Journal article
Loriot, A., Devis, J., Gatto, L., & De Smet, C. (2025). A survey of human cancer-germline genes: Linking X chromosome localization, DNA methylation and sex-biased expression in early embryos. PLOS Genetics, 21(10), e1011734. https://doi.org/10.1371/journal.pgen.1011734 (Original work published 2025)
Journal article
Fain, J., Wangermez, C., Loriot, A., Denoue, C., & De Smet, C. (2024). DNA Hypomethylation Underlies Epigenetic Swapping between AGO1 and AGO1-V2 Isoforms in Tumors. Transducers, 8(3), 24. https://doi.org/10.3390/epigenomes8030024 (Original work published 2024)
Journal article
Diacofotaki, A., Loriot, A., & De Smet, C. (2023). An abundance of brain-expressed genes show ectopic activation in lung adenocarcinoma. bioRxiv, 557389. https://doi.org/10.1101/2023.09.12.557389 (Original work published 2023)
De Smet, C. (2023). DNA methylation profiling in early lung adenocarcinoma to predict response to immunotherapy. Translational Lung Cancer Research, 12(4), 657-660. https://doi.org/10.21037/tlcr-23-96 (Original work published 2023)
Journal article
Diacofotaki, A., Loriot, A., & De Smet, C. (2022). Identification of tissue-specific gene clusters induced by DNA demethylation in lung adenocarcinoma: more than germline genes. Cancers, 14(4), 1007. https://doi.org/10.3390/cancers14041007 (Original work published 2022)
Journal article
Vander Linden, C., Corbet, C., Bastien, E., Martherus, R., Guilbaud, C., Petit, L., Wauthier, L., Loriot, A., De Smet, C., & Feron, O. (2021). Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition. Cell Reports, 35(9), 109202. https://doi.org/10.1016/j.celrep.2021.109202 (Original work published 2021)
Viceconte, N., Loriot, A., Lona Abreu, P., Scheibe, M., Fradera Sola, A., Butter, F., De Smet, C., Azzalin, C. M., Arnoult, N., & Decottignies, A. (2021). PAR-TERRA is the main contributor to telomeric repeat-containing RNA transcripts in normal and cancer mouse cells. R N A, 27(1), 106-121. https://doi.org/10.1261/rna.076281.120 (Original work published 2021)
Fain, J., Loriot, A., Diacofotaki, A., Van Tongelen, A., & De Smet, C. (2021). Transcriptional overlap links DNA hypomethylation with DNA hypermethylation at adjacent promoters in cancer. Scientific Reports, 11, 17346. https://doi.org/10.1038/s41598-021-96844-0 (Original work published 2021)
Journal article
Fain, J., Van Tongelen, A., Loriot, A., & De Smet, C. (2019). Epigenetic Coactivation of MAGEA6 and CT-GABRA3 Defines Orientation of a Segmental Duplication in the Human X Chromosome. Cytogenetic and Genome Research. Published. https://doi.org/10.1159/000502933 (Original work published 2019)
Journal article
Van Tongelen, A., Loriot, A., & De Smet, C. (2017). Oncogenic roles of DNA hypomethylation through the activation of cancer-germline genes. Cancer Letters, 396, 130-137. https://doi.org/10.1016/j.canlet.2017.03.029 (Original work published 2017)
De Pauw, A., Andre, E., Sekkali, B., Bouzin, C., Esfahani, H., Barbier, N., Loriot, A., De Smet, C., Vanhoutte, L., Moniotte, S., Gerber, B., di Mauro, V., Catalucci, D., Feron, O., Hilfiker-Kleiner, D., & Balligand, J.-L. (2017). Dnmt3a-mediated inhibition of Wnt in cardiac progenitor cells improves differentiation and remote remodeling after infarction. JCI insight, 2(12). https://doi.org/10.1172/jci.insight.91810 (Original work published 2017)
Journal article
Van Tongelen, A., Loriot, A., De Backer, O., & De Smet, C. (2015). Application of CRISPR/cas9-Directed Homologous Recombination to the Generation of Human Tumor Cells with Conditional Knockout of an X-Linked MicroRNA Locus. Gene Technology, 04(02), 1000124. https://doi.org/10.4172/2329-6682.1000124 (Original work published 2015)
Cannuyer, J., Van Tongelen, A., Loriot, A., & De Smet, C. (2015). A gene expression signature identifying transient DNMT1 depletion as a causal factor of cancer-germline gene activation in melanoma. Clinical Epigenetics, 7(1), 114 [1-17]. https://doi.org/10.1186/s13148-015-0147-4 (Original work published 2015)
Journal article
Loriot, A., Van Tongelen, A., Blanco, J., Klaessens, S., Cannuyer, J., van Baren, N., Decottignies, A., & De Smet, C. (2014). A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors. Epigenetics, 9(8), 1163-1171. https://doi.org/10.4161/epi.29628 (Original work published 2014)
Hendrickx, A., Pierrot, N., Tasiaux, B., Schakman, O., Kienlen-Campard, P., De Smet, C., & Octave, J.-N. (2014). Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of Alzheimer disease. PLoS One, 9(6), e99467 [1-9]. https://doi.org/10.1371/journal.pone.0099467 (Original work published 2014)
Journal article
Hendrickx, A., Pierrot, N., Tasiaux, B., Schakman, O., Brion, J.-P., Kienlen-Campard, P., De Smet, C., & Octave, J.-N. (2013). Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty. PLoS One, 8(9), e74305. https://doi.org/10.1371/journal.pone.0074305 (Original work published 2013)
Cannuyer, J., Loriot, A., Parvizi, G. K., & De Smet, C. (2013). Epigenetic Hierarchy within the MAGEA1 Cancer-Germline Gene: Promoter DNA Methylation Dictates Local Histone Modifications. PLoS One, 8(3), e58743. https://doi.org/10.1371/journal.pone.0058743 (Original work published 2013)
Book chapter
De Smet, C., & Loriot, A. (2013). DNA hypomethylation and activation of germline-specific genes in cancer. In Adam R. Karpf (ed.), Epigenetic alterations in oncogenesis (pp. 149-166). Adam R. Karpf. https://doi.org/10.1007/978-1-4419-9967-2_7
Journal article
Loriot, A., Parvizi, G. K., Reister, S., & De Smet, C. (2012). Silencing of cancer-germline genes in human preimplantation embryos: evidence for active de novo DNA methylation in stem cells. Biochemical and Biophysical Research Communications, 417(1), 187-191. https://doi.org/10.1016/j.bbrc.2011.11.120 (Original work published 2012)
Tilman, G., Arnoult, N., Lenglez, S., Van Beneden, A., Loriot, A., De Smet, C., & Decottignies, A. (2012). Cancer-linked satellite 2 DNA hypomethylation does not regulate Sat2 non-coding RNA expression and is initiated by heat shock pathway activation. Epigenetics, 7(8), 903-913. https://doi.org/10.4161/epi.21107 (Original work published 2012)
Lucas, S., van Baren, N., De Smet, C., & Coulie, P. (2012). Demethylation of the FOXP3 gene in human melanoma cells precludes the use of this epigenetic mark for quantification of Tregs in unseparated melanoma samples. International Journal of Cancer, 130(8), 1960-1966. https://doi.org/10.1002/ijc.26198 (Original work published 2012)
Journal article
Bazhin, A. V., De Smet, C., Golovastova, M. O., Schmidt, J., & Philippov, P. P. (2010). Aberrant demethylation of the recoverin gene is involved in the aberrant expression of recoverin in cancer cells. Experimental Dermatology, 19(11), 1023-1025. https://doi.org/10.1111/j.1600-0625.2010.01126.x (Original work published 2010)
De Smet, C., & Loriot, A. (2010). DNA hypomethylation in cancer: Epigenetic scars of a neoplastic journey. Epigenetics : official journal of the DNA Methylation Society, 5(3). (Original work published 2010)
Journal article
Loriot, A., Reister, S., Parvizi, G. K., Lysy, P., & De Smet, C. (2009). DNA Methylation-Associated Repression of Cancer-Germline Genes in Human Embryonic and Adult Stem Cells. Stem Cells : the international journal of cell differentiation and proliferation, 27(4), 822-824. https://doi.org/10.1002/stem.8 (Original work published 2009)
Tilman, G., Loriot, A., Van Beneden, A., Arnoult, N., Londoño-Vallejo, J. A., De Smet, C., & Decottignies, A. (2009). Subtelomeric DNA hypomethylation is not required for telomeric sister chromatid exchanges in ALT cells. Oncogene : including Oncogene Reviews, 28(14), 1682-1693. https://doi.org/10.1038/onc.2009.23 (Original work published 2009)
Stockis, J., Fink, W., François, V., Connerotte, T., De Smet, C., Knoops, L., van der Bruggen, P., Boon, T., Coulie, P., & Lucas, S. (2009). Comparison of stable human Treg and Th clones by transcriptional profiling. European Journal of Immunology, 39(3), 869-882. https://doi.org/10.1002/eji.200838807 (Original work published 2009)
Journal article
Loriot, A., Sterpin, C., De Backer, O., & De Smet, C. (2008). Mouse embryonic stem cells induce targeted DNA demethylation within human MAGE-A1 transgenes. Epigenetics : official journal of the DNA Methylation Society, 3(1), 38-42. (Original work published 2008)
Kholmanskikh, O., Loriot, A., Brasseur, F., De Plaen, E., & De Smet, C. (2008). Expression of BORIS in melanoma: lack of association with MAGE-A1 activation. International journal of cancer. Journal international du cancer, 122(4), 777-784. https://doi.org/10.1002/ijc.23140 (Original work published 2008)
Journal article
Bazhin, A. V., Schadendorf, D., Willner, N., De Smet, C., Heinzelmann, A., Tikhemirova, N. K., Umansky, V., Philippov, P. P., & Eichmüller, S. B. (2007). Photoreceptor proteins as cancer-retina antigens. International Journal of Cancer, 120(6), 1268-1276. https://doi.org/10.1002/ijc.22458 (Original work published 2007)
Journal article
Loriot, A., De Plaen, E., Boon, T., & De Smet, C. (2006). Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells. Journal of Biological Chemistry, 281(15), 10118-10126. https://doi.org/10.1074/jbc.M510469200 (Original work published 2006)
Journal article
Brenner, C., Deplus, R., Didelot, C., Loriot, A., Vire, E., De Smet, C., Gutierrez, A., Danovi, D., Bernard, D., Boon, T., Pelicci, P. G., Amati, B., Kouzarides, T., de Launoit, Y., Di Croce, L., & Fuks, F. (2005). Myc represses transcription through recruitment of DNA methyltransferase corepressor. The EMBO journal, 24(2), 336-346. https://doi.org/10.1038/sj.emboj.7600509 (Original work published 2005)
Journal article
Laduron, S., Deplus, R., Zhou, S., Kholmanskikh, O., GODELAINE, D., De Smet, C., Hayward, S. D., Fuks, F., Boon, T., & De Plaen, E. (2004). MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription. Nucleic Acids Research, 32(14), 4340-4350. https://doi.org/10.1093/nar/gkh735 (Original work published 2004)
De Smet, C., Loriot, A., & Boon, T. (2004). Promoter-dependent mechanism leading to selective hypomethylation within the 5 ′ region of gene MAGE-A1 in tumor cells. Molecular and Cellular Biology, 24(11), 4781-4790. https://doi.org/10.1128/MCB.24.11.4781-4790.2004 (Original work published 2004)
Journal article
Karanikas, V., Lurquin, C., Colau, D., van Baren, N., De Smet, C., Lethé, B., Connerotte, T., Corbiere, V., Demoitie, M., Lienard, D., Dréno, B., Velu, T., Boon, T., & Coulie, P. (2003). Monoclonal anti-MAGE-3 CTL responses in melanoma patients displaying tumor regression after vaccination with a recombinant canarypox virus. Journal of Immunology, 171(9), 4898-4904. https://doi.org/10.4049/jimmunol.171.9.4898 (Original work published 2003)
Rousseau, E., Ruchoux, M.-M., Scaravilli, F., Chapon, F., Vinchon, M., De Smet, C., Godfraind, C., & Vikkula, M. (2003). CDKN2A, CDKN2B and p14ARF are frequently and differentially methylated in ependymal tumours. Neuropathology and Applied Neurobiology, 29(6), 574-583. https://doi.org/10.1046/j.0305-1846.2003.00505.x (Original work published 2003)
Loriot, A., Boon, T., & De Smet, C. (2003). Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia. International Journal of Cancer, 105(3), 371-376. https://doi.org/10.1002/ijc.11104 (Original work published 2003)
Journal article
De Smet, C., Nishimori, H., Furnari, F. B., Bögler, O., Huang, H.-J. S., & Cavenee, W. K. (2002). A novel seven transmembrane receptor induced during the early steps of astrocyte differentiation identified by differential expression. Journal of neurochemistry, 81(3), 575-588. (Original work published 2002)
Journal article
Martelange, V., De Smet, C., De Plaen, E., Lurquin, C., & Boon, T. (2000). Identification on a human sarcoma of two new genes with tumor-specific expression. Cancer research, 60(14), 3848-3855. (Original work published 2000)
Journal article
De Smet, C., Lurquin, C., Lethé, B., Martelange, V., & Boon, T. (1999). DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. Molecular and Cellular Biology, 19(11), 7327-7335. https://doi.org/10.1128/mcb.19.11.7327 (Original work published 1999)
De Backer, O., Arden, K. C., Boretti, M., Vantomme, V., De Smet, C., Czekay, S., Viars, C. S., De Plaen, E., Brasseur, F., Chomez, P., Van den Eynde, B., Boon-Falleur, T., & van der Bruggen, P. (1999). Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. Cancer Research, 59(13), 3157-3165. (Original work published 1999)
Louahed, J., Grasso, L., De Smet, C., Van Roost, E., Wildmann, C., Nicolaides, N. C., Levitt, R. C., & Renauld, J.-C. (1999). Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in T-helper clones. Blood, 94(5), 1701-1710. https://doi.org/10.1182/blood.V94.5.1701 (Original work published 1999)
Janssen, B., van de Locht, L., Fourkour, A., De Smet, C., Mensink, E., van Muijen, G., & de Vries, T. (1999). Transcription of the MAGE-1 gene and the methylation status of its Ets binding promoter elements: a quantitative analysis in melanoma cell lines using a real-time polymerase chain reaction technique. Melanoma Research : an international journal of rapid communications of basic and clinical research in melanoma, 9(3), 213-222. https://doi.org/10.1097/00008390-199906000-00002 (Original work published 1999)
Journal article
Lucas, S., De Smet, C., Arden, KC., Viars, C., Lethé, B., Lurquin, C., & Boon, T. (1998). Identification of a new MAGE gene with tumor-specific expression by representational difference analysis. Cancer Research, 58(4), 743-752. (Original work published 1998)
Lethé, B., Lucas, S., Michaux, L., De Smet, C., Godelaine, D., Serrano, A., De Plaen, E., & Boon, T. (1998). LAGE-1, a new gene with tumor specificity. International journal of cancer. Journal international du cancer, 76(6), 903-908. https://doi.org/10.1002/(SICI)1097-0215(19980610)76:6<903::AID-IJC22>3.0.CO;2-1 (Original work published 1998)
Journal article
De Smet, C., Martelange, V., Lucas, S., Brasseur, F., Lurquin, C., & Boon-Falleur, T. (1997). Identification of human testis-specific transcripts and analysis of their expression in tumor cells. Biochemical and Biophysical Research Communications, 241(3), 653-657. https://doi.org/10.1006/bbrc.1997.7868 (Original work published 1997)
Lurquin, C., De Smet, C., Brasseur, F., Muscatelli, F., Martelange, V., De Plaen, E., Brasseur, R., Monaco, A. P., & Boon-Falleur, T. (1997). Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. Genomics, 46(3), 397-408. https://doi.org/10.1006/geno.1997.5052 (Original work published 1997)
De Plaen, E., Naerhuyzen, B., De Smet, C., Szikora, J.-P., & Boon-Falleur, T. (1997). Alternative promoters of gene MAGE4a. Genomics, 40(2), 305-313. https://doi.org/10.1006/geno.1996.4566 (Original work published 1997)
De Smet, C., Lurquin, C., De Plaen, E., Brasseur, F., Zarour, H., De Backer, O., Coulie, P., & Boon-Falleur, T. (1997). Genes coding for melanoma antigens recognised by cytolytic T lymphocytes. Eye, 11, 243-248. https://doi.org/10.1038/eye.1997.59 (Original work published 1997)
Ikeda, H., Lethé, B., Lehmann, F., van Baren, N., Baurain, J.-F., De Smet, C., Chambost, H., Vitale, M., Moretta, A., Boon-Falleur, T., & Coulie, P. (1997). Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. Immunity, 6(2), 199-208. https://doi.org/10.1016/S1074-7613(00)80426-4 (Original work published 1997)
Journal article
De Smet, C., Debacker, O., Faraoni, I., Lurquin, C., Brasseur, F., & Boon, T. (1996). The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation. National Academy of Sciences. Proceedings, 93(14), 7149-7153. https://doi.org/10.1073/pnas.93.14.7149 (Original work published 1996)
Zarour, H., De Smet, C., Lehmann, F., Marchand, M., Lethé, B., Romero, P., Boon, T., & Renauld, J.-C. (1996). The majority of autologous cytolytic T-lymphocyte clones derived from peripheral blood lymphocytes of a melanoma patient recognize an antigenic peptide derived from gene Pmel17/gp100. The Journal of Investigative Dermatology, 107(1), 63-67. https://doi.org/10.1111/1523-1747.ep12298177 (Original work published 1996)
Journal article
De Smet, C., Courtois, SJ., Faraoni, I., Lurquin, C., Szikora, J.-P., Debacker, O., & Boon, T. (1995). Involvement of 2 Ets Binding-sites in the Transcriptional Activation of the Mage1 Gene. Immunogenetics, 42(4), 282-290. (Original work published 1995)
Journal article
De Plaen, E., Arden, K., Traversari, C., Gaforio, J. J., Szikora, J.-P., De Smet, C., Brasseur, F., van der Bruggen, P., Lethé, B., Lurquin, C., Brasseur, R., Chomez, P., De Backer, O., Cavenee, W., & Boon-Falleur, T. (1994). Structure, Chromosomal Localization, and Expression of 12 Genes of the Mage Family. Immunogenetics, 40(5), 360-369. https://doi.org/10.1007/BF01246677 (Original work published 1994)
van der Bruggen, P., Bastin, J., Gajewski, T., Coulie, P., Boël, P., De Smet, C., Traversari, C., Townsend, A., & Boon-Falleur, T. (1994). A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3. European Journal of Immunology, 24(12), 3038-3043. https://doi.org/10.1002/eji.1830241218 (Original work published 1994)
De Smet, C., Lurquin, C., van der Bruggen, P., De Plaen, E., Brasseur, F., & Boon-Falleur, T. (1994). Sequence and Expression Pattern of the Human Mage2 Gene. Immunogenetics, 39(2), 121-129. https://doi.org/10.1007/BF00188615 (Original work published 1994)
Journal article
Dyson, PJ., De Smet, C., Knight, AM., Simonchazottes, D., Guénet, J.-L., & Boon, T. (1992). Mapping of the Genes Encoding Tum- Transplantation Antigen-p91a, Antigen-p35b, and Antigen-p198. Immunogenetics. https://doi.org/10.1007/BF00189894
Dyson, P. J., De Smet, C., Knight, A. M., Simon-Chazottes, D., Guénet, J. L., & Boon, T. (1992). Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198. Immunogenetics, 35(5), 316-323. (Original work published 1992)
Chomez, P., De Plaen, E., Van Pel, A., De Smet, C., Szikora, J.-P., Lurquin, C., Lebacqverheyden, AM., & Boon, T. (1992). Efficient Expression of Tum- Antigen P91a By Transfected Subgenic Fragments. Immunogenetics, 35(4), 241-252. https://doi.org/10.1007/BF00166829 (Original work published 1992)
