CV / teaching

SHORT CV-BERNARD HALLET

Date of birth: October 28, 1966
Citizenship: Belgian

EDUCATION

1988-1993:	PhD in bacterial genetics at UCL (Biology Dpt, Prof. J. Delcour)
1984-1988:	Master degree in Biology at UCL

 

PROFESSIONAL

2006-present:	Senior Lecturer at UCL
2001-2006:	Research associate at the FNRS, Lecturer at UCL
1998-2001:	Senior research fellow at the FNRS
1994-1998:	Postdoctoral training at the University of Oxford, UK (Biochemistry Dpt, Prof. D.J. Sherratt)

 

UCL TEACHING (2009-2010)

BIO1321:	Molecular genetics
BIO1322:	Integrated practicals in biochemistry and molecular genetics
BBMC2107:	Microbial cell physiology
BBMC2106:	Molecular genetics and genomics of microbes
BBMC2102:	Integrated molecular and cell biology
BBMC2205:	Research training placement - 1st part
BBMC2103:	Rotation
BBMC2206:	Research training placement - 2nd part
BBMC2203:	Interuniversity workshops
CEMO3001:	Molecular and cellular biology of microbes

 

FIELDS OF EXPERTISE

• Molecular and bacterial genetics
• Biochemistry of protein-DNA interactions
• Mechanisms of DNA recombination and transposition
• Genome plasticity and Bacterial cell cycle

 

PUBLICATIONS (ARTICLES AND BOOKS)

2008

• RUTH N, QUINTING B, MAINIL J, HALLET B, FRERE JM, HUYGEN K, GALLENI M. Creating hybrid proteins by insertion of exogenous peptides into permissive sites of a class A beta-lactamase. FEBS J., 275; 2008, 5150-60.

2007

• DEGHORAIN M, GOFFIN P, FONTAINE L, MAINARDI J-L, DANIEL R, ERRINGTON J, HALLET B, HOLS P, Selectivity for D-lactate incorporation into the peptidoglycan precursors of Lactobacillus plantarum: role of Aad, a VanX-like D-alanyl-D-alanine dipeptidase, J. Bacteriol., 189, 2007, 4332-4337.
• GILBERT Y, DEGHORAIN M, WANG L, XU B, POLLHEIMER P, GRUBER H, ERRINGTON J, HALLET B, HAULOT X, VERBELEN C, HOLS P, DUFRÊNE Y, Single-molecule force spectroscopy and imaging of the vancomycin/D-Ala-D-Ala interaction, Nano Lett., 7, 2007, 796-801.
• ZHENG W, GALLOY C, HALLET B, VASQUEZ M, The Tangle Model for Site-specific Recombination: A Computer Implementation and the TnpI-IRS Recombination System Knot Theory for Scientific Objects, OCAMI Studies, 1, 2, 2007, 251-272.

2006

• VANHOOFF V, GALLOY C, AGAISSE H, LERECLUS D, RÉVET B, HALLET B, Self-control in DNA site-specific recombination mediated by the tyrosine recombinase TnpI, Mol. Microbiol., 60, 2006, 617-629.

2004

• HALLET B, VANHOOFF V, CORNET F, DNA site-specific resolution systems, In: The Biology of Plasmids, ASM Press ed., 2004, 145-180.

2003

• DERZELLE S, HALLET B, FERAIN T, DELCOUR J, HOLS P, Improved adaptation to cold-shock, stationary-phase, or freezing stresses in Lactobacillus plantarum overproducing cold-shock proteins, Appl. Environ. Microbiol., 69, 7, 2003, 4285-4290.

2002

• DERZELLE S, HALLET B, FERAIN T, DELCOUR J, HOLS P, Cold shock induction of the cspL gene in Lactobacillus plantarum involves transcriptional regulation, J. Bacteriol., 184, 19, 2002, 5518-5523.

2001

• HALLET B, Playing Dr Jekyll and Mr Hyde : combined mechanisms of phase variation in bacteria, Curr. Opin. Microbiol., 4, 2001, 570-581.

2000

• DERZELLE S, HALLET B, FRANCIS K, FERAIN T, DELCOUR J, HOLS P, Changes in cspL, cspP, and cspC mRNA abundance as a function of cold shock and growth phase in Lactobacillus plantarum, J. Bacteriol., 182, 2000, 5105-5113.
• ARCISZEWSKA L, BAKER R, HALLET B, SHERRATT D, Coordinated control of XerC and XerD catalytic activities during Holliday junction resolution, J. Mol. Biol., 299, 2, 2000, 391-403.
• HAYES F, HALLET B, Pentapeptide scanning mutagenesis : encouraging old proteins to execute unusual tricks, Trends Microbiol., 8, 2000, 569-574.

1999

• HALLET B, ARCISZEWSKA L, SHERRATT D, Reciprocal control of catalysis by the tyrosine recombinases XerC and XerD : an enzymatic switch in site-specific recombination, Mol. Cell., 4, 1999, 949-959.

1997

• HAYES F, HALLET B, CAO Y, Insertion mutagenesis as a tool in the modification of protein function. Extended substrate specificity conferred by pentapeptide insertions in the omega-loop of TEM-1 beta-lactamase, J. Biol Chem., 272, 1997, 28833-28836.
• HALLET B, SHERRATT D, HAYES F, Pentapeptide scanning mutagenesis : random insertion of a variable five amino acid cassette in a target protein, Nucleic Acids Res., 25, 1997, 1866-1867.
• CAO Y, HALLET B, SHERRATT D, HAYES F, Structure-function correlations in the XerD site-specific recombinase revealed by pentapeptide scanning mutagenesis, J. Mol. Biol., 274, 1, 1997, 39-53.
• HALLET B, SHERRATT D, Transposition and site-specific recombination : adapting DNA cut-and-paste mechanisms to a variety of genetic rearrangements, FEMS Microbiol Rev., 21, 1997, 157-178.
• CORNET F, HALLET B, SHERRATT D, Xer recombination in Escherichia coli. Site-specific DNA topoisomerase activity of the XerC and XerD recombinases, J. Biol Chem., 272, 35, 1997, 21927-21931.

1994

• MAHILLON J, REZSOHAZY R, HALLET B, DELCOUR J, IS231 and other Bacillus thurigiensis transposable elements : a review, Genetica, 93, 1994, 13-26.
• HALLET B, REZSOHAZY R, MAHILLON J, DELCOUR J, IS231A insertion specificity : consensus sequence and DNA bending at the target site, Mol. Microbiol., 14, 1994, 131-139.

1993

• REZSOHAZY R, HALLET B, MAHILLON J, DELCOUR J, IS231V and W from Bacillus thuringiensis subsp. israelensis, two distant members of the IS231 family of insertion sequences, Plasmid, 30, 1993, 141-149.
• REZSOHAZY R, HALLET B, DELCOUR J, MAHILLON J, The IS4 family of insertion sequences : evidence for a conserved transposase motif, Mol. Microbiol., 9, 1993, 1283-1295.

1992

• REZSOHAZY R, HALLET B, DELCOUR J, IS231D, E and F, three new insertion sequences in Bacillus thuringiensis : extension of the IS231 family, Mol. Microbiol., 6, 1992, 1959-1967.

1991

• HALLET B, REZSOHAZY R, DELCOUR J, IS231A from Bacillus thuringiensis is functional in Escherichia coli: transposition and insertion specificity, J. Bacteriol., 173, 1991, 4526-9.