Friday April 10, 2026 – 4:30 pm – Auditoire B (Auditoires centraux - 51 Av. E. Mounier - 1200 Bxl)
Darius MAZHARI DOROOEE – CMFA
Structural and mechanistic investigation of the acyl-CoA synthetase long-chain family member 4 (ACSL4) inhibition in the context of ferroptosis-related diseases and cancer
Promotor: Prof. Raphaël Frédérick
Co-promotor: Dr Jamal El Bakali (Université de Lille)
Related publications:
• Mazhari Dorooee Darius, Ravez Séverine, Vertommen Didier, Renault Nicolas, Papadopoulos Nicolas, Marteau Romain, Charnelle Emeline, Porte Karine, Gobert Alexandre, Hennuyer Nathalie, Herinckx Gaetan, Pautric Maëla, Jonneaux Aurélie, Devedjian Jean Christophe, Devos David, Staels Bart, Melnyk Patricia, Constantinescu Stefan N, Frédérick Raphaël°, El Bakali Jamal°. LIBX-A401: A Novel Selective Inhibitor of Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) and Its Binding Mode (2025) Angewandte Chemie - International Edition, e202500518.
• Marteau Romain*, Ravez Séverine*, Mazhari Dorooee Darius, Bouchaoui Hind, Porte Karine, Devedjian Jean Christophe, Melnyk Patricia, Devos David, Frédérick Raphaël°, El Bakali Jamal°. Repositioning of FDA-Approved antifungal agents to interrogate Acyl-CoA synthetase long chain family member 4 (ACSL4) in ferroptosis (2022) Biochemical Pharmacology, 204: 115239
• Charnelle Emeline*, Gobert Alexandre*, Marteau Romain, Pautric Maëla, Renault Nicolas, Jonneaux Aurélie, Mazhari Dorooee Darius, Laversin Amélie, Devedjian Jean-christophe, Melnyk Patricia, Yous Saïd, Devos David, Frédérick Raphaël, Ravez Séverine°, El Bakali Jamal°. Discovery of Potent Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) Inhibitors with Antiferroptotic Properties (2025) Journal of Medicinal Chemistry.