Nanostructured surfaces for cell engineering

 
 Elaboration of nanostructured surfaces
Nanostructuration of protein layers by means 
of self-assembly and interaction 
with nanostructured surfaces
Evaluation of cell behavior on such nanostructured protein layers

 

Head of the group


    

Aim of the research

The general aim of the ongoing research projects is the design of biomimetic surfaces through the controlled assembly of proteins. This includes the following working lines:
(i) creation and characterization of materials with a surface architecture able to affect the organization of adsorbed proteins;
(ii) design of methods to induce protein assembly;
(iii) development of analytical tools to probe the orientation, conformation and organization of proteins at interfaces. The obtained biomimetic surfaces are then further used to trigger particular cell behaviors. This could hopefully lead to the design of biomaterials with new properties or to the development of new strategies for tissue engineering.

The techniques and methods involved in the research include the preparation of nanostructured organic surfaces and protein layers, surface characterization by atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS) and wetting measurements, and cell culture experiments.

Ongoing projects

Art Jean-François  Study of the mechanism of interaction between antigens and aluminium-based adjuvants, used in vaccine formulation

Degand Simon  Design of surfaces with mechanical nano-heterogeneities for a better control of cell-material interactions.

Delcroix Marie  Towards a better control of protein adsorption through the study of the effect of molecular mobility at interfaces.

de Thier Pierre  Étude des mécanismes d’adsorption des anticorps sur le polystyrène pour l’optimisation des tests ELISA.

Matos Ruiz Mireya  Design of biocompatible nanofilms for Nitinol surfaces

Mc Evoy Kevin  Improving quantification of proteins at interfaces through a better and practical modeling of quartz crystal microbalance response.

Yang Yi   Mechanisms of competitive adsorption of biomacromolecules on metallic surfaces used in cooling circuits – influence on bioc.

Zuyderhoff Emilienne   Nano-organisation of extracellular matrix proteins : influence of cell behaviour.

 

Useful links

Nanowal

The team

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Teaching

  • LBIRC2104  Analytical chemistry II
  • LBIR1319    Surface and colloid chemistry (I)
  • LBIR1320    Laboratories, seminars and integrated practice of analytical chemistry
  • LBRNA2102 Material surface characterisation
  • LBRNA2202 Nanobiotechnology
  • LCHM1321  Analytical chemistry I
  • LCHM1322  Exercices in analytical chemistry I
  • LFSAB1230 Project in biomedical engineering
  • LGBIO2030 Biomaterials

 

| 28/11/2011 |