• Chiara BRUSTENGA (CMFA/LDRI & FATH/IREC): “Disrupting LDH tetramerization site, small molecules approach as a new anticancer strategy.”
• Jérôme CONQ (REMA/LDRI & ADDB/LDRI): “Strategies for a transient opening of the blood brain barrier to increase the delivery of nanomedicines to glioblastoma.”
• Juliette LAGREULA (CLIP/LDRI & PMGK/LDRI): “Optimizing pharmacotherapy of antipsychotics in clinical daily practice: moving toward individualized care.”
• Anne-Sophie MALAPERT (GNOS/LDRI): “Characterizing the antiparasitic molecules of an African traditional medicinal plant using molecular networks.”
• Emilie MOENS DE HASE (MNUT/LDRI): “Investigation of the effects of newly discovered bacteria Dysosmobacter welbionis on metabolism and inflammation.”
• Mingchao WANG (ADDB/LDRI): “Glioblastoma Resection MicroEnvironment Treatment”
• Zhifen WANG (FACM/LDRI): “Evaluation of the activity of antibiotics and adjuvant strategies against dual species biofilms in the context of cystic fibrosis.”

info: Giulio Muccioli 02.764.72.31 

• Hafsa AMERAOUI (BPBL/LDRI): “Contribution to the study of oxysterols in inflammatory bowel diseases: from their quantification in patients to the study of their properties in vitro and in vivo.”
• Chantale FARAH (REMA/LDRI & MIRO/IREC): “Imaging metabolic plasticity in melanoma: relevance of combining metabolic modulators with BRAF or immune checkpoint inhibitors.”
• DE SOIR Steven (FACM/LDRI & Military Hospital Queen Astrid): “Phage-Antibiotic Synergy for the Treatment of biofilm related infections on Orthopedic implants (PASTOR).”
• Emilia HOSTE (PMGK/LDRI & LTAP/IREC): “Toxicokinetics and muscle-related toxicity of atorvastatin in vitro.”
• Paola PAONE (MNUT/LDRI): “Studying and modulating mucosal-gut microbiota interface: impact on the pathophysiology of obesity, diabetes and cardiometabolic disorders.”
• Perrine SAVOYEN (CMFA/LDRI): “Design and synthesis of peptide macrocycle inhibiting LDHB.”
• Justine VAN DE VELDE (FATH/IREC): “Is there a metabolic control of liver-specific metastasis in pancreatic cancer?”

info: G. Muccioli 02.764.72.31 <giulio.muccioli@uclouvain.be>

info: G. Muccioli 02.764.72.31 <giulio.muccioli@uclouvain.be>

Related publications :

• dos Santos AG*, Bay​iha JC*, Dufour G, Cataldo D, Evrard B, Silva LC, Deleu M, Mingeot-Leclercq M-P (2017) Changes in membrane biophysical properties induced by the Budesonide/Hydroxypropyl-β-cyclodextrin complex, Biochim. Biophys. Acta - Biomembr. 1859 (10) 1930-1940 (* co-first authors)
• Bayiha JC, Evrard B, Cataldo D, De Tullio P, Mingeot-Leclercq M-P, Cellular response to oxidative/inflammatory signals: beneficial effects of the budesonide-hydroxypropyl-β-cyclodextrin complex (submitted)

Promotor : Marie-Paule MINGEOT-LECLERCQ (marie-paule.mingeot@uclouvain.be)

• Thevelin S, Spinewine A, Beuscart JB, Boland B, Marien S, Vaillant F, Wilting I, Vondeling A, Floriani C, Schneider C, Donzé J, Rodondi N, Cullinan S, O'Mahony D, Dalleur O. Development of a standardised chart review method to identify drug-related hospital admissions in older people. British Journal of Clinical Pharmacology. 2018; 84(11):2600-2614.
• Thevelin S, Mounaouar LE, Marien S, Boland B, Henrard S, Dalleur O. Potentially inappropriate prescribing and related hospital admissions in geriatric patients: A comparative analysis between the STOPP and START criteria versions 1 and 2. Drugs & Aging. 2019; 36(5):453-459.

Promotor : Olivia Dalleur (olivia.dalleur@uclouvain.be) / Co-promotor: Anne Spinewine (anne.spinewine@uclouvain.be)

Related publications :

• Acciardo S, Mignion L, Lacomblez E, Schoonjans C, Joudiou N, Gourgue F, Bouzin C, Baurain JF, Gallez B, Jordan BF. J Cell Mol Med. 2019 Dec 13. doi: 10.1111/jcmm.14890. Metabolic imaging using hyperpolarized 13 C-pyruvate to assess sensitivity to the B-Raf inhibitor vemurafenib in melanoma cells and xenografts.
• Acciardo S, Mignion L, Joudiou N, Bouzin C, Baurain JF, Gallez B, Jordan BF. Imaging markers of response to combined BRAF and MEK inhibition in BRAF mutated vemurafenib-sensitive and resistant melanomas. Oncotarget. 2018 Mar 30;9(24):16832-16846. doi: 10.18632/oncotarget.24709.

Promotor : Bénédicte Jordan - Co-promotor : Jean-François Baurain

Promotor : Véronique Préat (veronique.preat@uclouvain.be) - Co-promotor : Arnaud Vigneron (Centre de Recherche contre le Cancer - Lyon)
     

Partie 2 : Stratégies de modulation de la réponse inflammatoire pulpaire, exemple d’un microgel biphasique en tant que système à libération de lipoxine - Alexis Gaudin

related publications:

• Flégeau K, Pace R, Gautier H, Rethore G, Guicheux J, Le Visage C, Weiss P. Toward the development of biomimetic injectable and macroporous biohydrogels for regenerative medicine. Adv Colloid Interface Sci. 2017 Sep;247:589-609.
• Xie F, Boyer C, Gaborit V, Rouillon T, Guicheux J, Tassin JF, Geoffroy V, Réthoré G, Weiss P. A Cellulose/Laponite Interpenetrated Polymer Network (IPN) Hydrogel: Controllable Double-Network Structure with High Modulus. Polymers (Basel). 2018 Jun 8;10(6). pii: E634.
• Gaudin A, Tolar M, Peters OA. Lipoxin A4 Attenuates the Inflammatory Response in Stem Cells of the Apical Papilla via ALX/FPR2. Sci Rep. 2018 Jun 11;8(1):8921.

Seminar of the doctoral school in biomedical and pharmaceutical sciences –  Data-club 

Alice de Wouters d'Oplinter (Metabolism and Nutrition research group (MNUT/LDRI)):

“Gut microbes and food intake : beyond the hypothalamus”

Viridiane Gratpain (Advanced Drug Delivery and Biomaterials research group (ADDB/LDRI)):

“Non-invasive delivery of Activin A-loaded extracellular vesicles to stimulate remyelination in the central nervous system”

info: G. Muccioli 02.764.72.31 <giulio.muccioli@uclouvain.be>

• Liberelle M, Magnez R, Thuru X, Bencheikh Y, Ravez S, Quenon C, Drucbert AS, Foulon C, Melnyk P, Van Seuningen I, Lebègue N. Sci Rep, 9, 16678, 2019 "MUC4-ErbB2 Oncogenic Complex: Binding studies using Microscale Thermophoresis"
• Liberelle M, Jonckheere, N ,Melnyk P, Van Seuningen I, Lebègue N. J. Med. Chem., 2020, accepted "EGF-containing Membrane-bound Mucins: a hidden ErbB2 targeting pathway"

Seminar of the doctoral school in biomedical and pharmaceutical sciences 

Mathilde Bausart  (ADDB/LDRI) “Combination of Systemic Immunotherapies with Local Chemotherapy for the Treatment of Unresectable Glioblastoma”

Romano Terrasi (BPBL/LDRI) “Setting up of a LC-MS/MS method for the absolute quantification of lysophospholipids and phospholipids”

info: G. Muccioli 02.764.72.31 <giulio.muccioli@uclouvain.be

Seminar of the doctoral school in biomedical and pharmaceutical sciences 

Camille Amadieu (MNUT/LDRI) “Study of the effectiveness of a nutritional intervention targeting the gut microbiota on biological and psychological symptoms associated with alcohol use disorders”

Mandeep Kaur (FACM/LDRI) “Outer membrane asymmetry of P. aeruginosa: a target for new amphiphilic aminoglycosides?” 

info: G. Muccioli 02.764.72.31 <giulio.muccioli@uclouvain.be

Seminar of the doctoral school in biomedical and pharmaceutical sciences 

Perrine Evrard (CLIP/LDRI) “Benzodiazepines use and deprescribing in Belgian Nursing Homes”

Caner Yelek (MNUT-REMA/LDRI) “Obesity-associated imbalances driving breast cancer progression : Understanding the role of the gut microbiota”

info: G. Muccioli 02.764.72.31 <giulio.muccioli@uclouvain.be

Auditoire Maisin. Registration is compulsory before Monday 24/08 and the number of places is limited. Registration on: https://doodle.com/poll/w5vk456sb2pm3g7d
Videoconference on Microsoft Teams, link to the meeting: https://urlz.fr/dDQ7

Promotor: Prof. Véronique Préat

Related references: Inhibition of colorectal cancer-associated fibroblasts by lipid nanocapsules loaded with acriflavine or paclitaxel, Thibaut Fourniols, Estelle Bastien, Alizée Canevat, Olivier Feron, Véronique Préat, International journal of Pharmaceutics 584, 119337 (2020)

Info: veronique.preat@uclouvain.be

Videoconference on Microsoft Teams

Promotor: Prof. Patrice D. Cani – Co-promotor: Prof. Amandine Everard

Related references:

Depommier, C.*; Everard, A*.; et al., (*equivalent authors), “Supplementation with Akkermansia muciniphila in overweight and obese human volunteers : a proof-of-concept exploratory study” Nature medicine, 2019, 25, 1096-110.

Depommier, C.; et al., “Impact of pasteurized Akkermansia muciniphila on whole-body energy metabolism : new insight from indirect calorimetry in diet-induced obese mice” Gut microbes, 2020, 11(5), 1231-1245.

Plovier, H.; Everard, A. *; Druart, C.*; Depommier, C.*; et al., (*equivalent authors), “A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice” Nature medicine, 2017, 23, 107-113.

Cani P. D.*; Van hul, M.*; Lefort, C.*; Depommier, C.*; Rastelli, M.*; Everard, A.*(*equivalent author) “Microbial regulation of organisma energy homeostasis” Nature Metabolism, 2019, 1, 34-36.

Info: patrice.cani@uclouvain.be

Supervisor: Prof. Giulio G. Muccioli – Co-supervisor: Dr. Mireille Alhouayek

Related references:

• Prostaglandin D2-glycerol ester decreases carrageenan-induced inflammation and hyperalgesia in mice, Baptiste Buisseret, Owein Guillemot-Legris, Giulio G. Muccioli, Mireille Alhouayek, Biochim Biophys Acta Mol Cell Biol Lipids, 2019, 1864(5), 609-618.

• Endocannabinoid and Prostanoid Crosstalk in Pain, Baptiste Buisseret, Mireille Alhouayek, Owein Guillemot-Legris, Giulio G. Muccioli, Trends Mol Med. 2019, 25(10), 882-896

• R-flurbiprofen and the oxygenated metabolites of endocannabinoids in inflammatory pain mice models, Baptiste Buisseret, Owein Guillemot-Legris, Youssef Ben Kouidar, Adrien Paquot, Giulio G. Muccioli, Mireille Alhouayek (submitted)

Info: giulio.muccioli@uclouvain.be or mireille.alhouayek@uclouvain.be

Related references:

25-hydroxycholesterol metabolism is altered by lung inflammation and its local administration modulates lung inflammation. Bottemanne P, Paquot A, Ameraoui H, Guillemot-Legris O, Alhouayek M, Muccioli GG, submitted

N-acylethanolamine-hydrolyzing acid amidase inhibition, but not fatty acid amide hydrolase inhibition, prevents the development of experimental autoimmune encephalomyelitis in mice. Bottemanne P, Guillemot-Legris O, Paquot A, Masquelier J, Malamas M, Makriyannis A, Alhouayek M, Muccioli GG, in revision

The α/β-hydrolase domain 6 inhibitor WWL70 decreases endotoxin-induced lung inflammation in mice, potential contribution of 2-arachidonoylglycerol, and lysoglycerophospholipids. Bottemanne P, Paquot A, Ameraoui H, Alhouayek M, Muccioli GG. FASEB J. 2019;33(6):7635-7646.

N-acylethanolamine hydrolyzing acid amidase inhibition: tools and potential therapeutic opportunities. Bottemanne P, Muccioli GG, Alhouayek M. Drug Discov Today. 2018;23(8):1520-1529.

Info: giulio.muccioli@uclouvain.be 

Yvan Diaz Iglesias, Pharmacologie cellulaire et moléculaire, LDRI

Activity of antibiotics against in vitro mon-species biofilms of P. aeruginosa and S. aureus in the context of cystic fibrosis: The influence of the culture medium

Registration mandatory to be in the room: https://doodle.com/poll/n7fyyv9pwr8uueit

Live event on teams: https://cutt.ly/vfVnOMl

Associated publications:

Diaz Iglesias Y et al. Activity of antibiotics against Staphylococcus aureus in an in vitro model of biofilms in the context of cystic fibrosis: influence of the culture medium. Antimicrobial Agents and Chemotherapy (2019) 63:e00602-19

Diaz Iglesias Y, Van Bambeke F. Activity of antibiotics against Pseudomonas aeruginosa in an in vitro model of biofilms in the context of cystic fibrosis : influence of the culture medium. Antimicrobial Agents and Chemotherapy (2020) ;64(4):e02204-19

Promoter: Françoise Van Bambeke

Info : francoise.vanbambeke@uclouvain.be

Sohaib Mahri

Advanced Drug Delivery and Biomaterials, LDRI

Mechanisms of retention of PEGylated recombinant human deoxyribonuclease I (rhDNase) in the lungs

Mandatory registration for people attending in person : https://bit.ly/3mLfzex

Live event on Teams: https://teams.microsoft.com/l/meetup-join/19%3ameeting_MzIzY2VkODgtOWZkMS00Mzc1LWIxZGUtODQ5MjY0NDM5YjNh%40thread.v2/0?context=%7b%22Tid%22%3a%227ab090d4-fa2e-4ecf-bc7c-4127b4d582ec%22%2c%22Oid%22%3a%22904d15ec-2b2a-4b50-bb75-6a1f392662a8%22%2c%22IsBroadcastMeeting%22%3atrue%7d

Promotor: Rita Vanbever

Co-Promotor: Cynthia Bosquillon

Related publications:

• Mahri, S. et al. , Biodistribution and elimination pathways of PEGylated recombinant human deoxyribonuclease I after pulmonary delivery in mice. Mahri, S., Rondon, A., Bosquillon, C., Vanbever, R. Submitted to Journal of Controlled Release (under revision).
• Mahri, S. et al, PEGylation decreases transport across lung epithelial cells and macrophage uptake of recombinant human deoxyribonuclease I. Hardy, E., De Keersmaecker, H., Braeckmans, K., De Smedt, S., Bosquillon, C., Vanbever, R. Submitted to International Journal of Pharmaceutics (under revision).
• Guichard, M.J, Wilms, T., Mahri S. et al, PEGylation of recombinant human deoxyribonuclease I provides a longacting version of the mucolytic for patients with cystic fibrosis. Submitted to Advanced Therapeutics (under revision).

Info: Rita.vanbever@uclouvain.be

Marialetizia Rastelli

Metabolism and Nutrition group (MNut)

Intestinal epithelial NAPE-PLD controls food intake and energy homeostasis in response to dietary lipids: insight on the mechanisms

Mandatory registration for attending in person: https://doodle.com/poll/nnxtq2z6kcy7vike

Live event on Teams: https://teams.microsoft.com/l/meetup-join/19%3ameeting_N2QyM2RkYmYtM2ViOC00NzZmLWEzODctMjMwNDhhMzZmNGU2%40thread.v2/0?context=%7b%22Tid%22%3a%227ab090d4-fa2e-4ecf-bc7c-4127b4d582ec%22%2c%22Oid%22%3a%22e3ef1b78-a2d0-46d9-aca5-cd462e179840%22%2c%22IsBroadcastMeeting%22%3atrue%7d

Supervisor: Prof. Patrice D. Cani

Related references:

• Intestinal NAPE-PLD contributes to short-term regulation of food intake via gut to brain axis. Rastelli M, Van Hul M, Terrasi R, Lefort C, Régnier M, Beiroa D, Delzenne NM, Everard A, Nogueiras R, Luquet S, Muccioli GG, Cani PD. Am J Physiol Endocrinol Metab. 2020 Sep 1;319(3):E647-E657
• Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis. Everard A*, Plovier H*, Rastelli M*, Van Hul M, de Wouters d’Oplinters A, Geurts L, Druart C, Robine S, Delzenne NM, Muccioli GG, Flamand N, de Vos WM, Di Marzo V Luquet S & Cani PD. Nat Commun. 2019 Jan 28;10(1):457 * authors equally contributing
• The gut microbiome influences host endocrine functions. Rastelli M*, Cani PD*, Knauf C* Endocrine reviews, 2019 Oct 1;40(5):1271-1284. * authors equally contributing
• Microbial regulation of organismal energy homeostasis. Cani PD*, Van Hul M*, Lefort C*, Depommier C*, Rastelli M* and Everard A* Nat Metab. 2019 Jan;1(1):34-46 * authors equally contributing
• Gut microbes and health: a focus on the mechanisms linking microbes, obesity and related disorders. Rastelli M*, Knauf C* & Cani PD* Obesity (Silver Spring). 2018 May;26(5):792-800. * authors equally contributing

Info: patrice.cani@uclouvain.be

Prof. Bruno Sarmento

INEB - Instituto de Engenheria Biomédica and I3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto

Bioengineered-surface nanomedicines for the no-invasive delivery of anti-diabetic peptides

Live event only on Teams

Related references:

• Sarmento B. et al: Development and characterization of lipid-polymeric nanoparticles for oral insulin delivery, Expert Opinion on Drug Delivery, 15, 213-222, 2018
• Sarmento B. et al: Functionalized materials for multistage platforms in the oral delivery of biopharmaceuticals, Progress in Material Sciences, 306-344, 89, 2017
• Sarmento B. et al, In vivo dual-delivery of glucagon like peptide -1 (GLP-1) and dipeptidyl peptidase-4 (DPP4) inhibitor through composites prepared by microfluidics for diabetes therapy, Nanoscale, 8, 10706 – 10713, 2016

Info: ana.beloqui@uclouvain.be

Fanta FALL- PhD-Pharmacognosy GNOS/LDRI

Etude métabolomique de la polarisation des macrophages pulmonaires humains

Auditoire Maisin, reservation required: https://doodle.com/poll/9gwyu759in5dz6xn

Live event also on Microsoft Teams

Related references:

• Fall F. et al: A split-range acquisition method for the non-targeted metabolomic profiling of human plasma with hydrophilic interaction chromatography - high-resolution mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Aug 28
• Fall F. et al: (2020) Metabolic reprograming of LPS-stimulated human lung macrophages involves tryptophan metabolism and the aspartate-arginosuccinate shunt. PLoS ONE 15(4): e0230813. https://doi.org/10.1371/journal.pone.0230813

Info: Joëlle Quetin-Leclercq, joelle.leclercq@uclouvain.be

Léopold Thabault

Medicinal Chemistry (CMFA) - LDRI

Interrogating the Lactate Dehydrogenase Tetrameric Interface Using (Stapled) Peptides and Short Proteins: An Original Approach to Protein Inhibition

Event Teams : https://teams.microsoft.com/l/meetup-join/19%3ameeting_MmM4NzVjZmMtMTczYi00YjcyLWExMDctNjNjMzQwMTdjMDE5%40thread.v2/0?context=%7b%22Tid%22%3a%227ab090d4-fa2e-4ecf-bc7c-4127b4d582ec%22%2c%22Oid%22%3a%2234e84350-e4dc-4ccf-a85d-22195e1fa0f9%22%2c%22IsBroadcastMeeting%22%3atrue%7d

Promotors: Raphaël Frédérick and Pierre Sonveaux

Related publications :

• Thabault, L., Brisson, L., Brustenga, C., Gache, S. A. M., Kozlova, A., Spillier, Q., Liberelle, M., Benyahia, Z., Messens, J., Copetti, T., Sonveaux, P., and Frédérick, R. (2020) Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides. J. Med. Chem. 63, 4628–4643.
• Thabault, L., Liberelle, M., Frédérick, R. Targeting Proteins Self-Association in Drug Design. Drug Discov. Today. provisionnally accepted
• Thabault, L., Liberelle, M., Koruza, K., Yildiz, E., Messens, J., Wouters, J., Sonveaux, P., Frédérick, R. Exploration of Lactate dehydrogenase Tetrameric Interface Unravels a New Tetrameric Site with Related Peptide Ligands. Under preparation.

Info: raphael.frederick@uclouvain.be

Jérôme Duisit, IREC

"Vascularized composite tissues and organ decellularized scaffolds: the ideal biomaterials?”

Mandatory registration for people attending in person (28 persons max): https://doodle.com/poll/zqwufc53wnc8efsh

Event on Teams

Related references:

• Duisit J. et al: Perfusion-decellularization of human ear grafts enables ECM-based scaffolds for auricular vascularized composite tissue engineering. Acta Biomater. 2018 Jun;73:339-354. doi: 10.1016/j.actbio.2018.04.009. Epub 2018 Apr 11.
• Duisit J. et al: Bioengineering a Human Face Graft: The Matrix of Identity. Ann Surg. 2017 Nov;266(5):754-764. doi: 10.1097/SLA.0000000000002396.

Info: anne des Rieux, anne.desrieux@uclouvain.be

Charlotte Lefort

Metabolism and Nutrition group (MNut)

“Hepatocyte endocannabinoid system and innate immunity influence whole-body lipid metabolism: investigation of the molecular mechanisms in the context of obesity.”

Only on Teams : https://teams.microsoft.com/l/meetup-join/19%3ameeting_YjY4NTEyOGQtNGY0NS00ODQ4LThlZjAtMDFiY2VmMTNmMTBm%40thread.v2/0?context=%7b%22Tid%22%3a%227ab090d4-fa2e-4ecf-bc7c-4127b4d582ec%22%2c%22Oid%22%3a%226e779d8f-3bcd-47c5-a0cd-fd0d9e2ebbb7%22%2c%22IsBroadcastMeeting%22%3atrue%7d

Supervisor: Prof. Patrice D. Cani

Related publications :

• Lefort, C., Roumain, M., Van Hul, M., Rastelli, M., Manco, R., Leclercq, I., Delzenne, N. M., Marzo, V. D., Flamand, N., Luquet, S., Silvestri, C., Muccioli, G. G., & Cani, P. D. (2020). Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism. Cells, 9(5), 1247. https://doi.org/10.3390/cells9051247
• Lefort, C., Van Hul, M., Delzenne, N. M., Everard, A., & Cani, P. D. (2019). Hepatic MyD88 regulates liver inflammation by altering synthesis of oxysterols. American journal of physiology. Endocrinology and metabolism, 317(1), E99–E108. https://doi.org/10.1152/ajpendo.00082.2019.
• Cani, P. D., Van Hul, M., Lefort, C., Depommier, C., Rastelli, M., & Everard, A. (2019). Microbial regulation of organismal energy homeostasis. Nature metabolism, 1(1), 34-46. https://doi.org/10.1038/s42255-018-0017-4.

Info : patrice.cani@uclouvain.be

Alessio MALFANTI, PhD, ADDB, “Polymer therapeutics: old-fashioned tools for the next generation nanomedicine”

Only on TEAMS

Related publications: 

• L. Moura, A. Malfanti, C. Peres, A. Matos, E. Guegain, V. Sainz, M. Zloh, M. Vicent and H. Florindo. “Functionalized branched polymers: promising immunomodulatory tools for the treatment of cancer and immune disorders”. doi:10.1039/c9mh00628a
• A. Malfanti, A. Scomparin, S. Pozzi, H. Gibori, A. Krivitsky, R. Blau, R. Satchi-Fainaro, F. Mastrotto, P. Caliceti, S. Salmaso. “Oligo-guanidyl targeted bioconjugates forming rod shaped polyplexes as a new nanoplatform for oligonucleotide delivery”. doi:10.1016/j.jconrel.2019.08.005

Info: veronique.preat@uclouvain.be

• Emilia HOSTE, TFAR, PMGK, “Toxicokinetics and muscle-related toxicity of atorvastatin in vitro”
• Justine VAN de VELDE, IREC, FATH, “Is there a metabolic control of organ-specific metastasis in pancreatic cancer?”

Only on TEAMS

Info: giulio.muccioli@uclouvain.be

Aline UWIMANA, MNut, "Presence of k13 561H artemisinin resistance mutations in Plasmodium falciparum infections in Rwanda"

Only on Teams

Related publications:

Uwimana, A., Legrand, E., Stokes, B.H. et al. Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda. Nat Med 26, 1602–1608 (2020). https://doi.org/10.1038/s41591-020-1005-2

Info: amandine.everard@uclouvain.be

Prof. David ALSTEENS, LIBST, Nanobiophysics lab, UCLouvain, "Probing virus binding to cell surfaces in physiologically relevant conditions using AFM"

Only on Teams

Related publications:

• J. Yang et al., Nat Commun. 11 (2020) 4541: "Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor"
• M. Koehler et al., Nat. Commun. 10 (2019) 4460: "Glycan-mediated enhancement of reovirus receptor binding"

Info: francoise.vanbambeke@uclouvain.be

Giulia LIBERATI, phD, Institute of Neuroscience (IoNS), UCLouvain, "In search of a neural biomarker for pain: insights from intracerebral electroencephalography"

Only on TEAMS: Cliquez ici pour participer à la réunion

https://teams.microsoft.com/l/meetup-join/19%3ameeting_OGJmOWU0ODYtNjA1MC00M2E5LTgxYzQtYjhlODAzNGUzOGE0%40thread.v2/0?context=%7b%22Tid%22%3a%227ab090d4-fa2e-4ecf-bc7c-4127b4d582ec%22%2c%22Oid%22%3a%22ada7cec0-3c05-4900-86a2-ed720b4812e0%22%7d

Related publications:

• Liberati G, Klöcker A, Safronova M M, Ferrão Santos S, Ribeiro Vaz J-G, Raftopoulos C, Mouraux A. "Nociceptive Local Field Potentials Recorded from the Human Insula Are Not Specific for Nociception", https://pubmed.ncbi.nlm.nih.gov/26734726/
• Liberati G, Algoet M, Ferrao Santos S, Ribeiro-Vaz J-G, Raftopoulos C, Mouraux A. "Tonic thermonociceptive stimulation selectively modulates ongoing neural oscillations in the human posterior insula: Evidence from intracerebral EEG". https://pubmed.ncbi.nlm.nih.gov/30529399/

Info: francoise.vanbambeke@uclouvain.be

Lorène ZERAH, phD, CLIP, TFAR, "Prescription of oral antithrombotics in adults in outpatient settings"

Only on TEAMS: Cliquez ici pour participer à la réunion

https://teams.microsoft.com/l/meetup-join/19%3ameeting_MDIxOTM2NDgtOGNkYi00MDMyLTliY2ItMTFmNGUzNTg5NzVj%40thread.v2/0?context=%7b%22Tid%22%3a%227ab090d4-fa2e-4ecf-bc7c-4127b4d582ec%22%2c%22Oid%22%3a%22ada7cec0-3c05-4900-86a2-ed720b4812e0%22%7d

Related publications:

• Zerah L, Bun RS, Guillo S, Collet JP, Bonnet-Zamponi D, Tubach F. A prescription support-tool for chronic management of oral antithrombotic combinations in adults based on a systematic review of international guidelines. PLoS One. 2019;14(2):e0211695.
• Zerah L, Bonnet-Zamponi D, Frappé P, Hauguel-Moreau M, De Rycke Y, Magnier AM, Pautas E, Charles P, Collet JP, Dechartres A, Tubach F. Evaluation of a prescription support-tool for chronic management of oral antithrombotic combinations in adults using clinical vignettes: protocol of a randomised controlled trial. BMJ Open. 2019;9: e025544.
• Zerah L, Bonnet-Zamponi D, Dechartres A, Frappé P, Hauguel-Moreau M, Collet JP, De Rycke Y, Tubach F. Impact of a prescription support tool to improve adherence to the guidelines for the prescription of oral antithrombotics: the COMBI-AT randomized controlled trial using clinical vignettes. J Clin Med. 2019 ;8(11). pii: E1919.
• Zerah L, Bonnet-Zamponi D, Ajrouche A, Collet JP, De Rycke Y, Tubach F. Innapropriate use of oral antithrombotics in an outpatient setting and associated risk: A French nationwide cohort study (under review)

Info: anne.spinewine@uclouvain.be

Céline Schoonjans

REMA (Biomedical Magnetic Resonance), LDRI, UCL and FATH (Pharmacologie et Thérapeutique), IREC, UCL

Tumor microenvironment involvement in the metabolic reprogramming induced by the PDK inhibitor dichloroacetate

Only on TEAMS : https://teams.microsoft.com/l/meetup-join/19%3ameeting_MDIxMDNkMjktNWM3Yi00NWMxLTgzYTUtMjQ0YTNlMDlhNDMy%40thread.v2/0?context=%7b%22Tid%22%3a%227ab090d4-fa2e-4ecf-bc7c-4127b4d582ec%22%2c%22Oid%22%3a%2200b6c117-953b-47f8-8a63-cfcba01b1a60%22%2c%22IsBroadcastMeeting%22%3atrue%7d

Supervisors : Bernard Gallez (promotor) and Olivier Feron (co-promotor)

Related publications :

• Schoonjans, C. A., Joudiou, N., Brusa, D., Corbet, C., Feron, O., & Gallez, B. (2020). Acidosis-induced metabolic reprogramming in tumor cells enhances the anti-proliferative activity of the PDK inhibitor dichloroacetate. Cancer Letters, 470, 18-28.
• Schoonjans, C. A., Mathieu, B., Joudiou, N., Zampieri, L. X., Brusa, D., Sonveaux, P., ... & Gallez, B. (2020). Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1. Journal of clinical medicine, 9(10), 3308.
• Schoonjans, C. A., & Gallez, B. (2020). Metabolic Plasticity of Tumor Cells: How They Do Adapt to Food Deprivation. In Tumor Microenvironment (pp. 109-123). Springer, Cham.

Info: bernard.gallez@uclouvain.be

Céline Schoonjans

REMA (Biomedical Magnetic Resonance), LDRI, UCL and FATH (Pharmacologie et Thérapeutique), IREC, UCL

Tumor microenvironment involvement in the metabolic reprogramming induced by the PDK inhibitor dichloroacetate

Only on TEAMS : https://teams.microsoft.com/l/meetup-join/19%3ameeting_MDIxMDNkMjktNWM3Yi00NWMxLTgzYTUtMjQ0YTNlMDlhNDMy%40thread.v2/0?context=%7b%22Tid%22%3a%227ab090d4-fa2e-4ecf-bc7c-4127b4d582ec%22%2c%22Oid%22%3a%2200b6c117-953b-47f8-8a63-cfcba01b1a60%22%2c%22IsBroadcastMeeting%22%3atrue%7d

Supervisors : Bernard Gallez (promotor) and Olivier Feron (co-promotor)

Related publications :

• Schoonjans, C. A., Joudiou, N., Brusa, D., Corbet, C., Feron, O., & Gallez, B. (2020). Acidosis-induced metabolic reprogramming in tumor cells enhances the anti-proliferative activity of the PDK inhibitor dichloroacetate. Cancer Letters, 470, 18-28.
• Schoonjans, C. A., Mathieu, B., Joudiou, N., Zampieri, L. X., Brusa, D., Sonveaux, P., ... & Gallez, B. (2020). Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1. Journal of clinical medicine, 9(10), 3308.
• Schoonjans, C. A., & Gallez, B. (2020). Metabolic Plasticity of Tumor Cells: How They Do Adapt to Food Deprivation. In Tumor Microenvironment (pp. 109-123). Springer, Cham.

Info: bernard.gallez@uclouvain.be

Florian GOURGUE

REMA (Biomedical Magnetic Resonance) and MNut (Metabolism and Nutrition), LDRI, UCLouvain.

Investigation of the apelin adipokine as a potential therapeutic target for breast cancer patients in the context of obesity

Only on TEAMS :

https://teams.microsoft.com/l/meetup-join/19%3adb80bec0d47f4b4ba8ed7cce1a908947%40thread.tacv2/1607428364575?context=%7b%22Tid%22%3a%227ab090d4-fa2e-4ecf-bc7c-4127b4d582ec%22%2c%22Oid%22%3a%222a9cf939-c197-4992-a8af-f10c5093d646%22%7d

Supervisors : Prof. Bénédicte F. Jordan et Prof. Patrice D. Cani.

Related publications :

• Gourgue F., Mignion L., Van Hul M., Dehaen N., Bastien E., Payen V., Leroy B., Joudiou N., Vertommen D., Bouzin C., Delzenne N., Gallez B., Feron O., Jordan B.F. & Cani P.D. “Obesity & Triple Negative Breast Cancer: is Apelin a new key target?” Journal of Cellular and Molecular Medicine 2020 Sep;24(17):10233-10244. doi: 10.1111/jcmm.15639
• Gourgue F., Derouane F., van Marcke C., Villar E., Dano H., Desmet L., Bouzin C., Duhoux F.P., Cani P.D. & Jordan B.F. “Obesity and response to neoadjuvant chemotherapy in breast cancer: implication of the apelinergic system” submitted to Scientific Reports
• Jordan B.F., Gourgue F. & Cani P.D. “Adipose Tissue Metabolism and Cancer Progression: Novel Insights from Gut Microbiota?” Current Pathobiology Reports 2017;5(4):315-322. doi: 10.1007/s40139-017-0154-6.

Info : benedicte.jordan@uclouvain.be ou patrice.cani@uclouvain.be

January 18, 2021 - 1pm to 2.30 pm

On TEAMS: https://teams.microsoft.com/l/meetup-join/19%3ameeting_N2Q1Nzc4N2ItMWQ4YS00ZmI5LWExYWMtYmM1NDQ1Y2IzOGMy%40thread.v2/0?context=%7b%22Tid%22%3a%227ab090d4-fa2e-4ecf-bc7c-4127b4d582ec%22%2c%22Oid%22%3a%22ada7cec0-3c05-4900-86a2-ed720b4812e0%22%7d

• Marine ANCIA (CMFA research group (LDRI) & GEPI research group (DDUV))

“Discovery of TSPYL5/USP7 protein-protein interaction inhibitors to detail the Alternative Lengthening of Telomeres (ALT) mechanism”

• Youssef BEN KOUIDAR (BPBL research group (LDRI))

“Investigation of the interest of N-acylethanolamine acid amidase inhibition in diet-induced obesity, its inflammatory and neuroinflammatory consequences and the chronicization of post-operative pain”

• Chloé BUYSE (REMA research group (LDRI))

“pH imaging as a guidance tool for therapies targeting tumor extracellular acidification”

• Giuditta LEONE (ADDB research group (LDRI))

“Design of a long-acting vasodilator nanomedicine for inhalation in pulmonary arterial hypertension”

• Justin RONDEAU (FATH, Pole of Pharmacology and Therapeutics (IREC))

“Identification of genetic and metabolic controls of radiotherapy-induced breast cancer metastasis”

• Wunan ZHANG (ADDB research group (LDRI))

“An anti TNF-a antibody loaded foam for the treatment of inflammatory bowel disease via oral delivery”

January 25, 2021 - 1pm to 2.30 pm

On TEAMS: https://teams.microsoft.com/l/meetup-join/19%3ameeting_YWFmNGRhNjktMGQ0My00NmI3LTkyMGUtNDQ1MmQ5ZDk5NTA2%40thread.v2/0?context=%7b%22Tid%22%3a%227ab090d4-fa2e-4ecf-bc7c-4127b4d582ec%22%2c%22Oid%22%3a%22ada7cec0-3c05-4900-86a2-ed720b4812e0%22%7d

• Marie AUQUIÈRE (ADDB research group & BPBL research group (LDRI))

“Encapsulation of lipids and microARNs in extracellular vesicles for the treatment of multiple sclerosis ”

• Juhans DECHENNE (CMFA research group (LDRI)

“Interrogating the self-assembly of arginase and tryptophan 2,3-dioxygenase, two proteins involved in cancer immunotherapy”

• Natacha DEHAEN (REMA research group & MNUT research group (LDRI))

“Study of links between obesity and metastatic triple-negative breast cancer”

• Sabrina HUWART (MNUT research group (LDRI))

“Roles of gut microbiota induced neuroinflammation on hedonic and food reward alterations during obesity”

• Espoir KAMBALE KAVUNGERE (ADDB research group (LDRI), GNOS research group (LDRI) & UNIKIN)

“Lipid nanocapsules containing zinc oxide nanoparticles biosynthesized from Congolese plants extracts for the treatment of type 2 diabetes mellitus”

• Adam LAGHOUATI (BPBL research group (LDRI))

“Study of the involvement of the endocannabinoid system in the resolution of inflammation”

• Mona SHAHIN (FATH, Pole of Pharmacology and Therapeutics (IREC))

“Metabolic control of radioresistance in breast cancer”

Seminar of the doctoral school in biomedical and pharmaceutical sciences 

Jerome CONQ, Biomedical Magnetic Resonance Research Group (REMA) & Advanced Drug Delivery and Biomaterials Group (ADDB). "Strategies for a transient opening of the blood brain barrier to increase the delivery of nanomedicines to glioblastoma"

Emilie MOENS de HASE, Metabolism and Nutrition Research Group (MNUT). “Investigation of the effects of newly discovered bacteria Dysosmobacter welbionis on metabolism and inflammation"

On TEAMS.

Info: giulio.muccioli@uclouvain.be

Frédéric PEYRUSSON

Translational Research from Experimental and Clinical Pharmacology to Treatment Optimization (TFAR) - Cellular and Molecular Pharmacology (FACM)

Intracellular persistence of Staphylococcus aureus: From observations to mechanisms

Only on TEAMS: click here to join the meeting

Promoter: Françoise Van Bambeke

Related publications:

• Peyrusson et al. Intracellular Staphylococcus aureus persisters upon antibiotic exposure. . Nat Commun. 2020 May 4;11(1):2200. doi: 10.1038/s41467-020-15966-7.
• Peyrusson et al. Cellular pharmacokinetics and intracellular activity of the bacterial fatty acid synthesis inhibitor, afabicin desphosphono against different resistance phenotypes of Staphylococcus aureus in models of cultured phagocytic cells. Int J Antimicrob Agents. 2020 Feb;55(2):105848. doi: 10.1016/j.ijantimicag.2019.11.005
• Peyrusson et al. Cellular Pharmacokinetics and Intracellular Activity of Gepotidacin against Staphylococcus aureus Isolates with Different Resistance Phenotypes in Models of Cultured Phagocytic Cells. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e02245-17.
• Peyrusson et al. Cellular pharmacokinetics and intracellular activity of the novel peptide deformylase inhibitor GSK1322322 against Staphylococcus aureus laboratory and clinical strains with various resistance phenotypes: studies with human THP-1 monocytes and J774 murine macrophages. Antimicrob Agents Chemother. 2015 Sep;59(9):5747-60. doi: 10.1128/AAC.00827-15.

Info: francoise.vanbambeke@uclouvain.be

Seminar of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Hafsa AMERAOUI, Bioanalysis and Pharmacology of Bioactive Lipids Research Group (BPBL/LDRI). “Oxysterols in inflammatory bowel diseases : Investigation of the effect of oxysterols in murine colon tissue explants”

Chantale Farah, Biomedical Magnetic Resonance Research Group (REMA/LDRI) and Pôle d'imagerie moléculaire, radiothérapie et oncologie MIRO/IREC). ''Imaging metabolic plasticity in melanoma: Relevance of combining metabolic modulators with BRAF or Immune checkpoints inhibitors''

Only on TEAMS

Info: giulio.muccioli@uclouvain.be

LDRI seminar

Sergio ORTIZ, Post-Doc (GNOS - LDRI) : "Exploring the Traditional Medicine of Atacama People from North of Chile, as in inestimable source of bioactive compounds"

References :

• S. Ortiz, M. Lecsö-Bornet, C. Bonnal, S. Houze, S. Michel, R. Grougnet, S. Boutefnouchet. BIO-GUIDED IDENTIFICATION OF TRITERPENOIDS AND NEOLIGNANS AS BIOACTIVE COMPOUNDS FROM ANTI-INFECTIOUS MEDICINAL PLANTS OF THE TAIRA ATACAMA’S COMMUNITY (CALAMA, CHILE). Journal of Ethnopharmacology; 231: 217-229. 2018
• S. Ortiz, M. Lecsö-Bornet, S. Michel, R. Grougnet, S. Boutefnouchet. CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF ESSENTIAL OILS FROM ARTEMISIA COPA PHIL. VAR. COPA (ASTERACEAE) AND ALOYSIA DESERTICOLA (PHIL.) LU-IRVING & O’LEARY (VERBENACEAE), USED IN THE CHILEAN ATACAMA’S TAIRA COMMUNITY (ANTOFAGASTA, CHILE). Journal of Essential Oils Research; 31: 425-431. 2019
• O. Cecil Azuama, S. Ortiz, L. Quirós-Guerrero, E. Bouffartigues, D. Tortuel, O. Maillot, M. Feuilloley, P. Cornelis, O. Lesouhaitier, R. Grougnet, S. Boutefnouchet, J.-L. Wolfender, S. Chevalier and A. Tahrioui. TACKLING PSEUDOMONAS AERUGINOSA VIRULENCE BY MULINANE-LIKE DITERPENOIDS FROM AZORELLA ATACAMENSIS. Biomolecules; 10: 1626, 2020. doi:10.3390/biom10121626

Info : joelle.leclercq@uclouvain.be

Cliquez ici pour participer à la réunion

Seminar of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Paola PAONE (Metabolism and Nutrition Research group (MUNT/LDRI)): “Studying and modulating mucosal-gut microbiota interface: impact of the pathophysiology of obesity, diabetes and cardiometabolic disorders”

Perrine SAVOYEN (Medicinal Chemistry Research group (CMFA/LDRI) and Pole of Pharmacology and Therapeutics (FATH/IREC)): “Design and synthesis of macrocyclic peptides as inhibitors of Lactate Dehydrogenase”

Info: giulio.muccioli@uclouvain.be

Cliquez ici pour participer à la réunion

LDRI seminar

Gert-Jan WIJNANT, Post-Doc (TFAR, FACM): “Skin microdialysis in leishmaniasis: from bench to bedside”.

Related pulications :

• Gert-Jan Wijnant, SL Croft, R de la Flor, M Alavijeh, V Yardley S Braillard, C Mawbray, K Van Bocxlaer. "Pharmacokinetics and Pharmacodynamics of the Nitroimidazole DNDI-0690 in Mouse Models of Cutaneous Leishmaniasis" (DOI: 10.1128/AAC.00829-19). Published in Antimicrobial Agents and Chemotherapy (AAC), 2019
• Gert-Jan Wijnant, S Moulik, K Chatterjee, NK Das, R de la Flor, K Van Bocxlaer, SL Croft, M Chatterjee. "Dermal microdialysis: a method to determine drug levels in the skin of patients with Post Kala-azar Dermal Leishmaniasis (PKDL)". Submitted for publication in Journal of Investigative Dermatology (JID) Innovations, 2021

Info: francoise.vanbambeke@uclouvain.be

Cliquez ici pour participer à la réunion

Seminar of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Chiara BRUSTEGNA (Medicinal Chemistry Research group (CMFA/LDRI) and Pole of Pharmacology and Therapeutics (FATH/IREC)): “Disrupting the lactate dehydrogenase (LDH) tetramerization site with small molecule inhibitors as a new anticancer treatment”

Juliette LAGREULA (Clinical pharmacy (CLIP/LDRI) and Integrated pharmacometrics, pharmacogenomics and pharmacokinetics (PMGK/LDRI) research groups): “Prevalence of antipsychotic polypharmacy and evolution of prescribing patterns between admission and discharge of 5 Belgian hospitals”

Info: giulio.muccioli@uclouvain.be

Cliquez ici pour participer à la réunion

LDRI Seminar

Richard BROAHEAD, Field Application Scientist (UK & Ireland, Scandinavia and Benelux), Precision NanoSystems: “The NanoAssemblr Ignite: robust, adjustable and scalable production of nanoparticles for medicine and research"

Info: anne.desrieux@uclouvain.be

Cliquez ici pour participer à la réunion

Seminar of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Mingchao Wang (Advanced drug delivery and biomaterials (ADDB/LDRI)): “Development of Doxorubicin and α-Tocopherol based nanomedicine locally targeting the glioblastoma resection microenvironment”

Zhifen Wang (Celluar and Molecular pharmacology research group (FACM/LDRI)): “Evaluation of the activity of antibiotics and adjuvant strategies against dual species biofilms in the context of cystic fibrosis”

Info: giulio.muccioli@uclouvain.be

Cliquez ici pour participer à la réunion

Gabriel Stillemans

Integrated PharmacoMetrics, pharmacoGenomics and pharmacoKinetics (PMGK, LDRI)
Louvain centre for Toxicology and Applied Pharmacology (LTAP, IREC)

Optimization of darunavir therapy through population pharmacokinetic modeling and simulations

Link to join the meeting : https://zoom.us/j/94907639771

Directors : Laure Elens, Vincent Haufroid

Related publications :
- G. Stillemans, H.P. Djokoto, K-A. Delongie, H. El-Hamdaoui, N. Panin, V. Haufroid, L. Elens, Effect of four ABCB1 genetic polymorphisms on the accumulation of darunavir in HEK293 recombinant cell lines, Scientific Reports (Revision submitted, 2021).
- G. Stillemans, L. Belkhir, B. Vandercam, A. Vincent, V. Haufroid and L. Elens, Optimal sampling strategies for darunavir and external validation of the underlying population pharmacokinetic model, European Journal of Clinical Pharmacology 77 (2021), pp. 607-616
- G. Stillemans, L. Belkhir, B. Vandercam, A. Vincent, V. Haufroid and L. Elens, Exploration of reduced doses and short cycle therapy for darunavir/cobicistat in patients with HIV using population pharmacokinetic modeling and simulations, Clinical Pharmacokinetics 60 (2021), pp. 177-189.
- G. Stillemans, L. Belkhir, D.A. Hesselink, V. Haufroid and L. Elens, Pharmacogenetic associations with cytochrome P450 in antiretroviral therapy: what does the future hold?, Expert Opinion on Drug Metabolism & Toxicology 14 (2018), pp. 601–611.

Info : laure.elens@uclouvain.be
 

Seminar of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Steven De Soir (Cellular and Molecular Pharmacology Research group (FACM/LDRI) and Lab for Cellular and Molecular Technology (LabMCT) of the Queen Astrid Military Hospital)

“Phage-Antibiotic Synergy for the treatment of biofilm related infections on orthopedic implants”

Info: giulio.muccioli@uclouvain.be

Only on TEAMS

LDRI Seminar

Joan Bestard-Escalas, PhD (Bioanalysis and Pharmacology of Bioactive Lipids Research Group (BPBL/LDRI))

« Role of membrane lipids in colon differentiation unravelled by mass spectrometry: arachidonic acid beyond inflammation”

Related publications :

• Lipid fingerprint image accurately conveys human colon cell pathophysiologic state: A solid candidate as biomarker. (2016) Joan Bestard Escalas; Jone Garate; Albert Maimó Barceló; Roberto Fernández; Daniel Horacio Lopez; Sergio Lage; Rebeca Reigada; Sam Khorrami; Daniel Ginard; José Reyes; Isabel Amengual; José A Fernández; Gwendolyn Barceló Coblijn. Biochimica et biophysica acta.
• Tissue-selective alteration of ethanolamine plasmalogen metabolism in dedifferentiated colon mucosa. (2018) Daniel H. López; Joan Bestard Escalas; Jone Garate; Albert Maimó Barceló; Roberto Fernández;Rebeca Reigada; Sam Khorrami; Daniel Ginard; Toshiro Okazaki; José A. Fernández; Gwendolyn Barceló Coblijn. BBA - Molecular and Cell Biology of Lipids.
• Common and Differential Traits of the Membrane Lipidome of Colon Cancer Cell Lines and Their Secreted Vesicles: Impact on Studies Using Cell Lines. (2020) Joan Bestard Escalas; Albert Maimó Barceló; Daniel H. López; Rebeca Reigada; Francisca Guardiola Serrano; José Ramos Vivas; Thorsten Hornemann; Toshiro Okazaki; Gwendolyn Barceló Coblijn.

Info: giulio.muccioli@uclouvain.be

Only on TEAMS

LDRI Seminar

Dr Sophie Leclère (ADRE/FRON Coordination administrative & valorisation du doctorat)

Presentation of tools and brochures (VALO DOC): skills self-assessment booklet « Yes I can ! Assessing my doctoral skills », « Career opportunities brochure » and « Training catalogue ».

Valo Doc is the UCLouvain online platform for PhD candidates ! It a website entirely dedicated to answering your questions and give you all the information regarding your doctoral journey at UCLouvain. From how to register to how to organize your defense, Valo Doc provides you all you need to know how to successfully carry out research in an appropriate environment. Given the hybrid status of PhD students, the day-to-day management of their doctoral studies involves interactions with many different departments and tools (subject-specific doctoral committee, Admissions Office, Research Department, institutes, HR Department, Finance Department, International Relations Department, DIAL, etc.). This is why Valo Doc provides useful contacts to be sure you have all the information you need. You will also find information regarding other aspects like trainings, funding, career, mobility, etc.

Info: lionel.mignion@uclouvain.be

Only on TEAMS 

LDRI Seminar

Matthieu Giraud, Corden Pharma, specialist in the synthesis of therapeutic peptides.

“API from clinical trials to the market - a CDMO perspective”

Info: anne.desrieux@uclouvain.be

Only on TEAMS

LDRI Seminar

Prof. Vincent Van Pesch, IoNS and Cliniques Universitaires Saint Luc Brussels, neurologist specialized in multiple sclerosis.

“Multiple Sclerosis in 2021 : recent advances from bench to bedside “

Related publications:

• Absinta M, Lassmann H, Trapp BD. Mechanisms underlying progression in multiple sclerosis. Curr Opin Neurol. 2020 Jun;33(3):277-285. doi: 10.1097/WCO.0000000000000818.
• Perdaens O et al. CSF microRNAs discriminate MS activity and share similarity to other neuroinflammatory disorders. Neurol Neuroimmunol Neuroinflamm. 2020 Feb 7;7(2):e673. doi: 10.1212/NXI.0000000000000673.
• Maggi P et al. Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study. Ann Neurol. 2020 Nov;88(5):1034-1042. doi: 10.1002/ana.25877.
• Kuhle J et al. Blood neurofilament light chain as a biomarker of MS disease activity and treatment response. Neurology. 2019 Mar 5;92(10):e1007-e1015. doi: 10.1212/WNL.0000000000007032.
• Brown JWL et al.; MSBase Study Group. Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis. JAMA. 2019 Jan 15;321(2):175-187. doi: 10.1001/jama.2018.20588.

Info: anne.desrieux@uclouvain.be

Only on TEAMS

May 20-21, 2021, 1-5pm

Be with us virtually on Teams, and support the current LDRI PhD researchers.

20 oral presentations will be presented by the PhD candidates on Thursday 20 Rejoindre la conversation (microsoft.com) and Friday 21 Rejoindre la conversation (microsoft.com).

You can find the detailed scientific program in the booklet posted on the LDRI Oasis space, in the "PhD Day" folder.

23 posters are also available in the LDRI "PhD Day" oasis space.

Best poster and best oral presentation awards will be delivered to close the event.

With the support of our sponsors.

Arina KOZLOVA

Medicinal Chemistry (CMFA)

Design, Synthesis and Evaluation of Original 1-H-indol-3-yl Heterocyclic Derivatives as Tryptophan 2,3-Dioxygenase Inhibitors 

Director : Raphaël Frédérick, co-director : Benoît Van den Eynde.

Related publications :

• Kozlova A, Frédérick R. Current State on Tryptophan 2,3-Dioxygenase Inhibitors: A Patent Review. Expert Opin. Ther. Pat. 2019, 29 (1), 11–23. doi: 10.1080/13543776.2019.1556638
• Kozlova A, Thabault L, Liberelle M, Klaessens S, Prévost JRC, Mathieu C, Pilotte L, Stroobant V, Van den Eynde B, Frédérick R. Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase. J Med Chem. 2021 Aug 2. doi: 10.1021/acs.jmedchem.1c00323.
• Kozlova A, Thabault L, Dauguet N, Stroobant V, Pilotte L, Liberelle M, Van den Eynde B, Frédérick R. Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase. Eur J Med Chem 2021. Under revision.

Info: raphael.frederick@uclouvain.be

Hervé POILVACHE

NMSK - IREC and TFAR - FACM (Cellular and Molecular Pharmacology)

In-vitro and in-vivo study of biofilm disruption strategies for the treatment of Prosthetic Joint Infections

Directors: Olivier Cornu (NMSK - IREC) et Françoise Van Bambeke (TFAR - FACM)

Related publications:

• Poilvache, H., et al. (2020). "Synergistic Effects of Pulsed Lavage and Antimicrobial Therapy Against Staphylococcus aureus Biofilms in an in-vitro Model." Front Med (Lausanne) 7(527): 527
• Poilvache, H., et al. (2021). "In Vitro Study of the Synergistic Effect of an Enzyme Cocktail and Antibiotics against Biofilms in a Prosthetic Joint Infection Model." Antimicrob Agents Chemother 65(4)

Also on Teams: https://bit.ly/3jH6wM2 

Info: francoise.vanbambeke@uclouvain.be

Prof. Laurent GATTO, CBIO/DDUV

Présentation des activités de la plateforme de bioinformatique

Info: françoise.vanbambeke@uclouvain.be

Prof. Charles PILETTE, IREC/PNEU

Mucosal immunity in chronic obstructive pulmonary disease: focus on the airway epithelium

Related publications:

• Gohy S, Detry B, Lecocq M, Bouzin C, Weynand B, Sibille Y, and Pilette C. Polymeric immunoglobulin receptor downregulation in COPD: persistence in the cultured epithelium and role of transforming growth factor-b. Am J Respir Crit Care Med 2014; 190:509-521. https://pubmed.ncbi.nlm.nih.gov/25078120/
• Gohy ST, Hupin C, Fregimilicka C, Detry BR, Bouzin C, Gaide Chevronay H, Lecocq M, Weynand B, Ladjemi MZ, Pierreux CE, Birembaut P, Polette M, Pilette C. Imprinting of the COPD airway epithelium for dedifferentiation and mesenchymal transition. Eur Respir J 2015; 45: 1258-1272. https://pubmed.ncbi.nlm.nih.gov/25745049/
• Ladjemi MZ, Gras D, Detry B, Lecocq M, Dupasquier S, Garulli C, Fremmilicka C, Bouzin C, Gohy S, Chanez P, Pilette C. Bronchial epithelial IgA secretion is impaired in asthma: role of IL-4/IL-13. Am J Respir Crit Care Med 2018; 197(11):1396-1409. https://pubmed.ncbi.nlm.nih.gov/29652177/
• Carlier FM, Dupasquier S, Ambroise J, Detry B, Lecocq M, Biétry-Claudet C, Boukala Y, Gala JL, Bouzin C, Verleden SE, Hoton D, Gohy S, Bearzatto B, Pilette C. Canonical WNT pathway is activated in the airway epithelium in chronic obstructive pulmonary disease. EBioMed 2020 Nov; 61:103034. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559244/
• Carlier FM, de Fays C, Pilette C. Epithelial barrier dysfunction in chronic respiratory diseases. Frontiers Physiol 2021 Jun 24;12:691227. https://www.frontiersin.org/articles/10.3389/fphys.2021.691227/full

Info: rita.vanbever@uclouvain.be

Julie Vanacker, PhD, chargée des études cliniques académiques UCLouvain

Etudes cliniques académiques: mode d'emploi et requis réglementaires

Info : francoise.vanbambeke@uclouvain.be

Prof. Andrea Bonetto, Department of surgery, School of Medecine, Indiana University

Musculoskeletal defects induced by cancer and its treatments

Related publications :

• Joshua R Huot, Fabrizio Pin, Andrea Bonetto. Muscle weakness caused by cancer and chemotherapy is associated with loss of motor unit connectivity. Am J Cancer Res. 2021 Jun 15;11(6):2990-3001. eCollection 2021
• Joshua R Huot, Fabrizio Pin, Ashok Narasimhan, Leah J Novinger, Austin S Keith, Teresa A Zimmers, Monte S Willis, Andrea Bonetto. ACVR2B antagonism as a countermeasure to multi-organ perturbations in metastatic colorectal cancer cachexia. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1779-1798. doi: 10.1002/jcsm.12642. Epub 2020 Nov 16
• Joshua R Huot, Leah J Novinger, Fabrizio Pin, Ashok Narasimhan, Teresa A Zimmers, Thomas M O'Connell, Andrea Bonetto. Formation of colorectal liver metastases induces musculoskeletal and metabolic abnormalities consistent with exacerbated cachexia. JCI Insight. 2020 May 7;5(9):e136687. doi: 10.1172/jci.insight.136687
• Fabrizio Pin, Leah J Novinger, Joshua R Huot, Robert A Harris, Marion E Couch, Thomas M O'Connell, Andrea Bonetto. PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia. FASEB J. 2019 Jun;33(6):7778-7790. doi: 10.1096/fj.201802799R. Epub 2019 Mar 20

info: laure.bindels@uclouvain.be

Elia BOZZATO

Advanced Drug Delivery and Biomaterials (ADDB)

Multi-drug loaded nanomedicine hydrogel for the treatment of glioblastoma

Director: Prof. Véronique Préat – Co-director: Dr Chiara Bastiancich

Related publications:

• Bastiancich*, C., Bozzato*, E., et al. (2019). Drug combination using an injectable nanomedicine hydrogel for glioblastoma treatment. International journal of pharmaceutics, 559, 220-227. Published
• Bozzato, E., et al. (2021). Nanomedicine: A Useful Tool against Glioma Stem Cells. Cancers, 13(1), 9. Published
• Bastiancich*, C., Bozzato*, E., et al. (2021) "Does local drug delivery still hold therapeutic promise for brain cancer? A systematic review." Journal of Controlled Release. Published
• Bozzato, E., et al. GSC and GBM cells elimination by a dual-drug loaded nanomedicine hydrogel. In preparation
• Gazaille, C., Bozzato E., et al. NFL peptide enhances LNC-based hydrogel effect on glioblastoma cells and prolongs animal survival. In preparation

Info : veronique.preat@uclouvain.be

Prof. Jean-Paul Dehoux, DVM, MSc, PhD et Professeur extraordinaire, MEDE et ASS

Procédures et fonctionnement de la commission d'éthique pour l'expérimentation animale du secteur (UCL/SSS) selon les législations récentes.

Info: francoise.vanbambeke@uclouvain.be

Prof. Nick Van Gastel, DDUV

Targeting transient metabolic dependencies to overcome chemoresistance in leukemia

Related publication: 

van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee C, Oki T, Grace E, Soled HJ, Milosevic J, Sykes DB, Hsu PP, Vander Heiden MG, Vidoudez C, Trauger SA, Haigis MC, Scadden DT. Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. Cell Metab. 2020 Sep 1;32(3):391-403.

Info: francoise.vanbambeke@uclouvain.be

Seminar of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Natacha DEHAEN (LDRI/REMA & MNut): The study of links between obesity and triple negative metastatic breast cancer »

Sabrina HUWART (LDRI/MNut): Roles of gut microbiota-induced neuroinflammation on food reward alterations during obesity »

Info: giulio.muccioli@uclouvain.be

Prof. Sandrine GERBER, Ecole Polytechnique Fédérale de Lausanne, Group for Functionalized Biomaterials, Institute of chemical sciences & engineering; Deputy to the director of the Institute of Chemical Sciences and Engineering (ISIC)

Multicomponent Dual Ionic-Covalent Alginate-Based Hydrogels for Cell Transplantation Applications.

https://epfl.zoom.us/j/64794338083 - Meeting ID: 647 9433 8083

Related publications:

• Passemard, S.; Szabó, L.; Noverraz, F.; Montanari, E.; Gonelle-Gispert, C.; Bühler, L.; Wandrey, C.; Gerber-Lemaire, S. Synthesis strategies to extend the variety of alginate-based hybrid hydrogels for cell microencapsulation. Biomacromolecules 2017, 18, 2747-2755.
• Szabó, L.; Gonelle-Gispert, C.; Montanari, E.; Noverraz, F.; Bornet, A.; Bühler, L. H. ; Gerber-Lemaire, S. Cross-Reactive Alginate Derivatives for the Production of Dual Ionic−Covalent Hydrogel Microspheres Presenting Tunable Properties for Cell Microencapsulation. ACS Appl. Polym. 2019, 1, 1326-1333.
• Noverraz, F.; Montanari, E.; Pimenta, J.; Szabó, L.; Ortiz, D.; Gonelle-Gispert, C.; Bühler, L. H.; Gerber-Lemaire, S. Anti-Fibrotic Effect of Ketoprofen-Grafted Alginate Microcapsules in the Transplantation of Insulin Producing Cells. Bioconjugate Chem. 2018, 29, 1932−1941.

info: anne.desrieux@uclouvain.be

Aristote BUYA - LDRI/ADDB (Advanced Drug Delivery and Biomaterials)

Self-emulsifying systems for the oral delivery of anti-sickling agents

Director : Prof. Véronique Préat - Co-directors : Prof.  Ana Beloqui et Prof. Patrick Memvanga

Publications :

• Buya, A. B., Ucakar, B., Beloqui, A., Memvanga, P. B., & Préat, V. (2020). Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDSs) for senicapoc. International Journal of Pharmaceutics, 580, 119180. https://doi.org/https://doi.org/10.1016/j.ijpharm.2020.119180
• Buya, A. B., Beloqui, A., Memvanga, P. B., & Préat, V. (2020). Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery. Pharmaceutics, 12(12). https://doi.org/10.3390/pharmaceutics12121194
• Buya, A. B., Terrasi, R., Mbinze, J. K., Muccioli, G. G., Beloqui, A., Memvanga, P. B., & Préat, V. (2021). Quality-by-Design-Based Development of a Voxelotor Self-Nanoemulsifying Drug-Delivery System with Improved Biopharmaceutical Attributes. Pharmaceutics , Vol. 13. https://doi.org/10.3390/pharmaceutics13091388

Info: veronique.preat@uclouvain.be

Donatienne d’Hose - LDRI/REMA (Biomedical Magnetic Resonance)

Dual EPR measurement of oxygen consumption and superoxide production: principle and applications

Director: Prof. Bernard Gallez - Co-Director: Prof. Bénédicte Jordan

Publications linked to the PhD thesis:

• D. d’Hose, P. Danhier, H. Northshield, P. Isenborghs, B.F. Jordan, and B. Gallez. A versatile EPR toolbox for the simultaneous measurement of oxygen consumption and superoxide production. Redox. Biol. 2021, 40, 101852 (9pp)
• D. d’Hose and B. Gallez. Measurement of mitochondrial (dys)function in cellular systems using Electron Paramagnetic Resonance (EPR): oxygen consumption and superoxide production. Methods Mol. Biol. In press
• D. d’Hose, P. Isenborghs, D. Brusa, B.F. Jordan, and B. Gallez. The Short-Term Exposure to SDHI Fungicides Boscalid and Bixafen Induces a Mitochondrial Dysfunction in Selective Human Cell Lines. Molecules 2021, 26, 5842 (12pp)

Info: bernard.gallez@uclouvain.be

https://teams.microsoft.com/l/meetup-join/19%3ameeting_MzhiYjRhYWQtYjUyNS00ZWVkLTg5ZTctYTY4MTkyYTA2ODI3%40thread.v2/0?context=%7b%22Tid%22%3a%227ab090d4-fa2e-4ecf-bc7c-4127b4d582ec%22%2c%22Oid%22%3a%221e1a5afa-5d2e-4100-9409-2fe83b2f0929%22%7d

Albert RUIZ SORRIBAS -  LDRI/TFAR FACM (Cellular and Molecular Pharmacology)

Targeting inter-kingdom biofilms with antimicrobials and hydrolytic enzymes

Director: Prof. Françoise Van Bambeke. 

Publications linked to the PhD thesis:

• Ruiz-Sorribas A, Poilvache H, Kamarudin NHN, Braem A, Van Bambeke F. 2021. In vitro polymicrobial inter-kingdom three-species biofilm model: influence of hyphae on biofilm formation and bacterial physiology. Biofouling 37:481–493.
• Ruiz-Sorribas A, Poilvache H, Van Bambeke F. 2021. Pharmacodynamics of Moxifloxacin, Meropenem, Caspofungin and their Combinations Against In Vitro Polymicrobial Inter-kingdom Biofilms. Antimicrob Agents Chemother. (under revision)
• Ruiz-Sorribas A, Poilvache H, Kamarudin NHN, Braem A, Van Bambeke F. 2021. Hydrolytic enzymes as potentiators of antimicrobials against an inter-kingdom biofilm model. Antimicrob Agents Chemother. (ready for submission)
• Poilvache H, Ruiz-Sorribas A, Sakoulas G, Rodriguez-Villalobos H, Cornu O, Van Bambeke F. 2020. Synergistic Effects of Pulsed Lavage and Antimicrobial Therapy Against Staphylococcus aureus Biofilms in an in-vitro Model. Front Med 7:1–9.
• Poilvache H, Ruiz-Sorribas A, Cornu O, Van Bambeke F. 2021. In Vitro Study of the Synergistic Effect of an Enzyme Cocktail and Antibiotics against Biofilms in a Prosthetic Joint Infection Model. Antimicrob Agents Chemother 65:1–24.

Info: francoise.vanbambeke@uclouvain.be

December 06 -  1pm - Auditoire Maisin - Also on TEAMS : Cliquez ici pour participer à la réunion

Prof. Mireille Al Houayek, LDRI/BPBL (Bioanalysis and Pharmacology of Bioactive Lipids)

Info: mireille.alhouayek@uclouvain.be

December 13 - 1pm - Auditoire Maisin - Also on TEAMS: Cliquez ici pour participer à la réunion

Prof. Myriam Taverna, Institut Galien Paris Saclay, faculté de pharmacie

Info: anne.desrieux@uclouvain.be

“Omnis membrana e membrana”: do lipids tell proteins how to fold?

Prof. Mikhail Bogdanov, Department of Biochemistry and Molecular Biology, University of Texas-Houston, McGovern Medical School, Houston

Related publications:

• Cardiolipin is required in vivo for the stability of bacterial translocon and optimal membrane protein translocation and insertion. Sergey Ryabichko, Vilena de Melo Ferreira, Heidi Vitrac, Ramziya Kiyamova, William Dowhan, Mikhail Bogdanov. Sci Rep. 2020; 10: 6296. Published online 2020 Apr 14. doi: 10.1038/s41598-020-63280-5
• Phospholipid distribution in the cytoplasmic membrane of Gram-negative bacteria is highly asymmetric, dynamic, and cell shape-dependent. Mikhail Bogdanov, Kyrylo Pyrshev, Semen Yesylevskyy, Sergey Ryabichko, Vitalii Boiko, Pavlo Ivanchenko, Ramziya Kiyamova, Ziqiang Guan, Christophe Ramseyer, William Dowhan. Sci Adv. 2020 Jun; 6(23): eaaz6333. Published online 2020 Jun 3. doi: 10.1126/sciadv.aaz6333
• The phospholipid-repair system LplT/Aas in Gram-negative bacteria protects the bacterial membrane envelope from host phospholipase A2 attack. Yibin Lin, Mikhail Bogdanov, Shuo Lu, Ziqiang Guan, William Margolin, Jerrold Weiss, Lei Zheng. J Biol Chem. 2018 Mar 2; 293(9): 3386–3398. Published online 2018 Jan 19. doi: 10.1074/jbc.RA117.001231

Info: marie-paule.mingeot@uclouvain.be

Monday January 17, 2022 – 1pm – Auditoire Maisin and on TEAMS 

• DEBUISSON Floriane (ADDB/LDRI) : Mesenchymal stem cell delivery in hybrid spheroids for the treatment of spinal cord injury
• FUCHS Victoria (CLIP/LDRI) : Evaluation of the impact of adherence, drug-drug interactions, polypharmacy, and inappropriate prescribing on efficacy and safety criteria for Direct Oral Anticoagulants in people with Atrial Fibrillation in the routine clinical practice setting
• MA Zhanjun (ADDB/LDRI and BPBL/LDRI): Taking the best of two worlds to treat spinal cord injury: traditional Chinese medicine Rosmarinic acid combined with stem cell derived-extracellular vesicles
• MAHIEU Gwenaëlle (FACM/LDRI and PMGK/LDRI): Study of the parameters modulating the cellular pharmacokinetics and pharmacodynamics of fluoroquinolones in an in-vitro pharmacodynamic model
• LACOUR Séraphin (CMFA/LDRI) : Conception, synthesis and evaluation of new pharmacological tools to study the tryptophan-2,3-dioxygenase (TDO2) in cancer imminotherapy

Info: giulio.muccioli@uclouvain.be

Monday January 24, 2022 – 1pm – Auditoire Maisin and on TEAMS

• MAROTTI Valentina (ADDB/LDRI) : Gene silencing of TNFα in inflammatory bowel disease treatment through a dual-shielding strategy via bioadhesive beads
• MATHIEU Barbara (REMA/LDRI and FATH/IREC): Towards magnetic resonance detection of mitochondrial ROS in vivo in solid tumors
• MAZHARI Darius (CMFA/LDRI and Université Lille 2) : Deciphering the exact role of ACSL4 in cancer
• YANG Jingjing (ADDB/LDRI) : Development of rationally-designed stimuli-responsive nanoparticles for neuroprotective purposes in spinal cord injury repair
• WEHBI Mohammad (REMA/LDRI) : Multi Harmonics EPR for the characterization of skin melanoma
• LADEIRO DOMINGUES Inês (ADDB/LDRI) : Exploiting the biological effect exerted by nanocarriers in non-alcoholic fatty liver disease treatment

Info: giulio.muccioli@uclouvain.be

Auditoire Maisin and on TEAMS

Antoine CHRISTIAENS - LDRI/TFAR CLIP (Clinical Pharmacy)

"Implications of health status and metabolic heterogeneities for glycaemic management in older patients with type 2 diabetes". 

The presentation will be in French.

Promotor et Co-promotors : Prof. Séverine Henrard, Prof. Benoit Boland, Prof. Michel Hermans.

Related publications:

• Christiaens A, Henrard S, Boland B. Large discrepancy in glycaemic control appropriateness in geriatric patients with type 2 diabetes according to major clinical practice guidelines. 2021. European Geriatric Medicine.
• Christiaens A, Henrard S, Zerah L, Dalleur O, Bourdel-Marchasson I, Boland B. Individualisation of glycaemic management in older people with type 2 diabetes: a systematic review of clinical practice guidelines recommendations. 2021. Age and Ageing 50(6): 1935–1942.
• Christiaens A, Boland B, Germanidis M, Dalleur O, Henrard S. Poor health status, inappropriate glucose-lowering therapy and high one-year mortality in geriatric patients with type 2 diabetes. 2020. BMC Geriatrics 20:367.
• Christiaens A, Hermans MP, Boland B, Henrard S. Distinction of cardiometabolic profiles among people ≥75 years with type 2 diabetes: a latent profile analysis. 2019. BMC Endocrine Disorders 19:85.

Registration is free and possible until Friday 28 January, but is mandatory and can be done by clicking on the following link: https://uclouvainph.qualtrics.com/jfe/form/SV_eEc2SZE4qTIEaV0

Info: severine.henrard@uclouvain.be

February 07 – 1pm - Auditoire Maisin and on TEAMS

Karine Porte, PhD, LDRI/CMFA (Medicinal Chemistry)

Related publications :

• Controlled Release of a Micelle Payload via Sequential Enzymatic and Bioorthogonal Reactions in Living Systems. K. Porte, B. Renoux, E. Peraudeau, J. Clarhaut, B. Eddhif, P. Poinot, E. Gravel, E. Doris, A. Wijkhuisen, D. Audisio, S. Papot, F. Taran, Angew. Chem. Int. Ed. 2019, 58, 6366 – 6370.
• Click and Bio-Orthogonal Reactions with Mesoionic Compounds. K. Porte*, M. Riomet*, C. Figliola, D. Audisio, F. Taran, Chem. Rev. 2021, 121, 12, 6718 – 6743.
• Fluorogenic iminosydnones: bioorthogonal tools for double turn-on click-and-release reactions. M. Riomet, K. Porte, A. Wijkhuisen, D. Audisio, F. Taran, Chem. Commun. 2020, 56, 7183 – 7186.

Info : raphael.frederick@uclouvain.be

Thrusday, February 10, 2022 – 11am – Salle 42A and on TEAMS

Dr. Brice Korkmaz, Université de Tours, France

Related publications: 

• Cathepsin C inhibition as a potential treatment strategy in cancer. Korkmaz B, Lamort AS, Domain R, Beauvillain C, Gieldon A, Yildirim AÖ, Stathopoulos GT, Rhimi M, Jenne DE, Kettritz R. Biochem Pharmacol. 2021 Dec;194:114803.
• Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS? Korkmaz B, Lesner A, Marchand-Adam S, Moss C, Jenne DE. J Med Chem. 2020 Nov 25;63(22):13258-13265.
• Therapeutic targeting of cathepsin C: from pathophysiology to treatment. Korkmaz B, Caughey GH, Chapple I, Gauthier F, Hirschfeld J, Jenne DE, Kettritz R, Lalmanach G, Lamort AS, Lauritzen C, Łȩgowska M, Lesner A, Marchand-Adam S, McKaig SJ, Moss C, Pedersen J, Roberts H, Schreiber A, Seren S, Thakker NS. Pharmacol Ther. 2018 Oct;190:202-236

Info: rita.vanbever@uclouvain.be

Seminars of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Sabrina HUWART - MNUT research group, LDRI - “Roles of gut microbiota-induced neuroinflammation on food reward alterations during obesity”

Giuditta LEONE - ADDB and CMFA Research groups, LDRI - “Design of a long-acting vasodilator nanomedicine for inhalation in pulmonary arterial hypertension”

Info: giulio.muccioli@uclouvain.be

Seminars of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Marie AUQUIERE - ADDB and BPBL Research groups, LDRI - “Development of new therapies against multiple sclerosis based on lipid-loaded extracellular vesicles”

Juhans DECHENNE - CMFA Research Group, LDRI - “Disrupting Arginase-1 trimeric state: a new strategy to increase the anti-tumor immune response”

Info: giulio.muccioli@uclouvain.be

Auditoire Maisin (the presentation of the covid safe ticket will be mandatory to attend the face-to-face defence) and on TEAMS.

Camille AMADIEU -  LDRI (Metabolism and Nutrition group - MNut) and IoNS

Gut microbiota, biological and psychological alterations in alcohol use disorder

PhD Thesis in Biomedical and Pharmaceutical Science

Supervisors: Prof. Nathalie Delzenne (LDRI/Mnut), Prof. Philippe de Timary (IoNS), Dr Sophie Leclercq (LDRI/Mnut, IoNS)

Related publications:

• Amadieu C, Coste V, Neyrinck AM, et al. Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients. Gut Microbes. 2022;14(1):2007042.
• Amadieu C*, Leclercq S*, Coste V, Thijssen V, Neyrinck AM, Bindels LB, Cani PD, Piessevaux H, Stärkel P, de Timary P, Delzenne NM. Dietary fiber deficiency as a component of malnutrition associated with psychological alterations in alcohol use disorder. Clin Nutr. 2021 May;40(5):2673-2682. doi: 10.1016/j.clnu.2021.03.029. Epub 2021 Mar 30.
• Amadieu C, Maccioni L, Leclercq S, Neyrinck AM, Delzenne NM, de Timary P, Stärkel P. Inulin supplementation during alcohol withdrawal in alcohol use disorder patients does not improve liver alterations: a randomized, double-blind, placebo-controlled study. (in revision in EBiomedicine)

Info: nathalie.delzenne@uclouvain.be

Gang WANG - FACM/TFAR/LDRI

Reviving disused antibiotics against Gram-negative ESKAPE pathogens: combination with the polyaminoisoprenyl potentiator NV716

Promotor: Françoise Van Bambeke

Related publications:

• Wang, Brunel JM, Bolla JM, Van Bambeke F. The polyaminoisoprenyl potentiator NV716 revives old disused antibiotics against intracellular forms of infection by Pseudomonas aeruginosa. Antimicrob Ag Chemother 2021 Feb 17;65(3):e02028-20
• Wang G, Brunel JM, Preusse M, Mozaheb N, Willger S, Baatsen P, Häussler S, Bolla JM, Van Bambeke F. The polyaminoisoprenyl potentiator NV716 re-sensitizes old disused antibiotics against Pseudomonas aeruginosa by perturbing outer membrane permeability. Submitted for publication
• Wang G, Brunel JM, Bolla JM, Van Bambeke F. The polyamino-isoprenyl potentiator NV716 revives disused antibiotics against intracellular forms of infection by Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii. Submitted for publication

Info : francoise.vanbambeke@uclouvain.be

Chloé MARTENS - ULB, Unité de recherche en Structure et Fonction des Membranes biologiques

H/D exchange coupled to Mass Spectrometry: a multifaceted tool to study membrane proteins

Abstract:

Membrane proteins participate in a myriad of vital biological processes, including nutrient transport, cell-cell signaling and toxin export. This central role makes them an attractive class of drug targets and uncovering their molecular mechanism is an intense area of research. Membrane proteins are, however, notoriously difficult to work with, mainly due to their localization within the heterogeneous of environment of the biological membrane and instability once extracted from the lipid bilayer.

Hydrogen‐deuterium exchange coupled to mass spectrometry (HDX‐MS) has recently emerged as a powerful method to investigate aspects eluding traditional biophysical tools, such as the conformational dynamics of membrane proteins and their interactions with substrates, ions and lipids. This technique measures the rate of H/D exchange of labile protons from backbone amides1. This exchange rate is directly correlated to solvent accessibility and local structural dynamics. Specifically, we have demonstrated that HDX-MS is an ideal tool to decipher the mechanism of membrane transporters2. Changes in the conformational landscape caused by different lipid environments lead to changes in global and local dynamics measurable by HDX-MS. In combination with predictions from molecular dynamics simulations, specific lipid-modulated changes in the conformational dynamics can be identified at the molecular level3. Similarly, the coupling between a substrate and an ion in a secondary transporter leads to a structural fingerprint that can be observed with this approach. A summary of the insights that HDX-MS applied to membrane transporters can reveal, as well as the practical means to obtain those will be presented.

Related references:

• Masson, G. R. et al. Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments. Nat. Methods 16, 595–602 (2019).
• Martens, C. et al. Direct protein-lipid interactions shape the conformational landscape of secondary transporters. Nat. Commun. 9, 4151 (2018).
• Martens, C., Shekhar, M., Lau, A. M., Tajkhorshid, E. & Politis, A. Integrating hydrogen–deuterium exchange mass spectrometry with molecular dynamics simulations to probe lipid-modulated conformational changes in membrane proteins. Nat. Protoc. 14, 3183–3204 (2019).

Info: françoise.vanbambeke@uclouvain.be

Seminars of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Marine ANCIA - CMFA research group (LDRI) and GEPI research group (DDUV)

“Towards the discovery of TSPYL5/USP7 protein-protein interaction inhibitors to detail the Alternative Lengthening of Telomeres mechanism”

Chloé BUYSE - REMA research group (LDRI)

“Monitoring the effect of anti-cancer drugs on the extracellular pH measurements using magnetic resonance “

Info: giulio.muccioli@uclouvain.be

Dr Maria Rohm - Head of Division Tissue Cross Talk in Cancer Metabolism, Institute for Diabetes and Cancer, Helmholtz Munich

https://www.helmholtz-munich.de/idc/forschung/arbeitsgruppen/division-tissue-crosstalk-in-cancer-metabolism/thema/index.html

Lipid metabolism in cancer cachexia

Related publications:

• Morigny P. et al. High levels of modified ceramides are a defining feature of murine and human cancer cachexia. J Cachexia Sarcopenia Muscle. 2020 Dec. PMID: 33090732
• Rohm M. et al. An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice. Nat Med. 2016 Oct. PMID: 27571348

Info: laure.bindels@uclouvain.be

Princess Lilian Foundation – Visiting Professorship of Pr Christine & Jonathan Seidman

UCLouvain & ULB – Detailled scientific program

Part 1- Deciphering heterogeneity in cardiovascular diseases: insights from the bench

UCLouvain – Maisin auditorium, Avenue Emmanuel Mounier, Woluwe-Saint-Lambert – 10am-12am

Part 2 – A Modern vision on Cardiomyopathies and Cardiovascular diseases

Salle de conférence de la Verrière (Route 278) Avenue Hippocrate, Woluwe-Saint-Lambert (Cliniques Universitaires Saint-Luc) – 2pm-4pm

Xiao LIU - ADDB/LDRI

Development of a long-acting version of alpha1antitrypsin for augmentation therapy in alpha 1 antitrypsin deficiency

Promotor: Rita Vanbever

Publication list:

• Liu X, Vanvarenberg K, Guy Wilfried Kouassi K, Mahri S, Vanbever R. Production and characterization of mono-PEGylated alpha-1 antitrypsin for augmentation therapy. International journal of pharmaceutics 2021:121355.
• Liu X, Guy Wilfried Kouassi K, Vanbever R, Dumoulin M. Impact of the PEG length and PEGylation site on the structural, thermodynamic and thermal stability of mono-PEGylated alpha-1 antitrypsin. Submitted to Prot Sc.

Info: rita.vanbever@uclouvain.be

Also on TEAMS :

https://teams.microsoft.com/l/meetup-join/19%3ameeting_N2MxODVlY2UtODY2OC00YWM3LWEzYjEtMzE2YTNjOGY4MTQ0%40thread.v2/0?context=%7b%22Tid%22%3a%227ab090d4-fa2e-4ecf-bc7c-4127b4d582ec%22%2c%22Oid%22%3a%228481296a-5a6e-427c-8c19-0b18c3e0de54%22%7d

Yasmine LABRAK - Advanced Drug Delivery and Biomaterials (ADDB) and Bioanalysis and Pharmacology of Bioactive Lipids (BPBL)

Targeted nanomedicines to stimulate the differentiation of oligodendrocyte progenitor cells in the scope of multiple sclerosis

Promotors : Anne des Rieux et Giulio Muccioli

Related publications :

• Labrak, Y., Heurtault, B., Frisch, B., Saulnier, P., Lepeltier, E., Miron, V. E., Muccioli, G. & Des Rieux, A. (2022). Impact of anti-PDGFRα antibody surface functionalization on LNC uptake by oligodendrocyte progenitor cells. International Journal of Pharmaceutics, 121623.
• Xu, Y*., Fourniols, T*., Labrak, Y*, Preat V. Beloqui A. & Des Rieux, A. (2022). Surface modification of lipid-based nanoparticles. Under revision in ACS Nano

*equal contribution

Info: anne.desrieux@uclouvain.be – giulio.muccioli@uclouvain.be

Monday April 25, 2022 - 1pm - Auditoire Maisin

Kristelle HUGHES, PhD, LDRI/Pharmacognosy (GNOS)

Related publications:

• Hughes, K., Ho, R., Greff, S., Herbette, G., Filaire, E., Ranouille, E., Berthon, J.-Y., Raharivelomanana, P., 2022. Feature-Based Molecular Networks Identification of Bioactive Metabolites from Three Plants of the Polynesian Cosmetopoeia Targeting the Dermal Papilla Cells of the Hair Cycle. Molecules 27, 105.
• Hughes, K., Ho, R., Chazaud, C., Hermitte, S., Greff, S., Butaud, J.-F., Filaire, E., Ranouille, E., Berthon, J.-Y., Raharivelomanana, P., 2021. In Vitro Hair Dermal Papilla Cells Induction by Fagraea berteroana, a Tree of the Marquesan Cosmetopoeia (French Polynesia). Cosmetics 8, 13.
• Hughes, K., Ho, R., Butaud, J.-F., Filaire, E., Ranouille, E., Berthon, J.-Y., Raharivelomanana, P., 2019. A selection of eleven plants used as traditional Polynesian cosmetics and their development potential as anti-aging ingredients, hair growth promoters and whitening products. Journal of Ethnopharmacology 245, 112–159.

Info: joelle.leclercq@uclouvain.be

Morgane THIBAUT - LDRI/ MNut

Contribution of the alterations in bile acid pathways to cancer cachexia

Director : Prof. Laure Bindels

Related publications :

• Morgane M. Thibaut, Martina Sboarina, Martin Roumain, Sarah A. Pötgens, Audrey M. Neyrinck, Florence Destrée, Justine Gillard, Isabelle A. Leclercq, Guillaume Dachy, Jean‐Baptiste Demoulin, Anne Tailleux, Sophie Lestavel, Marialetizia Rastelli, Amandine Everard, Patrice D. Cani, Paolo E. Porporato, Audrey Loumaye, Jean‐Paul Thissen, Giulio G. Muccioli, Nathalie M. Delzenne & Laure B. Bindels. Inflammation-induced cholestasis in cancer cachexia. Journal of Cachexia, Sarcopenia and Muscle. 2021. Feb;12(1):70-90. doi: 10.1002/jcsm.12652. Epub 2020 Dec 22. PMID: 33350058; PMCID: PMC7890151.
• Morgane M. Thibaut, Justine Gillard, Adeline Dolly, Martin Roumain, Isabelle A. Leclercq, Nathalie M. Delzenne, Giulio G. Muccioli, Laure B. Bindels. Bile Acid Dysregulation Is Intrinsically Related to Cachexia in Tumor-Bearing Mice. Cancers. 2021. Dec 20;13(24):6389. doi: 10.3390/cancers13246389. PMID: 34945009; PMCID: PMC8699129.
• Morgane M. Thibaut and Laure B. Bindels. (Review) Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation. Trends in Molecular Medicine. 2022. Mar;28(3):223-236. doi: 10.1016/j.molmed.2021.12.006. Epub 2022 Jan 21. PMID: 35074252.

Info: laure.bindels@uclouvain.be

Seminar of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Espoir Kavungere KAMBALE - ADDB and GNOS research groups (LDRI) and University of Kinshasa

“Lipid nanocapsules containing zinc oxide nanoparticles biosynthesized from plants extracts for the treatment of type 2 diabetes”

Adam LAGHOUATI - BPBL research group (LDRI)

“Investigation of the role of monoacylglycerol lipase in the resolution of zymosan-induced peritonitis “

Justin RONDEAU - Pole of Pharmacology and Therapeutics (FATH/IREC)

“Genetic and metabolic control of radiotherapy-induced breast cancer metastasis”

Info: giulio.muccioli@uclouvain.be

UCLouvain will award its highest distinction to: Menno P. Witter, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

All the information on the IoNS website.

Dr. Patrick Van Der Smissen – DDUV/PICT (Plateforme technologique d'imagerie cellulaire et tissulaire)

The Zeiss LSM980, a new generation confocal microscope equipped with a multiphoton laser installed at PICT in 2020: from equipment overview to applications

Monday, May 9, 2022 – Auditoire Maisin – 1 pm

Info: anne.desrieux@uclouvain.be

Hafiz ABDUL KHALIQ – Pharmacognosy (GNOS) Research Group and Bioanalysis & Pharmacology of Bioactive Lipids (BPBL) Research Group

Evaluation of the potential of Pakistani plants used in traditional medicine for the treatment of inflammatory bowel diseases (IBD) and identification of their active molecules

Promoter: Joëlle Quetin-Leclercq 

Co-promoter: Giulio G. Muccioli

Related publications:

• Khaliq HA, Ortiz S, Alhouayek M, Muccioli GG, Quetin-Leclercq J. Dereplication and quantification of major compounds of Convolvulus arvensis L. extracts and assessment of their effect on LPS-activated J774 macrophages. Molecules, 27(3), 963. (2022). DOI: 10.3390/molecules27030963.
• Khaliq HA, Ortiz S, Alhouayek M, Neyts T, Muccioli GG, Quetin-Leclercq J. Effect of a methanolic extract of Salvadora oleoides Decne. on LPS-activated J774 macrophages, its in vitro and in vivo toxicity study and dereplication of its chemical constituents. Submitted.

Info: joelle.leclercq@uclouvain.be

May 23, 2022 - 1-2pm - Auditoire Maisin

Dr Vianney DELPLACE - groupe Regenerative Medicine and Skeletonde (RMeS) de l’Université de Nantes

Info: anne.desrieux@uclouvain.be

May 30, 2022 - 1-2pm – Salle Adrienne Gommers (unusual location!)

Dr Ferran NADAL BUFI - Postdoc Medicinal Chemistry (CMFA), LDRI

Related publications:

• Nadal-Bufi F, Mason JM, Chan LY, Craik DJ, Kaas Q, Henriques ST*. (2021). Designed β-hairpins Inhibit LDH5 Oligomerization and Enzymatic Activity. Journal of Medicinal Chemistry 64, 7. https://doi.org/10.1021/acs.jmedchem.0c01898
• Nadal-Bufi F*, Henriques ST. How to overcome endosomal entrapment of cell penetrating peptides to release the therapeutic potential of peptides. (2020). Peptide Science 112, 6. https://doi.org/10.1002/pep2.24168

Info: raphael.frederick@uclouvain.be

Prof. Souleymane MBOUP - IRESSEF: Institute for Health Research, Epidemiological Surveillance and Training, Dakar, Senegal

A unique Research Platform in West Africa - Presentation of the institution and the research conducted there.

Info: olivia.dalleur@uclouvain.be

Professor Yolanda Sanz, Professor of Research of the National Research Council (CSIC) at the Institute of Agrochemistry and Food Technology (IATA-CSIC). Valencia, Spain

Identifying microbiome signatures linked to obesity

Papers related:

• López-Almela I, Romaní-Pérez M, Bullich-Vilarrubias C, Benítez-Páez A, Gómez Del Pulgar EM, Francés R, Liebisch G, Sanz Y. Bacteroides uniformis combined with fiber amplifies metabolic and immune benefits in obese mice. Gut Microbes. 2021 Jan-Dec;13(1):1-20.
• Romaní-Pérez M, López-Almela I, Bullich-Vilarrubias C, Rueda-Ruzafa L, Gómez Del Pulgar EM, Benítez-Páez A, Liebisch G, Lamas JA, Sanz Y. Holdemanella biformis improves glucose tolerance and regulates GLP-1 signaling in obese mice. FASEB J. 2021 Jul;35(7):e21734.
• Rampelli S, Guenther K, Turroni S, Wolters M, Veidebaum T, Kourides Y, Molnár D, Lissner L, Benitez-Paez A, Sanz Y, Fraterman A, Michels N, Brigidi P, Candela M, Ahrens W. Pre-obese children's dysbiotic gut microbiome and unhealthy diets may predict the development of obesity. Commun Biol. 2018 Dec 7;1:222.

Info: amandine.everard@uclouvain.be

Sarah Pötgens - Metabolim and Nutrition research group (MNut)

Exploration of the Contribution of the Gut Microbiota and its Metabolism to Cancer Cachexia

Promotor : Professor Laure Bindels

Related publications:

• Pötgens, S. A., M. Sboarina and L. B. Bindels (2018). "Polyunsaturated fatty acids, polyphenols, amino acids, prebiotics: can they help to tackle cancer cachexia and related inflammation?" Curr Opin Clin Nutr Metab Care 21(6): 458-464.
• Pötgens, S. A., H. Brossel, M. Sboarina, E. Catry, P. D. Cani, A. M. Neyrinck, N. M. Delzenne and L. B. Bindels (2018). "Klebsiella oxytoca expands in cancer cachexia and acts as a gut pathobiont contributing to intestinal dysfunction." Sci Rep 8(1): 12321.
• Pötgens, S. A., M. M. Thibaut, N. Joudiou, M. Sboarina, A. M. Neyrinck, P. D. Cani, S. P. Claus, N. M. Delzenne and L. B. Bindels (2021). "Multi-compartment metabolomics and metagenomics reveal major hepatic and intestinal disturbances in cancer cachectic mice." J Cachexia Sarcopenia Muscle 12(2): 456-475.

Info: laure.bindels@uclouvain.be

Alice de WOUTERS d'OPLINTER - Metabolim and Nutrition research group (MNut)

Roles of gut microbes in the gut-to-brain axis controlling hedonic/reward responses to food intake in physiological condition and in the pathology of obesity

Promotor: Prof. Amandine Everard and co-promotor: Prof. Patrice Cani.

Related publications :

• Gut microbes participate in food preference alterations during obesity; A de Wouters d'Oplinter, M Rastelli, M Van Hul, NM Delzenne, PD Cani & A Everard; Gut microbes 2021
• Gut microbes and food reward : from the gut to the brain; A de Wouters d'Oplinter, SJP Huwart, PD Cani & A Everard; submitted
• Obese-associated gut microbes and derived phenolic metabolite as mediators of excessive motivation for food reward; A de Wouters d'Oplinter , M Verce , SJP Huwart , C Depommier , M Van Hul , PD Cani & A Everard; submitted
• Food reward alterations during obesity are associated with inflammation in the striatum: beneficial effects of Akkermansia muciniphila; SJP Huwart*, A de Wouters d’Oplinter*, M Rastelli, M Van Hul, WM de Vos, S Luquet, PD Cani & A Everard; submitted
• Dietary sugar and fat: Links with obesity, inflammation, microbial load, and gut microbiota; F Suriano, S Vieira-Silva, G Falony, A de Wouters d'Oplinter, P Paone, NM Delzenne, A Everard, J Raes, M Van Hul & PD Cani; submitted

Info: amandine.everard@uclouvain.be

Prof. Jean-Baptiste WOILLARD, Limoges University, FRANCE

“Estimation of immunosuppressant exposure using machine learning: towards a new way to perform therapeutic drug monitoring?”

References:

• Tacrolimus Exposure Prediction Using Machine Learning. Woillard JB, et al. Clinical Pharmacol Ther 2021 110 (2) 361-369
• Estimation of drug exposure by machine learning based on simulations from published pharmacokinetic models: The example of tacrolimus. Woillard JB, et al. Pharmacol Res. 2021 May;167:105578.
• Mycophenolic Acid Exposure Prediction Using Machine Learning. Woillard JB et al. Clicical Pharmacol Ther 2021 110 (2) 370-379.

Info: laure.elens@uclouvain.be

Perrin NGOUGNI POKEM – TFAR/ FACM and PMGK

CLINICAL PHARMACOKINETICS OF TEMOCILLIN: A way to optimize personalized dosing

Promotor: Prof. Françoise Van Bambeke

Co-promotors: Prof. Laure Elens et Dr Arnaud Capron

Related publications :

• Ngougni Pokem P, Miranda Bastos AC, Tulkens PM, Wallemacq P, Van Bambeke F, Capron A. Validation of a HPLC-MS/MS assay for the determination of total and unbound concentration of temocillin in human serum. Clin Biochem. 2015 May;48(7-8):542-5.
• Perrin Ngougni P, Peter Matzneller, Steven Vervaeke, Xavier Wittebole, Lieven Goeman, Marie Coessens, Eleonora Cottone, Arnaud Capron, Beatrix Wulkersdorfer, Pierre Wallemacq, Johan W. Mouton, Anouk E. Muller, Markus Zeitlinger, Pierre-François Laterre, Paul M. Tulkens, Françoise Van Bambeke. Binding of temocillin to plasma proteins in-vitro and in-vivo: the importance of plasma protein levels in different populations and of comedications. J Antimicrob Chemother. In press. doi: 10.1093/jac/dkac286.
• Ngougni Pokem P, Capron A, Wallemacq P, Tulkens PM, Van Bambeke F, Laterre PF. Temocillin plasma and pancreatic tissue concentrations in a critically ill patient with septic shock. J Antimicrob Chemother. 2019 May 1;74(5):1459-1461.
• Ngougni Pokem P, Wittebole X, Collienne C, Rodriguez-Villalobos H, Tulkens PM, Elens L, Van Bambeke F, Laterre PF. Population Pharmacokinetics of Temocillin Administered by Continuous Infusion in Patients with Septic Shock Associated with Intra-Abdominal Infection and Ascitic Fluid Effusion. Antibiotics (Basel). 2022 Jul 5;11(7):898. doi: 10.3390/antibiotics11070898.
• Perrin Ngougni P, Xavier Stéphenne, Dimitri Van der Linden, Marie-Laura Godet, Gert-Jan Wijnant, Olga Chatzis, Laurent Houtekie, Astrid Haenecour, Pierre Wallemacq, Paul M. Tulkens, Etienne Sokal, Laure Elens, Françoise Van Bambeke. Population pharmacokinetics and dosing simulation of the β-lactam temocillin in liver transplanted paediatric patients: a prospective, open-label, non-randomized study. Clinical Microbiology and Infection. Submitted, June 2022.

Info: francoise.vanbambeke@uclouvain.be

Dr Emily REEVE, Centre for Medicine Use and Safety, Monash University, Australia

Informing implementation of deprescribing into clinical practice: Consumer attitudes towards deprescribing and the role of guidelines

Related papers:

• Weir KR, Ailabouni NJ, Schneider CR, Hilmer SN, Reeve E (2021) “Consumer attitudes towards deprescribing: a systematic review and meta-analysis.” The Journals of Gerontology: Series A (Medical Sciences); Published online 14th Aug 2021.
• Reeve E, Low LF, Hilmer SN (2019) “Attitudes of Older Adults and Caregivers in Australia toward Deprescribing” Journal of the American Geriatrics Society; 67(6):1204-1210.
• Reeve E, Farrell B, Thompson W, Herrmann N, Sketris I, Magin P, Chenoweth L, Gorman M, Quirke L, Bethune G, Hilmer S (2019) “Deprescribing cholinesterase inhibitors and memantine in dementia: guideline summary.” Medical Journal of Australia; 210(4):174-179.
• Reeve E, Anthony AC, Kouladjian O’Donnell L, Low L-F, Ogle, SJ, Glendenning JE, Lorang CEB, Hilmer SN (2018) “Development and pilot testing of the revised Patients’ Attitudes Towards Deprescribing questionnaire for people with cognitive impairment.” Australasian Journal on Ageing; 37(4):E150-4.

Info : anne.spinewine@uclouvain.be

Jeremy GRIMSHAW, MBChB, PhD, Senior Scientist and Full Professor

Affiliations :

• Centre for Implementation Research, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Canada
• Faculty of Medicine, University of Ottawa, Canada

De-implementing Wisely – the science of de-implementing low value care

Related paper :

Grimshaw JM, Patey AM, Kirkham KR, Hall A, Dowling SK, Rodondi N, et al. De-implementing wisely: developing the evidence base to reduce low-value care. BMJ Qual Saf. 2020;29(5):409-17

Info : anne.spinewine@uclouvain.be

Prof. Séverin ANAGONOU, Université d'Abomey-Calavi, Bénin

Management Tuberculosis and HIV co infection in Cotonou Benin

Related paper:

Management Tuberculosis and HIV co infection in Cotonou Benin. G Agodokpessi, G Ade, S Ade, A P Wachinou, D Affolabi, S Anagonou, M Gninafon. Médecine et Maladies infectieuses 42,2012 ,561-566.

Info: olivia.dalleur@uclouvain.be

Alain NINANE, PhD. - Expert/Analyste Cybersécurité UCLouvain

Cybersécurité, la théorie, ses ratés.. Comment s’en prémunir ?

Info: bernard.gallez@uclouvain.be

Laura SCHIOPPA - GNOS Research Group

Contribution to the drug development of natural and hemi-synthetic triterpenic esters as antiparasitic drugs

Promotor: Joelle Leclercq

Related publications:

• Schioppa L, Beaufay C, Bonneau N, Sanchez M, Girardi C, Leverrier A, Ortiz S, Palermo J, Poupaert JH, Quetin-Leclercq J. Design, Synthesis and Biological Activity of C3 Hemisynthetic Triterpenic Esters as Novel Antitrypanosomal Hits. ChemistryOpen. 2021 Sep;10(9):896-903. doi: 10.1002/open.202100159. PMID: 34499412; PMCID: PMC8428374.
• Schioppa L, Fall F, Ortiz S, Poupaert JH, Quetin-Leclercq J. A Validated HPLC-PDA-HRMS Method to Investigate the Biological Stability and Metabolism of Antiparasitic Triterpenic Esters. Molecules. 2021 Nov 26;26(23):7154. doi: 10.3390/molecules26237154. PMID: 34885738; PMCID: PMC8659078.
• Catteau L, Schioppa L, Beaufay C, Girardi C, Hérent MF, Frédérich M, Quetin-Leclercq J. Antiprotozoal activities of Triterpenic Acids and Ester Derivatives Isolated from the Leaves of Vitellaria paradoxa. Planta Med. 2021 Aug;87(10-11):860-867. doi: 10.1055/a-1286-1879. Epub 2020 Dec 7. PMID: 33285591.
• Fall F, Mamede L, Schioppa L, Ledoux A, De Tullio P, Michels P, Frédérich M, Quetin-Leclercq J. Trypanosoma brucei: Metabolomics for analysis of cellular metabolism and drug discovery. Metabolomics. 2022 Mar 19;18(4):20. doi: 10.1007/s11306-022-01880-0. PMID: 35305174.

Info: joelle.leclercq@uclouvain.be

Prof. Greet KERCKHOFS, UCLouvain -SST/SSS - Biomechanics Lab, Institute of Mechanics, Materials, and Civil Engineering (IMMC) and Institute of Experimental and Clinical Research (IREC)

X-Ray based 3D histology of biological tissues

Related publications :

• de Bournonville et al. Contrast Media & Molecular Imaging (2019) 1-9.
• Kerckhofs, G. et al. Biomaterials 159 (2018) 1-12
• de Bournonville & S., Vangrunderbeeck et al. Acta Biomaterialia (2020). 105, 253-262.
• De Clercq, K. et al. PNAS doi: 10.1073/pnas.1902688116
• Kerckhofs, G. et al. Contrast-enhanced microCT to visualize and quantify the 3D vasculature in biological tissues without the need for perfusion. Bruker User Meeting Brussels 2017

Info: anne.desrieux@uclouvain.be

Prof. Maria José ALONSO FERNANDEZ, University of Santiago de Compostela, Spain

The alliance of pharmaceutical nanotechnology, biotechnology and functional materials

Related publications:

• Dacoba T. G., Anthiya S., Berrecoso G., Fernández-Mariño I., Fernández-Varela C., Crecente-Campo J., Teijeiro-Osorio D., Torres-Andón F., Alonso M.J., Nano‐Oncologicals: A Tortoise Trail Reaching New Avenues, Adv. Funct. Mater., 2009860 (1-36) (2021)
• Samaridou E., Walgrave H., Salta E., Moreira Álvarez D., Castro-López V., Loza M., Alonso M.J., Nose-to-brain delivery of enveloped RNA – cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases, Biomaterials, 230, 119657 (2020)
• Storozhylova N., Crecente-Campo J., Cabaleiro D., Lugo L., Dussouy C., Simoes S., Monteiro M., Grandjean C., Alonso M.J., An in Situ Hyaluronic Acid-Fibrin Hydrogel Containing Drug-Loaded Nanocapsules for Intra-Articular Treatment of Inflammatory Joint Diseases, Regen. Transl. Med., 6, 201–216 (2020)

Info: ana.beloqui@uclouvain.be

Carina CARBIA SINDE, PhD - UCLouvain, Psychological Science Research Institute (IPSY), Louvain for Experimental Psychopathology research group (LEP)

Microbiome gut brain axis as a regulator of craving and social cognition in young binge drinkers.

Related publication: Emotional memory bias in binge drinking women. C. Carbia, M. Corral, F. Caamano-Isorna, F. Cadaveira

Info: laure.bindels@uclouvain.be

Mathilde BAUSART - Advanced Drug Delivery and Biomaterials (ADDB) Research Group

Combination of immunotherapy and local chemotherapy for the treatment of unresectable glioblastoma

Promotor: Véronique Préat

Co-promotor: Alessio Malfanti

Related publications:

• Bausart M, Vanvarenberg K, Ucakar B, Lopes A, Vandermeulen G, Malfanti A, Préat V. Combination of DNA vaccine and immune checkpoint blockades improves the immune response in an orthotopic unresectable glioblastoma model. Pharmaceutics 2022;14:1025.
• Bausart M, Préat V, Malfanti A. Immunotherapy for glioblastoma: the promise of combination strategies. J. Exp. Clin. Cancer Res. 2022;41:35.
• Lopes A*, Bastiancich C*, Bausart M, Ligot S, Lambricht L, Vanvarenberg K, Ucakar B, Gallez B, Préat V, Vandermeulen G. New generation of DNA-based immunotherapy induces a potent immune response and increases the survival in different tumor models. J. Immunother. Cancer 2021;9:e001243.

Info: veronique.preat@uclouvain.be

3D printing of medicines

Anna LECHANTEUR, Pharmacist, PhD, Professeure invitée - Laboratory of Pharmaceutical Technology and Biopharmacy (LPTB) - CIRM, Department of Pharmacy, Uliege

Related pubications:

• Three-dimensional printing technology as a promising tool in bioavailability enhancement of poorly water-soluble molecules: A review. Olivier Jennotte, Nathan Koch, Anna Lechanteur, Brigitte Evrard. International Journal of Pharmaceutics 580, 2020. DOI: 10.1016/j.ijpharm.2020.119200
• Challenges of fused deposition modeling 3D printing in pharmaceutical applications: Where are we now? Chloé Parulski, Olivier Jennotte, Anna Lechanteur, Brigitte Evrard. Advanced Drug Delivery Reviews 175, 2021. DOI: 10.1016/j.addr.2021.05.020
• Fused deposition modeling 3D printing of solid oral dosage forms containing amorphous solid dispersions: How to elucidate drug dissolution mechanisms through surface spectral analysis techniques? Chloé Parulski, Eva Gresse, Olivier Jennotte, Alexandre Felten, Eric Ziemons, Anna Lechanteur, Brigitte Evrard. International Journal of Pharmaceutics 626, 2022. DOI: 10.1016/j.ijpharm.2022.122157

Info: anne.desrieux@uclouvain.be

Biological function of the Usual Suspects in metabolomics : examples of fumarate and succinate

Prof. Jean-Marie Colet, Human Biology and Toxicology Unit, UMons

Related publications :

• Metabonomics in the preclinical and environmental toxicity field. Colet JM. Drug Discov Today Technol. 2015 Jun;13:3-10. doi: 10.1016/j.ddtec.2015.01.002. Epub 2015 Jan 28.
• GPR91 Receptor Mediates Protection against Doxorubicin-Induced Cardiotoxicity without Altering Its Anticancer Efficacy. An In Vitro Study on H9C2 Cardiomyoblasts and Breast Cancer-Derived MCF-7 Cells. Dallons M, Alpan E, Schepkens C, Tagliatti V, Colet JM. Cells. 2020 Sep 27;9(10):2177. doi: 10.3390/cells9102177
• Investigation of Mitochondrial Adaptations to Modulation of Carbohydrate Supply during Adipogenesis of 3T3-L1 Cells by Targeted 1H-NMR Spectroscopy. Delcourt M, Delsinne V, Colet JM, Declèves AE, Tagliatti V.Biomolecules. 2021 Apr 29;11(5):662. doi: 10.3390/biom11050662

Info: laure.bindels@uclouvain.be

Carine YEHOUENOU - Translational Research from Experimental and Clinical Pharmacology to Treatment Optimization (TFAR) – Clinical Pharmacy (CLIP)

Surgical site infections in Benin: what about hand hygiene practices and antibiotic resistance

Promotors : Prof. Olivia Dalleur, Louvain Drug Research Institute, UCLouvain and Prof. Francis Moise Dossou, Faculté des Sciences de la Santé, UAC.

Co-promotor : Prof. Anne Simon : Centre hospitalier Jolimont, Prévention et contrôle des infections, Groupe Jolimont.

Related publications :

• Hand hygiene in surgery in Benin: opportunities and challenges. Carine Laurence YEHOUENOU, Angèle Modupe DOHOU, Ariane Dessièdé FIOGBE, Marius ESSE, Cyriaque DEGBEY, Anne SIMON and Olivia DALLEUR. Antimicrobial Resistance and Infection Control (2020) 9 :85.
• First Detection of a Plasmid-Encoded New-Delhi Metallo-Beta-Lactamase-1 (NDM-1) Producing Acinetobacter Baumannii Using Whole Genome Sequencing, Isolated in a Clinical Setting in Benin. Yehouenou, C.; Bogaerts, B.; Vanneste, K.; Roosens, N.H.C.; De Keersmaecker, S.C.J.; Marchal, K.; Affolabi, D.; Soleimani, R.; Rodriguez-Villalobos, H.; Van Bambeke, F.; et al. Annals of Clinical Microbiology and Antimicrobials 2021, 20, 1–7.
• Whole-Genome Sequencing-based Antimicrobial Resistance Characterization and Phylogenomic investigation of 19 Multidrug-Resistant and Extended-Spectrum Beta-lactamase-Positive Escherichia coli Strains collected from Hospital patients in Benin in 2019. Yehouenou, C.; Bogaerts, B.; Vanneste, K; Roosens, N.H.C.; De Keersmaecker, S.C.J.; Marchal, K.; Tchiakpe E, Affolabi D, et al. Front. Microbiol, 2021 Dec 9;12:752883
• Carbapenem-resistant organisms isolated in surgical site infections in Benin: a public health problem. Carine Laurence YEHOUENOU, Reza Soleimani, Arsène A. Kpangon, Anne Simon, Francis M. Dossou and Olivia Dalleur. Med Infect. Dis. 2022,7,200.
• Understanding hand hygiene behavior in a public hospital in Benin using the Theoretical Domain Frameworks. Carine Laurence YEHOUENOU, Aynaz ABEDINZADEH, Roch HOUNGNIHIN, Carine BAXERRES, Francis M. DOSSOU, Anne SIMON, Olivia DALLEUR. Healthcare 2022,10,1924.

Info: olivia.dalleur@uclouvain.be

Angèle Dohou - Translational Research from Experimental and Clinical Pharmacology to Treatment Optimization (TFAR) – Clinical Pharmacy (CLIP)

Infections Prevention and Control in caesarean section: multifacet analysis of determinants of rational use of antibiotics in Benin.

Promotors and co-promotors:

• Prof. Olivia Dalleur, Louvain Drug Research Institute, UCLouvain
• Prof. Francis Moise Dossou, Faculté des Sciences de la Santé, UAC
• Prof. Françoise Van Bambeke, Louvain Drug Research Institute, UCLouvain
• Prof. Severin Anagonou, Faculté des Sciences de la Santé, UAC

Related publications :

• Antibiotic Usage in Patients Having Undergone Caesarean Section: A Three-Level Study in Benin. Angèle Modupè Dohou*, Valentina Oana Buda, Loconon Achille Yemoa, Severin Anagonou, Françoise Van Bambeke, Thierry Van Hees, Francis Moïse Dossou and Olivia Dalleur. Antibiotics May 2022, 11, 617. 
• Assessment of the Quality of Injectable Antibiotics in Benin. Angèle Modupè Dohou*, Achille Loconon Yémoa, Dodji Boris Aurel Guidan, Seyive Hélène Solange Ahouandjinou, Ahmed Amoussa, Francis Moïse Dossou, Roland Marini Djang’eing’a, and Olivia Dalleur. American Journal of Tropical Medecine and Hygiene, June 2022.
• Healthcare Professionals’ Knowledge and Beliefs on Antibiotic Prophylaxis in Cesarean Section: A Mixed-Methods Study in Benin. Angèle Modupè Dohou*, Valentina Oana Buda, Severin Anagonou, Françoise Van Bambeke, Thierry Van Hees, Francis Moïse Dossou and Olivia Dalleur. Antibiotics June 2022, 11, 872. 

Info: olivia.dalleur@uclouvain.be

Radu BACHMANN – Metabolism and Nutrition Research Group (LDRI - MNUT) and Institute of Experimental and Clinical Research (IREC)

The influence of Akkermansia muciniphila on intestinal wound healing

Promotor : Professeur Patrice D. CANI

Co-Promotors: Professeur Alex H. KARTHEUSER and Professeur Daniel F. LEONARD

Related publications :

• Bachmann R et al., Novel insight into the role of microbiota in colorectal surgery. Gut 2017; 66(4): 738-49.
• Bachmann R et al., The colonoscopic leakage model: a new model to study the intestinal wound healing at molecular level. Gut 2020; 69(12): 2071-3.
• Bachmann R et al., Akkermansia muciniphila Reduces Peritonitis and Improves Intestinal Tissue Wound Healing after a Colonic Transmural Defect by a MyD88-Dependent Mechanism. Cells 2022; 11 (17): 1-19.

Info: patrice.cani@uclouvain.be

Seminars of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Inês LADEIRO DOMINGUES – ADDB Research Group, LDRI – “Exploiting the biological effect exerted by nanocarriers in non-alcoholic fatty liver disease treatment”

Gwenaëlle MAHIEU – TFAR/FACM Research Group, LDRI- “Impact of efflux transporters and their polymorphism on fluoroquinolone transport in eukaryotic cells”

Info: mireille.alhouayek@uclouvain.be

Exploiting codon usage bias in bacterial pathogens to develop novel anti-virulence strategies

Dr. Frédéric GOORMAGHTIGH*, Host-Pathogen interactions (Dirk Bumann), Biozentrum (Switzerland)

*Currently at FACM/LDRI in the group of Françoise Van Bambeke

Related publications :

• Frumkin I, Lajoie MJ, Gregg CJ, Hornung G, Church GM, Pilpel Y. Codon usage of highly expressed genes affects proteome-wide translation efficiency. PNAS, 2018;115(21):E4940-E9.
• Hanson G, Coller J. Codon optimality, bias and usage in translation and mRNA decay. Nat Rev Mol Cell Biol. 2018;19(1):20-30.
• Koh CS, Sarin LP. Transfer RNA modification and infection - Implications for pathogenicity and host responses. Biochim Biophys Acta Gene Regul Mech. 2018;1861(4):419-32.

Info: francoise.vanbambeke@uclouvain.be

Investigation of the gut-brain axis in alcohol-dependent patients

Sophie Leclercq, PhD, F.R.S-FNRS Research Associate - Institute of Neuroscience – Cellular and Molecular division (IoNS/CEMO) - LDRI/MNUT

Related publications:

• Leclercq S. Le Roy T., Furgiuele S., Coste V., Bindels L., Leyrolle Q, Neyrinck A., Quoilin C., Amadieu C., Petit G, Dricot L, Tagliatti V., Cani P., Verbeke K., Colet J-M., Stärkel P., de Timary P., Delzenne N. (2020) Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder. Cell Reports. Vol. 33, no.2, p. 108238 [1-24] (2020)
• S. Leclercq, S. Matamoros, P. D Cani, A. Neyrinck, F. Jamar, P.Stärkel, K. Windey, V. Tremaroli, F. Bäckhed, K. Verbeke, P. de Timary and N. M Delzenne (2014). Intestinal permeability, gut bacterial dysbiosis and behavioral markers of alcohol dependence severity. Proceedings of the National Academy of Sciences (PNAS). Oct 21;111(42):E4485-93
• Amadieu C., Coste V., Neyrinck AM., Thijssen V., Leyrolle Q., Bindels LB., Piessevaux H., Stärkel P., de Timary P., Delzenne NM. & Leclercq S. (2022) Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients, Gut Microbes, 14:1.

Info: nathalie.delzenne@uclouvain.be

Dietary lipids as regulator of dopamine-associated reward processes

Serge LUQUET, Directeur de recherche CNRS à l'Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, 75013 Paris, France

Related publications :

• Berland, C., et al and Luquet, S.H. (2020). Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons. Cell Metab 31, 773-790 e711. (IF 2021: 31.373)
• Cansell, C., et al , Luquet., S (2014). Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Mol Psychiatry 19, 1095-1105
• Berland, C., Small, DM., Luquet, S* and Gangarossa, G*. (2021). Dietary lipids as regulators of reward processes: when multimodal integration matters. Trends Endocrinol Metab 32, 693-705

Info: amandine.everard@uclouvain.be

Prof. Massimiliano MAZZONE - Laboratory of Tumor Inflammation and Angiogenesis - VIB-KU Leuven.

Harnessing tumor metabolism to overcome immunosuppression

Related publications :

• Cappellesso F, Orban M-P, Shirgaonkar N, Berardi E, Serneels J, Neveu M-A, di Molfetta D, Piccapane F, Caroppo R, Debellis L, Ostyn T, Joudiou N, Mignion L, Richiardone E, Jordan B.F., Gallez B, Corbet C, Roskams T, Dasgupta R, Tejpar S, Di Matteo M, Taverna D, Reshkin S.J., Topal B, Virga F, Mazzone M#. Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nature Cancer, doi : 10.1038/s43018-022-00470-2.
• Shang M, Cappellesso F, Amorim R, Serneels J, Virga F, Di Matteo M, Eelen G, Carobbio S, Rincon MY, De Bock K, Maechler P, Ho PC, Sandri M, Ghesquière B, Carmeliet P, Berardi E, and Mazzone M#. Macrophage-derived glutamine boosts satellite cells and muscle regeneration. Nature, 587(7835):626-631 (2020).
• Wenes M, Shang M, Di Matteo M, Goveia J, Martín-Pérez R, Serneels J, Prenen H, Ghesquière B, Carmeliet P, and Mazzone M#. Macrophage metabolism controls tumor blood vessel morphogenesis and metastasis. Cell Metabolism, 24(5): 701-715, (2016). Selected for the special issue on Cancer Metabolism.

Info: benedicte.jordan@uclouvain.be

Caroline MATHIEU - LDRI/CMFA - Towards the targeting of Tryptophan 2,3-dioxygenase self-association as an inhibition strategy

Matthieu DELTOMBE - IoNS/NCHM - LDRI/BPBL - The role of extracellular vesicle-associated microRNAs in the pathophysiology of multiple sclerosis

Céline CASSIERS - LDRI/ADDB - Formulation approaches to overcome clearance mechanisms in the lungs

Paria RASOULI - LDRI/FACM - Pharmacological evaluation of newly designed potentiators of antibiotics against Gram-negative bacteria: An innovative strategy against multiresistant germs

Cheng CHEN - LDRI/ADDB - Metal-organic framework for oral antibody delivery for inflammatory bowel disease and colorectal cancer treatment

Savannah EECKHOUT - LDRI/MNUT - Bacterial amino acid metabolites against muscle wasting

Info: mireille.alhouayek@uclouvain.be

Khoi Nguyen NGUYEN - LDRI/MNUT - Exploring the role of Dysosmobacter welbionis in health and diseases: Towards personalising nutritional strategy

Romane LELOUP - LDRI/BPBL - GPR183 and its ligands as modulators of adipose tissue inflammation during obesity

Vanessa GODARD - LDRI/ADDB - Design of long-acting nanomedicines for inhalation

Ahmad SLEIMAN - LDRI/FACM - The role of bacterial membrane microdomains in antimicrobial resistance in Staphylococcus aureus

Sophie LECOP- LDRI/MNUT - Evaluation of the interest of novel probiotic candidates to improve gut barrier function in the context of cancer cachexia

Manon AUTUORI - LDRI/MNUT - Breath volatolome as a new tool to study gut microbiome – nutrition – host interactions

Info: mireille.alhouayek@uclouvain.be

PUFA-derived endocannabinoids in inflammation and caloric restriction; Is there a role for nutrition?

Dr Jocelijn MEIJERINK - Wageningen University

Related publications :

• Schutte S et al., Diverging metabolic effects of 2 energy-restricted diets differing in nutrient quality: a 12-week randomized controlled trial in subjects with abdominal obesity. Am J Clin Nutr. 2022 Jul 6;116(1):132-150. doi: 10.1093/ajcn/nqac025.
• Meijerink J. The Intestinal Fatty Acid-Enteroendocrine Interplay, Emerging Roles for Olfactory Signaling and Serotonin Conjugates. Molecules. 2021; 26(5):1416. https://doi.org/10.3390/molecules26051416
• Pierluigi Plastina et al., Identification of hydroxytyrosyl oleate, a derivative of hydroxytyrosol with anti-inflammatory properties, in olive oil by-products, Food Chemistry, 2019, P 105-113, doi.org/10.1016/j.foodchem.2018.12.007.
• Wang Y et al., Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N-acyl serotonins identified in human intestinal tissue. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 1862(9):823-831. doi: 10.1016/j.bbalip.2017.05.008.
• Wang Y et al., Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2. ACS Chem Neurosci. 2017 Mar 15;8(3):548-557. doi: 10.1021/acschemneuro.6b00298
• Poland M et al., Docosahexaenoyl serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23-IL-17 signaling in macrophages. Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):2020-2028. doi: 10.1016/j.bbalip.2016.09.012.
• Meijerink J, et al., Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoid N-docosahexaenoylethanolamine (DHEA) in macrophages. Br J Pharmacol. 2015 Jan;172(1):24-37. doi: 10.1111/bph.12747

Info: mireille.alhouayek@uclouvain.be

Elisabeth VAN BOXSTAEL - LDRI/BPBL - IoNS/NCHM - In vitro study of the N-acylethanolamines and prostamides as modulators of glial cell functions in the context of multiple sclerosis

Pauline HENDRICKX - LDRI/ADDB - Programmable Biomaterials Laboratory/EPFL - Exploring the use of DNA nanotechnology for the cytoplasmic delivery of therapeutic miRNA for spinal cord injury repair

Ilaria COLAUZZI - IREC/FATH - Identification of a mitochondrial control of radioresistance in human breast cancer models

Axell-Natalie KOUAKOU - LDRI/REMA-MNUT-BPBL - Role of obesity on melanoma growth and response to therapy in preclinical melanoma model

Chi-hsien LEE - LDRI/MNUT - Isolating and characterizing new microbes from the human gut to improve health

Info: mireille.alhouayek@uclouvain.be

Seminars of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Aline UWIMANA – LDRI/MNUT - Impact of Nutrition on the Malaria outcome

Giulia RODELLA – LDRI/ADDB and REMA - Design of hyaluronic acid-based chemo-immunotherapy for glioblastoma treatment

Info: mireille.alhouayek@uclouvain.be

Seminars of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Victoria FUCHS – LDRI/TFAR CLIP – Evaluation of the impact of adherence, drug-drug interactions, polypharmacy, and inappropriate prescribing on efficacy and safety criteria for Direct Oral Anticoagulants in people with Atrial Fibrillation in the routine clinical practice setting.

Barbara MATHIEU – LDRI/REMA and IREC/FATH – Magnetic resonance detection of mtROS in vivo in solid tumors: mtROS, friends or foes in radiotherapy ?

Info: mireille.alhouayek@uclouvain.be

The world of gut microbiomes through the lens of cultivation

Prof. Thomas CLAVEL - Functional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Germany.

Related publications:

• Enhanced cultured diversity of the mouse gut microbiota enables custom-made synthetic communities, Afrizal et al, Cell Host Microbes 2022
• Anaerobic single-cell dispensing facilitates the cultivation of human gut bacteria. Afrizal et al, Environ Microbiol 2022
• A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity. Wylensek et al, Nat Comm 2020

Info: laure.bindels@uclouvain.be

Mesenchymal stromal cell-based therapeutic approaches for immunomodulation and regeneration: cell therapy and beyond

Prof. Edorta SANTOS VIZCAINO - University of the Basque Country

Related publications:

• Ainhoa Gonzalez-Pujana, Kyle H Vining, David KY Zhang, Edorta Santos-Vizcaino, Manoli Igartua, Rosa Maria Hernandez, David J Mooney. Multifunctional biomimetic hydrogel systems to boost the immunomodulatory potential of mesenchymal stromal cells. Biomaterials, 257, 120266. 2020.
• Ainhoa Gonzalez-Pujana, Ana Beloqui, José Javier Aguirre, Manoli Igartua, Edorta Santos-Vizcaino†, Rosa Maria Hernandez†. Mesenchymal stromal cells encapsulated in licensing hydrogels exert delocalized systemic protection against ulcerative colitis via subcutaneous xenotransplantation. European Journal of Pharmaceutics and Biopharmaceutics, 172: 31-40, 2022.
• Kevin Las Heras, Félix Royo, Clara Garcia-Vallicrosa, Manoli Igartua, Edorta Santos-Vizcaino, Juan M Falcon-Perez, Rosa Maria Hernandez. Extracellular vesicles from hair follicle-derived mesenchymal stromal cells: isolation, characterization and therapeutic potential for chronic wound healing. Stem Cell Research & Therapy. 13(1): 1-18, 2022.

Info: ana.beloqui@uclouvain.be

Seminars of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Séraphin LACOUR – LDRI/CMFA - Design, synthesis and evaluation of new pharmacological tools to study the tryptophan-2,3-dioxygenase (TDO2) in cancer immunotherapy

Zhanjun MA – LDRI/ADDB and BPBL - Ginger derived-extracellular vesicles loaded Rosmarinic acid for spinal cord injury repair

Medicinal plants used for the treatment of type 2 diabetes in French West Indies : evolution of the practice from 1980s to 2000s, chemical study and biological activities of Phyllanthus amarus used by patients in Guadeloupe.

Dr Sylvie BERCION - Vulnérabilité Cardiovasculaire, Pathologie Métabolique et Endocrinienne, EA7525 - Université des Antilles.

Related publications:

• Matou, M., Bercion, S., Marianne-Pepin, T., Haddad, P., & Merciris, P. (2021). Phenolic profiles and biological properties of traditional Phyllanthus amarus aqueous extracts used for diabetes. Journal of Functional Foods, 83, 104571.
• Matou, M., Merciris, P., Haddad, P., Sanchez, M., Herbette, G., Marianne-Pepin, T., & Bercion, S. (2019, October). Study of antidiabetic properties and chemical composition of two Phyllanthus species usually consumed by Guadeloupean. In Caribbean Science and Innovation Meeting 2019.

Info: joelle.leclercq@uclouvain.be

Mandeep KAUR - Translational Research from Experimental and Clinical Pharmacology to Treatment Optimization (TFAR) – Cellular and Molecular Pharmacy (FACM)

VacJ, a regulatory hub for Pseudomonas aeruginosa outer membrane asymmetry, modulates virulence factors, lipid composition, mechanical, biophysical and functional properties of the cell envelope

Related publications:

Review paper: Key roles and interest in therapeutics of VacJ, a lipoprotein of the Mla system that maintains outer membrane lipid asymmetry in Gram-negative bacteria (Submitted). Kaur M, M.-P.Mingeot -Leclercq

Research articles:

• Deficient P. aeruginosa in VacJ/MlaA outer membrane lipoprotein shows decrease of rhamnolipids secretion, motility, and biofilm formation, and increase in fluoroquinolones susceptibility and innate immune response (in revision). Kaur M, J.M. Buyck, J.-L. Decout, N. Mozaheb, M.-P. Mingeot-Leclercq
• Role of VacJ on lipid composition and mechanobiology of the bacterial envelope in Pseudomonas aeruginosa (Submitted). Kaur M, N. Mozaheb, T.O. Paiva, M.-F. Herent, A. Paquot, R. Terrasi, E. Mignolet, J.-L. Décout, J. H. Lorent, Y. Larondelle, G.G. Muccioli, J. Quetin-Leclercq, Y. Dufrêne, M.-P. Mingeot -Leclercq
• A mildly acidic environment alters Pseudomonas aeruginosa virulence and causes remodeling of the bacterial surface (in revision). N. Mozaheb, P. Rasouli, M. Kaur, P. Van Der Smissen, G. Larrouy-Maumus, M.-P. Mingeot-Leclercq

Info: marie-paule.mingeot@uclouvain.be

Ariane MWEMA - Avanced Drug Delivery and Biomaterials (ADDB) and Bioanalysis and Pharmacology of Bioactive Lipids (BPBL)

Nose-to-brain delivery of nanomedicines to stimulate remyelination in the scope of multiple sclerosis

Promotor: Prof. Anne des Rieux - Copromotor : Prof. Giulio Muccioli

Related references:

• Mwema A., Bottemanne P., Paquot A., Ucakar B., Vanvarenberg K., Alhouayek M., Muccioli G.G., des Rieux A, Lipid nanocapsules for the nose-to-brain delivery of the anti-inflammatory bioactive lipid PGD2-G, Nanomedicine, 2022, 102633.
• Mwema A., Labrak Y., Gratpain V., Ucakar B., Vanvarenberg K., Muccioli G.G., des Rieux A., Impact of calcitriol and PGD2-G-loaded lipid nanocapsules on OPC differentiation and remyelination (submitted).
• Mwema A., Muccioli G.G., des Rieux A., New drug delivery strategies for the treatment of multiple sclerosis (submitted).

Info: anne.desrieux@uclouvain.be

Justine GILLARD - IREC and LDRI/Metabolism and Nutrition (MNut)

Bile acids and the enterohepatic cycle: from old dogmas to new potential therapeutic targets for non-alcoholic steatohepatitis

Promotor: Prof. Isabelle Leclercq - Copromotor : Prof. Laure Bindels

Related references:

• Gillard J, Clerbaux LA, Nachit M, Sempoux C, Staels B, Bindels LB, Tailleux A, Leclercq IA. Bile acids contribute to the development of non-alcoholic steatohepatitis in mice. JHEP Reports. 2022;4:100387.
• Gillard J, Picalausa C, Ullmer C, Adorini L, Staels B, Tailleux A, Leclercq IA. Enterohepatic Takeda G-Protein Coupled Receptor 5 Agonism in Metabolic Dysfunction-Associated Fatty Liver Disease and Related Glucose Dysmetabolism. Nutrients. 2022;14:2707.
• Gillard J, Leclercq IA. Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease. Clinical Science. 2023; 137:65-85.

Info : laure.bindels@uclouvain.be

Seminars of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Jingjing YANG – LDRI/ADDB - Development of rationally-designed stimuli-responsive nanoparticles for neuroprotective purposes in spinal cord injury repair

Mohammad WEHBI – LDRI/REMA - Multi-Harmonics EPR in the characterization of skin melanoma

Info: mireille.alhouayek@uclouvain.be

Seminars of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Jingjing YANG – LDRI/ADDB - Development of rationally-designed stimuli-responsive nanoparticles for neuroprotective purposes in spinal cord injury repair

Mohammad WEHBI – LDRI/REMA - Multi-Harmonics EPR in the characterization of skin melanoma

Info: mireille.alhouayek@uclouvain.be

Laser-induced nanobubbles for advanced therapies in the eye

Prof. Félix SAUVAGE, Laboratory for General Biochemistry and Physical Pharmacy – Ghent University

Related publications:

• Laser-induced nanobubbles safely ablate vitreous opacities in vivo. Sauvage F, Nguyen VP, Li Y, Harizaj A, Sebag J, Roels D, Van Havere V, Peynshaert K, Xiong R, Fraire JC, Tassignon MJ, Remaut K, Paulus YM, Braeckmans K, De Smedt SC. Nat Nanotechnol. 2022 May;17(5):552-559. doi: 10.1038/s41565-022-01086-4
• Photoablation of Human Vitreous Opacities by Light-Induced Vapor Nanobubbles. Sauvage F, Fraire JC, Remaut K, Sebag J, Peynshaert K, Harrington M, Van de Velde FJ, Xiong R, Tassignon MJ, Brans T, Braeckmans K, De Smedt SC. ACS Nano. 2019 Jul 23;13(7):8401-8416. doi: 10.1021/acsnano.9b04050

Info: rita.vanbever@uclouvain.be

Seminars of the doctoral school in biomedical and pharmaceutical sciences - Data-Club

Darius MAZHARI DOROOEE – LDRI/CMFA - Deciphering the role of ACSL4 in cancer with new chemical tools

Jad ATRISSI – LDRI/TFAR FACM - Evolution of intracellular uropathogenic Escherichia coli persisters under antibiotic exposure

Info: mireille.alhouayek@uclouvain.be

Biomimicking approaches to understand and direct nerve regeneration & remyelination

Sing Yian CHEW, Ph.D - School of Chemistry, Chemical Engineering and Biotechnology | Lee Kong Chian School of Medicine | School of Materials Science and Engineering | Nanyang Technological University N1.2-B2-20 Singapore

Abstract:

The microenvironment that surrounds cells plays critical roles in dictating cell fate and tissue regeneration. Biophysical signals, such as extracellular matrix architecture and compliance affect cellular response. In combination with biochemical signals from drugs, growth factors, nucleic acids and/or cells, synergistic effects on directing cell phenotypic changes and tissue regrowth are often seen. Here, we will present our approaches towards designing scaffolding constructs that recapitulate important characteristics of the extracellular microenvironment to understand and direct cell fate. We will also share our findings of combining the appropriate biophysical and biochemical signals into tissue-engineered scaffolds to promote nerve regeneration and remyelination in the central nervous system.

Related publications:

• Ong W, Marinval N, Lin J, Nai MH, Chong Y-S, Pinese C, Sajikumar S, Lim CT, Ffrench-Constant C, Bechler ME, Chew SY. Biomimicking Fiber Platform with Tunable Stiffness to Study Mechanotransduction Reveals Stiffness Enhances Oligodendrocyte Differentiation but Impedes Myelination through YAP-Dependent Regulation. Small 2020;16:2003656. https://doi.org/https://doi.org/10.1002/smll.202003656.
• Zhang N, Lin J, Lin VPH, Milbreta U, Chin JS, Chew EGY, Lian MM, Foo JN, Zhang K, Wu W, Chew SY. A 3D Fiber-Hydrogel Based Non-Viral Gene Delivery Platform Reveals that microRNAs Promote Axon Regeneration and Enhance Functional Recovery Following Spinal Cord Injury. Adv Sci 2021;8:2100805. https://doi.org/https://doi.org/10.1002/advs.202100805.
• Zhang N, Lin J, Chew SY. Neural Cell Membrane-Coated Nanoparticles for Targeted and Enhanced Uptake by Central Nervous System Cells. ACS Appl Mater Interfaces 2021;13:55840–50. https://doi.org/10.1021/acsami.1c16543.

Info : anne.desrieux@uclouvain.be

Forgoing animal experiments: a case study in intervertebral disc regenerative medicine

Prof. Catherine LE VISAGE - Research director - French Institute of Health and Medical Research - Inserm - Regenerative Medicine and Skeleton

Related publications:

• B. Le Moal, E. Lepeltier, D. Rouleau, C. Le Visage, J-P Benoit, C. Passirani, J. Guicheux, M. Fusellier, J. Clouet. Lipid nanocapsules for intracellular delivery of microRNA: a first step towards intervertebral disc degeneration therapy. International Journal of Pharmaceutics, 2022, 624: 121941. DOI: 10.1016/j.ijpharm.2022.121941
• L. Frapin, J. Clouet, C. Chedeville, C. Moraru, E. Samarut, N. Henry, M. André, E. Bord, B. Halgand, J. Lesoeur, M. Fusellier, J. Guicheux*, C. Le Visage*. Controlled release of biological factors for endogenous progenitor cell migration and intervertebral disc extracellular matrix remodelling. Biomaterials, 2020, 253: 120107. DOI: 10.1016/j.biomaterials.2020.120107
• L. Frapin, J. Clouet, V. Delplace, M. Fusellier, J. Guicheux*, C. Le Visage*. Lessons learned from intervertebral disc pathophysiology to guide rational design of sequential delivery systems for therapeutic biological factors. Advanced Drug Delivery Reviews, 2019, pii: S0169-409X(19)30143-7. DOI: 10.1016/j.addr.2019.08.007

Info : anne.desrieux@uclouvain.be

Advances in the area of Gastrointestinal Delivery Technologies

Prof. Giovanni TRAVERSO, associate professor at the Department of Mechanical Engineering at the MIT, USA

Abstract:

Medication non-adherence (non-compliance) represents a major barrier to effective clinical care. In developed nations, only 50% of patients take their medications as prescribed, manifesting in more than $100 billion in avoidable hospitalizations every year in the United states alone and the numbers are far worse in the developing world. In his seminar, Dr. Traverso will present a series of novel technologies being developed with the goal to enhance and facilitate medication administration.

Related publications:

• Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors. Abramson A, Frederiksen MR, Vegge A, Jensen B, Poulsen M, Mouridsen B, Jespersen MO, Kirk RK, Windum J, Hubálek F, Water JJ, Fels J, Gunnarsson SB, Bohr A, Straarup EM, Ley MWH, Lu X, Wainer J, Collins J, Tamang S, Ishida K, Hayward A, Herskind P, Buckley ST, Roxhed N, Langer R, Rahbek U, Traverso G. Nat Biotechnol. 2022 Jan;40(1):103-109. doi: 10.1038/s41587-021-01024-0.
• An ingestible self-orienting system for oral delivery of macromolecules. Abramson A, Caffarel-Salvador E, Khang M, Dellal D, Silverstein D, Gao Y, Frederiksen MR, Vegge A, Hubálek F, Water JJ, Friderichsen AV, Fels J, Kirk RK, Cleveland C, Collins J, Tamang S, Hayward A, Landh T, Buckley ST, Roxhed N, Rahbek U, Langer R, Traverso G. Science. 2019 Feb 8;363(6427):611-615. doi: 10.1126/science.aau2277.
• A once-a-month oral contraceptive. Kirtane AR, Hua T, Hayward A, Bajpayee A, Wahane A, Lopes A, Bensel T, Ma L, Stanczyk FZ, Brooks S, Gwynne D, Wainer J, Collins J, Tamang SM, Langer R, Traverso G. Sci Transl Med. 2019 Dec 4;11(521):eaay2602. doi: 10.1126/scitranslmed.aay2602.

Info: ana.beloqui@uclouvain.be

Monday, June 12, 2023 - 5pm - Auditoire Maisin 

Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer

Jorge Luis Galeano Niño, MD, PhD - Fred Hutchinson Cancer Center, Seattle, WA, USA

Introduction by Jeroen Raes (KULeuven), Laure Bindels (UCLouvain - LDRI) and Philippe Stevens (UCLouvain - IREC)

Related publication: https://www.nature.com/articles/s41586-022-05435-0

Info: laure.bindels@uclouvain.be

Commission d'éthique relative à l'expérimentation: évaluation des projets et communication au public via les résumés non-techniques et les analyses rétrospectives

Prof. Jean-Paul DEHOUX, Président de la Commission d'Ethique relative à l'Expérimentation Animale du Secteur des Sciences de la Santé, UCLouvain

Related informations:

https://environnement.brussels/pro/gestion-environnementale/assurer-le-bien-etre-animal/lexperimentation-animale-une-pratique-tres-encadree

https://environment.ec.europa.eu/topics/chemicals/animals-science_fr

Info: amandine.everard@uclouvain.be

Sexually-dimorphic role of the constitutive androstane receptor (CAR) in the gut microbiota-liver cross-talk during non-alcoholic fatty liver disease pathogenesis

Dr. Sandrine Ellero-Simatos - Research Center for Food Toxicology (Toxalim), UMR1331 INRAe, Toulouse University, Toulouse

Related publications:

• The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice. Sharon Ann Barretto et coll. Microbiome. 2021 Apr 20;9(1):93.
• Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target. Sarra Smati et coll. Gut. 2022 Apr;71(4):807-821.
• Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolism. Huillet Marine et coll. bioRXiv. April 2023.

Info: laure.bindels@uclouvain.be and laure.elens@uclouvain.be

Matrix assisted and matrix free laser desorption ionization as a versatile tool for the characterization of complex mixtures of natural products

Andreas Schinkovitz, PhD, Pharm D, Maître de conférences, HDR - Université d'Angers, UFR Santé

Related publications:

• Jaber A, et al. Bithiophenic MALDI matrices as valuable leads for the selective detection of alkaloids. Analytical and Bioanalytical Chemistry, 2017 409, 6791-801. doi: 10.1007/s00216-017-0634-x
• Schinkovitz A, et al. Matrix-free laser desorption ionization mass spectrometry as a functional tool for the analysis and differentiation of complex phenolic mixtures in propolis: a new approach to quality control. Analytical and Bioanalytical Chemistry, 2018, 410, 6187–95. doi: 10.1007/s00216-018-1225-1
• Le Pogam P, et al. A thorough evaluation of matrix-free laser desorption ionization on structurally diverse alkaloids and their direct detection in plant extracts. Analytical and Bioanalytical Chemistry 2020, 412, 7405-7416. doi: 10.1007/s00216-020-02872-6
• Meunier M, et al. Matrix free laser desorption ionization assisted by 13C NMR dereplication: A complementary approach to LC-MS2 based chemometrics, Talanta, 2023, 253, 123998. doi: 10.1016/j.talanta.2022.123998

Info: joelle.leclercq@uclouvain.be

Alexandra Degraeve - LDRI/PharmacoMetrics, pharmacogenomics and pharmacokinetics (PMGK) and Metabolism and Nutrition (MNut)

Tacrolimus pharmacokinetics and gut microbiota: From mechanistic to clinical investigations

Promotor: Prof. Laure Elens

Co-promotor : Prof. Laure Bindels

Related references:

• Degraeve, A. L., Moudio, S., Haufroid, V., Chaib Eddour, D., Mourad, M., Bindels, L. B., & Elens, L. (2020). Predictors of tacrolimus pharmacokinetic variability: current evidences and future perspectives. Expert opinion on drug metabolism & toxicology, 16(9), 769-782.
• Degraeve, A. L., Haufroid, V., Loriot, A., Gatto, L., Andries, V., Vereecke, L., Elens, L. & Bindels, L. B. (2023). Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1. Microbiome, 11(1), 1-20.
• Degraeve, A. L., Bindels, L. B., Haufroid, V., Moudio, S., Boland, L., Delongie, K.-A., Dewulf, J., Chaib Eddour, D., Mourad, M., & Elens, L. Tacrolimus pharmacokinetics is associated with gut microbiota diversity in kidney transplant patients: results from a pilot cross-sectional study. Submitted in Clinical Pharmacology & Therapeutics (2023).

Info : laure.elens@uclouvain.be

Emilie Moens de Hase – LDRI, Metabolism and Nutrition (MNUT)

Investigation of the effects of the newly discovered Dysosmobacter welbionis J115T on metabolism and inflammation

Promotor: Prof. Patrice D. Cani

Related references:

• Le Roy, T.*, Moens de Hase, E.*, Van Hul, M., Paquot, A., Pelicaen, R., Régnier, M., Depommier, C., Druart, C., Everard, A., Maiter, D., Delzenne, N. M., Bindels, L. B., de Barsy, M., Loumaye, A., Hermans, M. P., Thissen, J-P., Vieira-Silva, S., Falony, G., Raes, J., Muccioli, G. G., Cani, P. D. (2022). Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice. Gut, 71: 534-543.
• Cani, P. D., Moens de Hase, E., Van Hul, M. (2021). Gut microbiota and host metabolism: from proof of concept to therapeutic intervention. Microorganisms, 9(6):1302.
• Moens de Hase, E., Petitfils, C., Alhouayek, M., Depommier, C., Le Faouder, P., Delzenne, N. M., Van Hul, M., Muccioli, G. G., Cenac, N., Cani, P.D. Dysosmobacter welbionis effects on glucose, lipid and energy metabolism are associated with specific bioactive lipids. Submitted in Journal of Lipid Research.
• Moens de Hase, E., Neyrinck, A. M., Rodriguez, J., Cnop, M., Paquot, N., Thissen, J-P., Xu, Y., Beloqui, A., Bindels, L. B., Delzenne, N. M. Impact of metformin and Dysosmobacter welbionis on diet-induced obesity and diabetes: from clinical observations to preclinical intervention. Submitted in Diabetologia.

Info: patrice.cani@uclouvain.be

Caner YELEK – Resonance Magnetic Biomedical (REMA) & Metabolism and Nutrition (MNUT)

Obesity-associated alterations driving breast cancer progression: Understanding the role of the gut microbiota and characterizing tumor metabolism

Promotors: Prof. Bénédicte F. Jordan & Prof. Patrice D. Cani

Related references:

• Yelek, C., Mignion, L., Joudiou, N., Terrasi, R., Gourgue, F., Van Hul, M., Delzenne, N., Gallez, B., Corbet, C., Muccioli, G. G., Feron, O., Cani, P. D., & Jordan, B. F. (2020). Acetate: Friend or foe against breast tumour growth in the context of obesity?. Journal of cellular and molecular medicine.
• Yelek, C., Mignion, L., Paquot, A., Bouzin, C., Corbet, C., Muccioli, G. G., Cani, P. D., & Jordan, B. F. (2022). Tumor Metabolism Is Affected by Obesity in Preclinical Models of Triple-Negative Breast Cancer. Cancers.

Info : benedicte.jordan@uclouvain.be

Exploiting membrane lipid heterogeneities in human and bacterial cells for pharmacotherapy

Prof. Joseph LORENT - Translational Research from Experimental and Clinical Pharmacology to Treatment Optimization (TFAR), Cellular and Molecular Pharmacology (FACM), LDRI

Related publications:

• Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape. J. H. Lorent, K. R. Levental, L. Ganesan, G. Rivera-Longsworth, E. Sezgin, M. Doktorova, E. Lyman, I. Levental. Nature Chemical Biology, volume 16, pages 644–652 (2020). https://doi.org/10.1038/s41589-020-0529-6
• Structural determinants and functional consequences of protein affinity for membrane rafts. J. H. Lorent, B. Diaz-Rohrer, X. Lin, K. Spring, A. A. Gorfe, K. R. Levental, I. Levental. Nature Communications volume 8, Article number: 1219 (2017). https://doi.org/10.1038/s41467-017-01328-3
• Structural Modifications Controlling Membrane Raft Partitioning and Curvature in Human and Viral Proteins. Deniz Yurtsever and Joseph Helmuth Lorent. J. Phys. Chem. B 2020, 124, 35, 7574–7585. https://pubs.acs.org/doi/10.1021/acs.jpcb.0c03435

Info: laure.bindels@uclouvain.be

Discovery of a novel antibiotic against Gram-negative ‘superbugs’

Prof. Jian LI - Laboratory of Antimicrobial Systems Pharmacology, Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Australia

Related publication:

A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens. Roberts et al, Nat Commun 2022 Mar 25;13(1):1625. doi: 10.1038/s41467-022-29234-3.

Info: francoise.vanbambeke@uclouvain.be

Chantale FARAH - Biomedical Magnetic Resonance Group (REMA)/LDRI

Assessment of early metabolic markers of response to targeted and immune therapies using 13C Magnetic Resonance Spectroscopy in melanoma xenografts

Promotor: Prof. Bénédicte Jordan

Co-promotor: Prof. Jean François Baurain

Related references:

• Farah C, Neveu MA, Yelek C, Bouzin C, Gallez B, Baurain JF, Mignion L, Jordan BF. Combined HP 13C Pyruvate and 13C-Glucose Fluxomic as a Potential Marker of Response to Targeted Therapies in YUMM1.7 Melanoma Xenografts Biomedicines. 2022;10(3):717
• Farah C, Neveu MA, Bouzin C, Knezevic Z, Gallez B, Leucci E, Baurain JF, Mignion L, Jordan BF. Hyperpolarized 13C-Pyruvate to Assess Response to Anti-PD1 Immune Checkpoint Inhibition in YUMMER 1.7 Melanoma Xenografts. Int J Mol Sci. 2023 ;24(3):2499.

Info: benedicte.jordan@uclouvain.be

Deprescribing psychotropic medication with focus on long-term antidepressants

Prof. Ellen VAN LEEUWEN - GP & Clinical pharmacologist - Clinical Pharmacology & Unit General Practice, Department of Basic and Applied Medical Sciences & Department of Public Health and Primary Care, Ghent University, Belgium - Chief in Editor BCFI/CBIP.

Related publications:

• Van Leeuwen E, van Driel M, Horowitz M, Kendrick T, Donald M, De Sutter A, et al. Approaches for discontinuation versus continuation of long-term antidepressant use for depressive and anxiety disorders in adults. Cochrane database of systematic reviews. 2021;(4).
• Van Leeuwen E, Anthierens S, van Driel M, De Sutter A, van den Branden E, Christiaens T. “Never change a winning team”: GPs’ perspectives on discontinuation of long-term antidepressants. Scandinavian Journal of Primary Health Care. 2021;1–10.
• Van Leeuwen E, Anthierens S, van Driel ML, De Sutter A, De Beir R, Christiaens T. Should I, can I, dare I? Patients' view on stopping long-term antidepressant use, a qualitative study. Acta Clin Belg. 2022;77(6):962-969.

Info : olivia.dalleur@uclouvain.be

Paola PAONE – Metabolism and Nutrition (MNUT)

Unravelling the mechanisms by which prebiotics improve metabolic disorders: interactions between gut microbes and intestinal mucus

Promotor: Prof. Patrice Cani

Related references:

• Paone P, Latousakis D, Terrasi R, Vertommen D, Jian C, Borlandelli V, Delzenne N. M., Salonen A, Juge N, Florea B. I., Muccioli G. G., Overkleeft H. S., Van Hul M., Cani P.D. The human milk oligosaccharide 2’-fucosyllactose protects against high-fat diet induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and fecal proteome profiles. Submitted in Gut in May 2023.
• Suriano F, Vieira-Silva S, Falony G, de Wouters d'Oplinter A, Paone P, Delzenne NM, Everard A, Raes J, Van Hul M, Cani PD. Fat and not sugar as the determining factor for gut microbiota changes, obesity, and related metabolic disorders in mice. Am J Physiol Endocrinol Metab. 2023; 324:E85-E96.
• Paone P, Suriano F, Jian C, Korpela K, Delzenne NM, Van Hul M, Salonen A, Cani PD. Prebiotic oligofructose protects against high-fat diet-induced obesity by changing the gut microbiota, intestinal mucus production, glycosylation and secretion. Gut Microbes. 2022; 14:2152307.
• Paone P, Cani PD. Mucus barrier, mucins and gut microbiota: the expected slimy partners? Gut 2020; 69:2232-43.

Info : patrice.cani@uclouvain.be

Pharmacological neuroprotection against cognitive damage induced by abusive ethanol consumption

Dr. Nuria MORALES PUERTO – MNUT LDRI

Related publications:

• Morales-Puerto N, Vidal R, Gil de Biedma-Elduayen L, Giménez-Gómez P, Pérez-Hernández M, Núñez-de la Calle C, Gutiérrez-López MD, Colado MI, O’Shea E. Prevention of memory deficit induced by intensive ethanol exposure in mice by the neuroprotective compound 3,3’-diindolylmethane. Submitted to Biochemical Pharmacology.
• Gil de Biedma-Elduayen L, Giménez-Gómez P, Morales-Puerto N, Vidal R, Núñez-de la Calle C, Gutiérrez-López MD, O'Shea E, Colado MI. Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61-8048 after chronic intermittent ethanol in mice. Br J Pharmacol. 2022 Jul;179(14):3711-3726. doi: 10.1111/bph.15825. Epub 2022 Mar 7. PMID: 35189673; PMCID: PMC9314579.
• Morales-Puerto N, Giménez-Gómez P, Pérez-Hernández M, Abuin-Martínez C, Gil de Biedma-Elduayen L, Vidal R, Gutiérrez-López MD, O'Shea E, Colado MI. Addiction and the kynurenine pathway: A new dancing couple? Pharmacol Ther. 2021 Jul;223:107807. doi: 10.1016/j.pharmthera.2021.107807. Epub 2021 Jan 19. PMID: 33476641.

Info: amandine.everard@uclouvain.be

Pharmacogenetics: do YOU have your DNA passport?

Prof. Ron van SCHAIK - Professor Pharmacogenetics / European Specialist Laboratory Medicine / Head Dept. Clinical Chemistry / International (IFCC) Expert-center Pharmacogenetics - Dept. Clinical Chemistry, Erasmus MC Rotterdam, The Netherlands.

Related publications:

• Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy. Goetz MP, Sangkuhl K, Guchelaar HJ, Schwab M, Province M, Whirl-Carrillo M, Symmans WF, McLeod HL, Ratain MJ, Zembutsu H, Gaedigk A, van Schaik RH, Ingle JN, Caudle KE, Klein TE. Clin Pharmacol Ther. 2018 May;103(5):770-777.
• The need of the clinical implementation of pharmacogenetics in European health services for routine drug prescription. What's next? An urgent clinical unmet need for patients. Taron M, Llerena A, Manolopoulos VG, Rodriguez-Antona C, Stankovic S, van Schaik RHN. Drug Metab Pers Ther. 2020 Nov 13.

Info: laure.elens@uclouvain.be

Investigating and targeting the CoQ10 headgroup biosynthesis pathway

Dr. Quentin SPILLIER – CMFA LDRI

Related publication:

Banh RS, Kim ES, Spillier Q, Biancur DE, Yamamoto K, Sohn ASW, Shi G, Jones DR, Kimmelman AC, Pacold ME. The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway. Nature. 2021 Sep;597(7876):420-425.

Info: raphael.frederick@uclouvain.be

Linking vascular smooth muscle cell senescence, inflammation and metabolic dysfunction in cardiovascular disease

Assistant Prof Mandy GROOTAERT - Pole EDIN / IREC Institute

Related publications :

• SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis. Mandy O.J. Grootaert , Alison Finigan, Nichola L. Figg, Anna K. Uryga, Martin R. Bennett. Circulation Research. 2021;128:474–491. doi: 10.1161/CIRCRESAHA.120.318353
• Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis. Mandy O. J. Grootaert, Manon Moulis, Lynn Roth, Wim Martinet, Cécile Vindis, Martin R. Bennett, and Guido R. Y. De Meyer. Cardiovascular Research (2018) 114, 622–634. doi:10.1093/cvr/cvy007

Info: patrice.cani@uclouvain.be

Hélène THIROT - Translational Research from Experimental and Clinical Pharmacology to Treatment Optimization - FACM and CLIP

Overview of Linezolid use in Belgium: Towards a better appraisal for the risk of adverse drug reactions

Promotors: Prof. Françoise Van Bambeke and Prof. Anne Spinewine

Related references:

• Hélène Thirot, Caroline Briquet, Frédéric Frippiat, Frédérique Jacobs, Xavier Holemans, Séverine Henrard, Paul M. Tulkens , Anne Spinewine, Françoise Van Bambeke (2021) Clinical use and adverse drug reactions of linezolid: A retrospective study in four Belgian Hospital Centers, Antibiotics (Basel). 10 (5):530. doi: 10.3390/antibiotics10050530
• Hélène Thirot, David Fage, Antonia Leonahardt, Philippe Clevenbergh, Tatiana Besse, Jean-Cyr Yombi, Olivier Cornu, Caroline Briquet, Maya Hites, Frédérique Jacobs, Gert-Jan Wijnant, Sebastian G. Wicha, Frédéric Cotton, Paul M Tulkens, Anne Spinewine, Françoise Van Bambeke (2023) Towards a better detection of patients at-risk of linezolid toxicity in clinical practice: a prospective study in three Belgian hospital centres (submitted in Frontiers in Pharmacology)

Info: francoise.vanbambeke@uclouvain.be

Seminar of the doctoral school in biomedical and pharmaceutical sciences – Data-club

Cheng CHEN – LDRI/ADDB

Manganese-based metal-organic frameworks for oral antibody delivery in inflammatory bowel disease and colorectal cancer treatment

Pauline HENDRICKX – LDRI/ADDB and EPFL (École polytechnique fédérale de Lausanne)

Lipid-coated DNA Nanoparticles for Cell Uptake

Info: mireille.alhouayek@uclouvain.be

Juliette LAGREULA - Translational Research from Experimental and Clinical Pharmacology to Treatment Optimization – CLIP and PMGK

Optimising antipsychotic prescribing in schizophrenia - Understanding the factors contributing to antipsychotic polypharmacy and personalising treatment to improve pharmacotherapy

Promotors: Prof. Olivia Dalleur and Prof. Laure Elens

Related references:

• Lagreula J, de Timary T, Elens L, Dalleur O. Antipsychotic polypharmacy and clozapine prescribing patterns: evolution and correlates before and after a psychiatric hospitalisation. Therapeutic advances in psychopharmacology. 2022; 12:1-12
• Lagreula J, Dagenais-Beaulé V, de Timary P, Elens L, Dalleur O. Prescribing and deprescribing trends in schizophrenia: an overview of inpatients in Belgium and in the Canadian province of Québec. Basic & Clinical Pharmacology & Toxicology. 2023;1–12.
• Lagreula J*, Ferraiolo M*, de Timary T, Delatte B, Elens L, Hermans E, Dalleur O. Impact of a caffeine restriction policy on inpatients with schizophrenia: a pre-post comparison using electronic health records. Journal of clinical psychopharmacology. 2023, 43:167-170 *The first two authors equally contributed to this work.
• Lagreula J, Lorant V, Dalleur O. Assessing the professional social capital of psychiatrists: development of the Resource Generator for Psychiatrists (RG-Psy). Submitted

Info: olivia.dalleur@uclouvain.be

Mingchao WANG – Advanced Drug Delivery and Biomaterials (ADDB)

Development of doxorubicin-based nanomedicine for the local treatment of glioblastoma

Promotors: Véronique Préat (UCLouvain) and Chiara Bastiancich (Aix-Marseille Université / Université de Turin)

Related references:

• Wang M, Bergès R, Malfanti A, Préat V, Bastiancich C. Local delivery of doxorubicin prodrug via lipid nanocapsule-based hydrogel for the treatment of glioblastoma. Drug Deliv Transl Res. 2023 doi: 10.1007/s13346-023-01456-y.
• Wang M, Malfanti A, Bastiancich C, Préat V. Synergistic effect of doxorubicin lauroyl hydrazone derivative delivered by α-tocopherol succinate micelles for the treatment of glioblastoma. Int J Pharm X. 5:100147 (2022). doi: 10.1016/j.ijpx.2022.100147.

Info: chiara.bastiancich@univ-amu.fr

Dendritic cells in tumors: which subpopulations to use for novel cancer therapies?

Prof. Damya LAOUI 

Lab of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium

Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium.

Related publications :

• Clappaert EJ, Kancheva K, Brughmans J, Debraekeleer A, Bardet PMR, Elkrim Y, Lacroix D, Živalj M, Hamouda AEI, Van Ginderachter JA, Deschoemaeker S, Laoui D. Flt3L therapy increases the abundance of Treg-promoting CCR7 + cDCs in preclinical cancer models. Front Immunol. 2023 Aug 9;14:1166180.
• Murgaski A, Kiss M, Van Damme H, Kancheva D, Vanmeerbeek I, KeirsseJ, Hadadi E, Brughmans J, Arnouk SM, Hamouda AEI, Debraekeleer A, Bosteels V, ElkimY, Boon L, Hoves S, Vandamme N, Deschoemaeker S, Janssens S, Garg AD, Vande Velde G, Schmittnägel M, Ries CH, Laoui D. Efficacy of CD40 agonists is mediated by distinct cDC subsets and subverted by suppressive macrophages. Cancer Research. 2022 Oct 17;82(20):3785-3801.
• Laoui D, Keirsse J, Morias Y, Van Overmeire E, Geeraerts X, Elkrim Y, Kiss M, Bolli E, Lahmar Q, Sichien D, Serneels J, Scott CL, Boon L, De Baetselier P, Mazzone M, Guilliams M, Van Ginderachter JA. The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity. Nature Communications. 2016 Dec 23;7:13720.

Info : benedicte.jordan@uclouvain.be

Seminar of the doctoral school in biomedical and pharmaceutical sciences – Data-club

Léo GUILBAUD - LDRI/ADDB - Exploiting the cGAS-STING pathway as therapeutic target in inflammatory bowel disease treatment

Ilaria COLAUZZI - IREC/FATH - Identification of a mitochondrial control of X-rays radioresistance in human breast cancer models

Info: mireille.alhouayek@uclouvain.be

Similarity calculations and differential NMR as alternative for multivariate data analysis. Applications to the analysis of vegetable and essential oils

Prof. Jan SCHRIPSEMA - Grupo Metabolômica - Laboratório de Ciências Quimicas - Universidade Estadual do Norte Fluminense - Brazil.

Related publications :

• Schripsema, Jan; Merlim, Ronald D.S.; Parvan, Lais G.; Ribeiro, Helen S.S.; Schripsema, Leonardo D., Aleixo, Seldon; Becht, Alexander; Holzgrabe, U.; Dagnino, Denise. Towards a holistic view of tablet quality, an extensive study on paracetamol tablets with nuclear magnetic resonance using similarity calculations, differential NMR and hierarchical cluster analysis; J. Pharm. Biomed. Anal., v. 199, 114773, 2022.
• Schripsema, Jan; da Silva, Sonia M.; Dagnino, Denise. Differential NMR and chromatography for the detection and analysis of adulteration of vetiver essential oils; Talanta, v. 237, 122928, 2021.
• Schripsema, Jan. Similarity and differential NMR spectroscopy in metabolomics: application to the analysis of vegetable oils with 1H and 13C NMR. Metabolomics., v.15, p.39 - , 2019

Info: joelle.leclercq@uclouvain.be

Marine DESKEUVRE – Medicinal Chemistry (CMFA)

pH Low Insertion Peptides conjugated to fatty acid metabolism inhibitors to prevent cancer cell proliferation

Promotors: Raphaël Frédérick (UCLouvain, LDRI) & Olivier Feron (UCLouvain, IREC)

Related references:

• Marine Deskeuvre, Junjie Lan, Emeline Dierge, Olivier Riant, Cyril Corbet, Olivier Feron, Raphaël Frédérick. Targeting cancer cells in acidosis with conjugates between the carnitine palmitoyltransferase 1 inhibitor etomoxir and pH (low) Insertion Peptides. Int J Pharm. 2022 Aug 25:624:122041. doi: 10.1016/j.ijpharm.2022.122041.
• Marine Deskeurve, Junjie Lan, Joris Messens, Olivier Riant, Olivier Feron, Raphaël Frédérick. A Novel Approach to pH-Responsive Targeted Cancer Therapy: Inhibition of FaDu Cancer Cell Proliferation with a pH Low Insertion Peptide-Conjugated DGAT1 Inhibitor. Int J Pharm. Submitted

Info: raphael.frederick@uclouvain.be

Manon de MONTIGNY – LDRI CLIP - Management of patients with polymedication in primary care: How pills connect people?

Mélina CARBONE – LDRI REMA - Cocktails of fungicides targeting cellular respiration: which benefits to counteract resistance to cryptogamic diseases for which risks for human cells exposed?

Antoine GLORIEUX – LDRI FACM - Innovative strategies against multispecies infection of the lung in patients with cystic fibrosis: combinations of antibiotics with phages

Lisa MARTIN – LDRI BPBL - Involvement of the endocannabinoid system in the resolution of post-operative pain

Amandine NOBELS – LDRI MNUT - Ciclibiome, an exploration of the interactions between microbiome, circulating metabolism and immunity in HR-positive HER2-negative breast cancer treated with a CDK4/6 inhibitor

Info: mireille.alhouayek@uclouvain.be

Laudine ACKERMANS – LDRI CLIP - Improving competencies of future health care professionals for deprescribing

Alice BARBÉ – LDRI - PMGK, FACM and MNUT - Impact of antibiotic treatments on tacrolimus pharmacokinetics in renal transplant patients - potential influence of gut microbiota

Laurane BECKERS – IREC FATH - To understand and block the metabolic control responsible for prostate cancer bone metastasis

Ayham CHAMMAS – LDRI CMFA - Towards a Synergistic Multi-allosteric Strategy to Target Lactate Dehydrogenase

Claire CAUWELIER – LDRI MNUT/CER group - Studying the Effect of Hydrolysates containing Bio-active Peptides in Murine Models of Intestinal Inflammation and Obesity

Info: mireille.alhouayek@uclouvain.be

Prof. Joana AZEREDO - Laboratory of Applied Health Microbiology, Centre of Biological Engineering, Universidade do Minho, Braga, Portugal

Bacteriophages are effective anti-biofilm agents but need a little help

Related publications :

• Meneses et al. A systematic review of the use of bacteriophages for in vitro biofilm control. European Journal of Clinical Microbiology & Infectious Diseases, 42(8), 919-928, 2023
• Akturket al. Combining phages and antibiotic to enhance antibiofilm efficacy against an in vitro dual species wound biofilm. Biofilm, 6(100147), 2023
• Pires et al. An overview of the current state of phage therapy for the treatment of biofilm-related infections. Current Opinion in Virology, 53(101209), 2022

Info: francoise.vanbambeke@uclouvain.be

Fanny DETROZ - LDRI ADDB and ULiège - Development of nanomedicines to tackle cystic fibrosis lung disease

Clémence FAYT - MNUT - Roles of gut microbes in inter-individual food reward dysregulations during nutritional obesity

Laurie HOFLACK - BPBL and ADDB - Development and pharmacological assessment of a dual nanocarrier containing pro-resolutive drugs in models of rheumatoid arthritis

Barbara LUYENS - MNUT - Exploration of the pro-cognitive effect of Pycnogenol® on the gut microbiota (gut-brain axis) in children and adolescents with and without ADHD

Miryam LUZALA MUKANDE - LDRI FACM and UNIKIN - Green synthesis of silver nanoparticles using Congolese plant extracts to fight against intracellular bacterial infections

Info: mireille.alhouayek@uclouvain.be

THE GUT MICROBIOTA ROLE IN SARS-CoV-2 INFECTION

Dr. Patricia Brito RODRIGUES, PhD, Post-doctoral researcher - LDRI MNUT

Related publications :

• RODRIGUES, Patrícia Brito et al. Impact of Microbiota Depletion by Antibiotics on SARS-CoV-2 Infection of K18-hACE 2 Mice. Cells, v. 11, n. 16, p. 2572, 2022.
• PASCOAL, Lívia Bitencourt; RODRIGUES, Patrícia Brito et al. Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples. Gut Microbes, v. 13, n. 1, p. 1-9, 2021.

Info: amandine.everard@uclouvain.be

Manon AUTUORI - LDRI/MNUT - Breath volatolome as a new tool to study gut microbiome – nutrition – host interactions

Matthieu DELTOMBE - IoNS and LDRI/BPBL - The role of microRNAs associated with extracellular vesicles in the pathophysiology of multiple sclerosis

Info: mireille.alhouayek@uclouvain.be

Martin ROUMAIN – Bioanalysis and Pharmacology of Bioactive Lipids - BPBL

Advances in bioactive sterol research: Metabolism and quantification of oxysterols and bile acids

Promotor: Prof. Giulio Muccioli

Related references:

• Identification and in vivo detection of side-chain hydroxylated metabolites of 4β-hydroxycholesterol. Roumain M, Guillemot-Legris O, Ameraoui H, Alhouayek M, Muccioli GG. J Steroid Biochem Mol Biol. 2023;234:106376. doi: 10.1016/j.jsbmb.2023.106376
• Development of an LC-MS/MS method for the combined quantification of oxysterols and bile acids. Roumain M, Muccioli GG. Submitted.

Info: giulio.muccioli@uclouvain.be