CV / teaching

SHORT CV-BERNARD KNOOPS

Date of birth: March 6, 1962
Citizenship: Belgian

EDUCATION

PROFESSIONAL

Teaching at UCL  (2007-2008)

Fields of expertise 

• Enzymatic antioxidant protective mechanisms in animal cells. Molecular and cell biology of peroxiredoxins and associated thioredoxin systems.

SELECTED PUBLICATIONS

• SMEETS A, EVRARD C, LANDTMETERS M, MARCHAND C, KNOOPS B, DECLERCQ J-P, Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2., Protein Science, 14, 2005, 2610-2621.
• BANMEYER I, MARCHAND C, CLIPPE A, KNOOPS B, Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide., FEBS Letters, 579, 2005, 2327-2333.
• EVRARD C, CAPRON A, MARCHAND C, CLIPPE A, WATTIEZ R, SOUMILLION P, KNOOPS B, DECLERCQ J-P, Crystal Structure of a Dimeric Oxidized form of Human Peroxiredoxin 5, J. Mol. Biol., 337, 2004, 1079-1090
• DUBUISSON M, VANDER STRICHT D, CLIPPE A, ETIENNE F, NAUSER T, KISSNER R, KOPPENOL W, REES J-F, KNOOPS B, Human peroxiredoxin 5 is a peroxynitrite reductase., FEBS Letters, 571, 2004, 161-165.
• BANMEYER I, MARCHAND C, VERHAEGHE C, VUCIC B, REES J-F, KNOOPS B, Overexpression of human peroxiredoxin 5 in subcellular compartments of chinese hamster ovary cells: effects on cytotoxicity and DNA damage caused by peroxides., Free Radical Biology & Medicine, 1, 2004, 65-77.
• LEYENS G, DONNAY I, KNOOPS B, Cloning of bovine peroxiredoxins: gene exprssion in bovine tissues and amino acid sequence comparison with rat, mouse and primate , Comparative Biochemistry and Physiology part B, 136, 2003, 943-955.
• DECLERCQ J-P, EVRARD C, CLIPPE A, VANDER STRICHT D, BERNARD A, KNOOPS B, Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.54 Å resolution, Journal of Molecular Biology, 311, 2001, 751-759.
• KNOOPS B, CLIPPE A, BOGARD C, ARSALANE K, WATTIEZ R, HERMANS C, DUCONSEILLE E, FALMAGNE P, BERNARD A, Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family, J Biol Chem, 274, 43, 1999, 30451-30458.
• KNOOPS B, OCTAVE J-N, Alpha tubulin mRNA level is increased during neurite outgrowth of NG 108-15 cells but not during neurite outgrowth inhibition by CNS myelin., Neuroreport, 8, 1997, 795-798.
• KNOOPS B, PONSAR C, VAN DEN BOSCH SANCHEZ DE AGUILAR P, Axonal regeneration after peripheral nerve grafting and fibrin-fibronectin-containing matrix implantation on the lesioned septohipocampal pathway of the adult rat : a light and electron microscopic study., Restorative Neurology and Neurosciences, 5, 1993, 103-117.
• KNOOPS B, HUBERT I, HAUW J, VAN DEN BOSCH SANCHEZ DE AGUILAR P, Axonal growth and astrocyte migration from co-cultured septal and hippocampal slices into fibrin-fibronectin containing matrix of peripheral regeneration chambers: a light and electron microscope study., Brain Research, 540, 1991, 183-194.
• KNOOPS B, VAN DEN BOSCH SANCHEZ DE AGUILAR P, Rat sciatic nerve regeneration within an acrylic semipermeable tube and comparison with a silicon impermeable material., J. Neurol. Exp. Neuropathol., 49, 1990, 438-448.
• KNOOPS B, VAN DEN BOSCH SANCHEZ DE AGUILAR P, A new in vivo model to study the influence of the microenvironment in the regeneration of the central nervous system., Brain Research, 425, 1987, 191-197.