Diplômes

Clinical research : pediatric liver diseases, liver transplantation, inborn errors of liver etabolims, cell therapy

Pediatric pharmacology research: phase I,II,III trials of new medicine in chidlren

Lab research: stem cell research

Bibliography  (Pubmed )

1: Vajro P, Sokal EM, Maddaluno S, Esposito M, Caranci F, Capuano G, Caropreso M,
Lenta S. Brain abscess due to Klebsiella pneumoniae in a liver-transplanted
child. Transpl Infect Dis. 2009 Aug;11(4):341-5. Epub 2009 May 3. PubMed PMID:
19422671.

2: Lankisch TO, Mourier O, Sokal EM, Habes D, Lacaille F, Bridoux-Henno L,
Hermeziu B, Lenaerts C, Strassburg CP, Jacquemin E. AIRE gene analysis in
children with autoimmune hepatitis type I or II. J Pediatr Gastroenterol Nutr.
2009 Apr;48(4):498-500. PubMed PMID: 19322061.

3: Najimi M, Smets F, Sokal E. Hepatocyte apoptosis. Methods Mol Biol.
2009;481:59-74. Review. PubMed PMID: 19096793.

4: Sancho-Bru P, Najimi M, Caruso M, Pauwelyn K, Cantz T, Forbes S, Roskams T,
Ott M, Gehling U, Sokal E, Verfaillie CM, Muraca M. Stem and progenitor cells for
liver repopulation: can we standardise the process from bench to bedside? Gut.
2009 Apr;58(4):594-603. Epub 2008 Dec 17. Review. PubMed PMID: 19091822.

5: Bourdeaux C, Brunati A, Janssen M, de Magnée C, Otte JB, Sokal E, Reding R.
Liver retransplantation in children. A 21-year single-center experience. Transpl
Int. 2009 Apr;22(4):416-22. Epub 2008 Nov 25. PubMed PMID: 19040484.

6: Malla I, Lysy PA, Godefroid N, Smets F, Malaise J, Reding R, Sokal EM.
Two-step transplantation for primary hyperoxaluria: cadaveric liver followed by
living donor related kidney transplantation. Pediatr Transplant. 2009
Sep;13(6):782-4. Epub 2008 Nov 10. PubMed PMID: 19032423.

7: Mahadeb P, Gras J, Sokal E, Otte JB, Lerut J, Detaille T, de Cléty SC, Reding
R. Liver transplantation in children with fulminant hepatic failure: The UCL
experience. Pediatr Transplant. 2009 Jun;13(4):414-20. Epub 2008 Oct 7. PubMed
PMID: 19017285.

8: Sokal EM, Goldstein D, Ciocca M, Lewindon P, Ni YH, Silveira T, Sibal A,
Dhawan A, Mack C, Bucuvalas J; End-Stage Liver Disease Working Group. End-stage
liver disease and liver transplant: current situation and key issues. J Pediatr
Gastroenterol Nutr. 2008 Aug;47(2):239-46. PubMed PMID: 18664882.

9: Lysy PA, Najimi M, Stephenne X, Bourgois A, Smets F, Sokal EM. Liver cell
transplantation for Crigler-Najjar syndrome type I: update and perspectives.
World J Gastroenterol. 2008 Jun 14;14(22):3464-70. Review. PubMed PMID: 18567072;
PubMed Central PMCID: PMC2716606.

10: Lysy PA, Smets F, Najimi M, Sokal EM. Leukemia inhibitory factor contributes
to hepatocyte-like differentiation of human bone marrow mesenchymal stem cells.
Differentiation. 2008 Dec;76(10):1057-67. Epub 2008 Jun 13. PubMed PMID:
18557762.

11: Jonas MM, Kelly D, Pollack H, Mizerski J, Sorbel J, Frederick D, Mondou E,
Rousseau F, Sokal E. Safety, efficacy, and pharmacokinetics of adefovir dipivoxil
in children and adolescents (age 2 to <18 years) with chronic hepatitis B.
Hepatology. 2008 Jun;47(6):1863-71. PubMed PMID: 18433023.

12: Strautnieks SS, Byrne JA, Pawlikowska L, Cebecauerová D, Rayner A, Dutton L,
Meier Y, Antoniou A, Stieger B, Arnell H, Ozçay F, Al-Hussaini HF, Bassas AF,
Verkade HJ, Fischler B, Németh A, Kotalová R, Shneider BL, Cielecka-Kuszyk J,
McClean P, Whitington PF, Sokal E, Jirsa M, Wali SH, Jankowska I, Pawłowska J,
Mieli-Vergani G, Knisely AS, Bull LN, Thompson RJ. Severe bile salt export pump
deficiency: 82 different ABCB11 mutations in 109 families. Gastroenterology. 2008
Apr;134(4):1203-14. Epub 2008 Jan 18. PubMed PMID: 18395098.

13: Gras JM, Gerkens S, Beguin C, Janssen M, Smets F, Otte JB, Sokal E, Reding R.
Steroid-free, tacrolimus-basiliximab immunosuppression in pediatric liver
transplantation: clinical and pharmacoeconomic study in 50 children. Liver
Transpl. 2008 Apr;14(4):469-77. PubMed PMID: 18383091.

14: Sokal EM, Kelly D, Wirth S, Mizerski J, Dhawan A, Frederick D. The
pharmacokinetics and safety of adefovir dipivoxil in children and adolescents
with chronic hepatitis B virus infection. J Clin Pharmacol. 2008 Apr;48(4):512-7.
Epub 2008 Feb 14. PubMed PMID: 18276803.

15: Campard D, Lysy PA, Najimi M, Sokal EM. Native umbilical cord matrix stem
cells express hepatic markers and differentiate into hepatocyte-like cells.
Gastroenterology. 2008 Mar;134(3):833-48. Epub 2007 Dec 23. PubMed PMID:
18243183.

16: Lysy PA, Campard D, Smets F, Najimi M, Sokal EM. Stem cells for liver tissue
repair: current knowledge and perspectives. World J Gastroenterol. 2008 Feb
14;14(6):864-75. Review. PubMed PMID: 18240343; PubMed Central PMCID: PMC2687053.

17: Lysy PA, Campard D, Smets F, Malaise J, Mourad M, Najimi M, Sokal EM.
Persistence of a chimerical phenotype after hepatocyte differentiation of human
bone marrow mesenchymal stem cells. Cell Prolif. 2008 Feb;41(1):36-58. PubMed
PMID: 18211285.

18: Sokal EM, Hoppenbrouwers K, Vandermeulen C, Moutschen M, Léonard P, Moreels
A, Haumont M, Bollen A, Smets F, Denis M. Recombinant gp350 vaccine for
infectious mononucleosis: a phase 2, randomized, double-blind, placebo-controlled
trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr
virus vaccine in healthy young adults. J Infect Dis. 2007 Dec 15;196(12):1749-53.
PubMed PMID: 18190254.

19: Smets F, Najimi M, Sokal EM. Cell transplantation in the treatment of liver
diseases. Pediatr Transplant. 2008 Feb;12(1):6-13. Review. PubMed PMID: 18186884.

20: Lysy PA, Sibille C, Gillerot Y, Smets F, Sokal EM. Partial proximal 10q
trisomy: a new case associated with biliary atresia. Hereditas. 2007
Nov;144(5):191-4. PubMed PMID: 18031353.

21: Najimi M, Khuu DN, Lysy PA, Jazouli N, Abarca J, Sempoux C, Sokal EM.
Adult-derived human liver mesenchymal-like cells as a potential progenitor
reservoir of hepatocytes? Cell Transplant. 2007;16(7):717-28. PubMed PMID:
18019361.

22: Baker A, Stevenson R, Dhawan A, Goncalves I, Socha P, Sokal E. Guidelines for
nutritional care for infants with cholestatic liver disease before liver
transplantation. Pediatr Transplant. 2007 Dec;11(8):825-34. Review. PubMed PMID:
17976116.

23: Lysy PA, Smets F, Sibille C, Najimi M, Sokal EM. Human skin fibroblasts: From
mesodermal to hepatocyte-like differentiation. Hepatology. 2007
Nov;46(5):1574-85. PubMed PMID: 17969047.

24: Stéphenne X, Najimi M, Ngoc DK, Smets F, Hue L, Guigas B, Sokal EM.
Cryopreservation of human hepatocytes alters the mitochondrial respiratory chain
complex 1. Cell Transplant. 2007;16(4):409-19. PubMed PMID: 17658131.

25: Smets F, Bourgois A, Vermylen C, Brichard B, Slacmuylders P, Leyman S, Sokal
E. Randomised revaccination with pneumococcal polysaccharide or conjugate vaccine
in asplenic children previously vaccinated with polysaccharide vaccine. Vaccine.
2007 Jul 20;25(29):5278-82. Epub 2007 Jun 4. PubMed PMID: 17576024.

26: Maystadt I, Rezsöhazy R, Barkats M, Duque S, Vannuffel P, Remacle S, Lambert
B, Najimi M, Sokal E, Munnich A, Viollet L, Verellen-Dumoulin C. The nuclear
factor kappaB-activator gene PLEKHG5 is mutated in a form of autosomal recessive
lower motor neuron disease with childhood onset. Am J Hum Genet. 2007
Jul;81(1):67-76. Epub 2007 May 16. PubMed PMID: 17564964; PubMed Central PMCID:
PMC1950913.

27: Moutschen M, Léonard P, Sokal EM, Smets F, Haumont M, Mazzu P, Bollen A,
Denamur F, Peeters P, Dubin G, Denis M. Phase I/II studies to evaluate safety and
immunogenicity of a recombinant gp350 Epstein-Barr virus vaccine in healthy
adults. Vaccine. 2007 Jun 11;25(24):4697-705. Epub 2007 Apr 18. PubMed PMID:
17485150.

28: Khuu DN, Najimi M, Sokal EM. Epithelial cells with hepatobiliary phenotype:
is it another stem cell candidate for healthy adult human liver? World J
Gastroenterol. 2007 Mar 14;13(10):1554-60. PubMed PMID: 17461448.

29: Stéphenne X, Vosters O, Najimi M, Beuneu C, Dung KN, Wijns W, Goldman M,
Sokal EM. Tissue factor-dependent procoagulant activity of isolated human
hepatocytes: relevance to liver cell transplantation. Liver Transpl. 2007
Apr;13(4):599-606. Erratum in: Liver Transpl. 2007 Jul;13(7):1070. PubMed PMID:
17394166.

30: Gras J, Wieërs G, Vaerman JL, Truong DQ, Sokal E, Otte JB, Délépaut B, Cornet
A, de Ville de Goyet J, Latinne D, Reding R. Early immunological monitoring after
pediatric liver transplantation: cytokine immune deviation and graft acceptance
in 40 recipients. Liver Transpl. 2007 Mar;13(3):426-33. PubMed PMID: 17318867.

31: Brunati A, Feruzi Z, Sokal E, Smets F, Fervaille C, Gosseye S, Clapuyt P, de
Ville de Goyet J, Reding R. Early occurrence of hepatocellular carcinoma in
biliary atresia treated by liver transplantation. Pediatr Transplant. 2007
Feb;11(1):117-9. PubMed PMID: 17239135.

32: Bourdeaux C, Darwish A, Jamart J, Tri TT, Janssen M, Lerut J, Otte JB, Sokal
E, de Ville de Goyet J, Reding R. Living-related versus deceased donor pediatric
liver transplantation: a multivariate analysis of technical and immunological
complications in 235 recipients. Am J Transplant. 2007 Feb;7(2):440-7. Epub 2006
Dec 6. PubMed PMID: 17173657.

33: Cutillo L, Najimi M, Smets F, Janssen M, Reding R, de Ville de Goyet J, Sokal
EM. Safety of living-related liver transplantation for progressive familial
intrahepatic cholestasis. Pediatr Transplant. 2006 Aug;10(5):570-4. PubMed PMID:
16856993.

34: Sokal EM. Liver transplantation for inborn errors of liver metabolism. J
Inherit Metab Dis. 2006 Apr-Jun;29(2-3):426-30. PubMed PMID: 16763913.

35: Nussler A, Konig S, Ott M, Sokal E, Christ B, Thasler W, Brulport M, Gabelein
G, Schormann W, Schulze M, Ellis E, Kraemer M, Nocken F, Fleig W, Manns M, Strom
SC, Hengstler JG. Present status and perspectives of cell-based therapies for
liver diseases. J Hepatol. 2006 Jul;45(1):144-59. Epub 2006 Apr 27. Review.
PubMed PMID: 16730092.

36: Buts JP, Dekeyser N, Stilmant C, Delem E, Smets F, Sokal E. Saccharomyces
boulardii produces in rat small intestine a novel protein phosphatase that
inhibits Escherichia coli endotoxin by dephosphorylation. Pediatr Res. 2006
Jul;60(1):24-9. Epub 2006 May 11. PubMed PMID: 16690953.

37: Darwish AA, Bourdeaux C, Kader HA, Janssen M, Sokal E, Lerut J, Ciccarelli O,
Veyckemans F, Otte JB, de Goyet Jde V, Reding R. Pediatric liver transplantation
using left hepatic segments from living related donors: surgical experience in
100 recipients at Saint-Luc University Clinics. Pediatr Transplant. 2006
May;10(3):345-53. PubMed PMID: 16677359.

38: De Kerckhove L, De Meyer M, Verbaandert C, Mourad M, Sokal E, Goffette P,
Geubel A, Karam V, Adam R, Lerut J. The place of liver transplantation in
Caroli's disease and syndrome. Transpl Int. 2006 May;19(5):381-8. PubMed PMID:
16623873.

39: Stéphenne X, Najimi M, Sibille C, Nassogne MC, Smets F, Sokal EM. Sustained
engraftment and tissue enzyme activity after liver cell transplantation for
argininosuccinate lyase deficiency. Gastroenterology. 2006 Apr;130(4):1317-23.
PubMed PMID: 16618422.

40: Sokal EM, Kelly DA, Mizerski J, Badia IB, Areias JA, Schwarz KB, Vegnente A,
Little NR, Gardener SD, Jonas MM. Long-term lamivudine therapy for children with
HBeAg-positive chronic hepatitis B. Hepatology. 2006 Feb;43(2):225-32. PubMed
PMID: 16440364.

41: Sokal EM. Introduction: liver and liver cell transplantation for inborn
errors of liver metabolism. Acta Gastroenterol Belg. 2005 Oct-Dec;68(4):451-2.
PubMed PMID: 16433001.

42: Stephenne X, Najimi M, Janssen M, Reding R, de Ville de Goyet J, Sokal EM.
Liver allograft radiotherapy to treat rejection in children: efficacy in
orthotopic liver transplantation and long-term safety. Liver Int. 2005
Dec;25(6):1108-13. PubMed PMID: 16343059.

43: Reding R, Gras J, Bourdeaux C, Wieers G, Truong QD, Latinne D, Sokal E,
Janssen M, Lerut J, Otte JB, de Ville de Goyet J. Stepwise minimization of the
immunosuppressive therapy in pediatric liver transplantation. A conceptual
approach towards operational tolerance. Acta Gastroenterol Belg. 2005
Jul-Sep;68(3):320-2. PubMed PMID: 16268418.

44: Najimi M, Sokal E. Liver cell transplantation. Minerva Pediatr. 2005
Oct;57(5):243-57. Review. PubMed PMID: 16205608.

45: Pawłowska J, Sokal E, Jankowska I, Teisseyre M, Rokitka M, Socha J.
[Complications in a patient with liver cirrhosis and HCV coinfection during
treatment with peginterferon and ribavirin]. Przegl Epidemiol. 2005;59(2):605-9.
Polish. PubMed PMID: 16190573.

46: Roberton D, Marshall H, Nolan TM, Sokal E, Díez-Domingo J, Flodmark CE, Rombo
L, Lewald G, Flor Jde L, Casanovas JM, Verdaguer J, Marés J, Esso DV, Dieussaert
I, Stoffel M. Reactogenicity and immunogenicity profile of a two-dose combined
hepatitis A and B vaccine in 1-11-year-old children. Vaccine. 2005 Oct
17;23(43):5099-105. PubMed PMID: 16055231.

47: Rombaux P, Marque A, Hamoir M, Smets F, Sokal E. Post-transplant
lymphoproliferative disorder with supraglottic involvement. B-ENT.
2005;1(1):53-6. PubMed PMID: 15999677.

48: Stéphenne X, Najimi M, Smets F, Reding R, de Ville de Goyet J, Sokal EM.
Cryopreserved liver cell transplantation controls ornithine transcarbamylase
deficient patient while awaiting liver transplantation. Am J Transplant. 2005
Aug;5(8):2058-61. PubMed PMID: 15996260.

49: Van Maldergem L, Moser AB, Vincent MF, Roland D, Reding R, Otte JB, Wanders
RJ, Sokal E. Orthotopic liver transplantation from a living-related donor in an
infant with a peroxisome biogenesis defect of the infantile Refsum disease type.
J Inherit Metab Dis. 2005;28(4):593-600. PubMed PMID: 15902563.

50: Bourdeaux C, Tri TT, Gras J, Sokal E, Otte JB, de Ville de Goyet J, Reding R.
PELD score and posttransplant outcome in pediatric liver transplantation: a
retrospective study of 100 recipients. Transplantation. 2005 May 15;79(9):1273-6.
PubMed PMID: 15880084.

51: Dhawan A, Ferenci P, Geubel A, Houwen R, Lerut J, Sokal E. Genes and metals:
a deadly combination. Acta Gastroenterol Belg. 2005 Jan-Mar;68(1):26-32. Review.
PubMed PMID: 15832584.

52: Scheers I, Bachy V, Stephenne X, Sokal EM. Risk of hepatocellular carcinoma
in liver mitochondrial respiratory chain disorders. J Pediatr. 2005
Mar;146(3):414-7. PubMed PMID: 15756232.

53: Wanty C, Joomye R, Van Hoorebeek N, Paul K, Otte JB, Reding R, Sokal EM.
Fifteen years single center experience in the management of progressive familial
intrahepatic cholestasis of infancy. Acta Gastroenterol Belg. 2004
Oct-Dec;67(4):313-9. PubMed PMID: 15727074.

54: Vo Thi Diem H, Bourgois A, Bontems P, Goyens P, Buts JP, Nackers F, Tonglet
R, Sokal EM. Chronic hepatitis B infection: long term comparison of children
receiving interferon alpha and untreated controls. J Pediatr Gastroenterol Nutr.
2005 Feb;40(2):141-5. PubMed PMID: 15699686.

55: Theeten H, Van Damme P, Hoppenbrouwers K, Vandermeulen C, Leback E, Sokal EM,
Wolter J, Schuerman L. Effects of lowering the aluminium content of a dTpa
vaccine on its immunogenicity and reactogenicity when given as a booster to
adolescents. Vaccine. 2005 Feb 10;23(12):1515-21. PubMed PMID: 15670888.

56: Lamireau T, Cézard JP, Dabadie A, Goulet O, Lachaux A, Turck D, Maurage C,
Morali A, Sokal E, Belli D, Stoller J, Cadranel S, Ginies JL, Viola S, Huet F,
Languepin J, Lenaerts C, Bury F, Sarles J; French-Speaking Group for Pediatric
Gastroenterology Nutrition. Efficacy and tolerance of infliximab in children and
adolescents with Crohn's disease. Inflamm Bowel Dis. 2004 Nov;10(6):745-50.
PubMed PMID: 15626892.

57: Najimi M, Sokal E. Update on liver cell transplantation. J Pediatr
Gastroenterol Nutr. 2004 Oct;39(4):311-9. Review. PubMed PMID: 15448415.

58: Darwish AA, Sokal E, Stephenne X, Najimi M, de Goyet Jde V, Reding R.
Permanent access to the portal system for cellular transplantation using an
implantable port device. Liver Transpl. 2004 Sep;10(9):1213-5. PubMed PMID:
15350017.

59: Reding R, Bourdeaux C, Gras J, Evrard V, Buts JP, Carlier M, Ciccarelli O,
Clapuyt P, de Clety SC, De Kock M, Hermans D, Janssen M, Moulin D, Rahier J,
Saint-Martin C, Sempoux C, Van Obbergh L, Veyckemans F, Lerut J, de Ville de
Goyet J, Sokal E, Otte JB. The paediatric liver transplantation program at the
Université catholique de Louvain. Acta Gastroenterol Belg. 2004
Apr-Jun;67(2):176-8. PubMed PMID: 15285574.

60: Vanderborght M, Nassogne MC, Hermans D, Moniotte S, Seneca S, Van Coster R,
Buts JP, Sokal EM. Intractable ulcerative colitis of infancy in a child with
mitochondrial respiratory chain disorder. J Pediatr Gastroenterol Nutr. 2004
Mar;38(3):355-7. PubMed PMID: 15076640.

61: Evrard V, Otte JB, Sokal E, Rochet JS, Haccourt F, Gennari F, Latinne D,
Jamart J, Reding R. Impact of surgical and immunological parameters in pediatric
liver transplantation: a multivariate analysis in 500 consecutive recipients of
primary grafts. Ann Surg. 2004 Feb;239(2):272-80. PubMed PMID: 14745337; PubMed
Central PMCID: PMC1356222.

62: Reding R, Gras J, Sokal E, Otte JB, Davies HF. Steroid-free liver
transplantation in children. Lancet. 2003 Dec 20;362(9401):2068-70. PubMed PMID:
14697809.

63: Sokal EM, Smets F, Bourgois A, Van Maldergem L, Buts JP, Reding R, Bernard
Otte J, Evrard V, Latinne D, Vincent MF, Moser A, Soriano HE. Hepatocyte
transplantation in a 4-year-old girl with peroxisomal biogenesis disease:
technique, safety, and metabolic follow-up. Transplantation. 2003 Aug
27;76(4):735-8. PubMed PMID: 12973120.

64: Lerut JP, Ciccarelli O, Sempoux C, Danse E, deFlandre J, Horsmans Y, Sokal E,
Otte JB. Glycogenosis storage type I diseases and evolutive adenomatosis: an
indication for liver transplantation. Transpl Int. 2003 Dec;16(12):879-84. Epub
2003 Aug 7. PubMed PMID: 12904843.

65: Hermans D, Sokal EM, Collard JM, Romagnoli R, Buts JP. Primary duodenogastric
reflux in children and adolescents. Eur J Pediatr. 2003 Sep;162(9):598-602. Epub
2003 Jun 26. PubMed PMID: 12836018.

66: Diem HV, Evrard V, Vinh HT, Sokal EM, Janssen M, Otte JB, Reding R. Pediatric
liver transplantation for biliary atresia: results of primary grafts in 328
recipients. Transplantation. 2003 May 27;75(10):1692-7. PubMed PMID: 12777858.

67: Diem HV, Sokal EM, Janssen M, Otte JB, Reding R. Steroid withdrawal after
pediatric liver transplantation: a long-term follow-up study in 109 recipients.
Transplantation. 2003 May 27;75(10):1664-70. PubMed PMID: 12777853.

68: Jara P, Resti M, Hierro L, Giacchino R, Barbera C, Zancan L, Crivellaro C,
Sokal E, Azzari C, Guido M, Bortolotti F. Chronic hepatitis C virus infection in
childhood: clinical patterns and evolution in 224 white children. Clin Infect
Dis. 2003 Feb 1;36(3):275-80. Epub 2003 Jan 14. PubMed PMID: 12539067.

69: Huppert PE, Goffette P, Astfalk W, Sokal EM, Brambs HJ, Schott U, Duda SH,
Schweizer P, Claussen CD. Transjugular intrahepatic portosystemic shunts in
children with biliary atresia. Cardiovasc Intervent Radiol. 2002
Nov-Dec;25(6):484-93. Epub 2002 Nov 6. PubMed PMID: 12415417.

70: Nadal D, Leverger G, Sokal EM, Floret D, Perel Y, Leibundgut K, Weller S. An
investigation of the steady-state pharmacokinetics of oral valacyclovir in
immunocompromised children. J Infect Dis. 2002 Oct 15;186 Suppl 1:S123-30. PubMed
PMID: 12353197.

71: Wallot MA, Klepper J, Clapuyt P, Dirsch O, Malagó M, Reding R, Otte JB, Sokal
EM. Repeated detection of gas in the portal vein after liver transplantation: A
sign of EBV-associated post-transplant lymphoproliferation? Pediatr Transplant.
2002 Aug;6(4):332-6. PubMed PMID: 12234275.

72: Smets F, Sokal EM. Epstein-Barr virus-related lymphoproliferation in children
after liver transplant: role of immunity, diagnosis, and management. Pediatr
Transplant. 2002 Aug;6(4):280-7. Review. PubMed PMID: 12234267.

73: Wang LJ, Chen YM, George D, Smets F, Sokal EM, Bremer EG, Soriano HE.
Engraftment assessment in human and mouse liver tissue after sex-mismatched liver
cell transplantation by real-time quantitative PCR for Y chromosome sequences.
Liver Transpl. 2002 Sep;8(9):822-8. PubMed PMID: 12200785.

74: Sokal EM, Cleghorn G, Goulet O, Da Silveira TR, McDiarmid S, Whitington P.
Liver and intestinal transplantation in children: Working Group Report of the
First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J
Pediatr Gastroenterol Nutr. 2002;35 Suppl 2:S159-72. PubMed PMID: 12192185.

75: Marandi S, De Keyser N, Stilmant C, Saliez A, Sokal EM, Guiot Y, Buts JP.
Ontogeny of MAP kinases in rat small intestine: premature stimulation by insulin
of BBM hydrolases is regulated by ERKs but not by p-38 MAP kinase. Pediatr Res.
2002 Aug;52(2):180-8. PubMed PMID: 12149494.

76: Stephenne X, Sokal EM. Hepatitis C in children and adolescents: mode of
acquisition, natural history and treatment. Acta Gastroenterol Belg. 2002
Apr-Jun;65(2):95-8. Review. PubMed PMID: 12148447.

77: Wallot MA, Mathot M, Janssen M, Hölter T, Paul K, Buts JP, Reding R, Otte JB,
Sokal EM. Long-term survival and late graft loss in pediatric liver transplant
recipients--a 15-year single-center experience. Liver Transpl. 2002
Jul;8(7):615-22. PubMed PMID: 12089716.

78: Smets F, Sokal EM. Lymphoproliferation in children after liver
transplantation. J Pediatr Gastroenterol Nutr. 2002 May;34(5):499-505. Review.
PubMed PMID: 12050573.

79: Smets F, Latinne D, Bazin H, Reding R, Otte JB, Buts JP, Sokal EM. Ratio
between Epstein-Barr viral load and anti-Epstein-Barr virus specific T-cell
response as a predictive marker of posttransplant lymphoproliferative disease.
Transplantation. 2002 May 27;73(10):1603-10. PubMed PMID: 12042647.

80: Sokal E. Drug treatment of pediatric chronic hepatitis B. Paediatr Drugs.
2002;4(6):361-9. Review. PubMed PMID: 12038872.

81: Jonas MM, Mizerski J, Badia IB, Areias JA, Schwarz KB, Little NR, Greensmith
MJ, Gardner SD, Bell MS, Sokal EM; International Pediatric Lamivudine
Investigator Group. Clinical trial of lamivudine in children with chronic
hepatitis B. N Engl J Med. 2002 May 30;346(22):1706-13. Erratum in: N Engl J Med
2002 Sep 19;347(12):955. Kelley, Deirdre [corrected to Kelly, Deirdre]. PubMed
PMID: 12037150.

82: Reding R, Sokal E, Paul K, Janssen M, Evrard V, Wilmotte L, Chardot C, Otte
JB, Wallemacq P. Efficacy and pharmacokinetics of tacrolimus oral suspension in
pediatric liver transplant recipients. Pediatr Transplant. 2002 Apr;6(2):124-6.
PubMed PMID: 12000467.

83: Sokal E. [Hepatitis B in children: natural history and therapy]. Bull Mem
Acad R Med Belg. 2001;156(7-9):367-75; discussion 375-6. French. PubMed PMID:
11995183.

84: Buts JP, De Keyser N, Stilmant C, Sokal E, Marandi S. Saccharomyces boulardii
enhances N-terminal peptide hydrolysis in suckling rat small intestine by
endoluminal release of a zinc-binding metalloprotease. Pediatr Res. 2002
Apr;51(4):528-34. PubMed PMID: 11919341.

85: Nchimi A, Khamis J, Langhendries JP, Clapuyt P, Saint Martin C, Sokal E,
Reding R. [Diagnosis and follow-up of a large intrahepatic portocaval fistula in
a newborn]. J Radiol. 2001 Nov;82(11):1642-4. French. PubMed PMID: 11894551.

86: Sokal E. Lamivudine for the treatment of chronic hepatitis B. Expert Opin
Pharmacother. 2002 Mar;3(3):329-39. Review. PubMed PMID: 11866682.

87: Nouwen J, Smets F, Rombaux P, Hamoir M, Sokal EM. Acute tonsillitis as the
first manifestation of post-transplant lymphoproliferative disorder. Ann Otol
Rhinol Laryngol. 2002 Feb;111(2):165-8. PubMed PMID: 11860070.

88: Chardot C, Saint Martin C, Gilles A, Brichard B, Janssen M, Sokal E, Clapuyt
P, Lerut J, Reding R, Otte JB. Living-related liver transplantation and vena cava
reconstruction after total hepatectomy including the vena cava for
hepatoblastoma. Transplantation. 2002 Jan 15;73(1):90-2. PubMed PMID: 11792985.

89: Lacaille F, Sokal E. Living-related liver transplantation. J Pediatr
Gastroenterol Nutr. 2001 Oct;33(4):431-8. Review. PubMed PMID: 11698758.

90: Brichard B, Smets F, Sokal E, Clapuyt P, Vermylen C, Cornu G, Rahier J, Otte
JB. Unusual evolution of an Epstein-Barr virus-associated leiomyosarcoma
occurring after liver transplantation. Pediatr Transplant. 2001 Oct;5(5):365-9.
PubMed PMID: 11560757.

91: Ovaert C, Germeau C, Barrea C, Moniotte S, Van Obbergh L, Sokal E, Reding R,
Otte JB, Sluysmans T. Elevated right ventricular pressures are not a
contraindication to liver transplantation in Alagille syndrome. Transplantation.
2001 Jul 27;72(2):345-7. PubMed PMID: 11477367.

92: Shapira R, Mor E, Bar-Nathan N, Sokal EM, Tur-Kaspa R, Dinari G, Ben-Ari Z.
Efficacy of lamivudine for the treatment of hepatitis B virus infection after
liver transplantation in children. Transplantation. 2001 Jul 27;72(2):333-6.
PubMed PMID: 11477362.

93: Andries S, Casamayou L, Sempoux C, Burlet M, Reding R, Bernard Otte J, Buts
JP, Sokal E. Posttransplant immune hepatitis in pediatric liver transplant
recipients: incidence and maintenance therapy with azathioprine. Transplantation.
2001 Jul 27;72(2):267-72. PubMed PMID: 11477351.

94: Liu HF, Sokal E, Goubau P. Wide variety of genotypes and geographic origins
of hepatitis B virus in Belgian children. J Pediatr Gastroenterol Nutr. 2001
Mar;32(3):274-7. PubMed PMID: 11345175.

95: Lerut JP, Ciccarelli O, Roggen FM, Reding R, Laterre PF, Lengele B, Janssen
M, Chardot C, Clement de Clety S, Danse E, Goffette P, Matterne R, Sokal E,
Horsmans Y, Otte JB. Adult-to-adult living related liver transplantation: initial
experience. Acta Gastroenterol Belg. 2001 Jan-Mar;64(1):9-14. PubMed PMID:
11322066.

96: Jacquemin E, De Vree JM, Cresteil D, Sokal EM, Sturm E, Dumont M, Scheffer
GL, Paul M, Burdelski M, Bosma PJ, Bernard O, Hadchouel M, Elferink RP. The wide
spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to
cirrhosis of adulthood. Gastroenterology. 2001 May;120(6):1448-58. PubMed PMID:
11313315.

97: Reding R, Chardot C, Paul K, Veyckemans F, Van Obbergh L, De Clety SC,
Detaille T, Clapuyt P, Saint-Martin C, Janssen M, Lerut J, Sokal E, Otte JB.
Living-related liver transplantation in children at Saint-Luc University Clinics:
a seven year experience in 77 recipients. Acta Chir Belg. 2001
Jan-Feb;101(1):17-9. PubMed PMID: 11301941.

98: Comanor L, Minor J, Conjeevaram HS, Roberts EA, Alvarez F, Bern EM, Goyens P,
Rosenthal P, Lachaux A, Shelton M, Sarles J, Sokal EM. Impact of chronic
hepatitis B and interferon-alpha therapy on growth of children. J Viral Hepat.
2001 Mar;8(2):139-47. PubMed PMID: 11264734.

99: Chardot C, Nicoluzzi JE, Janssen M, Sokal E, Lerut J, Otte JB, Reding R. Use
of mycophenolate mofetil as rescue therapy after pediatric liver transplantation.
Transplantation. 2001 Jan 27;71(2):224-9. PubMed PMID: 11213063.

100: Marandi S, De Keyser N, Saliez A, Maernoudt AS, Sokal EM, Stilmant C, Rider
MH, Buts JP. Insulin signal transduction in rat small intestine: role of MAP
kinases in expression of mucosal hydrolases. Am J Physiol Gastrointest Liver
Physiol. 2001 Feb;280(2):G229-40. PubMed PMID: 11208545.

101: Smets F, Vajro P, Cornu G, Reding R, Otte JB, Sokal E. Indications and
results of chemotherapy in children with posttransplant lymphoproliferative
disease after liver transplantation. Transplantation. 2000 Mar 15;69(5):982-4.
PubMed PMID: 10755561.

102: Vajro P, DeVincenzo A, Lucariello S, Migliaro F, Sokal E, Bernard O, Vilei
T, Muraca M. Unusual early presentation of Gilbert syndrome in pediatric
recipients of liver transplantation. J Pediatr Gastroenterol Nutr. 2000
Sep;31(3):238-43. PubMed PMID: 10997365.

103: Vajro P, Lucariello S, Migliaro F, Sokal E, Gridelli B, Vegnente A, Iorio R,
Smets F, Quinto I, Scala G. Predictive value of Epstein-Barr virus genome copy
number and BZLF1 expression in blood lymphocytes of transplant recipients at risk
for lymphoproliferative disease. J Infect Dis. 2000 Jun;181(6):2050-4. Epub 2000
Jun 5. PubMed PMID: 10837191.

104: Comanor L, Minor J, Conjeevaram HS, Roberts EA, Alvarez F, Bern EM, Goyens
P, Rosenthal P, Lachaux A, Shelton M, Sarles J, Sokal EM. Statistical models for
predicting response to interferon-alpha and spontaneous seroconversion in
children with chronic hepatitis B. J Viral Hepat. 2000 Mar;7(2):144-52. PubMed
PMID: 10760045.

105: Sokal EM, Roberts EA, Mieli-Vergani G, McPhillips P, Johnson M, Barber J,
Dallow N, Boxall E, Kelly D. A dose ranging study of the pharmacokinetics,
safety, and preliminary efficacy of lamivudine in children and adolescents with
chronic hepatitis B. Antimicrob Agents Chemother. 2000 Mar;44(3):590-7. PubMed
PMID: 10681323; PubMed Central PMCID: PMC89731.

106: Silva ES, Lumbroso S, Medina M, Gillerot Y, Sultan C, Sokal EM.
Demonstration of McCune-Albright mutations in the liver of children with high
gammaGT progressive cholestasis. J Hepatol. 2000 Jan;32(1):154-8. PubMed PMID:
10673080.

107: Smets F, Bodeus M, Goubau P, Reding R, Otte JB, Buts JP, Sokal EM.
Characteristics of Epstein-Barr virus primary infection in pediatric liver
transplant recipients. J Hepatol. 2000 Jan;32(1):100-4. PubMed PMID: 10673073.

108: Campos M, Jouzdani E, Sempoux C, Buts JP, Reding R, Otte JB, Sokal EM.
Sclerosing cholangitis associated to cryptosporidiosis in liver-transplanted
children. Eur J Pediatr. 2000 Jan-Feb;159(1-2):113-5. PubMed PMID: 10653343.

109: Sokal EM, Sokol R, Cormier V, Lacaille F, McKiernan P, Van Spronsen FJ,
Bernard O, Saudubray JM. Liver transplantation in mitochondrial respiratory chain
disorders. Eur J Pediatr. 1999 Dec;158 Suppl 2:S81-4. PubMed PMID: 10603105.

110: Jansen PL, Strautnieks SS, Jacquemin E, Hadchouel M, Sokal EM, Hooiveld GJ,
Koning JH, De Jager-Krikken A, Kuipers F, Stellaard F, Bijleveld CM, Gouw A, Van
Goor H, Thompson RJ, Müller M. Hepatocanalicular bile salt export pump deficiency
in patients with progressive familial intrahepatic cholestasis. Gastroenterology.
1999 Dec;117(6):1370-9. PubMed PMID: 10579978.

111: Png K, Veyckemans F, De Kock M, Carlier M, Sluysmans T, Otte JB, Reding R,
Clement de Clety S, Sokal E, Van Obbergh L. Hemodynamic changes in patients with
Alagille's syndrome during orthotopic liver transplantation. Anesth Analg. 1999
Nov;89(5):1137-42. PubMed PMID: 10553824.

112: Sokal EM, Bortolotti F. Update on prevention and treatment of viral
hepatitis in children. Curr Opin Pediatr. 1999 Oct;11(5):384-9. Review. PubMed
PMID: 10555588.

113: Otte JB, Reding R, de Ville de Goyet J, Sokal E, Lerut J, Janssen M, Rosati
R, Hayez JY, Libert F, Paul K, Latinne D. Experience with living related liver
transplantation in 63 children. Acta Gastroenterol Belg. 1999
Jul-Sep;62(3):355-62. PubMed PMID: 10547903.

114: de Ville de Goyet J, Reding R, Lerut J, Sokal E, Janssen M, Otte JB.
Paediatric orthotopic liver transplantation: lessons from a 532 transplant single
centre experience with 532 transplants in 446 children. Acta Gastroenterol Belg.
1999 Jul-Sep;62(3):290-4. PubMed PMID: 10547894.

115: Reding R, Gennari F, Janssen M, Jamart J, de Ville de Goyet J, Lerut J,
Sokal E, Otte JB. The pediatric liver transplant program at the Université
Catholique de Louvain, Cliniques Saint-Luc, Brussels: overall results in 444
children (1984-1997). Acta Gastroenterol Belg. 1999 Jul-Sep;62(3):285-9. PubMed
PMID: 10547893.

116: de Ville de Goyet J, Alberti D, Falchetti D, Rigamonti W, Matricardi L,
Clapuyt P, Sokal EM, Otte JB, Caccia G. Treatment of extrahepatic portal
hypertension in children by mesenteric-to-left portal vein bypass: a new
physiological procedure. Eur J Surg. 1999 Aug;165(8):777-81. PubMed PMID:
10494645.

117: Bodéus M, Smets F, Reding R, Sokal E, Otte JB, Goubau P, Van Renterghem L.
Epstein-Barr virus infection in sixty pediatric liver graft recipients: diagnosis
of primary infection and virologic follow-up. Pediatr Infect Dis J. 1999
Aug;18(8):698-702. PubMed PMID: 10462339.

118: Buts JP, De Keyser N, Marandi S, Hermans D, Sokal EM, Chae YH, Lambotte L,
Chanteux H, Tulkens PM. Saccharomyces boulardii upgrades cellular adaptation
after proximal enterectomy in rats. Gut. 1999 Jul;45(1):89-96. PubMed PMID:
10369710; PubMed Central PMCID: PMC1727579.

119: Maes M, Sokal E, Otte JB. Growth factors in children with end-stage liver
disease before and after liver transplantation: a review. Pediatr Transplant.
1997 Nov;1(2):171-5. Review. PubMed PMID: 10084777.

120: Reding R, de Goyet Jde V, Delbeke I, Sokal E, Jamart J, Janssen M, Otte JB.
Pediatric liver transplantation with cadaveric or living related donors:
comparative results in 90 elective recipients of primary grafts. J Pediatr. 1999
Mar;134(3):280-6. PubMed PMID: 10064662.

121: Sokal EM, Melchior M, Cornu C, Vandenbroucke AT, Buts JP, Cohen BJ,
Burtonboy G. Acute parvovirus B19 infection associated with fulminant hepatitis
of favourable prognosis in young children. Lancet. 1998 Nov 28;352(9142):1739-41.
PubMed PMID: 9848349.

122: Wallemacq PE, Furlan V, Möller A, Schäfer A, Stadler P, Firdaous I, Taburet
AM, Reding R, Clement De Clety S, De Ville De Goyet J, Sokal E, Lykavieris L, Van
Leeuw V, Bernard O, Otte JB, Undre NA. Pharmacokinetics of tacrolimus (FK506) in
paediatric liver transplant recipients. Eur J Drug Metab Pharmacokinet. 1998
Jul-Sep;23(3):367-70. PubMed PMID: 9842978.

123: Strautnieks SS, Bull LN, Knisely AS, Kocoshis SA, Dahl N, Arnell H, Sokal E,
Dahan K, Childs S, Ling V, Tanner MS, Kagalwalla AF, Németh A, Pawlowska J, Baker
A, Mieli-Vergani G, Freimer NB, Gardiner RM, Thompson RJ. A gene encoding a
liver-specific ABC transporter is mutated in progressive familial intrahepatic
cholestasis. Nat Genet. 1998 Nov;20(3):233-8. PubMed PMID: 9806540.

124: Alberti D, Reding R, Otte JB, Falchetti D, Rigamonti W, Caccia G, Sokal E,
de Ville de Goyet J. Conversion from tacrolimus to microemulsion formulation of
cyclosporine in pediatric liver transplantation. Transplant Proc. 1998
Aug;30(5):1858-60. PubMed PMID: 9723310.

125: Trindade E, Maton P, Reding R, de Ville de Goyet J, Otte JB, Buts JP, Sokal
EM. Use of granulocyte macrophage colony stimulating factor in children after
orthotopic liver transplantation. J Hepatol. 1998 Jun;28(6):1054-7. PubMed PMID:
9672183.

126: Materne R, Clapuyt P, Saint-Martin C, Jespers S, Barrea C, de Ville de Goyet
J, Gosseye S, Sokal E. Gastric cystic duplication communicating with a bifid
pancreas: a rare cause of recurrent pancreatis. J Pediatr Gastroenterol Nutr.
1998 Jul;27(1):102-5. PubMed PMID: 9669736.

127: Sokal EM. Viral hepatitis throughout infancy to adulthood. Acta
Gastroenterol Belg. 1998 Apr-Jun;61(2):170-4. Review. PubMed PMID: 9658601.

128: Otte JB, de Ville de Goyet J, Reding R, Van Obbergh L, Veyckemans F, Carlier
MA, De Kock M, Clement de Clety S, Clapuyt P, Sokal E, Lerut J, Delbeke I,
Dierick V, Janssen M, Rosati R, Libert F. Pediatric liver transplantation: from
the full-size liver graft to reduced, split, and living related liver
transplantation. Pediatr Surg Int. 1998 Jul;13(5-6):308-18. Review. PubMed PMID:
9639606.

129: Sokal EM, Conjeevaram HS, Roberts EA, Alvarez F, Bern EM, Goyens P,
Rosenthal P, Lachaux A, Shelton M, Sarles J, Hoofnagle J. Interferon alfa therapy
for chronic hepatitis B in children: a multinational randomized controlled trial.
Gastroenterology. 1998 May;114(5):988-95. PubMed PMID: 9558288.

130: Buts JP, Duranton B, De Keyser N, Sokal EM, Maernhout AS, Raul F, Marandi S.
Premature stimulation of rat sucrase-isomaltase (SI) by exogenous insulin and the
analog B-Asp10 is regulated by a receptor-mediated signal triggering SI gene
transcription. Pediatr Res. 1998 May;43(5):585-91. PubMed PMID: 9585003.

131: de Ville de Goyet J, Alberti D, Clapuyt P, Falchetti D, Rigamonti V, Bax NM,
Otte JB, Sokal EM. Direct bypassing of extrahepatic portal venous obstruction in
children: a new technique for combined hepatic portal revascularization and
treatment of extrahepatic portal hypertension. J Pediatr Surg. 1998
Apr;33(4):597-601. PubMed PMID: 9574759.

132: de Ville de Goyet J, Struye de Swielande Y, Reding R, Sokal EM, Otte JB.
Delayed primary closure of the abdominal wall after cadaveric and living related
donor liver graft transplantation in children: a safe and useful technique.
Transpl Int. 1998;11(2):117-22. PubMed PMID: 9561677.

133: de Repentigny L, Ratelle J, Leclerc JM, Cornu G, Sokal EM, Jacqmin P, De
Beule K. Repeated-dose pharmacokinetics of an oral solution of itraconazole in
infants and children. Antimicrob Agents Chemother. 1998 Feb;42(2):404-8. PubMed
PMID: 9527794; PubMed Central PMCID: PMC105422.

134: Reding R, Wallemacq P, Moulin D, Manicourt D, Lambotte L, Jamart J, Sokal E,
de Ville de Goyet J, Otte JB. Early hepatocyte, endothelial, and bile duct cell
injury after pediatric liver transplantation from cadaveric or living-related
donors. Transplantation. 1998 Mar 15;65(5):681-5. PubMed PMID: 9521203.

135: Sokal EM, Antunes H, Beguin C, Bodeus M, Wallemacq P, de Ville de Goyet J,
Reding R, Janssen M, Buts JP, Otte JB. Early signs and risk factors for the
increased incidence of Epstein-Barr virus-related posttransplant
lymphoproliferative diseases in pediatric liver transplant recipients treated
with tacrolimus. Transplantation. 1997 Nov 27;64(10):1438-42. PubMed PMID:
9392308.

136: Reding R, de Ville de Goyet J, Gosseye S, Clapuyt P, Sokal E, Buts JP, Gibbs
P, Otte JB. Hirschsprung's disease: a 20-year experience. J Pediatr Surg. 1997
Aug;32(8):1221-5. PubMed PMID: 9269974.

137: Buts JP, De Keyser N, Sokal EM, Marandi S. Oral insulin is biologically
active on rat immature enterocytes. J Pediatr Gastroenterol Nutr. 1997
Aug;25(2):230-2. PubMed PMID: 9252916.

138: Buts JP, De Keyser N, Marandi S, Maernoudt AS, Sokal EM, Rahier J, Hermans
D. Expression of insulin receptors and of 60-kDa receptor substrate in rat mature
and immature enterocytes. Am J Physiol. 1997 Jul;273(1 Pt 1):G217-26. PubMed
PMID: 9252529.

139: Jacquemin E, Hermans D, Myara A, Habes D, Debray D, Hadchouel M, Sokal EM,
Bernard O. Ursodeoxycholic acid therapy in pediatric patients with progressive
familial intrahepatic cholestasis. Hepatology. 1997 Mar;25(3):519-23. PubMed
PMID: 9049190.

140: Verloes A, Lombet J, Lambert Y, Hubert AF, Deprez M, Fridman V, Gosseye S,
Rigo J, Sokal E. Tricho-hepato-enteric syndrome: further delineation of a
distinct syndrome with neonatal hemochromatosis phenotype, intractable diarrhea,
and hair anomalies. Am J Med Genet. 1997 Feb 11;68(4):391-5. PubMed PMID:
9021008.

141: Wallemacq PE, Reding R, Sokal EM, de Ville de Goyet J, Clement de Clety S,
Van Leeuw V, De Backer M, Otte JB. Clinical pharmacokinetics of Neoral in
pediatric recipients of primary liver transplants. Transpl Int.
1997;10(6):466-70. PubMed PMID: 9428122.

142: de Ville de Goyet J, Reding R, Sokal E, Otte JB. [Related living donor for
liver transplantation in children: results and impact]. Chirurgie.
1997;122(2):83-7. French. PubMed PMID: 9238797.

143: Buts JP, De Keyser N, Collette E, Bonsignore M, Lambotte L, Desjeux JF,
Sokal EM. Intestinal transport of calcium in rat biliary cirrhosis. Pediatr Res.
1996 Oct;40(4):533-41. PubMed PMID: 8888279.

144: Otte JB, de Ville de Goyet J, Reding R, Sokal E, Lerut J, Vanormelingen P,
Janssen M. Living related donor liver transplantation in children: the Brussels
experience. Transplant Proc. 1996 Aug;28(4):2378-9. PubMed PMID: 8769257.

145: de Ville de Goyet J, Gibbs P, Clapuyt P, Reding R, Sokal EM, Otte JB.
Original extrahilar approach for hepatic portal revascularization and relief of
extrahepatic portal hypertension related to later portal vein thrombosis after
pediatric liver transplantation. Long term results. Transplantation. 1996 Jul
15;62(1):71-5. PubMed PMID: 8693549.

146: Sokal EM, Baudoux MC, Collette E, Hausleithner V, Lambotte L, Buts JP.
Branched chain amino acids improve body composition and nitrogen balance in a rat
model of extra hepatic biliary atresia. Pediatr Res. 1996 Jul;40(1):66-71. PubMed
PMID: 8798248.

147: Verloes A, Temple IK, Hubert AF, Hope P, Gould S, Debauche C, Verellen G,
Deville JL, Koulischer L, Sokal EM. Recurrence of neonatal haemochromatosis in
half sibs born of unaffected mothers. J Med Genet. 1996 Jun;33(6):444-9. PubMed
PMID: 8782042; PubMed Central PMCID: PMC1050628.

148: Reding R, Feyaerts A, Vraux H, Latinne D, De La Parra B, Cornet A, Cormont
F, Jamart J, Sokal E, de Ville de Goyet J, Lerut J, Bazin H, Otte JB.
Prophylactic immunosuppression with anti-interleukin-2 receptor monoclonal
antibody LO-Tact-1 versus OKT3 in liver allografting. A two-year follow-up study.
Transplantation. 1996 May 15;61(9):1406-9. PubMed PMID: 8629306.

149: Alberti D, Wallemacq P, Falchetti D, de Ville de Goyet J, Rigamonti W,
Panzali A, Sokal E, Otte JB, Reding R. Microemulsion formulation of cyclosporine
in pediatric liver transplantation. Transplantation. 1996 Feb 15;61(3):512-4.
PubMed PMID: 8610371.

150: Santos Silva EE, Sarles J, Buts JP, Sokal EM. Successful medical treatment
of severely decompensated Wilson disease. J Pediatr. 1996 Feb;128(2):285-7.
PubMed PMID: 8636833.

151: Sokal EM, Reding R, de Ville de Goyet J, Otte JB. [Long-term outcome in
children with liver transplants]. Arch Pediatr. 1996;3 Suppl 1:132s-134s. French.
PubMed PMID: 8795992.

152: Lecouvet F, Clapuyt P, Van Nieuwenhuyse JP, Everarts P, Baudrez V, Reding R,
de Ville de Goyet J, Sokal E, Otte JB. Primary calcification in
post-transplantation lymphoproliferative disorder involving the hepatic graft: an
exceptional finding. Pediatr Radiol. 1996;26(2):152-4. PubMed PMID: 8587818.

153: Müller G, Veyckemans F, Calier M, Van Obbergh LJ, De Kock M, Sokal EM, Otte
JB. Anaesthetic considerations in progressive familial intrahepatic cholestasis
(Byler's disease). Can J Anaesth. 1995 Dec;42(12):1126-33. PubMed PMID: 8595689.

154: Sokal EM, Silva ES, Hermans D, Reding R, de Ville de Goyet J, Buts JP, Otte
JB. Orthotopic liver transplantation for Crigler-Najjar type I disease in six
children. Transplantation. 1995 Nov 27;60(10):1095-8. PubMed PMID: 7482714.

155: Boon-Falleur L, Sokal E, Nightingale PG, Peters M, Otte JB, Ketelslegers JM,
De Wilde E, Hasman A. Utilization of laboratory resources: developments in
knowledge-based ordering systems. Int J Biomed Comput. 1995 Sep;40(1):17-30.
PubMed PMID: 8557401.

156: Buts JP, De Keyser N, De Raedemaeker L, Collette E, Sokal EM. Polyamine
profiles in human milk, infant artificial formulas, and semi-elemental diets. J
Pediatr Gastroenterol Nutr. 1995 Jul;21(1):44-9. PubMed PMID: 8576813.

157: Pastore M, Willems M, Cornu C, Buts JP, Reding R, de Ville de Goyet J,
Rahier J, Otte JB, Yap SH, Sokal EM. Role of hepatitis C virus in chronic liver
disease occurring after orthotopic liver transplantation. Arch Dis Child. 1995
May;72(5):403-7. PubMed PMID: 7618905; PubMed Central PMCID: PMC1511101.

158: Sokal EM. Quality of life after orthotopic liver transplantation in
children. An overview of physical, psychological and social outcome. Eur J
Pediatr. 1995 Mar;154(3):171-5. Review. PubMed PMID: 7758511.

159: Sokal EM, Van Collie O, Buts JP. Horizontal transmission of hepatitis B from
children to adoptive parents. Arch Dis Child. 1995 Feb;72(2):191. PubMed PMID:
7702394; PubMed Central PMCID: PMC1511002.

160: Boon-Falleur L, Sokal E, Peters M, Ketelslegers JM. A rule-based decision
support application for laboratory investigations management. Proc Annu Symp
Comput Appl Med Care. 1995:314-8. PubMed PMID: 8563292; PubMed Central PMCID:
PMC2579106.

161: Sokal EM. [Should chronic hepatitis B in children be treated?].
Gastroenterol Clin Biol. 1995 Jan;19(1):51-2. French. PubMed PMID: 7720990.

162: Otte JB, de Ville de Goyet J, Reding R, Hausleithner V, Sokal E, Chardot C,
Debande B. Sequential treatment of biliary atresia with Kasai portoenterostomy
and liver transplantation: a review. Hepatology. 1994 Jul;20(1 Pt 2):41S-48S.
Review. PubMed PMID: 8005579.

163: Buts JP, Cadranel S, Deprettere A, Scaillon M, Sokal E, Van Caillie-Bertrand
M, Vandenplas Y, Vanwinckel M. Hypo-allergenic formulae: what's in a name? Eur J
Pediatr. 1994 May;153(5):390-2. PubMed PMID: 8033935.

164: Sokal EM, De Bilderling G, Clapuyt P, Opsomer RJ, Buts JP. Extracorporeal
shock-wave lithotripsy for calcified lower choledocholithiasis in an 18-month-old
boy. J Pediatr Gastroenterol Nutr. 1994 Apr;18(3):391-4. PubMed PMID: 8057227.

165: Buts JP, De Keyser N, Romain N, Dandrifosse G, Sokal E, Nsengiyumva T.
Response of rat immature enterocytes to insulin: regulation by receptor binding
and endoluminal polyamine uptake. Gastroenterology. 1994 Jan;106(1):49-59. PubMed
PMID: 8276208.

166: Baranski AG, Barker AP, Sokal E, Havaux X, Saliez A, Lambotte L, de Ville de
Goyet J. A new method for rat accessory hepatic transplantation--the cervical
approach. Transpl Int. 1994;7(6):398-404. PubMed PMID: 7865104.

167: Reding R, Wallemacq PE, Lamy ME, Rahier J, Sempoux C, Debande B, Jamart J,
Barker A, Sokal E, De Ville de Goyet J, et al. Conversion from cyclosporine to
FK506 for salvage of immunocompromised pediatric liver allografts. Efficacy,
toxicity, and dose regimen in 23 children. Transplantation. 1994
Jan;57(1):93-100. PubMed PMID: 7507272.

168: Stalens JP, Sokal E, Walon C, Verellen-Dumoulin C, Clapuyt P, Wese FX.
Autosomal dominant polycystic kidney disease in the first year of life. Report of
a case with no family history. Acta Urol Belg. 1993 Dec;61(4):25-8. PubMed PMID:
8296686.

169: Sokal EM, Caragiozoglou T, Lamy M, Reding R, Otte JB. Epstein-Barr virus
serology and Epstein-Barr virus-associated lymphoproliferative disorders in
pediatric liver transplant recipients. Transplantation. 1993 Dec;56(6):1394-8.
PubMed PMID: 8279009.

170: Van Obbergh L, Carlier M, de Clety SC, Sokal E, Rennotte MT, Veyckemans F,
Dekock M, Frans A, Otte JB. Liver transplantation and pulmonary gas exchanges in
hypoxemic children. Am Rev Respir Dis. 1993 Nov;148(5):1408-10. PubMed PMID:
8239183.

171: Buts JP, De Keyser N, Kolanowski J, Sokal E, Van Hoof F. Maturation of
villus and crypt cell functions in rat small intestine. Role of dietary
polyamines. Dig Dis Sci. 1993 Jun;38(6):1091-8. PubMed PMID: 8508705.

172: Sokal EM, Lopez-Silvarrey A, Buts JP, Otte JB. Orthotopic liver
transplantation for type I glycogenosis unresponsive to medical therapy. J
Pediatr Gastroenterol Nutr. 1993 May;16(4):465-7. PubMed PMID: 8315558.

173: Cilio MR, Danhaive O, Gadisseux JF, Otte JB, Sokal EM. Unusual cyclosporin
related neurological complications in recipients of liver transplants. Arch Dis
Child. 1993 Mar;68(3):405-7. PubMed PMID: 8466245; PubMed Central PMCID:
PMC1793864.

174: Reding R, Vraux H, de Ville de Goyet J, Sokal E, de Hemptinne B, Latinne D,
Rahier J, Jamart J, Vincenzotto C, Cormont F, et al. Monoclonal antibodies in
prophylactic immunosuppression after liver transplantation. A randomized
controlled trial comparing OKT3 and anti-IL-2 receptor monoclonal antibody
LO-Tact-1. Transplantation. 1993 Mar;55(3):534-41. PubMed PMID: 8456474.

175: Reding R, Clapuyt P, Lengele B, Veyckemans F, Noel H, Sokal E, Otte JB.
Intestinal hemorrhage three years after incidental appendectomy by total
inversion. Eur J Pediatr Surg. 1993 Feb;3(1):59-60. PubMed PMID: 8466880.

176: Sokal EM, Ulla L, Harvengt C, Otte JB. Liver transplantation for familial
hypercholesterolemia before the onset of cardiovascular complications.
Transplantation. 1993 Feb;55(2):432-3. PubMed PMID: 8434397.

177: Sokal EM, Collette E, Buts JP. Continuous increase of alcohol dehydrogenase
activity along the liver plate in normal and cirrhotic human livers. Hepatology.
1993 Feb;17(2):202-5. PubMed PMID: 8428716.

178: Sokal EM, Wirth S, Goyens P, Depreterre A, Cornu C. Interferon alfa-2b
therapy in children with chronic hepatitis B. Gut. 1993;34(2 Suppl):S87-90.
PubMed PMID: 8314496; PubMed Central PMCID: PMC1374019.

179: Buts JP, Sokal EM, Van Hoof F. Prenatal exposure to ethanol in rats: effects
on postnatal maturation of the small intestine and liver. Pediatr Res. 1992
Nov;32(5):574-9. PubMed PMID: 1480459.

180: Sokal EM, Bustos R, Van Hoof F, Otte JB. Liver transplantation for
hereditary tyrosinemia--early transplantation following the patient's
stabilization. Transplantation. 1992 Nov;54(5):937-9. PubMed PMID: 1440864.

181: Wirth S, Sokal E, Schaefer E, Pohlenz J, Keller KM. [Chronic hepatitis B.
Treatment in childhood with alpha-interferon]. Monatsschr Kinderheilkd. 1992
Oct;140(10):775-9. German. PubMed PMID: 1435800.

182: Sokal EM, Ulla L, Otte JB. Hepatitis B vaccine response before and after
transplantation in 55 extrahepatic biliary atresia children. Dig Dis Sci. 1992
Aug;37(8):1250-2. PubMed PMID: 1499450.

183: Sokal EM, Van Hoorebeeck N, Van Obbergh L, Otte JB, Buts JP. Upper
gastro-intestinal tract bleeding in cirrhotic children candidates for liver
transplantation. Eur J Pediatr. 1992 May;151(5):326-8. PubMed PMID: 1396883.

184: Sokal EM, Mostin J, Buts JP. Liver metabolic zonation in rat biliary
cirrhosis: distribution is reverse of that in toxic cirrhosis. Hepatology. 1992
May;15(5):904-8. PubMed PMID: 1314772.

185: Sokal EM, Van Hoof F, Alberti D, de Ville de Goyet J, de Barsy T, Otte JB.
Progressive cardiac failure following orthotopic liver transplantation for type
IV glycogenosis. Eur J Pediatr. 1992 Mar;151(3):200-3. PubMed PMID: 1601012.

186: Danhaive O, Ninane J, Sokal E, Latinne D, Philippe M, Gosseye S, Clapuyt P,
Otte JB. Hepatic localization of a fibrosarcoma in a child with a liver
transplant. J Pediatr. 1992 Mar;120(3):434-7. PubMed PMID: 1538293.

187: Cames B, Rahier J, Burtomboy G, de Ville de Goyet J, Reding R, Lamy M, Otte
JB, Sokal EM. Acute adenovirus hepatitis in liver transplant recipients. J
Pediatr. 1992 Jan;120(1):33-7. PubMed PMID: 1731021.

188: Sokal E. [The dietetic basis of infant nutrition]. J Pharm Belg. 1992
Jan-Feb;47(1):50-3. Review. French. PubMed PMID: 1625163.

189: Libert R, Hermans D, Draye JP, Van Hoof F, Sokal E, de Hoffmann E. Bile
acids and conjugates identified in metabolic disorders by fast atom bombardment
and tandem mass spectrometry. Clin Chem. 1991 Dec;37(12):2102-10. PubMed PMID:
1722438.

190: Reding R, de Ville de Goyet J, Sokal E, Moulin D, Clement de Clety S,
Wallemacq P, Otte JB. Compassionate use of FK 506 in pediatric liver
transplantation: a pilot study. Transplant Proc. 1991 Dec;23(6):3002-4. PubMed
PMID: 1721341.

191: Sokal EM, Collette E, Buts JP. Persistence of a liver metabolic zonation in
extra-hepatic biliary atresia cirrhotic livers. Pediatr Res. 1991
Sep;30(3):286-9. PubMed PMID: 1658719.

192: Vanclaire J, Cornu C, Sokal EM. Fulminant hepatitis B in an infant born to a
hepatitis Be antibody positive, DNA negative carrier. Arch Dis Child. 1991
Aug;66(8):983-5. PubMed PMID: 1929497; PubMed Central PMCID: PMC1793473.

193: Brichard B, Sokal E, Gosseye S, Buts JP, Gadisseux JF, Cornu G.
Coombs-positive giant cell hepatitis of infancy: effect of steroids and
azathioprine therapy. Eur J Pediatr. 1991 Mar;150(5):314-7. PubMed PMID: 2044600.

194: Brant de Carvalho F, Reding R, Falchetti D, de Ville de Goyet J, de
Hemptinne B, Sokal E, Otte JB. Analysis of liver graft loss in infants and
children below 4 years. Transplant Proc. 1991 Feb;23(1 Pt 2):1454-5. PubMed PMID:
1989262.

195: Sokal EM, Trivedi P, Portmann B, Mowat AP. Adaptative changes of metabolic
zonation during the development of cirrhosis in growing rats. Gastroenterology.
1990 Sep;99(3):785-92. PubMed PMID: 2165952.

196: Sokal EM, Veyckemans F, de Ville de Goyet J, Moulin D, Van Hoorebeeck N,
Alberti D, Buts JP, Rahier J, Van Obbergh L, Clapuyt P, et al. Liver
transplantation in children less than 1 year of age. J Pediatr. 1990 Aug;117(2 Pt
1):205-10. PubMed PMID: 2380818.

197: Sokal EM, Ville de Goyet J, Buts JP, Habets S, Gosseye S, Clapuyt P, Claus
D, Otte JB. Unifocal stricture of the common bile duct in two children: a
localized form of primary sclerosing cholangitis. J Pediatr Gastroenterol Nutr.
1990 Aug;11(2):268-74. PubMed PMID: 2203891.

198: Otte JB, de Ville de Goyet J, Sokal E, Alberti D, Moulin D, de Hemptinne B,
Veyckemans F, van Obbergh L, Carlier M, Clapuyt P, et al. Size reduction of the
donor liver is a safe way to alleviate the shortage of size-matched organs in
pediatric liver transplantation. Ann Surg. 1990 Feb;211(2):146-57. PubMed PMID:
2301994; PubMed Central PMCID: PMC1357958.

199: Sokal EM, Trivedi P, Cheeseman P, Portmann B, Mowat AP. The application of
quantitative cytochemistry to study the acinar distribution of enzymatic
activities in human liver biopsy sections. J Hepatol. 1989 Jul;9(1):42-8. PubMed
PMID: 2549121.

200: Sokal EM, Trivedi P, Portmann B, Mowat AP. Developmental changes in the
intra-acinar distribution of succinate dehydrogenase, glutamate dehydrogenase,
glucose-6-phosphatase, and NADPH dehydrogenase in the rat liver. J Pediatr
Gastroenterol Nutr. 1989 May;8(4):522-7. PubMed PMID: 2542510.

201: Otte JB, de Ville de Goyet J, Alberti D, de Hemptinne B, Sokal E, Moulin D,
Veyckemans F, Carlier MA, Van Obbergh L, Rahier J, et al. Liver transplantation
in children: University of Louvain Medical School (Brussels) experience with the
first 139 patients. Clin Transpl. 1989:143-52. PubMed PMID: 2487559.

202: Michel M, Vermylen C, Sokal E, Ninane J, Latinne D, De Bruyére M, Cornu G.
Bone marrow transplantation for poor prognosis ALL in children. Relapse rate,
infections and immunological recovery. Acta Clin Belg. 1988;43(4):254-60. PubMed
PMID: 3055782.

203: Sokal E, Michel M, Ninane J, Latinne D, de Bruyere M, Cornu G. Bone marrow
transplantation from an unrelated donor for Fanconi's anaemia: two unusual
complications. Bone Marrow Transplant. 1987 Jun;2(1):99-102. PubMed PMID:
3139115.

PROFESSEUR ETIENNE SOKAL – Curriculum Vitae Résumé

Position actuelle 

Université Catholique de Louvain :

- Professeur ordinaire, faculté de médecine, Université Catholique de Louvain

- Responsable d’unité de recherche PEDI

- Président du département de pédiatrie

Cliniques Saint Luc 

- Chef de clinique

- Responsable d’unité de gastroentérologie pédiatrique, Cliniques St Luc

- Président  du comité clinique de génétique humaine

- Directeur du centre d’investigation clinique pédiatrique

Promethera Biosciences

- Directeur  fondateur  et directeur scientifique (02/2009)

Etudes

- Humanité gréco latines Collège Saint Michel, 1976.

- Docteur en médecine, chirurgie et accouchement UCL 1983, maximum cum laude

- License spéciale en Pédiatrie, UCL 1989.

- Agrégation enseignement supérieur UCL 1993 â€“ Thèse intitulée « La zonation métabolique du foie normal et cirrhotique Â» Leçon publique « L’hépatite B de l’enfant Â».

Fellowship

1986-1988 : Honorary registrar  & Research fellow, Kig’s College Hospital , London

British Council fellowship

Royal Society fellowship

Boursier Fondation St Luc

Membre de sociétés scientifiques 

European associaton for the study of the liver (EASL), european society pediatric gastroenterology, hepatology & nutrition (ESGHAN) (fondateur du liver committee),société belge de pédiatrie (SBP), Pediatric research society (UK),  groupe belge  et groupe francophone de gastroentérologie et nutrition pédiatrique, International Society of Stem Cell research ( membre du « translational research committee Â»), société belge de transplantation, société belge de gastroentérologie.

Académie Royale Belge de Médecine (membre ordinaire) (2002)

Reviewer- Editorial board

 Editorial board :    World Journal Gastroenterology , cell transplantation

Reviewer : Lancet, Hepatology, Transplantation, Gastroenterology, Journal of Hepatology,

Journal of Pediatrics, European Journal of Pediatrics, Journal of Pediatric Gastroenterology and Nutrition, Acta Gastroenterologica Belgica….

Principaux domaines de recherche

- Les maladies du foie de l’enfant

- La transplantation hépatique pédiatrique

- Les syndromes lymphoprolifératifs à EBV

- Les hépatites virales de l’enfant

- Les maladies métaboliques du foie

- La thérapie cellulaire et les cellules souches hépatiques

- La recherche clinique pharmacologique pédiatrique

Publications et conférences

- 204 publications reprises sur Pubmed dans les domaines de recherche précités

- ~ 350 conférences scientifiques en tant que   conférencier invité ou communications   

Enseignement (UCL)

Croissance et développement 1^er master, secteurs digestifs, uro-néphrologie, maladies infectieuses,  séminaires de stage, license en nutrition.

Notoriété

Membre de réseaux  nationaux et internationaux  dans les domaines de  l’hépatologie pédiatrique  et de transplantation / thérapie cellulaire; expertise clinique, recherche clinique et translationelle :  transplantation, maladies métaboliques, hépatites virales, thérapie cellulaire et cellules souches.

Patente

Adult derived Hepatic Mesenchymal Stem Cell

Orphan drug status : déficit cycle de l’urée, maladie de Crigler Najjar

Biographie

Diplômes

Recherche

Clinical research : pediatric liver diseases, liver transplantation, inborn errors of liver etabolims, cell therapy

Pediatric pharmacology research: phase I,II,III trials of new medicine in chidlren

Lab research: stem cell research

Bibliography  (Pubmed )

1: Vajro P, Sokal EM, Maddaluno S, Esposito M, Caranci F, Capuano G, Caropreso M,
Lenta S. Brain abscess due to Klebsiella pneumoniae in a liver-transplanted
child. Transpl Infect Dis. 2009 Aug;11(4):341-5. Epub 2009 May 3. PubMed PMID:
19422671.

2: Lankisch TO, Mourier O, Sokal EM, Habes D, Lacaille F, Bridoux-Henno L,
Hermeziu B, Lenaerts C, Strassburg CP, Jacquemin E. AIRE gene analysis in
children with autoimmune hepatitis type I or II. J Pediatr Gastroenterol Nutr.
2009 Apr;48(4):498-500. PubMed PMID: 19322061.

3: Najimi M, Smets F, Sokal E. Hepatocyte apoptosis. Methods Mol Biol.
2009;481:59-74. Review. PubMed PMID: 19096793.

4: Sancho-Bru P, Najimi M, Caruso M, Pauwelyn K, Cantz T, Forbes S, Roskams T,
Ott M, Gehling U, Sokal E, Verfaillie CM, Muraca M. Stem and progenitor cells for
liver repopulation: can we standardise the process from bench to bedside? Gut.
2009 Apr;58(4):594-603. Epub 2008 Dec 17. Review. PubMed PMID: 19091822.

5: Bourdeaux C, Brunati A, Janssen M, de Magnée C, Otte JB, Sokal E, Reding R.
Liver retransplantation in children. A 21-year single-center experience. Transpl
Int. 2009 Apr;22(4):416-22. Epub 2008 Nov 25. PubMed PMID: 19040484.

6: Malla I, Lysy PA, Godefroid N, Smets F, Malaise J, Reding R, Sokal EM.
Two-step transplantation for primary hyperoxaluria: cadaveric liver followed by
living donor related kidney transplantation. Pediatr Transplant. 2009
Sep;13(6):782-4. Epub 2008 Nov 10. PubMed PMID: 19032423.

7: Mahadeb P, Gras J, Sokal E, Otte JB, Lerut J, Detaille T, de Cléty SC, Reding
R. Liver transplantation in children with fulminant hepatic failure: The UCL
experience. Pediatr Transplant. 2009 Jun;13(4):414-20. Epub 2008 Oct 7. PubMed
PMID: 19017285.

8: Sokal EM, Goldstein D, Ciocca M, Lewindon P, Ni YH, Silveira T, Sibal A,
Dhawan A, Mack C, Bucuvalas J; End-Stage Liver Disease Working Group. End-stage
liver disease and liver transplant: current situation and key issues. J Pediatr
Gastroenterol Nutr. 2008 Aug;47(2):239-46. PubMed PMID: 18664882.

9: Lysy PA, Najimi M, Stephenne X, Bourgois A, Smets F, Sokal EM. Liver cell
transplantation for Crigler-Najjar syndrome type I: update and perspectives.
World J Gastroenterol. 2008 Jun 14;14(22):3464-70. Review. PubMed PMID: 18567072;
PubMed Central PMCID: PMC2716606.

10: Lysy PA, Smets F, Najimi M, Sokal EM. Leukemia inhibitory factor contributes
to hepatocyte-like differentiation of human bone marrow mesenchymal stem cells.
Differentiation. 2008 Dec;76(10):1057-67. Epub 2008 Jun 13. PubMed PMID:
18557762.

11: Jonas MM, Kelly D, Pollack H, Mizerski J, Sorbel J, Frederick D, Mondou E,
Rousseau F, Sokal E. Safety, efficacy, and pharmacokinetics of adefovir dipivoxil
in children and adolescents (age 2 to <18 years) with chronic hepatitis B.
Hepatology. 2008 Jun;47(6):1863-71. PubMed PMID: 18433023.

12: Strautnieks SS, Byrne JA, Pawlikowska L, Cebecauerová D, Rayner A, Dutton L,
Meier Y, Antoniou A, Stieger B, Arnell H, Ozçay F, Al-Hussaini HF, Bassas AF,
Verkade HJ, Fischler B, Németh A, Kotalová R, Shneider BL, Cielecka-Kuszyk J,
McClean P, Whitington PF, Sokal E, Jirsa M, Wali SH, Jankowska I, Pawłowska J,
Mieli-Vergani G, Knisely AS, Bull LN, Thompson RJ. Severe bile salt export pump
deficiency: 82 different ABCB11 mutations in 109 families. Gastroenterology. 2008
Apr;134(4):1203-14. Epub 2008 Jan 18. PubMed PMID: 18395098.

13: Gras JM, Gerkens S, Beguin C, Janssen M, Smets F, Otte JB, Sokal E, Reding R.
Steroid-free, tacrolimus-basiliximab immunosuppression in pediatric liver
transplantation: clinical and pharmacoeconomic study in 50 children. Liver
Transpl. 2008 Apr;14(4):469-77. PubMed PMID: 18383091.

14: Sokal EM, Kelly D, Wirth S, Mizerski J, Dhawan A, Frederick D. The
pharmacokinetics and safety of adefovir dipivoxil in children and adolescents
with chronic hepatitis B virus infection. J Clin Pharmacol. 2008 Apr;48(4):512-7.
Epub 2008 Feb 14. PubMed PMID: 18276803.

15: Campard D, Lysy PA, Najimi M, Sokal EM. Native umbilical cord matrix stem
cells express hepatic markers and differentiate into hepatocyte-like cells.
Gastroenterology. 2008 Mar;134(3):833-48. Epub 2007 Dec 23. PubMed PMID:
18243183.

16: Lysy PA, Campard D, Smets F, Najimi M, Sokal EM. Stem cells for liver tissue
repair: current knowledge and perspectives. World J Gastroenterol. 2008 Feb
14;14(6):864-75. Review. PubMed PMID: 18240343; PubMed Central PMCID: PMC2687053.

17: Lysy PA, Campard D, Smets F, Malaise J, Mourad M, Najimi M, Sokal EM.
Persistence of a chimerical phenotype after hepatocyte differentiation of human
bone marrow mesenchymal stem cells. Cell Prolif. 2008 Feb;41(1):36-58. PubMed
PMID: 18211285.

18: Sokal EM, Hoppenbrouwers K, Vandermeulen C, Moutschen M, Léonard P, Moreels
A, Haumont M, Bollen A, Smets F, Denis M. Recombinant gp350 vaccine for
infectious mononucleosis: a phase 2, randomized, double-blind, placebo-controlled
trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr
virus vaccine in healthy young adults. J Infect Dis. 2007 Dec 15;196(12):1749-53.
PubMed PMID: 18190254.

19: Smets F, Najimi M, Sokal EM. Cell transplantation in the treatment of liver
diseases. Pediatr Transplant. 2008 Feb;12(1):6-13. Review. PubMed PMID: 18186884.

20: Lysy PA, Sibille C, Gillerot Y, Smets F, Sokal EM. Partial proximal 10q
trisomy: a new case associated with biliary atresia. Hereditas. 2007
Nov;144(5):191-4. PubMed PMID: 18031353.

21: Najimi M, Khuu DN, Lysy PA, Jazouli N, Abarca J, Sempoux C, Sokal EM.
Adult-derived human liver mesenchymal-like cells as a potential progenitor
reservoir of hepatocytes? Cell Transplant. 2007;16(7):717-28. PubMed PMID:
18019361.

22: Baker A, Stevenson R, Dhawan A, Goncalves I, Socha P, Sokal E. Guidelines for
nutritional care for infants with cholestatic liver disease before liver
transplantation. Pediatr Transplant. 2007 Dec;11(8):825-34. Review. PubMed PMID:
17976116.

23: Lysy PA, Smets F, Sibille C, Najimi M, Sokal EM. Human skin fibroblasts: From
mesodermal to hepatocyte-like differentiation. Hepatology. 2007
Nov;46(5):1574-85. PubMed PMID: 17969047.

24: Stéphenne X, Najimi M, Ngoc DK, Smets F, Hue L, Guigas B, Sokal EM.
Cryopreservation of human hepatocytes alters the mitochondrial respiratory chain
complex 1. Cell Transplant. 2007;16(4):409-19. PubMed PMID: 17658131.

25: Smets F, Bourgois A, Vermylen C, Brichard B, Slacmuylders P, Leyman S, Sokal
E. Randomised revaccination with pneumococcal polysaccharide or conjugate vaccine
in asplenic children previously vaccinated with polysaccharide vaccine. Vaccine.
2007 Jul 20;25(29):5278-82. Epub 2007 Jun 4. PubMed PMID: 17576024.

26: Maystadt I, Rezsöhazy R, Barkats M, Duque S, Vannuffel P, Remacle S, Lambert
B, Najimi M, Sokal E, Munnich A, Viollet L, Verellen-Dumoulin C. The nuclear
factor kappaB-activator gene PLEKHG5 is mutated in a form of autosomal recessive
lower motor neuron disease with childhood onset. Am J Hum Genet. 2007
Jul;81(1):67-76. Epub 2007 May 16. PubMed PMID: 17564964; PubMed Central PMCID:
PMC1950913.

27: Moutschen M, Léonard P, Sokal EM, Smets F, Haumont M, Mazzu P, Bollen A,
Denamur F, Peeters P, Dubin G, Denis M. Phase I/II studies to evaluate safety and
immunogenicity of a recombinant gp350 Epstein-Barr virus vaccine in healthy
adults. Vaccine. 2007 Jun 11;25(24):4697-705. Epub 2007 Apr 18. PubMed PMID:
17485150.

28: Khuu DN, Najimi M, Sokal EM. Epithelial cells with hepatobiliary phenotype:
is it another stem cell candidate for healthy adult human liver? World J
Gastroenterol. 2007 Mar 14;13(10):1554-60. PubMed PMID: 17461448.

29: Stéphenne X, Vosters O, Najimi M, Beuneu C, Dung KN, Wijns W, Goldman M,
Sokal EM. Tissue factor-dependent procoagulant activity of isolated human
hepatocytes: relevance to liver cell transplantation. Liver Transpl. 2007
Apr;13(4):599-606. Erratum in: Liver Transpl. 2007 Jul;13(7):1070. PubMed PMID:
17394166.

30: Gras J, Wieërs G, Vaerman JL, Truong DQ, Sokal E, Otte JB, Délépaut B, Cornet
A, de Ville de Goyet J, Latinne D, Reding R. Early immunological monitoring after
pediatric liver transplantation: cytokine immune deviation and graft acceptance
in 40 recipients. Liver Transpl. 2007 Mar;13(3):426-33. PubMed PMID: 17318867.

31: Brunati A, Feruzi Z, Sokal E, Smets F, Fervaille C, Gosseye S, Clapuyt P, de
Ville de Goyet J, Reding R. Early occurrence of hepatocellular carcinoma in
biliary atresia treated by liver transplantation. Pediatr Transplant. 2007
Feb;11(1):117-9. PubMed PMID: 17239135.

32: Bourdeaux C, Darwish A, Jamart J, Tri TT, Janssen M, Lerut J, Otte JB, Sokal
E, de Ville de Goyet J, Reding R. Living-related versus deceased donor pediatric
liver transplantation: a multivariate analysis of technical and immunological
complications in 235 recipients. Am J Transplant. 2007 Feb;7(2):440-7. Epub 2006
Dec 6. PubMed PMID: 17173657.

33: Cutillo L, Najimi M, Smets F, Janssen M, Reding R, de Ville de Goyet J, Sokal
EM. Safety of living-related liver transplantation for progressive familial
intrahepatic cholestasis. Pediatr Transplant. 2006 Aug;10(5):570-4. PubMed PMID:
16856993.

34: Sokal EM. Liver transplantation for inborn errors of liver metabolism. J
Inherit Metab Dis. 2006 Apr-Jun;29(2-3):426-30. PubMed PMID: 16763913.

35: Nussler A, Konig S, Ott M, Sokal E, Christ B, Thasler W, Brulport M, Gabelein
G, Schormann W, Schulze M, Ellis E, Kraemer M, Nocken F, Fleig W, Manns M, Strom
SC, Hengstler JG. Present status and perspectives of cell-based therapies for
liver diseases. J Hepatol. 2006 Jul;45(1):144-59. Epub 2006 Apr 27. Review.
PubMed PMID: 16730092.

36: Buts JP, Dekeyser N, Stilmant C, Delem E, Smets F, Sokal E. Saccharomyces
boulardii produces in rat small intestine a novel protein phosphatase that
inhibits Escherichia coli endotoxin by dephosphorylation. Pediatr Res. 2006
Jul;60(1):24-9. Epub 2006 May 11. PubMed PMID: 16690953.

37: Darwish AA, Bourdeaux C, Kader HA, Janssen M, Sokal E, Lerut J, Ciccarelli O,
Veyckemans F, Otte JB, de Goyet Jde V, Reding R. Pediatric liver transplantation
using left hepatic segments from living related donors: surgical experience in
100 recipients at Saint-Luc University Clinics. Pediatr Transplant. 2006
May;10(3):345-53. PubMed PMID: 16677359.

38: De Kerckhove L, De Meyer M, Verbaandert C, Mourad M, Sokal E, Goffette P,
Geubel A, Karam V, Adam R, Lerut J. The place of liver transplantation in
Caroli's disease and syndrome. Transpl Int. 2006 May;19(5):381-8. PubMed PMID:
16623873.

39: Stéphenne X, Najimi M, Sibille C, Nassogne MC, Smets F, Sokal EM. Sustained
engraftment and tissue enzyme activity after liver cell transplantation for
argininosuccinate lyase deficiency. Gastroenterology. 2006 Apr;130(4):1317-23.
PubMed PMID: 16618422.

40: Sokal EM, Kelly DA, Mizerski J, Badia IB, Areias JA, Schwarz KB, Vegnente A,
Little NR, Gardener SD, Jonas MM. Long-term lamivudine therapy for children with
HBeAg-positive chronic hepatitis B. Hepatology. 2006 Feb;43(2):225-32. PubMed
PMID: 16440364.

41: Sokal EM. Introduction: liver and liver cell transplantation for inborn
errors of liver metabolism. Acta Gastroenterol Belg. 2005 Oct-Dec;68(4):451-2.
PubMed PMID: 16433001.

42: Stephenne X, Najimi M, Janssen M, Reding R, de Ville de Goyet J, Sokal EM.
Liver allograft radiotherapy to treat rejection in children: efficacy in
orthotopic liver transplantation and long-term safety. Liver Int. 2005
Dec;25(6):1108-13. PubMed PMID: 16343059.

43: Reding R, Gras J, Bourdeaux C, Wieers G, Truong QD, Latinne D, Sokal E,
Janssen M, Lerut J, Otte JB, de Ville de Goyet J. Stepwise minimization of the
immunosuppressive therapy in pediatric liver transplantation. A conceptual
approach towards operational tolerance. Acta Gastroenterol Belg. 2005
Jul-Sep;68(3):320-2. PubMed PMID: 16268418.

44: Najimi M, Sokal E. Liver cell transplantation. Minerva Pediatr. 2005
Oct;57(5):243-57. Review. PubMed PMID: 16205608.

45: Pawłowska J, Sokal E, Jankowska I, Teisseyre M, Rokitka M, Socha J.
[Complications in a patient with liver cirrhosis and HCV coinfection during
treatment with peginterferon and ribavirin]. Przegl Epidemiol. 2005;59(2):605-9.
Polish. PubMed PMID: 16190573.

46: Roberton D, Marshall H, Nolan TM, Sokal E, Díez-Domingo J, Flodmark CE, Rombo
L, Lewald G, Flor Jde L, Casanovas JM, Verdaguer J, Marés J, Esso DV, Dieussaert
I, Stoffel M. Reactogenicity and immunogenicity profile of a two-dose combined
hepatitis A and B vaccine in 1-11-year-old children. Vaccine. 2005 Oct
17;23(43):5099-105. PubMed PMID: 16055231.

47: Rombaux P, Marque A, Hamoir M, Smets F, Sokal E. Post-transplant
lymphoproliferative disorder with supraglottic involvement. B-ENT.
2005;1(1):53-6. PubMed PMID: 15999677.

48: Stéphenne X, Najimi M, Smets F, Reding R, de Ville de Goyet J, Sokal EM.
Cryopreserved liver cell transplantation controls ornithine transcarbamylase
deficient patient while awaiting liver transplantation. Am J Transplant. 2005
Aug;5(8):2058-61. PubMed PMID: 15996260.

49: Van Maldergem L, Moser AB, Vincent MF, Roland D, Reding R, Otte JB, Wanders
RJ, Sokal E. Orthotopic liver transplantation from a living-related donor in an
infant with a peroxisome biogenesis defect of the infantile Refsum disease type.
J Inherit Metab Dis. 2005;28(4):593-600. PubMed PMID: 15902563.

50: Bourdeaux C, Tri TT, Gras J, Sokal E, Otte JB, de Ville de Goyet J, Reding R.
PELD score and posttransplant outcome in pediatric liver transplantation: a
retrospective study of 100 recipients. Transplantation. 2005 May 15;79(9):1273-6.
PubMed PMID: 15880084.

51: Dhawan A, Ferenci P, Geubel A, Houwen R, Lerut J, Sokal E. Genes and metals:
a deadly combination. Acta Gastroenterol Belg. 2005 Jan-Mar;68(1):26-32. Review.
PubMed PMID: 15832584.

52: Scheers I, Bachy V, Stephenne X, Sokal EM. Risk of hepatocellular carcinoma
in liver mitochondrial respiratory chain disorders. J Pediatr. 2005
Mar;146(3):414-7. PubMed PMID: 15756232.

53: Wanty C, Joomye R, Van Hoorebeek N, Paul K, Otte JB, Reding R, Sokal EM.
Fifteen years single center experience in the management of progressive familial
intrahepatic cholestasis of infancy. Acta Gastroenterol Belg. 2004
Oct-Dec;67(4):313-9. PubMed PMID: 15727074.

54: Vo Thi Diem H, Bourgois A, Bontems P, Goyens P, Buts JP, Nackers F, Tonglet
R, Sokal EM. Chronic hepatitis B infection: long term comparison of children
receiving interferon alpha and untreated controls. J Pediatr Gastroenterol Nutr.
2005 Feb;40(2):141-5. PubMed PMID: 15699686.

55: Theeten H, Van Damme P, Hoppenbrouwers K, Vandermeulen C, Leback E, Sokal EM,
Wolter J, Schuerman L. Effects of lowering the aluminium content of a dTpa
vaccine on its immunogenicity and reactogenicity when given as a booster to
adolescents. Vaccine. 2005 Feb 10;23(12):1515-21. PubMed PMID: 15670888.

56: Lamireau T, Cézard JP, Dabadie A, Goulet O, Lachaux A, Turck D, Maurage C,
Morali A, Sokal E, Belli D, Stoller J, Cadranel S, Ginies JL, Viola S, Huet F,
Languepin J, Lenaerts C, Bury F, Sarles J; French-Speaking Group for Pediatric
Gastroenterology Nutrition. Efficacy and tolerance of infliximab in children and
adolescents with Crohn's disease. Inflamm Bowel Dis. 2004 Nov;10(6):745-50.
PubMed PMID: 15626892.

57: Najimi M, Sokal E. Update on liver cell transplantation. J Pediatr
Gastroenterol Nutr. 2004 Oct;39(4):311-9. Review. PubMed PMID: 15448415.

58: Darwish AA, Sokal E, Stephenne X, Najimi M, de Goyet Jde V, Reding R.
Permanent access to the portal system for cellular transplantation using an
implantable port device. Liver Transpl. 2004 Sep;10(9):1213-5. PubMed PMID:
15350017.

59: Reding R, Bourdeaux C, Gras J, Evrard V, Buts JP, Carlier M, Ciccarelli O,
Clapuyt P, de Clety SC, De Kock M, Hermans D, Janssen M, Moulin D, Rahier J,
Saint-Martin C, Sempoux C, Van Obbergh L, Veyckemans F, Lerut J, de Ville de
Goyet J, Sokal E, Otte JB. The paediatric liver transplantation program at the
Université catholique de Louvain. Acta Gastroenterol Belg. 2004
Apr-Jun;67(2):176-8. PubMed PMID: 15285574.

60: Vanderborght M, Nassogne MC, Hermans D, Moniotte S, Seneca S, Van Coster R,
Buts JP, Sokal EM. Intractable ulcerative colitis of infancy in a child with
mitochondrial respiratory chain disorder. J Pediatr Gastroenterol Nutr. 2004
Mar;38(3):355-7. PubMed PMID: 15076640.

61: Evrard V, Otte JB, Sokal E, Rochet JS, Haccourt F, Gennari F, Latinne D,
Jamart J, Reding R. Impact of surgical and immunological parameters in pediatric
liver transplantation: a multivariate analysis in 500 consecutive recipients of
primary grafts. Ann Surg. 2004 Feb;239(2):272-80. PubMed PMID: 14745337; PubMed
Central PMCID: PMC1356222.

62: Reding R, Gras J, Sokal E, Otte JB, Davies HF. Steroid-free liver
transplantation in children. Lancet. 2003 Dec 20;362(9401):2068-70. PubMed PMID:
14697809.

63: Sokal EM, Smets F, Bourgois A, Van Maldergem L, Buts JP, Reding R, Bernard
Otte J, Evrard V, Latinne D, Vincent MF, Moser A, Soriano HE. Hepatocyte
transplantation in a 4-year-old girl with peroxisomal biogenesis disease:
technique, safety, and metabolic follow-up. Transplantation. 2003 Aug
27;76(4):735-8. PubMed PMID: 12973120.

64: Lerut JP, Ciccarelli O, Sempoux C, Danse E, deFlandre J, Horsmans Y, Sokal E,
Otte JB. Glycogenosis storage type I diseases and evolutive adenomatosis: an
indication for liver transplantation. Transpl Int. 2003 Dec;16(12):879-84. Epub
2003 Aug 7. PubMed PMID: 12904843.

65: Hermans D, Sokal EM, Collard JM, Romagnoli R, Buts JP. Primary duodenogastric
reflux in children and adolescents. Eur J Pediatr. 2003 Sep;162(9):598-602. Epub
2003 Jun 26. PubMed PMID: 12836018.

66: Diem HV, Evrard V, Vinh HT, Sokal EM, Janssen M, Otte JB, Reding R. Pediatric
liver transplantation for biliary atresia: results of primary grafts in 328
recipients. Transplantation. 2003 May 27;75(10):1692-7. PubMed PMID: 12777858.

67: Diem HV, Sokal EM, Janssen M, Otte JB, Reding R. Steroid withdrawal after
pediatric liver transplantation: a long-term follow-up study in 109 recipients.
Transplantation. 2003 May 27;75(10):1664-70. PubMed PMID: 12777853.

68: Jara P, Resti M, Hierro L, Giacchino R, Barbera C, Zancan L, Crivellaro C,
Sokal E, Azzari C, Guido M, Bortolotti F. Chronic hepatitis C virus infection in
childhood: clinical patterns and evolution in 224 white children. Clin Infect
Dis. 2003 Feb 1;36(3):275-80. Epub 2003 Jan 14. PubMed PMID: 12539067.

69: Huppert PE, Goffette P, Astfalk W, Sokal EM, Brambs HJ, Schott U, Duda SH,
Schweizer P, Claussen CD. Transjugular intrahepatic portosystemic shunts in
children with biliary atresia. Cardiovasc Intervent Radiol. 2002
Nov-Dec;25(6):484-93. Epub 2002 Nov 6. PubMed PMID: 12415417.

70: Nadal D, Leverger G, Sokal EM, Floret D, Perel Y, Leibundgut K, Weller S. An
investigation of the steady-state pharmacokinetics of oral valacyclovir in
immunocompromised children. J Infect Dis. 2002 Oct 15;186 Suppl 1:S123-30. PubMed
PMID: 12353197.

71: Wallot MA, Klepper J, Clapuyt P, Dirsch O, Malagó M, Reding R, Otte JB, Sokal
EM. Repeated detection of gas in the portal vein after liver transplantation: A
sign of EBV-associated post-transplant lymphoproliferation? Pediatr Transplant.
2002 Aug;6(4):332-6. PubMed PMID: 12234275.

72: Smets F, Sokal EM. Epstein-Barr virus-related lymphoproliferation in children
after liver transplant: role of immunity, diagnosis, and management. Pediatr
Transplant. 2002 Aug;6(4):280-7. Review. PubMed PMID: 12234267.

73: Wang LJ, Chen YM, George D, Smets F, Sokal EM, Bremer EG, Soriano HE.
Engraftment assessment in human and mouse liver tissue after sex-mismatched liver
cell transplantation by real-time quantitative PCR for Y chromosome sequences.
Liver Transpl. 2002 Sep;8(9):822-8. PubMed PMID: 12200785.

74: Sokal EM, Cleghorn G, Goulet O, Da Silveira TR, McDiarmid S, Whitington P.
Liver and intestinal transplantation in children: Working Group Report of the
First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J
Pediatr Gastroenterol Nutr. 2002;35 Suppl 2:S159-72. PubMed PMID: 12192185.

75: Marandi S, De Keyser N, Stilmant C, Saliez A, Sokal EM, Guiot Y, Buts JP.
Ontogeny of MAP kinases in rat small intestine: premature stimulation by insulin
of BBM hydrolases is regulated by ERKs but not by p-38 MAP kinase. Pediatr Res.
2002 Aug;52(2):180-8. PubMed PMID: 12149494.

76: Stephenne X, Sokal EM. Hepatitis C in children and adolescents: mode of
acquisition, natural history and treatment. Acta Gastroenterol Belg. 2002
Apr-Jun;65(2):95-8. Review. PubMed PMID: 12148447.

77: Wallot MA, Mathot M, Janssen M, Hölter T, Paul K, Buts JP, Reding R, Otte JB,
Sokal EM. Long-term survival and late graft loss in pediatric liver transplant
recipients--a 15-year single-center experience. Liver Transpl. 2002
Jul;8(7):615-22. PubMed PMID: 12089716.

78: Smets F, Sokal EM. Lymphoproliferation in children after liver
transplantation. J Pediatr Gastroenterol Nutr. 2002 May;34(5):499-505. Review.
PubMed PMID: 12050573.

79: Smets F, Latinne D, Bazin H, Reding R, Otte JB, Buts JP, Sokal EM. Ratio
between Epstein-Barr viral load and anti-Epstein-Barr virus specific T-cell
response as a predictive marker of posttransplant lymphoproliferative disease.
Transplantation. 2002 May 27;73(10):1603-10. PubMed PMID: 12042647.

80: Sokal E. Drug treatment of pediatric chronic hepatitis B. Paediatr Drugs.
2002;4(6):361-9. Review. PubMed PMID: 12038872.

81: Jonas MM, Mizerski J, Badia IB, Areias JA, Schwarz KB, Little NR, Greensmith
MJ, Gardner SD, Bell MS, Sokal EM; International Pediatric Lamivudine
Investigator Group. Clinical trial of lamivudine in children with chronic
hepatitis B. N Engl J Med. 2002 May 30;346(22):1706-13. Erratum in: N Engl J Med
2002 Sep 19;347(12):955. Kelley, Deirdre [corrected to Kelly, Deirdre]. PubMed
PMID: 12037150.

82: Reding R, Sokal E, Paul K, Janssen M, Evrard V, Wilmotte L, Chardot C, Otte
JB, Wallemacq P. Efficacy and pharmacokinetics of tacrolimus oral suspension in
pediatric liver transplant recipients. Pediatr Transplant. 2002 Apr;6(2):124-6.
PubMed PMID: 12000467.

83: Sokal E. [Hepatitis B in children: natural history and therapy]. Bull Mem
Acad R Med Belg. 2001;156(7-9):367-75; discussion 375-6. French. PubMed PMID:
11995183.

84: Buts JP, De Keyser N, Stilmant C, Sokal E, Marandi S. Saccharomyces boulardii
enhances N-terminal peptide hydrolysis in suckling rat small intestine by
endoluminal release of a zinc-binding metalloprotease. Pediatr Res. 2002
Apr;51(4):528-34. PubMed PMID: 11919341.

85: Nchimi A, Khamis J, Langhendries JP, Clapuyt P, Saint Martin C, Sokal E,
Reding R. [Diagnosis and follow-up of a large intrahepatic portocaval fistula in
a newborn]. J Radiol. 2001 Nov;82(11):1642-4. French. PubMed PMID: 11894551.

86: Sokal E. Lamivudine for the treatment of chronic hepatitis B. Expert Opin
Pharmacother. 2002 Mar;3(3):329-39. Review. PubMed PMID: 11866682.

87: Nouwen J, Smets F, Rombaux P, Hamoir M, Sokal EM. Acute tonsillitis as the
first manifestation of post-transplant lymphoproliferative disorder. Ann Otol
Rhinol Laryngol. 2002 Feb;111(2):165-8. PubMed PMID: 11860070.

88: Chardot C, Saint Martin C, Gilles A, Brichard B, Janssen M, Sokal E, Clapuyt
P, Lerut J, Reding R, Otte JB. Living-related liver transplantation and vena cava
reconstruction after total hepatectomy including the vena cava for
hepatoblastoma. Transplantation. 2002 Jan 15;73(1):90-2. PubMed PMID: 11792985.

89: Lacaille F, Sokal E. Living-related liver transplantation. J Pediatr
Gastroenterol Nutr. 2001 Oct;33(4):431-8. Review. PubMed PMID: 11698758.

90: Brichard B, Smets F, Sokal E, Clapuyt P, Vermylen C, Cornu G, Rahier J, Otte
JB. Unusual evolution of an Epstein-Barr virus-associated leiomyosarcoma
occurring after liver transplantation. Pediatr Transplant. 2001 Oct;5(5):365-9.
PubMed PMID: 11560757.

91: Ovaert C, Germeau C, Barrea C, Moniotte S, Van Obbergh L, Sokal E, Reding R,
Otte JB, Sluysmans T. Elevated right ventricular pressures are not a
contraindication to liver transplantation in Alagille syndrome. Transplantation.
2001 Jul 27;72(2):345-7. PubMed PMID: 11477367.

92: Shapira R, Mor E, Bar-Nathan N, Sokal EM, Tur-Kaspa R, Dinari G, Ben-Ari Z.
Efficacy of lamivudine for the treatment of hepatitis B virus infection after
liver transplantation in children. Transplantation. 2001 Jul 27;72(2):333-6.
PubMed PMID: 11477362.

93: Andries S, Casamayou L, Sempoux C, Burlet M, Reding R, Bernard Otte J, Buts
JP, Sokal E. Posttransplant immune hepatitis in pediatric liver transplant
recipients: incidence and maintenance therapy with azathioprine. Transplantation.
2001 Jul 27;72(2):267-72. PubMed PMID: 11477351.

94: Liu HF, Sokal E, Goubau P. Wide variety of genotypes and geographic origins
of hepatitis B virus in Belgian children. J Pediatr Gastroenterol Nutr. 2001
Mar;32(3):274-7. PubMed PMID: 11345175.

95: Lerut JP, Ciccarelli O, Roggen FM, Reding R, Laterre PF, Lengele B, Janssen
M, Chardot C, Clement de Clety S, Danse E, Goffette P, Matterne R, Sokal E,
Horsmans Y, Otte JB. Adult-to-adult living related liver transplantation: initial
experience. Acta Gastroenterol Belg. 2001 Jan-Mar;64(1):9-14. PubMed PMID:
11322066.

96: Jacquemin E, De Vree JM, Cresteil D, Sokal EM, Sturm E, Dumont M, Scheffer
GL, Paul M, Burdelski M, Bosma PJ, Bernard O, Hadchouel M, Elferink RP. The wide
spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to
cirrhosis of adulthood. Gastroenterology. 2001 May;120(6):1448-58. PubMed PMID:
11313315.

97: Reding R, Chardot C, Paul K, Veyckemans F, Van Obbergh L, De Clety SC,
Detaille T, Clapuyt P, Saint-Martin C, Janssen M, Lerut J, Sokal E, Otte JB.
Living-related liver transplantation in children at Saint-Luc University Clinics:
a seven year experience in 77 recipients. Acta Chir Belg. 2001
Jan-Feb;101(1):17-9. PubMed PMID: 11301941.

98: Comanor L, Minor J, Conjeevaram HS, Roberts EA, Alvarez F, Bern EM, Goyens P,
Rosenthal P, Lachaux A, Shelton M, Sarles J, Sokal EM. Impact of chronic
hepatitis B and interferon-alpha therapy on growth of children. J Viral Hepat.
2001 Mar;8(2):139-47. PubMed PMID: 11264734.

99: Chardot C, Nicoluzzi JE, Janssen M, Sokal E, Lerut J, Otte JB, Reding R. Use
of mycophenolate mofetil as rescue therapy after pediatric liver transplantation.
Transplantation. 2001 Jan 27;71(2):224-9. PubMed PMID: 11213063.

100: Marandi S, De Keyser N, Saliez A, Maernoudt AS, Sokal EM, Stilmant C, Rider
MH, Buts JP. Insulin signal transduction in rat small intestine: role of MAP
kinases in expression of mucosal hydrolases. Am J Physiol Gastrointest Liver
Physiol. 2001 Feb;280(2):G229-40. PubMed PMID: 11208545.

101: Smets F, Vajro P, Cornu G, Reding R, Otte JB, Sokal E. Indications and
results of chemotherapy in children with posttransplant lymphoproliferative
disease after liver transplantation. Transplantation. 2000 Mar 15;69(5):982-4.
PubMed PMID: 10755561.

102: Vajro P, DeVincenzo A, Lucariello S, Migliaro F, Sokal E, Bernard O, Vilei
T, Muraca M. Unusual early presentation of Gilbert syndrome in pediatric
recipients of liver transplantation. J Pediatr Gastroenterol Nutr. 2000
Sep;31(3):238-43. PubMed PMID: 10997365.

103: Vajro P, Lucariello S, Migliaro F, Sokal E, Gridelli B, Vegnente A, Iorio R,
Smets F, Quinto I, Scala G. Predictive value of Epstein-Barr virus genome copy
number and BZLF1 expression in blood lymphocytes of transplant recipients at risk
for lymphoproliferative disease. J Infect Dis. 2000 Jun;181(6):2050-4. Epub 2000
Jun 5. PubMed PMID: 10837191.

104: Comanor L, Minor J, Conjeevaram HS, Roberts EA, Alvarez F, Bern EM, Goyens
P, Rosenthal P, Lachaux A, Shelton M, Sarles J, Sokal EM. Statistical models for
predicting response to interferon-alpha and spontaneous seroconversion in
children with chronic hepatitis B. J Viral Hepat. 2000 Mar;7(2):144-52. PubMed
PMID: 10760045.

105: Sokal EM, Roberts EA, Mieli-Vergani G, McPhillips P, Johnson M, Barber J,
Dallow N, Boxall E, Kelly D. A dose ranging study of the pharmacokinetics,
safety, and preliminary efficacy of lamivudine in children and adolescents with
chronic hepatitis B. Antimicrob Agents Chemother. 2000 Mar;44(3):590-7. PubMed
PMID: 10681323; PubMed Central PMCID: PMC89731.

106: Silva ES, Lumbroso S, Medina M, Gillerot Y, Sultan C, Sokal EM.
Demonstration of McCune-Albright mutations in the liver of children with high
gammaGT progressive cholestasis. J Hepatol. 2000 Jan;32(1):154-8. PubMed PMID:
10673080.

107: Smets F, Bodeus M, Goubau P, Reding R, Otte JB, Buts JP, Sokal EM.
Characteristics of Epstein-Barr virus primary infection in pediatric liver
transplant recipients. J Hepatol. 2000 Jan;32(1):100-4. PubMed PMID: 10673073.

108: Campos M, Jouzdani E, Sempoux C, Buts JP, Reding R, Otte JB, Sokal EM.
Sclerosing cholangitis associated to cryptosporidiosis in liver-transplanted
children. Eur J Pediatr. 2000 Jan-Feb;159(1-2):113-5. PubMed PMID: 10653343.

109: Sokal EM, Sokol R, Cormier V, Lacaille F, McKiernan P, Van Spronsen FJ,
Bernard O, Saudubray JM. Liver transplantation in mitochondrial respiratory chain
disorders. Eur J Pediatr. 1999 Dec;158 Suppl 2:S81-4. PubMed PMID: 10603105.

110: Jansen PL, Strautnieks SS, Jacquemin E, Hadchouel M, Sokal EM, Hooiveld GJ,
Koning JH, De Jager-Krikken A, Kuipers F, Stellaard F, Bijleveld CM, Gouw A, Van
Goor H, Thompson RJ, Müller M. Hepatocanalicular bile salt export pump deficiency
in patients with progressive familial intrahepatic cholestasis. Gastroenterology.
1999 Dec;117(6):1370-9. PubMed PMID: 10579978.

111: Png K, Veyckemans F, De Kock M, Carlier M, Sluysmans T, Otte JB, Reding R,
Clement de Clety S, Sokal E, Van Obbergh L. Hemodynamic changes in patients with
Alagille's syndrome during orthotopic liver transplantation. Anesth Analg. 1999
Nov;89(5):1137-42. PubMed PMID: 10553824.

112: Sokal EM, Bortolotti F. Update on prevention and treatment of viral
hepatitis in children. Curr Opin Pediatr. 1999 Oct;11(5):384-9. Review. PubMed
PMID: 10555588.

113: Otte JB, Reding R, de Ville de Goyet J, Sokal E, Lerut J, Janssen M, Rosati
R, Hayez JY, Libert F, Paul K, Latinne D. Experience with living related liver
transplantation in 63 children. Acta Gastroenterol Belg. 1999
Jul-Sep;62(3):355-62. PubMed PMID: 10547903.

114: de Ville de Goyet J, Reding R, Lerut J, Sokal E, Janssen M, Otte JB.
Paediatric orthotopic liver transplantation: lessons from a 532 transplant single
centre experience with 532 transplants in 446 children. Acta Gastroenterol Belg.
1999 Jul-Sep;62(3):290-4. PubMed PMID: 10547894.

115: Reding R, Gennari F, Janssen M, Jamart J, de Ville de Goyet J, Lerut J,
Sokal E, Otte JB. The pediatric liver transplant program at the Université
Catholique de Louvain, Cliniques Saint-Luc, Brussels: overall results in 444
children (1984-1997). Acta Gastroenterol Belg. 1999 Jul-Sep;62(3):285-9. PubMed
PMID: 10547893.

116: de Ville de Goyet J, Alberti D, Falchetti D, Rigamonti W, Matricardi L,
Clapuyt P, Sokal EM, Otte JB, Caccia G. Treatment of extrahepatic portal
hypertension in children by mesenteric-to-left portal vein bypass: a new
physiological procedure. Eur J Surg. 1999 Aug;165(8):777-81. PubMed PMID:
10494645.

117: Bodéus M, Smets F, Reding R, Sokal E, Otte JB, Goubau P, Van Renterghem L.
Epstein-Barr virus infection in sixty pediatric liver graft recipients: diagnosis
of primary infection and virologic follow-up. Pediatr Infect Dis J. 1999
Aug;18(8):698-702. PubMed PMID: 10462339.

118: Buts JP, De Keyser N, Marandi S, Hermans D, Sokal EM, Chae YH, Lambotte L,
Chanteux H, Tulkens PM. Saccharomyces boulardii upgrades cellular adaptation
after proximal enterectomy in rats. Gut. 1999 Jul;45(1):89-96. PubMed PMID:
10369710; PubMed Central PMCID: PMC1727579.

119: Maes M, Sokal E, Otte JB. Growth factors in children with end-stage liver
disease before and after liver transplantation: a review. Pediatr Transplant.
1997 Nov;1(2):171-5. Review. PubMed PMID: 10084777.

120: Reding R, de Goyet Jde V, Delbeke I, Sokal E, Jamart J, Janssen M, Otte JB.
Pediatric liver transplantation with cadaveric or living related donors:
comparative results in 90 elective recipients of primary grafts. J Pediatr. 1999
Mar;134(3):280-6. PubMed PMID: 10064662.

121: Sokal EM, Melchior M, Cornu C, Vandenbroucke AT, Buts JP, Cohen BJ,
Burtonboy G. Acute parvovirus B19 infection associated with fulminant hepatitis
of favourable prognosis in young children. Lancet. 1998 Nov 28;352(9142):1739-41.
PubMed PMID: 9848349.

122: Wallemacq PE, Furlan V, Möller A, Schäfer A, Stadler P, Firdaous I, Taburet
AM, Reding R, Clement De Clety S, De Ville De Goyet J, Sokal E, Lykavieris L, Van
Leeuw V, Bernard O, Otte JB, Undre NA. Pharmacokinetics of tacrolimus (FK506) in
paediatric liver transplant recipients. Eur J Drug Metab Pharmacokinet. 1998
Jul-Sep;23(3):367-70. PubMed PMID: 9842978.

123: Strautnieks SS, Bull LN, Knisely AS, Kocoshis SA, Dahl N, Arnell H, Sokal E,
Dahan K, Childs S, Ling V, Tanner MS, Kagalwalla AF, Németh A, Pawlowska J, Baker
A, Mieli-Vergani G, Freimer NB, Gardiner RM, Thompson RJ. A gene encoding a
liver-specific ABC transporter is mutated in progressive familial intrahepatic
cholestasis. Nat Genet. 1998 Nov;20(3):233-8. PubMed PMID: 9806540.

124: Alberti D, Reding R, Otte JB, Falchetti D, Rigamonti W, Caccia G, Sokal E,
de Ville de Goyet J. Conversion from tacrolimus to microemulsion formulation of
cyclosporine in pediatric liver transplantation. Transplant Proc. 1998
Aug;30(5):1858-60. PubMed PMID: 9723310.

125: Trindade E, Maton P, Reding R, de Ville de Goyet J, Otte JB, Buts JP, Sokal
EM. Use of granulocyte macrophage colony stimulating factor in children after
orthotopic liver transplantation. J Hepatol. 1998 Jun;28(6):1054-7. PubMed PMID:
9672183.

126: Materne R, Clapuyt P, Saint-Martin C, Jespers S, Barrea C, de Ville de Goyet
J, Gosseye S, Sokal E. Gastric cystic duplication communicating with a bifid
pancreas: a rare cause of recurrent pancreatis. J Pediatr Gastroenterol Nutr.
1998 Jul;27(1):102-5. PubMed PMID: 9669736.

127: Sokal EM. Viral hepatitis throughout infancy to adulthood. Acta
Gastroenterol Belg. 1998 Apr-Jun;61(2):170-4. Review. PubMed PMID: 9658601.

128: Otte JB, de Ville de Goyet J, Reding R, Van Obbergh L, Veyckemans F, Carlier
MA, De Kock M, Clement de Clety S, Clapuyt P, Sokal E, Lerut J, Delbeke I,
Dierick V, Janssen M, Rosati R, Libert F. Pediatric liver transplantation: from
the full-size liver graft to reduced, split, and living related liver
transplantation. Pediatr Surg Int. 1998 Jul;13(5-6):308-18. Review. PubMed PMID:
9639606.

129: Sokal EM, Conjeevaram HS, Roberts EA, Alvarez F, Bern EM, Goyens P,
Rosenthal P, Lachaux A, Shelton M, Sarles J, Hoofnagle J. Interferon alfa therapy
for chronic hepatitis B in children: a multinational randomized controlled trial.
Gastroenterology. 1998 May;114(5):988-95. PubMed PMID: 9558288.

130: Buts JP, Duranton B, De Keyser N, Sokal EM, Maernhout AS, Raul F, Marandi S.
Premature stimulation of rat sucrase-isomaltase (SI) by exogenous insulin and the
analog B-Asp10 is regulated by a receptor-mediated signal triggering SI gene
transcription. Pediatr Res. 1998 May;43(5):585-91. PubMed PMID: 9585003.

131: de Ville de Goyet J, Alberti D, Clapuyt P, Falchetti D, Rigamonti V, Bax NM,
Otte JB, Sokal EM. Direct bypassing of extrahepatic portal venous obstruction in
children: a new technique for combined hepatic portal revascularization and
treatment of extrahepatic portal hypertension. J Pediatr Surg. 1998
Apr;33(4):597-601. PubMed PMID: 9574759.

132: de Ville de Goyet J, Struye de Swielande Y, Reding R, Sokal EM, Otte JB.
Delayed primary closure of the abdominal wall after cadaveric and living related
donor liver graft transplantation in children: a safe and useful technique.
Transpl Int. 1998;11(2):117-22. PubMed PMID: 9561677.

133: de Repentigny L, Ratelle J, Leclerc JM, Cornu G, Sokal EM, Jacqmin P, De
Beule K. Repeated-dose pharmacokinetics of an oral solution of itraconazole in
infants and children. Antimicrob Agents Chemother. 1998 Feb;42(2):404-8. PubMed
PMID: 9527794; PubMed Central PMCID: PMC105422.

134: Reding R, Wallemacq P, Moulin D, Manicourt D, Lambotte L, Jamart J, Sokal E,
de Ville de Goyet J, Otte JB. Early hepatocyte, endothelial, and bile duct cell
injury after pediatric liver transplantation from cadaveric or living-related
donors. Transplantation. 1998 Mar 15;65(5):681-5. PubMed PMID: 9521203.

135: Sokal EM, Antunes H, Beguin C, Bodeus M, Wallemacq P, de Ville de Goyet J,
Reding R, Janssen M, Buts JP, Otte JB. Early signs and risk factors for the
increased incidence of Epstein-Barr virus-related posttransplant
lymphoproliferative diseases in pediatric liver transplant recipients treated
with tacrolimus. Transplantation. 1997 Nov 27;64(10):1438-42. PubMed PMID:
9392308.

136: Reding R, de Ville de Goyet J, Gosseye S, Clapuyt P, Sokal E, Buts JP, Gibbs
P, Otte JB. Hirschsprung's disease: a 20-year experience. J Pediatr Surg. 1997
Aug;32(8):1221-5. PubMed PMID: 9269974.

137: Buts JP, De Keyser N, Sokal EM, Marandi S. Oral insulin is biologically
active on rat immature enterocytes. J Pediatr Gastroenterol Nutr. 1997
Aug;25(2):230-2. PubMed PMID: 9252916.

138: Buts JP, De Keyser N, Marandi S, Maernoudt AS, Sokal EM, Rahier J, Hermans
D. Expression of insulin receptors and of 60-kDa receptor substrate in rat mature
and immature enterocytes. Am J Physiol. 1997 Jul;273(1 Pt 1):G217-26. PubMed
PMID: 9252529.

139: Jacquemin E, Hermans D, Myara A, Habes D, Debray D, Hadchouel M, Sokal EM,
Bernard O. Ursodeoxycholic acid therapy in pediatric patients with progressive
familial intrahepatic cholestasis. Hepatology. 1997 Mar;25(3):519-23. PubMed
PMID: 9049190.

140: Verloes A, Lombet J, Lambert Y, Hubert AF, Deprez M, Fridman V, Gosseye S,
Rigo J, Sokal E. Tricho-hepato-enteric syndrome: further delineation of a
distinct syndrome with neonatal hemochromatosis phenotype, intractable diarrhea,
and hair anomalies. Am J Med Genet. 1997 Feb 11;68(4):391-5. PubMed PMID:
9021008.

141: Wallemacq PE, Reding R, Sokal EM, de Ville de Goyet J, Clement de Clety S,
Van Leeuw V, De Backer M, Otte JB. Clinical pharmacokinetics of Neoral in
pediatric recipients of primary liver transplants. Transpl Int.
1997;10(6):466-70. PubMed PMID: 9428122.

142: de Ville de Goyet J, Reding R, Sokal E, Otte JB. [Related living donor for
liver transplantation in children: results and impact]. Chirurgie.
1997;122(2):83-7. French. PubMed PMID: 9238797.

143: Buts JP, De Keyser N, Collette E, Bonsignore M, Lambotte L, Desjeux JF,
Sokal EM. Intestinal transport of calcium in rat biliary cirrhosis. Pediatr Res.
1996 Oct;40(4):533-41. PubMed PMID: 8888279.

144: Otte JB, de Ville de Goyet J, Reding R, Sokal E, Lerut J, Vanormelingen P,
Janssen M. Living related donor liver transplantation in children: the Brussels
experience. Transplant Proc. 1996 Aug;28(4):2378-9. PubMed PMID: 8769257.

145: de Ville de Goyet J, Gibbs P, Clapuyt P, Reding R, Sokal EM, Otte JB.
Original extrahilar approach for hepatic portal revascularization and relief of
extrahepatic portal hypertension related to later portal vein thrombosis after
pediatric liver transplantation. Long term results. Transplantation. 1996 Jul
15;62(1):71-5. PubMed PMID: 8693549.

146: Sokal EM, Baudoux MC, Collette E, Hausleithner V, Lambotte L, Buts JP.
Branched chain amino acids improve body composition and nitrogen balance in a rat
model of extra hepatic biliary atresia. Pediatr Res. 1996 Jul;40(1):66-71. PubMed
PMID: 8798248.

147: Verloes A, Temple IK, Hubert AF, Hope P, Gould S, Debauche C, Verellen G,
Deville JL, Koulischer L, Sokal EM. Recurrence of neonatal haemochromatosis in
half sibs born of unaffected mothers. J Med Genet. 1996 Jun;33(6):444-9. PubMed
PMID: 8782042; PubMed Central PMCID: PMC1050628.

148: Reding R, Feyaerts A, Vraux H, Latinne D, De La Parra B, Cornet A, Cormont
F, Jamart J, Sokal E, de Ville de Goyet J, Lerut J, Bazin H, Otte JB.
Prophylactic immunosuppression with anti-interleukin-2 receptor monoclonal
antibody LO-Tact-1 versus OKT3 in liver allografting. A two-year follow-up study.
Transplantation. 1996 May 15;61(9):1406-9. PubMed PMID: 8629306.

149: Alberti D, Wallemacq P, Falchetti D, de Ville de Goyet J, Rigamonti W,
Panzali A, Sokal E, Otte JB, Reding R. Microemulsion formulation of cyclosporine
in pediatric liver transplantation. Transplantation. 1996 Feb 15;61(3):512-4.
PubMed PMID: 8610371.

150: Santos Silva EE, Sarles J, Buts JP, Sokal EM. Successful medical treatment
of severely decompensated Wilson disease. J Pediatr. 1996 Feb;128(2):285-7.
PubMed PMID: 8636833.

151: Sokal EM, Reding R, de Ville de Goyet J, Otte JB. [Long-term outcome in
children with liver transplants]. Arch Pediatr. 1996;3 Suppl 1:132s-134s. French.
PubMed PMID: 8795992.

152: Lecouvet F, Clapuyt P, Van Nieuwenhuyse JP, Everarts P, Baudrez V, Reding R,
de Ville de Goyet J, Sokal E, Otte JB. Primary calcification in
post-transplantation lymphoproliferative disorder involving the hepatic graft: an
exceptional finding. Pediatr Radiol. 1996;26(2):152-4. PubMed PMID: 8587818.

153: Müller G, Veyckemans F, Calier M, Van Obbergh LJ, De Kock M, Sokal EM, Otte
JB. Anaesthetic considerations in progressive familial intrahepatic cholestasis
(Byler's disease). Can J Anaesth. 1995 Dec;42(12):1126-33. PubMed PMID: 8595689.

154: Sokal EM, Silva ES, Hermans D, Reding R, de Ville de Goyet J, Buts JP, Otte
JB. Orthotopic liver transplantation for Crigler-Najjar type I disease in six
children. Transplantation. 1995 Nov 27;60(10):1095-8. PubMed PMID: 7482714.

155: Boon-Falleur L, Sokal E, Nightingale PG, Peters M, Otte JB, Ketelslegers JM,
De Wilde E, Hasman A. Utilization of laboratory resources: developments in
knowledge-based ordering systems. Int J Biomed Comput. 1995 Sep;40(1):17-30.
PubMed PMID: 8557401.

156: Buts JP, De Keyser N, De Raedemaeker L, Collette E, Sokal EM. Polyamine
profiles in human milk, infant artificial formulas, and semi-elemental diets. J
Pediatr Gastroenterol Nutr. 1995 Jul;21(1):44-9. PubMed PMID: 8576813.

157: Pastore M, Willems M, Cornu C, Buts JP, Reding R, de Ville de Goyet J,
Rahier J, Otte JB, Yap SH, Sokal EM. Role of hepatitis C virus in chronic liver
disease occurring after orthotopic liver transplantation. Arch Dis Child. 1995
May;72(5):403-7. PubMed PMID: 7618905; PubMed Central PMCID: PMC1511101.

158: Sokal EM. Quality of life after orthotopic liver transplantation in
children. An overview of physical, psychological and social outcome. Eur J
Pediatr. 1995 Mar;154(3):171-5. Review. PubMed PMID: 7758511.

159: Sokal EM, Van Collie O, Buts JP. Horizontal transmission of hepatitis B from
children to adoptive parents. Arch Dis Child. 1995 Feb;72(2):191. PubMed PMID:
7702394; PubMed Central PMCID: PMC1511002.

160: Boon-Falleur L, Sokal E, Peters M, Ketelslegers JM. A rule-based decision
support application for laboratory investigations management. Proc Annu Symp
Comput Appl Med Care. 1995:314-8. PubMed PMID: 8563292; PubMed Central PMCID:
PMC2579106.

161: Sokal EM. [Should chronic hepatitis B in children be treated?].
Gastroenterol Clin Biol. 1995 Jan;19(1):51-2. French. PubMed PMID: 7720990.

162: Otte JB, de Ville de Goyet J, Reding R, Hausleithner V, Sokal E, Chardot C,
Debande B. Sequential treatment of biliary atresia with Kasai portoenterostomy
and liver transplantation: a review. Hepatology. 1994 Jul;20(1 Pt 2):41S-48S.
Review. PubMed PMID: 8005579.

163: Buts JP, Cadranel S, Deprettere A, Scaillon M, Sokal E, Van Caillie-Bertrand
M, Vandenplas Y, Vanwinckel M. Hypo-allergenic formulae: what's in a name? Eur J
Pediatr. 1994 May;153(5):390-2. PubMed PMID: 8033935.

164: Sokal EM, De Bilderling G, Clapuyt P, Opsomer RJ, Buts JP. Extracorporeal
shock-wave lithotripsy for calcified lower choledocholithiasis in an 18-month-old
boy. J Pediatr Gastroenterol Nutr. 1994 Apr;18(3):391-4. PubMed PMID: 8057227.

165: Buts JP, De Keyser N, Romain N, Dandrifosse G, Sokal E, Nsengiyumva T.
Response of rat immature enterocytes to insulin: regulation by receptor binding
and endoluminal polyamine uptake. Gastroenterology. 1994 Jan;106(1):49-59. PubMed
PMID: 8276208.

166: Baranski AG, Barker AP, Sokal E, Havaux X, Saliez A, Lambotte L, de Ville de
Goyet J. A new method for rat accessory hepatic transplantation--the cervical
approach. Transpl Int. 1994;7(6):398-404. PubMed PMID: 7865104.

167: Reding R, Wallemacq PE, Lamy ME, Rahier J, Sempoux C, Debande B, Jamart J,
Barker A, Sokal E, De Ville de Goyet J, et al. Conversion from cyclosporine to
FK506 for salvage of immunocompromised pediatric liver allografts. Efficacy,
toxicity, and dose regimen in 23 children. Transplantation. 1994
Jan;57(1):93-100. PubMed PMID: 7507272.

168: Stalens JP, Sokal E, Walon C, Verellen-Dumoulin C, Clapuyt P, Wese FX.
Autosomal dominant polycystic kidney disease in the first year of life. Report of
a case with no family history. Acta Urol Belg. 1993 Dec;61(4):25-8. PubMed PMID:
8296686.

169: Sokal EM, Caragiozoglou T, Lamy M, Reding R, Otte JB. Epstein-Barr virus
serology and Epstein-Barr virus-associated lymphoproliferative disorders in
pediatric liver transplant recipients. Transplantation. 1993 Dec;56(6):1394-8.
PubMed PMID: 8279009.

170: Van Obbergh L, Carlier M, de Clety SC, Sokal E, Rennotte MT, Veyckemans F,
Dekock M, Frans A, Otte JB. Liver transplantation and pulmonary gas exchanges in
hypoxemic children. Am Rev Respir Dis. 1993 Nov;148(5):1408-10. PubMed PMID:
8239183.

171: Buts JP, De Keyser N, Kolanowski J, Sokal E, Van Hoof F. Maturation of
villus and crypt cell functions in rat small intestine. Role of dietary
polyamines. Dig Dis Sci. 1993 Jun;38(6):1091-8. PubMed PMID: 8508705.

172: Sokal EM, Lopez-Silvarrey A, Buts JP, Otte JB. Orthotopic liver
transplantation for type I glycogenosis unresponsive to medical therapy. J
Pediatr Gastroenterol Nutr. 1993 May;16(4):465-7. PubMed PMID: 8315558.

173: Cilio MR, Danhaive O, Gadisseux JF, Otte JB, Sokal EM. Unusual cyclosporin
related neurological complications in recipients of liver transplants. Arch Dis
Child. 1993 Mar;68(3):405-7. PubMed PMID: 8466245; PubMed Central PMCID:
PMC1793864.

174: Reding R, Vraux H, de Ville de Goyet J, Sokal E, de Hemptinne B, Latinne D,
Rahier J, Jamart J, Vincenzotto C, Cormont F, et al. Monoclonal antibodies in
prophylactic immunosuppression after liver transplantation. A randomized
controlled trial comparing OKT3 and anti-IL-2 receptor monoclonal antibody
LO-Tact-1. Transplantation. 1993 Mar;55(3):534-41. PubMed PMID: 8456474.

175: Reding R, Clapuyt P, Lengele B, Veyckemans F, Noel H, Sokal E, Otte JB.
Intestinal hemorrhage three years after incidental appendectomy by total
inversion. Eur J Pediatr Surg. 1993 Feb;3(1):59-60. PubMed PMID: 8466880.

176: Sokal EM, Ulla L, Harvengt C, Otte JB. Liver transplantation for familial
hypercholesterolemia before the onset of cardiovascular complications.
Transplantation. 1993 Feb;55(2):432-3. PubMed PMID: 8434397.

177: Sokal EM, Collette E, Buts JP. Continuous increase of alcohol dehydrogenase
activity along the liver plate in normal and cirrhotic human livers. Hepatology.
1993 Feb;17(2):202-5. PubMed PMID: 8428716.

178: Sokal EM, Wirth S, Goyens P, Depreterre A, Cornu C. Interferon alfa-2b
therapy in children with chronic hepatitis B. Gut. 1993;34(2 Suppl):S87-90.
PubMed PMID: 8314496; PubMed Central PMCID: PMC1374019.

179: Buts JP, Sokal EM, Van Hoof F. Prenatal exposure to ethanol in rats: effects
on postnatal maturation of the small intestine and liver. Pediatr Res. 1992
Nov;32(5):574-9. PubMed PMID: 1480459.

180: Sokal EM, Bustos R, Van Hoof F, Otte JB. Liver transplantation for
hereditary tyrosinemia--early transplantation following the patient's
stabilization. Transplantation. 1992 Nov;54(5):937-9. PubMed PMID: 1440864.

181: Wirth S, Sokal E, Schaefer E, Pohlenz J, Keller KM. [Chronic hepatitis B.
Treatment in childhood with alpha-interferon]. Monatsschr Kinderheilkd. 1992
Oct;140(10):775-9. German. PubMed PMID: 1435800.

182: Sokal EM, Ulla L, Otte JB. Hepatitis B vaccine response before and after
transplantation in 55 extrahepatic biliary atresia children. Dig Dis Sci. 1992
Aug;37(8):1250-2. PubMed PMID: 1499450.

183: Sokal EM, Van Hoorebeeck N, Van Obbergh L, Otte JB, Buts JP. Upper
gastro-intestinal tract bleeding in cirrhotic children candidates for liver
transplantation. Eur J Pediatr. 1992 May;151(5):326-8. PubMed PMID: 1396883.

184: Sokal EM, Mostin J, Buts JP. Liver metabolic zonation in rat biliary
cirrhosis: distribution is reverse of that in toxic cirrhosis. Hepatology. 1992
May;15(5):904-8. PubMed PMID: 1314772.

185: Sokal EM, Van Hoof F, Alberti D, de Ville de Goyet J, de Barsy T, Otte JB.
Progressive cardiac failure following orthotopic liver transplantation for type
IV glycogenosis. Eur J Pediatr. 1992 Mar;151(3):200-3. PubMed PMID: 1601012.

186: Danhaive O, Ninane J, Sokal E, Latinne D, Philippe M, Gosseye S, Clapuyt P,
Otte JB. Hepatic localization of a fibrosarcoma in a child with a liver
transplant. J Pediatr. 1992 Mar;120(3):434-7. PubMed PMID: 1538293.

187: Cames B, Rahier J, Burtomboy G, de Ville de Goyet J, Reding R, Lamy M, Otte
JB, Sokal EM. Acute adenovirus hepatitis in liver transplant recipients. J
Pediatr. 1992 Jan;120(1):33-7. PubMed PMID: 1731021.

188: Sokal E. [The dietetic basis of infant nutrition]. J Pharm Belg. 1992
Jan-Feb;47(1):50-3. Review. French. PubMed PMID: 1625163.

189: Libert R, Hermans D, Draye JP, Van Hoof F, Sokal E, de Hoffmann E. Bile
acids and conjugates identified in metabolic disorders by fast atom bombardment
and tandem mass spectrometry. Clin Chem. 1991 Dec;37(12):2102-10. PubMed PMID:
1722438.

190: Reding R, de Ville de Goyet J, Sokal E, Moulin D, Clement de Clety S,
Wallemacq P, Otte JB. Compassionate use of FK 506 in pediatric liver
transplantation: a pilot study. Transplant Proc. 1991 Dec;23(6):3002-4. PubMed
PMID: 1721341.

191: Sokal EM, Collette E, Buts JP. Persistence of a liver metabolic zonation in
extra-hepatic biliary atresia cirrhotic livers. Pediatr Res. 1991
Sep;30(3):286-9. PubMed PMID: 1658719.

192: Vanclaire J, Cornu C, Sokal EM. Fulminant hepatitis B in an infant born to a
hepatitis Be antibody positive, DNA negative carrier. Arch Dis Child. 1991
Aug;66(8):983-5. PubMed PMID: 1929497; PubMed Central PMCID: PMC1793473.

193: Brichard B, Sokal E, Gosseye S, Buts JP, Gadisseux JF, Cornu G.
Coombs-positive giant cell hepatitis of infancy: effect of steroids and
azathioprine therapy. Eur J Pediatr. 1991 Mar;150(5):314-7. PubMed PMID: 2044600.

194: Brant de Carvalho F, Reding R, Falchetti D, de Ville de Goyet J, de
Hemptinne B, Sokal E, Otte JB. Analysis of liver graft loss in infants and
children below 4 years. Transplant Proc. 1991 Feb;23(1 Pt 2):1454-5. PubMed PMID:
1989262.

195: Sokal EM, Trivedi P, Portmann B, Mowat AP. Adaptative changes of metabolic
zonation during the development of cirrhosis in growing rats. Gastroenterology.
1990 Sep;99(3):785-92. PubMed PMID: 2165952.

196: Sokal EM, Veyckemans F, de Ville de Goyet J, Moulin D, Van Hoorebeeck N,
Alberti D, Buts JP, Rahier J, Van Obbergh L, Clapuyt P, et al. Liver
transplantation in children less than 1 year of age. J Pediatr. 1990 Aug;117(2 Pt
1):205-10. PubMed PMID: 2380818.

197: Sokal EM, Ville de Goyet J, Buts JP, Habets S, Gosseye S, Clapuyt P, Claus
D, Otte JB. Unifocal stricture of the common bile duct in two children: a
localized form of primary sclerosing cholangitis. J Pediatr Gastroenterol Nutr.
1990 Aug;11(2):268-74. PubMed PMID: 2203891.

198: Otte JB, de Ville de Goyet J, Sokal E, Alberti D, Moulin D, de Hemptinne B,
Veyckemans F, van Obbergh L, Carlier M, Clapuyt P, et al. Size reduction of the
donor liver is a safe way to alleviate the shortage of size-matched organs in
pediatric liver transplantation. Ann Surg. 1990 Feb;211(2):146-57. PubMed PMID:
2301994; PubMed Central PMCID: PMC1357958.

199: Sokal EM, Trivedi P, Cheeseman P, Portmann B, Mowat AP. The application of
quantitative cytochemistry to study the acinar distribution of enzymatic
activities in human liver biopsy sections. J Hepatol. 1989 Jul;9(1):42-8. PubMed
PMID: 2549121.

200: Sokal EM, Trivedi P, Portmann B, Mowat AP. Developmental changes in the
intra-acinar distribution of succinate dehydrogenase, glutamate dehydrogenase,
glucose-6-phosphatase, and NADPH dehydrogenase in the rat liver. J Pediatr
Gastroenterol Nutr. 1989 May;8(4):522-7. PubMed PMID: 2542510.

201: Otte JB, de Ville de Goyet J, Alberti D, de Hemptinne B, Sokal E, Moulin D,
Veyckemans F, Carlier MA, Van Obbergh L, Rahier J, et al. Liver transplantation
in children: University of Louvain Medical School (Brussels) experience with the
first 139 patients. Clin Transpl. 1989:143-52. PubMed PMID: 2487559.

202: Michel M, Vermylen C, Sokal E, Ninane J, Latinne D, De Bruyére M, Cornu G.
Bone marrow transplantation for poor prognosis ALL in children. Relapse rate,
infections and immunological recovery. Acta Clin Belg. 1988;43(4):254-60. PubMed
PMID: 3055782.

203: Sokal E, Michel M, Ninane J, Latinne D, de Bruyere M, Cornu G. Bone marrow
transplantation from an unrelated donor for Fanconi's anaemia: two unusual
complications. Bone Marrow Transplant. 1987 Jun;2(1):99-102. PubMed PMID:
3139115.

CV résumé

PROFESSEUR ETIENNE SOKAL – Curriculum Vitae Résumé

Position actuelle 

Université Catholique de Louvain :

- Professeur ordinaire, faculté de médecine, Université Catholique de Louvain

- Responsable d’unité de recherche PEDI

- Président du département de pédiatrie

Cliniques Saint Luc 

- Chef de clinique

- Responsable d’unité de gastroentérologie pédiatrique, Cliniques St Luc

- Président  du comité clinique de génétique humaine

- Directeur du centre d’investigation clinique pédiatrique

Promethera Biosciences

- Directeur  fondateur  et directeur scientifique (02/2009)

Etudes

- Humanité gréco latines Collège Saint Michel, 1976.

- Docteur en médecine, chirurgie et accouchement UCL 1983, maximum cum laude

- License spéciale en Pédiatrie, UCL 1989.

- Agrégation enseignement supérieur UCL 1993 â€“ Thèse intitulée « La zonation métabolique du foie normal et cirrhotique Â» Leçon publique « L’hépatite B de l’enfant Â».

Fellowship

1986-1988 : Honorary registrar  & Research fellow, Kig’s College Hospital , London

British Council fellowship

Royal Society fellowship

Boursier Fondation St Luc

Membre de sociétés scientifiques 

European associaton for the study of the liver (EASL), european society pediatric gastroenterology, hepatology & nutrition (ESGHAN) (fondateur du liver committee),société belge de pédiatrie (SBP), Pediatric research society (UK),  groupe belge  et groupe francophone de gastroentérologie et nutrition pédiatrique, International Society of Stem Cell research ( membre du « translational research committee Â»), société belge de transplantation, société belge de gastroentérologie.

Académie Royale Belge de Médecine (membre ordinaire) (2002)

Reviewer- Editorial board

 Editorial board :    World Journal Gastroenterology , cell transplantation

Reviewer : Lancet, Hepatology, Transplantation, Gastroenterology, Journal of Hepatology,

Journal of Pediatrics, European Journal of Pediatrics, Journal of Pediatric Gastroenterology and Nutrition, Acta Gastroenterologica Belgica….

Principaux domaines de recherche

- Les maladies du foie de l’enfant

- La transplantation hépatique pédiatrique

- Les syndromes lymphoprolifératifs à EBV

- Les hépatites virales de l’enfant

- Les maladies métaboliques du foie

- La thérapie cellulaire et les cellules souches hépatiques

- La recherche clinique pharmacologique pédiatrique

Publications et conférences

- 204 publications reprises sur Pubmed dans les domaines de recherche précités

- ~ 350 conférences scientifiques en tant que   conférencier invité ou communications   

Enseignement (UCL)

Croissance et développement 1^er master, secteurs digestifs, uro-néphrologie, maladies infectieuses,  séminaires de stage, license en nutrition.

Notoriété

Membre de réseaux  nationaux et internationaux  dans les domaines de  l’hépatologie pédiatrique  et de transplantation / thérapie cellulaire; expertise clinique, recherche clinique et translationelle :  transplantation, maladies métaboliques, hépatites virales, thérapie cellulaire et cellules souches.

Patente

Adult derived Hepatic Mesenchymal Stem Cell

Orphan drug status : déficit cycle de l’urée, maladie de Crigler Najjar

Publications