Dr Alexandra DEGRAEVE - MNUT - Postdoctoral Researcher in Pharmacomicrobiomics
Contribution of the gut microbiome to pharmacokinetics to explain inter-patient variabilities: Tacrolimus and Methotrexate as Case Studies
Related publications:
• Degraeve, A. L., Haufroid, V., Loriot, A., Gatto, L., Andries, V., Vereecke, L., Elens L. & Bindels, L. B. (2023). Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1. Microbiome, 11(1), 138. doi : 10.1186/s40168-023-01578-y
• Degraeve, A. L., Villa Soto, V. S., Heath, C. M., Orellana, D. A., Reilly, E. R., Mukherjee, M., ... & Nayak, R. R. (2025). The gut microbiome shapes pharmacology and treatment outcomes for a key anti-inflammatory therapy. bioRxiv, 2025-06. https://www.biorxiv.org/content/10.1101/2025.06.26.661733v2.abstract
