm. Sci 90: 1897-1906, 2001.

Brunelle FM and Verbeeck RK: Conjugation-deconjugation cycling of diflunisal via beta-glucuronidase catalysed hydrolysis of its acyl glucuronide in the rat. Life Sci. 60: 2013-2021, 1997.

Raoof AA, Van Obbergh LJ, de Ville de Goyet J and Verbeeck RK: Extrahepatic metabolism of propofol in man: possible contribution of gut wall and kidney. Eur. J. Clin. Pharmacol. 50: 91-96, 1996.

Evrard PA, Deridder G and Verbeeck RK: Intravenous microdialysis in the mouse and the rat: development and pharmacokinetic application of a new probe. Pharm. Res. 13: 12-17, 1996.

Raoof AA, Van Obbergh LJ and Verbeeck RK: Propofol pharmacokinetics in children with biliary atresia. Br. J. Anaest. 74: 46-49, 1995.

Publications représentatives dans la recherche en Nutrition

Cani P, Hoste S, Guiot Y, Delzenne N Dietary non digestible carbohydrates promote L cell differentiation in the proximal colon of rat. Br J Nutr  98, 32-37  (2007)

Cani PD, Amaer J, Iglesias MA, Poggi M, Knauf C, Baxtelica D, Neyrinck A, Fava F, Tuohy KM, Chabo C, Waget A, Delmée E, Cousin B, Sulpice T, Chamontin B, Ferrières J, Tanti JF, Gibson G, Casteilla L, Delzenne N, Alessi MC, Burcelin R. Metabolic endotoxemia initiates obesity and insulin resistance Diabetes, Epub ahead of print april 24,2007. DOI:10.2337/db06-1491. (2007)

Neyrinck A, Delzenne N. Dietary supplementation with laminarin, a fermentable marine beta 1-3 glucan, protects against hepatotoxicity induced by LPS in rat by modulating immune response in the hepatic tissue. International Immunopharmacology accepted (2007)

Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, Tuohy KM, Gibson GR, Delzenne N. Selective increases of bifidobacteria in gut microflora improves high-fat diet – induced diabetes through a mechanisms associated with endotoxemia. Diabetologia  revision submitted;

Neyrinck A.M., Mouson A., Delzenne N.M. Dietary supplementation with laminarin, a fermentable marine b (1-3) glucan, protects against hepatotoxicity induced by LPS in rat by modulating immune response in the hepatic tissue. International Immunopharmacology 7: 1497-1506, 2007.

Cani P.D., Neyrinck A.M., Fava G., Knauf C., Burcelin R.G., Tuohy K.M., Gibson G.R., Delzenne N.LM. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 50: 2374-2383, 2007.

Delzenne N.M., Cani P.D., and Neyrinck A.M. Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data 1-5. The Journal of Nutrition 2547S-2551S, 2007.

Cani P.D., and Delzenne N.M. Gut microflora as a target for energy and metabolic homeostasis. Current Opinion in Clinical Nutrition and Metabolic Care 10: 729-734, 2007.

Cabou C., Cani P.D., Campistron G., Knauf C., Mathieu C., Sartori C., Amar J., Scherrer U., and Burcelin R. Central insulin regulates heart rate and arterial blood flow. Diabetes 56: 2872-2877, 2007.

Urias J.E., Cani P.D., Delmée E., Neyrinck A., Lopez M.G., and Delzenne N.M. Physiological effects of dietary fructanes extracted from agave tequilana Gto. and Dasylirion spp. British Journal of Nutrition 99: 254-261, 2008.

 

Publications représentatives dans la recherche en Toxicologie

Lefebvre V., Goffin I., and Buc Calderon P. Fructose metbolism and cell survival in freshly isolated rat hepatocytes incubated under hypoxic conditions: proposals for potential clinical use. Hepatology 1567-1576, 1994

Buc Calderon P., Cadrobbi PJ., Marques C., Hong-Ngoc N. Jamison J.L., Gilloteaux J., Sumemrs J.L. and Taper H.S. Potential therapeutic appliation of the association of vitamine C and K3 in cancer treatment. Cur. Med. Chem. 9: 2271-2285, 2002

Verrax J., Stockis J., Tison A., Taper H.S., Buc Calderon P. Oxidate stress by ascorbate/menadione association kills K562 human chronic myelogeous leukaemia cells and inhibitis its tumor growth in nude mice. Biochemical Pharmacology 72: 671-680, 2006

Verrax J., Vanbever S., Stockis J., Taper H.S., and Buc Calderon P. Role of glycolysis inhibition and poly(ADP-ribose) polymerase activation in nectrotic-like cell death caused by ascorbate/menadione-induced oxidative stress in K562 human chronic myelogenous leukemic cells. Int. J. Cancer: 120: 1192-1197, 2007

 

| 14/10/2008 |