Basic concepts of pharmacokinetics and pharmacodynamics

Teacher(s)

. SOMEBODY; Elens Laure (coordinator); Hermans Emmanuel;

Language

English

Main themes

This course provides a comprehensive overview of pharmacokinetics and pharmacodynamics, covering routes of drug administration, physicochemical properties, drug behavior at the molecular level, and ADME mechanisms. It also explores PK parameters, dose-response models, variability in PK/PD, and changes in special patient populations. Additionally, it includes an introduction to compartmental versus non-compartmental methods of analysis.

Content

Module I : Pharmacodynamics

1. Generalities (MOA, receptors…)
2. Pharmacological response
3. Different classes of drugs
4. Notion of biomarkers
5. Dose-Response relationships (Hill, scale of action and response, hysteresis…)
6. Synergy, potentialization, antagonism, additivity
7. Influencing factors (extrinsic and intrinsic)

Module II : Pharmacokinetics

1. Generalities
2. PK parameters and interpretation
3. PK and PD experimental models
4. NCA and CA + ODE
5. Drug Absorption, Distribution, Metabolism & Excretion
6. Influencing factors
7. Steady state and TDM

Module III : Special populations

1. Obese patients
2. Neonates and pediatrics
3. Pregnant woman
4. Eldery
5. Critically ill

Teaching methods

Lectures
20 Lectures (1h30 or 3h)
Courses are given in 7 days in the beginning of Block 1 spread over 3 weeks (W1-3)
Practical aspects are covered in IW1 (WPMTX2005) hands-on
On Woluwe campus

Evaluation methods

Written exam during exam period

Other information

Slides available on Moodle. 

Teaching materials

• Moodle slides

Faculty or entity

> FARM