FETAL PROGRAMMING OF ADULT DISEASES
GROUP LEADERS
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CLAUDE REMACLE
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Profile
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Prof. Claude Remacle, Ph.D., is group leader at the Laboratory of Cell Biology in the Animal Biology Unit Master's degree (1968) and PhD (1974) at UCL, Laboratoire Arago (France), and Institute of Natural History (Brussels). Author of 135 peer-reviewed publications, 19 chapters and reviews.
Fields of expertise:
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Mechanisms of differentiation of fat cell precursors
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Mechanisms of early atherogenesis
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Development and ageing of the endocrine pancreas
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Metabolic programming
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Unité de Biologie Animale
Bt. Carnoy (a.141.10)
5 Place Croix du Sud (Box 2)
B-1348 Louvain-la-Neuve-Belgium
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Email :
Tel. +32 10 47 35 22
Fax. +32 10 47 35 15
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BRIGITTE REUSENS
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Profile
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Dr Brigitte Reusens is the group leader with Professor Claude Remacle at the laboratory of cell biology, at the Animal Biology Unit. She is senior research associate. Author of 45 peer-reviewed publications, 20 chapters and reviews in the field of diabetes, nutrition and fetal programming. Master's Degree in Biology and Ph.D. in Sciences at UCL (1985). Senior research associate at UCL (since 1991), and recently invited Professor at UCL.
Fields of expertise:
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Maternal and fetal physiology
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Primary and Cell line culture
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Histology, immunochemistry and morphometry
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Nutrition, metabolism, diabetes
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Proteome and microarray analysis
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Unité de Biologie Animale
Bt. Carnoy (a.137)
5 Place Croix du Sud (Box 2)
B-1348 Louvain-la-Neuve-Belgium
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Email :
Tel. +32 10 47 40 03
Fax. +32 10 47 35 15
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RESEARCH OVERVIEW
The research activity focuses on the mechanisms involved in the early programming of metabolic syndrome including diabetes, obesity, hypertension and cardiovascular diseases by maternal health alteration. The research also aims to investigate the early prevention by taurine.
Different models of malnutrition during gestation or/and lactation are currently used in rats and mice:
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Low protein diet
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Low calorie diet
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High fat, high sucrose diet
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Maternal diabetes
A multidisciplinary range of in vivo and in vitro approaches are used to evaluate the early and late consequence of the diets:
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Glucose metabolism and insulin sensitivity by glucose tolerance test and clamps
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Hypertension and heart rate by telemetry
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Analysis of blood parameters by ELISA
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Islets, beta cell, preadipocytes, adipocytes , endothelial cell, macrophages tested in culture in vitro.
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Analysis of genes expression in different tissue by microarrays and real time RT-PCR
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Morphometric analysis in tissues, cell proliferation, immunohistochemistry
The research is made in association with networks :
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NTERUNIVERSITY ATTRACTION POLES Project P5/02: Angiogenesis and vessel wall disease
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Early malnutrition and programming of adult degenerative diseases: experimental, epidemiological and preventive studies (NUTRIX)
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EARly Nutrition programming- long term follow up of Efficacy and Safety Trials and integrated epidemiological, genetic, animal, consumer and economic research. (EARNEST)
The three main research topics are :
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The impact of several modes of maternal malnutrition on the development of the endocrine pancreas and the long term consequences
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The mechanisms by which maternal malnutrition programs obesity later in life
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The Prevention by maternal taurine supplementation
More on research projects >
STAFF
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Staff 2007-2008
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Group leaders
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Ph.D students
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Technical assistants
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#mailto:Marie Thérèse Ahn:marie-threse.ahnuclouvain.be#, ,
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Secretary
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