Schneider Y.-J.

YVES-JACQUES SCHNEIDER	Profile
	Yves-Jacques SCHNEIDER is professor of biochemistry and related topics (molecular cell biology and pharmacology, cell bioengineering), as well as the head of the Laboratory of Cellular Biochemistry.  Co-author of more than 150 papers in international journals or books. Fields of expertise:  Cell culture systems based on mammalian cells In vitro models of the human intestinal barrier Transport across the intestinal barrier Interactions between nutrients and xenobiotics at the intestinal level Physiology and metabolism of CHO cells in bioreactors
Unité de Biochimie  Bt. Carnoy (a.243.10) 5 Croix du Sud B-1348 Louvain-la-Neuve-Belgium	Email: Tel.: +32 10 47 27 91; +32 475 46 76 58 (mobile) Fax.: +32 10 47 48 95

The research activities are focused on questions related to biochemistry, physio-pathology and pharmaco-toxicology of mammalian cells.  They are carried out with cell culture systems that are also used for innovative applications in cell bioengineering. 

Three main topics are currently investigated:

The understanding of the mechanisms whereby nutrients, xenobiotics and drugs interact with the human intestinal barrier.

With an in vitro model formed by Caco-2 cells, we have recently shown that polyunsaturated fatty acids affect the expression and the activity of delta9-desaturase and that some food polyphenols affect the expression of intestinal biotransformation enzymes and inhibit efflux systems, which modulate, f.i. the absorption of ochratoxin A, a mycotoxin currently present in food.  We have also reported that another mycotoxin, deoxynivalenol induces phosphorylation of MAPkinases in Caco-2 cells. 
(Collaboration with Prof. Y. Larondelle, UCL-ISV)

 

 

 

The selective targeting of polymeric nanoparticles to the surface of intestinal M cells and the understanding of the mechanisms by which they cross theses cells.

We have improved a cell culture system as an in vitro model of the human follicle associated epithelium, based on the co-culture of Caco-2 cells and human B lymphocytes.  We currently study the mechanisms of passage of nanoparticles and are searching for ligands for selective recognition of their apical surface.
(Collaboration with Prof. V. Preat, UCL-School of Pharmacy)

 


 



 

 

The understanding of the factors that control physiology and metabolism of cultivated mammalian cells in order to optimize their production and to control it. 

Our approach currently aims at optimizing the production of glycoproteins in bioreactor by genetically modified cells.  We have recently demonstrated that the addition of some vegetal peptones to a serum- and protein-free nutritive medium of CHO cells secreting interferon gamma (IFN) significantly increases cell growth, recombinant IFN secretion, as well as its glycosylation quality.  We are now looking to the bioactive constituents and their mode of action.
(Collaboration with Prof. S. Agathos, UCL-ISV)


 

   

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