CV Schneider YJ/teaching

SHORT CV-YVES-JACQUES SCHNEIDER

Date of birth: May 16, 1952
Citizenship: Belgian

EDUCATION

1977-1983:	Agrégation de l'enseignement supérieur, UCL, Be
1973-1977:	PhD thesis in Sciences, Cell Biology, UCL, Be
1969-1973:	Graduate in Sciences, Biochemistry, UCL, Be

 

PROFESSIONAL

	Full-time Professor at UCL
1993-2000:	Associate professor at UCL
1986-1993:	Senior research associate at UCL
1985-1986:	Head of the Biological research department at Celltarg SA, biotech spin off
1977-1985:	Assistant, associate and senior member at the Christian de Duve Institute of Cellular Pathology
1979-1985:	Research associate et UCL
1976-1979:	Research assistant at UCL
1973-1976:	Fellowship from the Belgian IRSIA

 

UCL TEACHING

VETE1395:	Animal cell biology
CHM1371:	Metabolic biochemistry
BRMC2202:	Cellular bioengineering
FSA1221:	Introduction to life sciences for engineers, part 1
FSA2221:	Introduction to life sciences for engineers, part 2
VETE1300:	Integrated Seminars
BBMC2102:	Molecular and cellular integrated biology
BBMC2104:	Animal biochemistry
BBMC2204:	Cellular and molecular pharmacology
BIO1338:	Integrated exercices
BRAL2102:	physiological and nutritional biochemistry
3001:	Patents and intellectual property

 

FIELDS OF EXPERTISE

Cell culture systems (animal cells) to investigate physiological biochemistry and pharmaco-toxicological topics:

• mechanisms by which nutrients, xenobiotics or drugs interact with the human intestinal barrier; application to food safety;
• mechanisms by which polymeric nanoparticles could be targeted to the surface of intestinal M cells to favor their transcytosis; application to mucosal vaccination.

 

PUBLICATIONS (ARTICLES AND BOOKS)

2009

• SART SEBASTIEN, SCHNEIDER YVES-JACQUES, AGATHOS SPIROS N., Ear mesenchymal stem cells : An efficient adult multipotent cell population fit for rapid and scalable expansion, Journal of Biotechnology, 139, 2009, p. 291-299.  
• DANYI S, BROSE F, BRASSEUR C., SCHNEIDER YVES-JACQUES, LARONDELLE YVAN, PUSSEMIER L., ROBBENS J., DE SAEGER S., MAGHUIN-ROGISTER G., SCIPPO M-L, Analysis of EU priority polycyclic aromatic hydrocarbons in food supplements using high performance liquid chromatography coupled to an ultraviolet, diode array or fluorescence detector, Analytica Chimica Acta, 633, 2009, p. 293-299.
• VAN DER HEIDEN E., BECHOUX N., MULLER M., SERGENT THÉRÈSE, SCHNEIDER YVES-JACQUES, LARONDELLE YVAN, MAGHUIN-ROGISTER G., SCIPPO M-L, Food flavonoid aryl hydrocarbon receptor-mediated agonistic/antagonistic/synergic activities in human and rat reporter gene assays, Anal Cim. Acta, 637, 2009, p. 337-345.
• ROMIER BÉATRICE, SCHNEIDER YVES-JACQUES, LARONDELLE YVAN, DURING ALEXANDRINE, Dietary polyphenols can modulate the intestinal inflammatory response, Nutr. Rev., 67, 7, 2009, p. 363-378.
• SERGENT THERESE, DUPONT ISABELLE, JASSOGNE C., RIBONNET LAURENCE, VAN DER HEYDEN EMMANUEL, SCIPPO M-L, MULLER M., MCALISTER D., PUSSEMIER LUC, LARONDELLE YVAN, SCHNEIDER YVES-JACQUES, CYP1A1 induction and CYP3A4 inhibition by the fungicide imazalil in the human intestinal Caco-2 cells - Comparison with other conazole pesticides, Toxicology Letters, 184, 2009, p. 159-168.

2008

• VANHULLE S, TROVASLET M, ENAUD E, LUCAS M, TAGHAVI S, VANDERLELIE D, VAN AKEN B, FORET M, ONDERWATER R, WESENBERG D, AGATHOS S, SCHNEIDER Y-J, CORBISIER A-M, Decolorization, Cytotoxicity, and Genotoxicity Reduction During a Combined Ozonation/Fungal Treatment of Dye-Contaminated Wastewater, Environ. Sci. Technol., 42, 2008, 584-589.
• • SERGENT Thèrése, RIBONNET Laurence, KOLOSOVA Anna, GARSOU Serge, SCHAUT Annelore, DE SAEGER Sarah, VAN PETEGHEM Carlos, LARONDELLE Yvan, PUSSEMIER Luc, SCHNEIDER Yves-Jacques, Molecular and cellular effects of food contaminants and secondary plant components and their plausible interactions at the intestinal level, Food and Chemical Toxicology, 46, 2008, p. 813-841.
• VAN DE WALLE Jacqueline, ROMIER Béatrice, LARONDELLE Yvan, SCHNEIDER Yves-Jacques, Influence of deoxynivalenol on NF-kB activation and IL-8 secretion in human intestinal Caco-2 cells, Toxicology Letters, 177, 2008, p. 205-214. (Publié).
• ROMIER Béatrice, VAN DE WALLE Jacqueline, DURING Alexandrine, LARONDELLE Yvan, SCHNEIDER Yves-Jacques, Modulation of signaling NF-kB activation pathway by polyphenols in human intestinal Caco-2 cells, British Journal of Nutrition, 100, 2008, p. 542-551.
• SCHAUT Annelore, DE SAEGER Sarah, SERGENT Thèrése, SCHNEIDER Yves-Jacques, LARONDELLE Yvan, PUSSEMIER Luc, BLANK R., VAN PETEGHEM Carlos, Liquid chromatographic methods for biotransformation studies of ochratoxin A, Biomedical Chromatography, 22, 2008, p. 1013-1020.
• SCHAUT Annelore, DE SAEGER Sarah, SERGENT Thèrése, SCHNEIDER Yves-Jacques, LARONDELLE Yvan, PUSSEMIER Luc, VAN PETEGHEM Carlos, Study of the gastrointestinal biotransformation of zearalenone in a Caco-2 cell culture system with liquid chromatographic methods, Journal of Applied Toxicology, 28, 2008, p. 966-973.

2007

• DES RIEUX A, FIEVEZ V, THÉATE I, MAST J, PREAT V, SCHNEIDER Y-J, An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells, European journal of pharmaceutical sciences, 30, 5, 2007, 380-391, 0928-0987.
• DRUGMAND J-C, SCHNEIDER Y-J, AGATHOS S,  Analysis and modeling of the metabolism of lepidopteran cells,, In: Cell Technology for Cell Products, R. Smith, Editor, ed., Dordrecht, Springer, 2007, ISBN1-4020-5475-4, 777-780.
• DRUGMAND J-C, MICHIELS J-F,AGATHOS S, SCHNEIDER Y-J, Growth of mammalian and lepidopteran cells on BioNOC II disks, a novel macroporous microcarrier, In: Cell Technology for Cell Products, R. Smith, Editor ed., Dordrecht, Springer, 2007, ISBN978-1-4020-5475-4, 781-784.
• DES RIEUX A, FIEVEZ V, MOMTAZ M, DETREMBLEUR C, ALONSO-SANDE M, VAN GELDER J, CAUVIN A, SCHNEIDER Y-J, PREAT V, Helodermin-loaded nanoparticles: characterization and transport across an in vitro model of the follicle-associated epithelium, Journal of controlled release, 118, 3, 2007, 294-302, 1873-4995.
• GARINOT M, FIEVEZ V, POURCELLE V, STOFFELBACH F, DES RIEUX A, PLAPIED L, THÉATE I, FREICHELS H, JEROME C, MARCHAND-BRYNAERT J, SCHNEIDER Y-J,, PREAT V, PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination., Journal of controlled release : official journal of the Controlled Release Society, 120, 3, 2007, 195 - 204, 1873-4995.
• MOLS J, CAVEZ N, AGATHOS S, SCHNEIDER Y-J, Plant peptones: Nutritional properties sustaining recombinant protein secretion by CHO cells, In: Cell Technology for Cell Products, R. Smith, Editor, ed., Dordrecht, Springer, 2007, ISBN978-1-4020-5475-4, 599-601.

2006

• ANSELME M, TANGNI E, PUSSEMIER L, MOTTE J, VAN HOVE F, SCHNEIDER Y-J,,VAN PETEGHEM C, LARONDELLE Y, Comparison of ochratoxin A and deoxynivalenol loads of organically and conventionally produced beers sold on the Belgian market, Food additives and contaminants, 23, 2006, 910-918.
• SERGENT T, PARYS M, GARSOU S, PUSSEMIER L, SCHNEIDER Y-J, LARONDELLE Y, Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellular metabolism at realistic intestinal concentrations, Toxicology Letters, 164, 2006, 167-176.
• NOLLEVAUX G, DEVILLE C, EL MOUALIJ B, ZORZI W, DELOYER P, SCHNEIDER Y-J, PEULEN O, DANDRIFOSSE G, Development of a serum-free co-culture of human intestinal epithelium cell-lines (Caco-2/HT29-5M21), BMC, Cell Biol., 2, 2006, 7-20.
• RENAVILLE B, MULLEN A, MOLONEY F, LARONDELLE Y, SCHNEIDER Y-J,, ROCHE H, EPA and 3,10 dithia stearic acid inhibit the desaturation of trans-vaccenic acid into c9, t11-CLA through different pathways in Caco-2 and T84 cells, British Journal of Nutrition, 95, 2006, 688-695.
• GEORGE F, VRANCKEN M, VERHAEGHE B, VERHOEYE F, SCHNEIDER Y-J, MASSIP A, DONNAY I, Freezing of in vitro produced bovine embryos in animal protein free medium containing vegetal peptones, Theriogenology, 66, 5, 2006, 1381-1390.
• LARONDELLE Y, SCHNEIDER Y-J, PUSSEMIER L, VAN PETEGHEM C, DE SAEGER S, Interaction between mycotoxins and other food contaminants : a new safety approach, In: Scientific support. Plan for a Sustainable Development Policy II, Belgian Science Policy ed., 2006, 71pp.
• PROVOST A, BASTIN G, AGATHOS S, SCHNEIDER Y-J, Metabolic design of macroscopic bioreaction models : Application to chinese hamster ovary cells, Bioprocess and Biosystems Engineering., 29, 5-6, 2006, 349-366.
• RINGOT D, CHANGO A, SCHNEIDER Y-J, LARONDELLE Y, Toxicokinetics and toxicodynamics of ochratoxin A, an uptade, Chemico-Biological Interactions, 159, 2006, 18-46.

2005

• SERGENT T, GARSOU S, SCHAUT A, DE SAEGER S, PUSSEMIER L, VAN PETEGHEM C, LARONDELLE Y, SCHNEIDER Y-J, Differential modulation of ochratoxin A absorption across CaCo-2 cells by dietary polyphenols, used at realistic intestinal concentrations, Toxicology Letters, 159, 2005, 60-70.
• SERGENT T, GARSOU S, SCHAUT A, DE SAEGER S, PUSSEMIER L, VAN PETEGHEM C, LARONDELLE Y, SCHNEIDER Y-J, Differential modulation of ochratoxin A by polyphenols in human Caco-2 cells, Toxicology Lett., 159, 2005, 60-70.
• DRUGMAND J-C, SCHNEIDER Y-J, AGATHOS S, Environmental effects of lactate on High-FiveTM insect cell metabolism, In: Animal Cell Technology Meets Genomics, F. Godia & M. Fussenegger, ed., Dordrecht, The Netherlands, Kluwer Academic Publishers, 2005, ISBN1-4020-2791-5, 91-94.
• LARONDELLE Y, MOTTE J, PEETERS J, VAN PETEGHEM C, SCHNEIDER Y-J, Mycotoxin contamination of regular and organic foodstuffs, In: Scientific Support Plan for a Sustainable Development Policy II, Belgian Science Policy ed., 2005.
• MOLS J, PEETERS-JORIS C, WATTIEZ R, AGATHOS S, SCHNEIDER Y-J, Recombinant interferon-gamma secreted by CHO-320 cells cultivated in suspension in protein-free media in producted against extracellular proteolysis by the expression of natural protease inhibitors and by the addition of plant protein hydrolysates to the culture medium, In Vitro Cell. Dev. Biol. - Animal, 41, 2005, 83-91.
• DES RIEUX A, RAGNARSSON E, GULLBERG E, PREAT V, SCHNEIDER Y-J, ARTURSSON P, Transport of nanoparticle across an in vitro model of the human intestinal Follicle Associated Epithelium, Eur. J. Pharm. Sci., 25, 2005, 455-465.

2004

• IKONOMOU L, BASTIN G, SCHNEIDER Y-J, AGATHOS S, Effect of partial medium replacement on cell growth and protein production for the high-five insect cell line, Cytotechnology, 44, 2004, 67-76.
• MOLS J, PEETERS-JORIS C, AGATHOS S, SCHNEIDER Y-J, Origin of rice protein hydrolysates added to protein-free media alters secretion and extracellular proteolysis of recombinant interferon as well as CHO-320 cell growth, Biotechnol. Lett., 26, 2004, 1043-1046.
• BALLEZ J, MOLS J, BURTEAU C, AGATHOS S, SCHNEIDER Y-J, Plant protein hydrolysates support CHO-320 cells proliferation and recombinant IFN-gamma production in suspension and inside microcarriers in protein-free media, Cytotechnology, 44, 2004, 103-114.

2003

• TRAORE A, BAUDRIMONT I, DANO S, SANNI A, LARONDELLE Y, SCHNEIDER Y-J, CREPPY E, Epigenetic properties of the diarrhetic marine toxin okadaic acid : inhibition of the gao junctional intercellular communication in a human intestine epithelial cell line, Archives of Toxicology, 77, 2003, 657-662.
• BURTEAU C, VERHOEYE F, MOLS J, BALLEZ J, AGATHOS S, SCHNEIDER Y-J, Fortification of a protein-free cell culture medium with plant peptones improves cultivation and productivity of an interferon-g-producing CHO cell line, Vitro Cell. Dev. Biol. - Animal, 39, 2003, 291-296.
• DUFRANE D, MCKAY I, DE AZA P, DELLOYE C, SCHNEIDER Y-J, ANSEAU M, Indirect cytotoxicity evaluation of pseudowollastonite, Journal of materials science : materials in medicine, 14, 1, 2003, 33-38, 0957-4530.
• IKONOMOU L, SCHNEIDER Y-J, AGATHOS S, Insect cells for industrial production of recombinant proteins , Appl. Microbiol. Biotechnol., 62, 2003, 1-20.
• BERGER V, GABRIEL A-F, SERGENT T, TROUET A, LARONDELLE Y, SCHNEIDER Y-J, Interaction of Ochratoxin A with human intestinal Caco-2 cells : possible implication of a Multidrug Resistance-associated Protein (MRP2), Toxicology Letters, 140-141, 2003, 465-476.

2002

• IKONOMOU L, DRUGMAND J-C, BASTIN G, SCHNEIDER Y-J, AGATHOS S, Microcarrier culture of lepîdopteran cell lines : implicationsfor growth and recombinant protein production, Biotechnol. Prog., 18, 2002, 1345-1355.
• DUFRANE D, CORNU O, DELLOYE C, SCHNEIDER Y-J, Physical and chemical processing for a human dura mater substitute, Biomaterials, 23, 14, 2002, 2979-2988, 0142-9612.
• IKONOMOU L, PEETERS-JORIS C, SCHNEIDER Y-J, AGATHOS S, Supernatant proteolytic activities of high-five insect cells grown in serum-free culture., Biotechnology Letters, 24, 2002, 965-969.

2001

• MOLS J, BURTEAU C, VERHOEYE F, PEETERS-JORIS C, BASTIN G, AGATHOS S, SCHNEIDER Y-J, Proteolytic potential during batch cultivation in serum free media on an IFN-gamma producing CHO cell line., In: Animal cell technology: from target to market., Lindner-Olsson E., Chatzissavidou N., Lüllau E. ed., Dordrecht, Kluwer Academic, 2001, ISBN1-4020-0264-5, 227-229.
• JAWORSKI K, KINARD F, GOLDSTEIN D, HOLVOET P, TROUET A, SCHNEIDER Y-J, REMACLE C, S-nitrosothios do not induce oxidative stress, contrary to other nitric oxide donors, in cultures of vascular endothelial or smooth muscle cells. , European Journal of Pharmacology, 425, 2001, 11-19.
• KINARD F, SERGENT - ENGELEN T, GOLDSTEIN D, VAN VELDHOVEN P, HOLVOET P, TROUET A, SCHNEIDER Y-J, REMACLE C, Smooth muscle cells influence monocyte response to LDL as well as their adhesion and transmigration in a coculture model of the arterial wall., Journal of Vascular Research, 38, 2001, 479-491.

2000

• NOISET O, SCHNEIDER Y-J, MARCHAND-BRYNAERT J, Adhesion and growth of CaCo2 cells on surface modified PEEK substrata, J. Biomater. Sci. Polymer Edn, 11, 2000, 767-786.
• BERGER V, DE BREMAEKER N, LARONDELLE Y, TROUET A, SCHNEIDER Y-J, Transport mechanisms of the imino acid L-Proline in the human intestinal epithelial Caco-2 cell line., Journal of nutrition, 130, 11, 2000, 2772-2779.
• BERGER V, LARONDELLE Y, TROUET A, SCHNEIDER Y-J, Transport mechanisms of the large neutral amino acid L phenyalanine in the human intestinal epithelial CaCo-2 cell line, Journal of nutrition, 130, 11, 2000, 2780-2788.

Most representative ones (1977-1999) 

• SCHNEIDER Y-J, TULKENS P, de DUVE C, TROUET A, The fate of plasma membrane during endocytosis : 2. Evidence for recycling (shuttle) of plasma membrane constituents, J. Cell Biol., 82, 1979, 466-474.
• OCTAVE J-N, SCHNEIDER Y-J, HOFFMANN P, CRICHTON RR, TROUET A, Transferrin and iron uptake by cultured rat fibroblasts FEBS letters, 108, 1979, 127-130.
• WIDNELL CC, SCHNEIDER Y-J, PIERRE-THOREAU B, BAUDHUIN P, TROUET A, Evidence for a continual exchange of 5'nucleotidase between the cell surface and membranes of the cytoplasm in cultured fibroblasts, Cell, 28, 1982, 61-70.
• LIMET JN, SCHNEIDER Y-J, VAERMAN J-P, TROUET A, Binding, uptake, intracellular digestion and processing of polymeric IgA in cultured rat hepatocytes, Eur. J. Biochem., 125, 1982, 437-443.
• SCHNEIDER Y-J, ABARCA J, ABOUD-PIRAK E, BAURAIN R, CEULEMANS F, DEPREZ-DE CAMPENEERE D, LESUR B, MASQUELIER M, OTTE-SLACHMUYLDER C, ROLIN-van SWIETEN D, TROUET A, Receptor mediated targeting of drugs, Nato Advanced Studies, (GREGORIADIS G, POSTE G, SENIOR J, TROUET A, eds.), Life Sciences, 1984, 1-25.
• ABOUD-PIRAK E, SERGENT T, OTTE-SLACHMUYLDER C, ABARCA J, TROUET A, SCHNEIDER Y-J, Binding and endocytosis of a monoclonal antibody to a high molecular weight human milk fat globule membrane associated antigen by cultured MCF 7 human breast carcinoma cells, Cancer Res., 48, 1988, 3188-3196.
• ABOUD-PIRAK E, LESUR B, RAO KSP, BAURAIN R, TROUET A, SCHNEIDER Y-J, Cytotoxic activity of daunorubicin or vindesin conjugated to a monoclonal antibody on cultured MCF 7 breast carcinoma cells, Biochem. Pharmacol., 38, 1989, 641-648.
• SCHNEIDER Y-J, Optimisation of hybridoma cell growth and monoclonal antibody secretion in a chemically defined, serum- and protein-free, culture medium, J. Immunol. Methods, 116, 1989, 65-77.
• SCHNEIDER Y-J, LAVOIX A, Monoclonal antibody production in semi-continuous serum-and protein-free culture: effect of glutamine concentration and culture conditions on cell growth and antibody secretion, J. Immunol. Methods, 129, 1990, 2, 251-268.
• HALLEUX C, Schneider Y-J, Iron absorption by intestinal epithelial cells : 1. CaCo 2 cells cultivated in serum-free medium, on polyethylene terephthalate microporous membranes, as an in vitro model, In Vitro Cell. Dev. Biol.-Animal, 27A, 4, 1991, 293-302.
• DEWEZ J-L, DOREN A, SCHNEIDER Y-J, LEGRAS R, ROUXHET PG, Surface study of new microporous polymeric membranes used as a substratum for animal cell culture, Interfaces in new materials, GRANGE P & DELMON B, eds., Elsevier London, 1991, 84-94.
• BOELAERT JR, de LOCHT M, VAN CUTSEM J, KERRELS V, CANTINIEAUX B, VERDONCK A, VAN LANDUYT HG, SCHNEIDER Y-J, Mucormycosis during deferoxamine therapy is a siderophore-mediated infection : in vitro and in vivo animal studies, J. Clin. Invest., 91, 1993, 5, 1979-1986.
• SERGENT-ENGELEN T, DELISTRIE V, SCHNEIDER Y-J, Phase I and II biotransformations in living CaCo 2 cells cultivated in serum-free conditions : selective apical excretion of reaction products, Biochem. Pharmacol., 46, 1993, 1393-1401.
• MARCHAND-BRYNAERT J, DELDIME M, DUPONT I, DEWEZ J-L, SCHNEIDER Y-J, Surface functionalization of poly (ethylene terephthalate) film and membrane by controlled wet chemistry: chemical characterization of carboxylated surfaces, J. Colloid. Interface Sci., 1994, 173, 236-244.
• SCHNEIDER Y-J, BERGER V, ENGLEBERT L, VERBEKE O, ERNENS I, LARONDELLE Y, In vitro cell culture systems as models to study nutrient, xenobiotics and drugs passage, Cell Biol. Intern., 21, 1997, 513-515.
• KINARD F, SERGENT-ENGELEN T, TROUET A, REMACLE C, SCHNEIDER Y-J, Compartimentalized coculture of procine arterial endothelial and smooth muscle cells on a microporous membrane, In Vitro Cell. Dev. Biol.-Animal, 33, 1997, 92-103.
• DEWEZ J-L, LHOEST J-B, DETRAIT E, BERGER V, DUPONT C, VINCENT L-M, Schneider Y-J, BERTRAND P, ROUXHET PG, Adhesion of mammalian cells to polymer surfaces: from physical chemistry of surfaces to selective adhesion on defined patterns, Biomaterials. 19, 1998, 1441-1445.