QUALITY CONTROL AND DEGRADATION OF YEAST MULTIRUG TRANSPORTERS
GROUP LEADER
| MICHEL GHISLAIN | Profile |
 | Prof. Michel Ghislain is the group leader of the research on proteasomal degradation of yeast membrane transporters in the Unit of physiological biochemistry. Author of 30 articles and reviews in the field of yeast transmembrane transport and protein degradation. Master's Degree in Biology and Ph.D. on yeast membrane ion-transport proteins at UCL (1990).
Postdoctoral trainings at the Commissariat à l'Energie Atomique (Centre of Saclay, France) and at the California Institute of Technology (Pasadena, U.S.A.). FNRS research associate since 1996. Fields of expertise: - Yeast genetics and molecular biology
- Biochemistry of membrane proteins
- Protein degradation
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| Unité de biochimie physiologique Bt. Carnoy (b.308 )
5 Croix du Sud (Box 15)
B-1348 Louvain-la-Neuve-Belgium | Email :
Tel. +32 10 47 36 23
Fax. +32 10 47 38 72 |
RESEARCH OVERVIEW
 | Research activity in the laboratory focuses on degradation of membrane proteins by the ubiquitin-proteasome system in yeast. We combine genetic and biochemical approaches to understand the role of the chaperone Cdc48p/Npl4p/Ufd1p complex, which releases non native membrane proteins from the ER and transfer them to the proteasome for degradation, through the ERAD pathway. In particular, we are studying the role of novel proteins interacting with Cdc48p. |
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STAFF
| Staff 2007-2008 | |
| Group leader | Michel Ghislain |
| Visiting scientist | Donata Wawrzycka |
| Ph. D. students | Myriam Manente, Nathalie Campagnolo, Agnieszka Goj |
| Staff shared within the whole research unit |
| secretary | Monique Leloup |
| Accounting officer | Michèle Rochat |
| Computer officer | Belkacem El Amraoui |
| Engineer | Hervé Degand, Bénédicte Purnelle |
| Technician | Anne-Marie Faber, Régeane Mathieu |
More on staff >
