SSS/LDRI Louvain Drug Research Institute (LDRI)
Christiaens, Antoine ; Cochard, Alexis ; Tubach, Florence ; Thompson, Wade ; Sinclair, Alan J ; Henrard, Séverine ; Boland, Benoît ; Slaouti-Jégou, Yannis ; Lekens, Béranger ; Bonnet-Zamponi, Dominique ; Simon-Tillaux, Noémie ; Zerah, Lorene. Association between hypoglycaemic drug de-intensification, mortality and hospital admission in older adults with type 2 diabetes: a cohort study emulating a target trial. In: Age and Ageing, Vol. 54, no.6, p. afaf160 (2025). doi:10.1093/ageing/afaf160.
Boccardi, Virginia ; Bahat, Gülistan ; Balci, Cafer ; Bourdel-Marchasson, Isabelle ; Christiaens, Antoine ; Donini, Lorenzo Maria ; Cavdar, Sibel ; Maggi, Stefania ; Özkök, Serdar ; Pavic, Tajana ; Perkisas, Stany ; Volpato, Stefano ; Zaidi, Muhammad Shoaib ; Zeyfang, Andrej ; Sinclair, Alan J.. Challenges, current innovations, and opportunities for managing type 2 diabetes in frail older adults: a position paper of the European Geriatric Medicine Society (EuGMS)—Special Interest Group in Diabetes. In: European Geriatric Medicine, (2025). doi:10.1007/s41999-025-01168-1 (Accepté/Sous presse).
Zeraatkar, Dena ; Nagraj, Sumanth Kumbargere ; Ling, Michael ; Jassal, Tanvir ; Kirsh, Sarah ; Lima, João Pedro ; Pitre, Tyler ; Couban, Rachel ; Hussain, Muizz ; Seterelv, Siri ; Van de Velde, Stijn ; Gustavsson, Katarzyna ; Wichniak, Adam ; Aubert, Carole E ; Christiaens, Antoine ; Spinewine, Anne ; Agoritsas, Thomas. Comparative effectiveness of interventions to facilitate deprescription of benzodiazepines and other sedative hypnotics: systematic review and meta-analysis. In: BMJ, Vol. 389, p. e081336 (2025). doi:10.1136/bmj-2024-081336.
Christiaens, Antoine ; Boureau, Anne-Sophie ; Guyomarch, Béatrice ; de Decker, Laure ; Boland, Benoit ; Hadjadj, Samy ; Cariou, Bertrand. Diabetes Overtreatment and Hypoglycemia in Older Patients With Type 2 Diabetes on Insulin Therapy: Insights From the HYPOAGE Cohort Study. In: Diabetes Care, Vol. 48, no.1, p. 61-66 (2025). doi:10.2337/dc24-1058.
Aponte Ribero, Valerie ; Efthimiou, Orestis ; Abolhassani, Nazanin ; Alwan, Heba ; Bauer, Douglas C. ; Henrard, Séverine ; Christiaens, Antoine ; O’Mahony, Denis ; Knol, Wilma ; Peters, Mike J. L. ; Chiolero, Arnaud ; Aujesky, Drahomir ; Waeber, Gérard ; Rodondi, Nicolas ; Del Giovane, Cinzia ; Gencer, Baris. Diabetes and the risk of cardiovascular events and all‐cause mortality among older adults: an individual participant data analysis of five prospective studies. In: European journal of clinical investigation, Vol. 55, no. 2, p. e14340 [1-12] (2025). doi:10.1111/eci.14340.
Christiaens, Antoine. Optimisation du traitement anti-hyperglycémiant chez les personnes âgées vivant avec diabète de type 2 : enjeux du surtraitement et de la déprescription. In: Louvain médical, Vol. 144, no. 3, p. 16-20 (2025).
Christiaens, Antoine ; Boureau, Anne-Sophie ; Hadjadj, Samy ; Cariou, Bertrand. Response to the Comment on Christiaens et al. Diabetes overtreatment and hypoglycemia in older patients with type 2 diabetes on insulin therapy: insights from the HYPOAGE cohort study. Diabetes Care 2025;48:61–66. In: Diabetes Care, (2025) (Accepté/Sous presse).
Christiaens, Antoine. 17 - Deintensification of therapy. In: Alan Sinclair, Ahmed Abdelhafiz, Care of Older People with Diabetes - A Manual for Healthcare Practice, Wiley-Blackwell: Hoboken, NJ, USA, 2025, p. 448. 978-1-394-20503-5 (Accepté/Sous presse).
Mellot, Marion ; Jawal, Lina ; Morel, Thomas ; Fournier, Jean-Pascal ; Tubach, Florence ; Cadwallader, Jean-Sébastien ; Christiaens, Antoine ; Zerah, Lorène. Barriers and Enablers for Deprescribing Glucose-Lowering Treatment in Older Adults: A Systematic Review. In: Journal of the American Medical Directors Association, Vol. 25, no.3, p. 439-447.e18 (2024). doi:10.1016/j.jamda.2023.11.025.
Christiaens, Antoine. Eerstelijnsaanpak van type 2-diabetes bij oudere personen : behandelingsstrategie op maat van de patiënt. In: Medi-Sfeer, Vol. 766, p. 20-[25] (2024).
Christiaens, Antoine. From burden to benefits: new promises of glucose-lowering treatments in older adults. In: Age and Ageing, Vol. 53, no.12, p. afae265 (2024). doi:10.1093/ageing/afae265.
Christiaens, Antoine. Prise en charge du diabète de type 2 chez les personnes âgées en première ligne : individualisation de la stratégie thérapeutique. In: Medi-Sphère, Vol. 766, p. 20-[25] (2024).
Morel, Thomas ; Heinrich, Clara H. ; Zerah, Lorène ; Hurley, Eoin ; Christiaens, Antoine ; Fournier, Jean‐Pascal. Use of deprescribing search filters in systematic review search strategies: A case study. In: Basic & clinical pharmacology & toxicology, Vol. 134, no. 1, p. 116-120 (2024). doi:10.1111/bcpt.13908.
Christiaens, Antoine. Deprescribing Antihyperglycemic Treatments and Hypoglycemia in Older Adults with Type 2 Diabetes. Geriatric Diabetes Days (Nantes, France).
Christiaens, Antoine. EFFECT OF DE-INTENSIFYING HYPOGLYCAEMIC DRUGS IN OLDER ADULTS WITH TYPE 2 DIABETES: A COHORT STUDY EMULATING A TARGET TRIAL. Di-Prescribe (Bruxelles, Belgique).
Christiaens, Antoine. Interactions between Comorbidities and Aging-related Conditions in Older Adults with Diabetes. International Geriatric Diabetes Society (Boston, USA).
Christiaens, Antoine. Overtreatment and Therapeutic De-escalation in Elderly Patients. National Days of Endocrinology (College of Endocrinology, Diabetes, and Metabolic Diseases Teachers) (Paris, France).
Christiaens, Antoine ; Baretella, Oliver ; Del Giovane, Cinzia ; Rodondi, Nicolas ; Knol, Wilma ; Peters, Mike ; Jennings, Emma ; O’Mahony, Denis ; Spinewine, Anne ; Boland, Benoît ; Henrard, Séverine. Association between diabetes overtreatment in older multimorbid patients and clinical outcomes: an ancillary European multicentre study. In: Age and Ageing, Vol. 52, no. 1 (2023), p. afac320 [1-8] (2023). doi:10.1093/ageing/afac320.
Ribero, Valerie Aponte ; Alwan, Heba ; Efthimiou, Orestis ; Abolhassani, Nazanin ; Bauer, Douglas C ; Henrard, Séverine ; Christiaens, Antoine ; Waeber, Gérard ; Rodondi, Nicolas ; Gencer, Baris ; Del Giovane, Cinzia. Cardiovascular disease and type 2 diabetes in older adults: a combined protocol for an individual participant data analysis for risk prediction and a network meta-analysis of novel anti-diabetic drugs.. In: medRxiv : the preprint server for health sciences, (2023). doi:10.1101/2023.03.13.23287105 (Accepté/Sous presse).
Christiaens, Antoine ; Sinclair, Alan J. Comment on: Data-driven classification of health status of older adults with diabetes: The diabetes and aging study.. In: Journal of the American Geriatrics Society, Vol. 71, no.9, p. 2995-2996 (2023). doi:10.1111/jgs.18470.
Christiaens, Antoine ; Henrard, Séverine ; Sinclair, Alan J. ; Tubach, Florence ; Bonnet-Zamponi, Dominique ; Zerah, Lorène. Deprescribing Glucose-Lowering Therapy in Older Adults with Diabetes: A Systematic Review of Recommendations. In: Journal of the American Medical Directors Association, Vol. 24, no.3, p. 400-402 (2023). doi:10.1016/j.jamda.2022.12.018.
Christiaens, Antoine ; Aubert, Carole E ; Wichniak, Adam ; Casanovas, Antoni Salvà ; Spinewine, Anne. Deprescribing benzodiazepine receptor agonists for insomnia in older adults.. In: Lancet, Vol. 402, no. 10411, p. 1421-1422 (2023). doi:10.1016/S0140-6736(23)01562-3.
Bourdel-Marchasson, Isabelle ; Maggi, Stefania ; Abdelhafiz, Ahmed ; Bellary, Sri ; Demurtas, Jacopo ; Forbes, Angus ; Ivory, Philip ; Rodríguez-Mañas, Leocadio ; Sieber, Cornel ; Strandberg, Timo ; Tessier, Daniel ; Vergara, Itziar ; Veronese, Nicola ; Zeyfang, Andrej ; Christiaens, Antoine ; Sinclair, Alan. Essential steps in primary care management of older people with Type 2 diabetes: an executive summary on behalf of the European geriatric medicine society (EuGMS) and the European diabetes working party for older people (EDWPOP) collaboration.. In: Aging clinical and experimental research, Vol. 35, no.11, p. 2279-2291 (2023). doi:10.1007/s40520-023-02519-3.
Christiaens, Antoine ; Simon-Tillaux, Noémie ; Thompson, Wade ; Sinclair, Alan J ; Henrard, Séverine ; Boland, Benoît ; Slaouti-Jégou, Yannis ; Lekens, Béranger ; Bonnet-Zamponi, Dominique ; Tubach, Florence ; Zerah, Lorène. Impact of deintensifying hypoglycaemic drugs in older adults with type 2 diabetes: protocol for an emulation of a target trial.. In: BMJ open, Vol. 13, no.11, p. e073081 [1-9] (2023). doi:10.1136/bmjopen-2023-073081.
Baretella, Oliver ; Alwan, Heba ; Feller, Martin ; Aubert, Carole E ; Del Giovane, Cinzia ; Papazoglou, Dimitrios ; Christiaens, Antoine ; Meinders, Arend-Jan ; Byrne, Stephen ; Kearney, Patricia M ; O'Mahony, Denis ; Knol, Wilma ; Boland, Benoît ; Gencer, Baris ; Aujesky, Drahomir ; Rodondi, Nicolas. Overtreatment and associated risk factors among multimorbid older patients with diabetes.. In: Journal of the American Geriatrics Society, Vol. 71, no.9, p. 2893-2901 (2023). doi:10.1111/jgs.18465.
Christiaens, Antoine ; Henrard, Séverine ; Boland, Benoît ; Sinclair, Alan J.. Overtreatment of older people with type 2 diabetes - a high impact frequent occurrence in need of a new definition. In: Diabetic medicine, Vol. 40, no. 2, p. e14994 [1-8] (2023). doi:10.1111/dme.14994.
Christiaens, Antoine ; Bordier, Lyse ; Doucet, Jean ; Bauduceau, Bernard. Particularités d’utilisation des traitements antihyperglycémiants chez les patients âgés. In: Médecine des Maladies Métaboliques, Vol. 17, no.8, p. 8S90-8S95 (2023). doi:10.1016/s1957-2557(23)00304-8.
Christiaens, Antoine. Choosing Therapeutic Targets for Antihyperglycemic Treatments in Elderly Patients with Type 2 Diabetes. Autumn Days of the French Society of Geriatrics and Gerontology (Paris, France).
Christiaens, Antoine ; Henrard, Séverine ; Boland, Benoît. Large discrepancy in glycaemic control appropriateness in geriatric patients with type 2 diabetes according to major clinical practice guidelines. In: European geriatric medicine, Vol. 13, no. 3, p. 753-758 (2022). doi:10.1007/s41999-021-00594-1.
Christiaens, Antoine ; Henrard, Séverine ; Dalleur, Olivia. 50th ESCP Symposium on Clinical Pharmacy, Polypharmacy and ageing - highly individualized, interprofessional, person-centered care, 19-21/10/2022. 50th ESCP Symposium on Clinical Pharmacy, Polypharmacy and ageing - highly individualized, interprofessional, person-centered ca (Prague, du 19/10/2022 au 21/10/2022). In: International Journal of Clinical Pharmacy, Vol. 2022, no.44, p. 1464-1566 (2022). doi:10.1007/s11096-022-01521-5.
Christiaens, Antoine ; Henrard, Séverine ; Bonnet-Zamponi, Dominique ; Zerah, Lorène. Abstracts of the 18th Congress of the European Geriatric Medicine Society : Live from London and Online, 28–30 September 2022. 18th Congress of the European Geriatric Medicine Society (London, UK, du 28/09/2022 au 30/09/2022). In: European Geriatric Medicine, Vol. 13, no.S1, p. 1-439 (2022). doi:10.1007/s41999-022-00711-8.
Christiaens, Antoine. Diabetes and Elderly Patients: Heterogeneities and Individualization of Treatment. Geriatrics Days in Nouvelle Aquitaine (Bordeaux, France).
Christiaens, Antoine. Implications of Health and Metabolic Heterogeneities for Glycemic Management in Older Patients with Type 2 Diabetes. Académie Royale de Médecine de Belgique, séance académique de remise des prix (Bruxelles, Belgique).
Christiaens, Antoine. The Elderly Diabetic Patient: A Comprehensive and Personalized Approach. Pharmacy Days URPS (Lille, France).
Christiaens, Antoine. Implications of health and metabolic heterogeneities for glycaemic management in older patients with type 2 diabetes, prom. : Boland, Benoit ; Hermans, Michel ; Henrard, Sévenine, 03/02/2022.
Christiaens, Antoine ; Henrard, Séverine ; Zerah, Lorène ; Dalleur, Olivia ; Bourdel-Marchasson, Isabelle ; Boland, Benoît. Individualisation of glycaemic management in older people with type 2 diabetes: a systematic review of clinical practice guidelines recommendations. In: Age and Ageing, Vol. 50, no. 6, p. 1935-1942 (2021). doi:10.1093/ageing/afab157.
Christiaens, Antoine ; Boland, Benoît ; Henrard, Séverine. 530 INTERPRETATION OF HBA1C VALUES IN GERIATRIC PATIENTS WITH TYPE 2 DIABETES: LARGE DIVERGENCE BETWEEN CLINICAL PRACTICE GUIDELINES. Spring meeting of the British Geriatrics Society (online, du 28/04/2021 au 30/04/2021). In: Age and Ageing, Vol. 50, no.Supplement_2, p. ii1-ii4 (2021). doi:10.1093/ageing/afab117.11.
Christiaens, Antoine ; Boland, Benoît ; Germanidis, Marie ; Dalleur, Olivia ; Henrard, Séverine. Poor health status, inappropriate glucose-lowering therapy and high one-year mortality in geriatric patients with type 2 diabetes. In: BMC Geriatrics, Vol. 20, no. 1, p. 367 [1-9] (2020). doi:10.1186/s12877-020-01780-9.
Baretella, O ; Papazoglou, D ; Feller, M ; Christiaens, Antoine ; Meinders, AJ ; Byrne, S ; Kearny, P ; O'Mahony, D ; Knol, W ; Boland, Benoît ; Aujesky, D ; Rodondi, N. Is type 2 diabetes mellitus appropriately treated in multimorbid elderly patients? Sources of potential overtreatment.. Spring Congress of the Swiss Society of General Internal Medicine (Basel (CH)).
Christiaens, Antoine ; Boland, Benoît ; Henrard, Séverine. Overuse of Glucose-Lowering Therapy Predicts Higher One-Year Mortality in Geriatric Patients with Type 2 Diabetes. 80th scientific sessions of the American Diabetes Association (Online (Chicago, IL, USA), du 12/06/2020 au 16/07/2021). In: Diabetes, Vol. 69, no.Suplement 1, p. - (2020). doi:10.2337/db20-1399-P.
Christiaens, Antoine ; Hermans, Michel ; Boland, Benoît ; Henrard, Séverine. Distinction of cardiometabolic profiles among people ≥ 75 years with type 2 diabetes: A latent profile analysis. In: BMC Endocrine Disorders, Vol. 19, p. 85 [1-10] (2019). doi:10.1186/s12902-019-0411-2.
Christiaens, Antoine ; Germanidis, Marie ; Henrard, Séverine ; Boland, Benoît. Appropriateness of glucose-lowering therapy in geriatric patients with type 2 diabetes: factors associated with glucose-lowering therapy at high risk of hypoglycaemia.. Doctoral day – Thematic doctoral school SPSS 2019 (Louvain-la-Neuve).
Christiaens, Antoine ; Hermans, Michel ; Boland, Benoît ; Henrard, Séverine. Classification of Older age patients with type 2 diabetes mellitus in terms of severity and glucose lowering therapy needs using latent class analysis. British Geriatrics Society - Autumn meeting 2018 (London, UK). In: Age and Ageing, Vol. 48, no. Supplement_1, p. i20. doi:10.1093/ageing/afy210.01.
Christiaens, Antoine ; Hermans, Michel ; Boland, Benoît ; Henrard, Séverine. Classification of older age patients with Type 2 Diabetes Mellitus in terms of severity and glucose lowering therapy needs using Latent Class Analysis.. Journées d'Automne 2018 - Société belge de gériatrie et gérontologie (SBGG) (Liège, BE).
Stevens, Philippe ; Christiaens, Antoine ; Beeckmans, Marianne ; Henrard, Séverine ; Boland, Benoît. Diabète de type 2 chez les patients gériatriques : des caractéristiques singulièrement prévalentes.. Journées d'Automne 2018 - Société belge de gériatrie et gérontologie (SBGG) (Liège, BE).
Vanderhofstadt, Maud ; Moreau, Amandine ; de La Serna, Ines ; Luyx, Catherine ; Repoussez, Catherine ; Christiaens, Antoine. Impact de la dysphagie sur l'administration des médicaments. 11ème Congrès international francophone de gérontologie et gériatrie (CIFGG) (Montreux, CH).
Christiaens, Antoine ; Hermans, Michel ; Boland, Benoît ; Henrard, Séverine. Latent Profile Analysis of the metabolic phenotype classified patients ≥75 years with type 2 diabetes into six distinct groups.. Doctoral day – Thematic doctoral school SPSS 2018 (Liège).
Boland, Benoît ; Germanidis, Marie ; Christiaens, Antoine ; Chérif, Mohammad ; Dalleur, Olivia ; Henrard, Séverine. Sur-traitement hypoglycémiant chez les patients gériatriques avec diabète de type 2.. 11ème Congrès international francophone de gérontologie et gériatrie (CIFGG) (Montreux, CH).
Christiaens, Antoine ; Ngueliapi, Yvan ; Henrard, Séverine ; Dalleur, Olivia ; Boland, Benoît. Prescription médicamenteuse cardiovasculaire inappropriée chez des patients âgés diabétiques.. Journées d'Automne - Société belge de gériatrie et gérontologie (SBGG) (Liège, BE).
Christiaens, Antoine ; Deprez, Pierre ; Amyere, Mustapha ; Mendola, Antonella ; Bernard, Pierre ; Gillerot, Yves ; Clapuyt, Philippe ; Godfraind, Catherine ; Lengelé, Benoît ; Vikkula, Miikka ; Behets Wydemans, Catherine. Isolated bilateral transverse agenesis of the distal segments of the lower limbs at the level of the knee joint in a human fetus.. In: American Journal of Medical Genetics. Part A, Vol. 170, no. 2, p. 523-530 (2016). doi:10.1002/ajmg.a.37462.
Christiaens, Antoine ; Beeckmans, Marianne ; Hermans, Michel ; Boland, Benoît. Easy-to-use clinical criteria for screening malnutrition in older patients with type 2 diabetes mellitus.. European union geriatric medicine society congress (EUGMS) (Oslo, NW). In: European Geriatric Medicine, Vol. 6, no.Suppl.1, p. S125 (2015).
Christiaens, Antoine ; Jonas, C ; Ahn, Sylvie A ; Boland, Benoît ; Rousseau, MF ; Hermans, Michel. Insulin sensitivity and secretion in older patients differ according to age at diabetes diagnosis.. European union geriatric medicine society congress (EUGMS) (Oslo, NW). In: European Geriatric Medicine, Vol. 6, no.Suppl.1, p. S125 (2015).
Christiaens, Antoine ; Beeckmans, Marianne ; Hermans, Michel ; Boland, Benoît. Malnutrition in older patients with type 2 diabetes is associated with increased frailty. European union geriatric medicine society congress (EUGMS) (Oslo, NW). In: European Geriatric Medicine, Vol. 6, no. Suppl.1, p. S124-125 (2015).
Christiaens, Antoine ; Boland, Benoît ; Hermans, Michel. Tailoring of glucose lowering therapy in older patients with diabetes mellitus.. RE.PO.SI. Targeting the Burden of Polypharmacy in the elderly. (Milan, IT). In: European journal of case reports in internal medicine, Vol. 2, no.Sup.1, p. 10 (2015). doi:10.12890/2015_S10001.
Christiaens, Antoine ; Beeckmans, Marianne ; Hermans, Michel ; Boland, Benoît. Easy-to-use clinical criteria for screening malnutrition in older patients with type 2 diabetes mellitus.. Journées d'Automne - Société belge de gériatrie et gérontologie (SBGG) (Liège, BE). In: Geriatrie et Psychologie Neuropsychiatrie du Vieillissement, Vol. 12, no.Suppl. 3, p. 16-17 (2014).
Christiaens, Antoine ; Beeckmans, Marianne ; Hermans, Michel ; Boland, Benoît. Increased frailty in older patients with type 2 diabetes and malnutrition.. Journées d'Automne - Société belge de gériatrie et gérontologie (SBGG) (Liège, BE). In: Geriatrie et Psychologie Neuropsychiatrie du Vieillissement, Vol. 12, no.Suppl. 3, p. 16 (2014).
Christiaens, Antoine ; Jonas, C ; Ahn, Sylvie A ; Rousseau, MF ; Boland, Benoît ; Hermans, Michel. Insulin sensitivity and secretion differ between elderly-onset and habitual-onset type 2 diabetes in older patients.. Journées d'Automne - Société belge de gériatrie et gérontologie (SBGG) (Liège, BE). In: Geriatrie et Psychologie Neuropsychiatrie du Vieillissement, Vol. 12, no.Suppl. 3, p. 15-16 (2014).
Christiaens, Antoine ; Deprez, Pierre ML ; Mendola, Antonella ; Bernard, Pierre ; Clapuyt, Philippe ; Godfraind, Catherine ; Lengelé, Benoît ; Vikkula, Miikka ; Behets Wydemans, Catherine. Isolated bilateral zeugo-autopodal segments agenesis of the lower limb: unusual malformation case report.. 6th International conference on Children's Bone Health (ICCBH) (Rotterdam, NL, du 22/06/2013 au 25/06/2013). In: Bone Abstracts, Vol. 2, no., p. P70 (2013).