Journal article
Glibert, H., Bridoux, L., Palate, M., Piget, C., Ahn, M.-T., Gualdani, R., Dominguez Bajo, A., Clotman, F., Rijli, F. M., & Gofflot, F. (2025). Primary Cell Cultures in Neurobiology: Optimized Protocol for Culture of Mouse Fetal Hindbrain Neurons. Cells, 14(11), 758. https://doi.org/10.3390/cells14110758 (Original work published 2025)
Vigneul, E., Krins, F., & Clotman, F. (2025). Of travelling homeoproteins and medulloblastomas. Oncogene : including Oncogene Reviews, 44(34), 3043-3051. https://doi.org/10.1038/s41388-025-03523-9 (Original work published 2025)
Journal article
Zupančič, M., Keimpema, E., Tretiakov, E. O., Eder, S. J., Lev, I., Englmaier, L., Bhandari, P., Fietz, S. A., Härtig, W., Renaux, E., Villunger, A., Hökfelt, T., Zimmer, M., Clotman, F., & Harkany, T. (2024). Concerted transcriptional regulation of the morphogenesis of hypothalamic neurons by ONECUT3. Nature Communications, 15(1), Published online. https://doi.org/10.1038/s41467-024-52762-z (Original work published 2024)
Goffin, L., Lemoine, D., & Clotman, F. (2024). Potential contribution of spinal interneurons to the etiopathogenesis of amyotrophic lateral sclerosis. Frontiers in Neuroscience, 18(None), Published online. https://doi.org/10.3389/fnins.2024.1434404 (Original work published 2024)
Renaux, E., Baudouin, C., Marchese, D., Clovis, Y., Lee, S.-K., Gofflot, F., Rezsohazy, R., & Clotman, F. (2024). Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons. Cellular and Molecular Life Sciences, 81(1), Published online. https://doi.org/10.1007/s00018-024-05316-x (Original work published 2024)
Renaux, E., Baudouin, C., Schakman, O., Gay, O., Martin, M., Marchese, D., Achouri, Y., Rezsohazy, R., Gofflot, F., & Clotman, F. (2024). Arid3c identifies an uncharacterized subpopulation of V2 interneurons during embryonic spinal cord development. Frontiers in Cellular Neuroscience, 18(None), Published online. https://doi.org/10.3389/fncel.2024.1466056 (Original work published 2024)
Dominguez Bajo, A., & Clotman, F. (2024). Potential Roles of Specific Subclasses of Premotor Interneurons in Spinal Cord Function Recovery after Traumatic Spinal Cord Injury in Adults. Cells, 13(8), 652. https://doi.org/10.3390/cells13080652 (Original work published 2024)
Journal article
Zupančič, M., Tretiakov, E., Máté, Z., Erdélyi, F., Szabó, G., Clotman, F., Hökfelt, T., Harkany, T., & Keimpema, E. (2023). Brain‐wide mapping of efferent projections of glutamatergic (Onecut3<sup>+</sup>) neurons in the lateral mouse hypothalamus. Acta Physiologica, 238(3), 1. https://doi.org/10.1111/apha.13973 (Original work published 2023)
Journal article
Baudouin, C., Pelosi, B., Courtoy, G. E., Achouri, Y., & Clotman, F. (2021). Generation and characterization of a tamoxifen-inducible Vsx1-CreER line to target V2 interneurons in the mouse developing spinal cord. Genesis: The Journal of Genetics and Development, e23435. https://doi.org/10.1002/dvg.23435 (Original work published 2021)
Journal article
Romanov, R. A., Tretiakov, E. O., Kastriti, M. E., Zupancic, M., Häring, M., Korchynska, S., Popadin, K., Benevento, M., Rebernik, P., Lallemend, F., Nishimori, K., Clotman, F., Andrews, W. D., Parnavelas, J. G., Farlik, M., Bock, C., Adameyko, I., Hökfelt, T., Keimpema, E., & Harkany, T. (2020). Molecular design of hypothalamus development. Nature, 582(7811), 246-252. https://doi.org/10.1038/s41586-020-2266-0 (Original work published 2020)
Toch, M., Harris, A., Schakman, O., Kondratskaya, E., Boulland, J.-L., Dauguet, N., Debrulle, S., Baudouin, C., Hidalgo-Figueroa, M., Gow, A., Glover, J. C., Tissir, F., & Clotman, F. (2020). Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits. Scientific Reports, 10(1), 996 [1-17]. https://doi.org/10.1038/s41598-020-57945-4 (Original work published 2020)
Gray de Cristoforis, A., Ferrari, F., Clotman, F., & Vogel, T. (2020). Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression. Molecular Brain, 13(1), 85. https://doi.org/10.1186/s13041-020-00623-3 (Original work published 2020)
Journal article
Debrulle, S., Baudouin, C., Hidalgo-Figueroa, M., Pelosi, B., Francius, C., Rucchin, V., Ronellenfitch, K., Chow, R. L., Tissir, F., Lee, S.-K., & Clotman, F. (2019). Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development. Cellular and Molecular Life Sciences. Accepted/in-press. https://doi.org/10.1007/s00018-019-03408-7 (Original work published 2019)
Masgutova, G., Harris, A., Jacob, B., Corcoran, L. M., & Clotman, F. (2019). Pou2f2 Regulates the Distribution of Dorsal Interneurons in the Mouse Developing Spinal Cord. Frontiers in Molecular Neuroscience, 12, 263. https://doi.org/10.3389/fnmol.2019.00263 (Original work published 2019)
Toch, M., & Clotman, F. (2019). CBP and p300 coactivators contribute to the maintenance of Isl1 expression by the Onecut transcription factors in embryonic spinal motor neurons. Molecular and Cellular Neuroscience, 101, 103411. https://doi.org/10.1016/j.mcn.2019.103411 (Original work published 2019)
Harris, A., Masgutova, G., Collin, A., Toch, M., Hidalgo-Figueroa, M., Jacob, B., Corcoran, L. M., Francius, C., & Clotman, F. (2019). Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Developing Spinal Cord. Frontiers in Cellular Neuroscience, 13(184), 1. https://doi.org/10.3389/fncel.2019.00184 (Original work published 2019)
Journal article
Clotman, F., & Tissir, F. (2018). Guidance of motor axons: where do we stand? Current Opinion in Physiology, 4, 76-81. https://doi.org/10.1016/j.cophys.2018.06.004 (Original work published 2018)
Journal article
Kabayiza, U. K., Masgutova, G., Harris, A., Rucchin, V., Jacob, B., & Clotman, F. (2017). The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development. Frontiers in Molecular Neuroscience, 10. https://doi.org/10.3389/fnmol.2017.00157 (Original work published 2017)
Journal article
Romanov, R. A., Zeisel, A., Bakker, J., Girach, F., Hellysaz, A., Tomer, R., Alpár, A., Mulder, J., Clotman, F., Keimpema, E., Hsueh, B., Crow, A. K., Martens, H., Schwindling, C., Calvigioni, D., Bains, J. S., Máté, Z., Szabó, G., Yanagawa, Y., et al. (2016). Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes. Nature Neuroscience, 20(2), 176-188. https://doi.org/10.1038/nn.4462 (Original work published 2017)
Francius, C., Hidalgo Figueroa, M., Debrulle, S., Pelosi, B., Rucchin, V., Ronellenfitch, K., Panayiotou, E., Makrides, N., Misra, K., Harris, A., Hassani, H., Schakman, O., Parras, C., Xiang, M., Malas, S., Chow, R. L., & Clotman, F. (2016). Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord. Frontiers in Molecular Neuroscience, 9, 145 [1-15]. https://doi.org/10.3389/fnmol.2016.00145 (Original work published 2016)
Stanga, S., Zanou, B. N., TASIAUX, B., Contino, S., Clotman, F., Gailly, P., Dewachter, I., Octave, J.-N., & Kienlen-Campard, P. (2016). APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation. The FASEB Journal, 30(5), 1696-1711. https://doi.org/10.1096/fj.15-278739 (Original work published 2016)
Journal article
Pirson, M., Debrulle, S., Clippe, A., Clotman, F., & Knoops, B. (2015). Thioredoxin-2 modulates neuronal programmed cell death in the embryonic chick spinal cord in basal and target-deprived conditions. PLoS One, 1-21. https://doi.org/10.1371/journal.pone.0142280 (Original work published 2015)
Journal article
Chai, G., Zhou, L., Manto, M., Helmbacher, F., Clotman, F., Goffinet, A., & Tissir, F. (2014). Celsr3 is required in motor neurons to steer their axons in the hindlimb. Nature Neuroscience, 17(9), 1171-1179. https://doi.org/10.1038/nn.3784 (Original work published 2014)
Francius, C., Ravassard, P., Hidalgo Figueroa, M., Mallet, J., Clotman, F., & Nardelli, J. (2014). Genetic dissection of Gata2 selective functions during specification of V2 interneurons in the developing spinal cord. Developmental Neurobiology. Published. https://doi.org/10.1002/dneu.22244 (Original work published 2014)
Francius, C., & Clotman, F. (2014). Generating spinal motor neuron diversity: a long quest for neuronal identity. Cellular and Molecular Life Sciences, 71(5), 813-829. https://doi.org/10.1007/s00018-013-1398-x (Original work published 2014)
des Rieux, A., De Berdt, P., Ansorena Artieda, E., Ucakar, B., Jacobs, D., Schakman, O., Audouard, E., Bouzin, C., Auhl, D., Simón-Yarza, T., Feron, O., Blanco-Prieto, M. J., Carmeliet, P., Bailly, C., Clotman, F., & Préat, V. (2014). Vascular endothelial growth factor-loaded injectable hydrogel enhances plasticity in the injured spinal cord. Journal of Biomedical Materials Research. Part A, 102(7), 2345-2355. https://doi.org/10.1002/jbm.a.34915 (Original work published 2014)
Journal article
Panayiotou, E., Panayi, E., Lapathitis, G., Francius, C., Clotman, F., Kessaris, N., Richardson, W. D., & Malas, S. (2013). Pax6 is expressed in subsets of V0 and V2 interneurons in the ventral spinal cord in mice. Gene Expression Patterns, 13(8), 328-334. https://doi.org/10.1016/j.gep.2013.06.004 (Original work published 2013)
Francius, C., Harris, A., Rucchin, V., Hendricks, T. J., Stam, F. J., Barber, M., Kurek, D., Grosveld, F. G., Pierani, A., Goulding, M., & Clotman, F. (2013). Identification of Multiple Subsets of Ventral Interneurons and Differential Distribution along the Rostrocaudal Axis of the Developing Spinal Cord. PLoS One, 8(8), e70325. https://doi.org/10.1371/journal.pone.0070325 (Original work published 2013)
Hermant, P., Francius, C., Clotman, F., & Michiels, T. (2013). IFN-ε Is Constitutively Expressed by Cells of the Reproductive Tract and Is Inefficiently Secreted by Fibroblasts and Cell Lines. PLoS One, 8(8), e71320. https://doi.org/10.1371/journal.pone.0071320 (Original work published 2013)
Audouard, E., Schakman, O., Ginion, A., Bertrand, L., Gailly, P., & Clotman, F. (2013). The Onecut transcription factor HNF-6 contributes to proper reorganization of Purkinje cells during postnatal cerebellum development. Molecular and Cellular Neuroscience, 56, 159-168. https://doi.org/10.1016/j.mcn.2013.05.001 (Original work published 2013)
Conference paper
Stanga, S., Tasiaux, B., Clotman, F., & Kienlen-Campard, P. (2013). APP-dependent regulation of GDNF expression and its involvement in neuromuscular junction. BELSPO IAP NEUROBRAINNET, VIB Antwerpen, Belgium.
Journal article
Chakrabarty, K., Von Oerthel, L., Hellemons, A., Clotman, F., Espana-Bessy, A., Groot Koerkamp, M., Holstege, F. C. P., Pasterkamp, R. J., & Smidt, M. P. (2012). Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development. Biology Open, 1(8), 693-704. https://doi.org/10.1242/bio.20121230 (Original work published 2012)
Roy, A., Francius, C., Rousso, D. L., Seuntjens, E., Debruyn, J., Luxenhofer, G., Huber, A. B., Huylebroeck, D., Novitch, B. G., & Clotman, F. (2012). Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification. Development (Cambridge, England), 139(17), 3109-3119. https://doi.org/10.1242/dev.078501 (Original work published 2012)
Audouard, E., Schakman, O., René, F., Huettl, R.-E., Huber, A. B., Loeffler, J.-P., Gailly, P., & Clotman, F. (2012). The Onecut Transcription Factor HNF-6 Regulates in Motor Neurons the Formation of the Neuromuscular Junctions. PLoS One, 7(12), e50509. https://doi.org/10.1371/journal.pone.0050509 (Original work published 2012)
Espana-Bessy, A., & Clotman, F. (2012). Onecut factors control development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus. Molecular and Cellular Neuroscience, 50(1), 93-102. https://doi.org/10.1016/j.mcn.2012.04.002 (Original work published 2012)
Journal article
Espana-Bessy, A., & Clotman, F. (2011). Onecut transcription factors are required for the second phase of development of the A13 dopaminergic nucleus in the mouse. The Journal of Comparative Neurology, 520(7), 1424-1441. https://doi.org/10.1002/cne.22803 (Original work published 2012)
Stam, F. J., Hendricks, T. J., Zhang, J., Geiman, E. J., Francius, C., Labosky, P. A., Clotman, F., & Goulding, M. (2011). Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program. Development, 139(1), 179-190. https://doi.org/10.1242/dev.071134 (Original work published 2012)
Journal article
Francius, C., & Clotman, F. (2010). Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development. Neuroscience, 165(1), 116-129. https://doi.org/10.1016/j.neuroscience.2009.09.076 (Original work published 2010)
Journal article
Antoniou, A., Raynaud, P., Cordi, S., Zong, Y., Tronche, F., Stanger, B., Jacquemin, P., Pierreux, C., Clotman, F., & Lemaigre, F. (2009). Intrahepatic Bile Ducts Develop According to a New Mode of Tubulogenesis Regulated by the Transcription Factor SOX9. Gastroenterology, 136(7), 2325-2333. https://doi.org/10.1053/j.gastro.2009.02.051 (Original work published 2009)
Journal article
Margagliotti, S., Clotman, F., Pierreux, C., Lemoine, P., Rousseau, G., Henriet, P., & Lemaigre, F. (2008). Role of metalloproteinases at the onset of liver development. Development, Growth and Differentiation, 50(5), 331-338. https://doi.org/10.1111/j.1440-169X.2008.01031.x (Original work published 2008)
Clotman, F., Libbrecht, L., Killingsworth, M. C., Loo, C. C. K., Roskams, T., & Lemaigre, F. (2008). Lack of cilia and differentiation defects in the liver of human foetuses with the Meckel syndrome. Liver International, 28(3), 377-384. https://doi.org/10.1111/j.1478-3231.2007.01617.x (Original work published 2008)
Conference paper
Espana, A., & Clotman, F. (2008). Roles of the onecut transcription factors in catecholaminergic neuron differentiation. International Journal of Developmental Neuroscience, 26(8), 875. https://doi.org/10.1016/j.ijdevneu.2008.09.151 (Original work published 2008)
Journal article
Margagliotti, S., Clotman, F., Pierreux, C., Beaudry, J.-B., Jacquemin, P., Rousseau, G., & Lemaigre, F. (2007). The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration. Developmental Biology Journal, 311(2), 579-589. https://doi.org/10.1016/j.ydbio.2007.09.013 (Original work published 2007)
Journal article
Veiga da Cunha, M., Jacquemin, P., Delpierre, G., Théate, I., Vertommen, D., Clotman, F., Lemaigre, F., Devuyst, O., & Van Schaftingen, E. (2006). Increased protein glycation in fructosamine 3-kinase-deficient mice. The Biochemical Journal, 399(2), 257-264. https://doi.org/10.1042/BJ20060684 (Original work published 2006)
Pierreux, C., Poll, A. V., Kemp, C. R., Clotman, F., Maestro, M. A., Cordi, S., Ferrer, J., Leyns, L., Rousseau, G., & Lemaigre, F. (2006). The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. Gastroenterology, 130(2), 532-541. https://doi.org/10.1053/j.gastro.2005.12.005 (Original work published 2006)
Clotman, F., & Lemaigre, F. (2006). Control of hepatic differentiation by activin/TGFbeta signaling. Cell Cycle, 5(2), 168-171. https://doi.org/10.4161/cc.5.2.2341 (Original work published 2006)
Journal article
Clotman, F., Courtoy, P., Jacquemin, P., Plumb-Rudewiez, N., Pierreux, C., Van Der Smissen, P., Dietz, H. C., Rousseau, G., & Lemaigre, F. (2005). Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. Genes & Development, 19(16), 1849-1854. https://doi.org/10.1101/gad.340305 (Original work published 2005)
Journal article
Plumb-Rudewiez, N., Clotman, F., Strick-Marchand, H., Pierreux, C., Weiss, M. C., Rousseau, G., & Lemaigre, F. (2004). Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver. Hepatology (Baltimore, Md.), 40(6), 1266-1274. https://doi.org/10.1002/hep.20459 (Original work published 2004)
Briançon, N., Bailly, A., Clotman, F., Jacquemin, P., Lemaigre, F., & Weiss, M. C. (2004). Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver. Journal of biological chemistry, 279(32), 33398-33408. https://doi.org/10.1074/jbc.M405312200 (Original work published 2004)
Journal article
Clotman, F., Libbrecht, L., Gresh, L., Yaniv, M., Roskams, T., Rousseau, G., & Lemaigre, F. (2003). Hepatic artery malformations associated with a primary defect in intrahepatic bile duct development. Journal of Hepatology, 39(5), 686-692. https://doi.org/10.1016/S0168-8278(03)00409-4 (Original work published 2003)
Bouzin, C., Clotman, F., Renauld, J.-C., Lemaigre, F., & Rousseau, G. (2003). The onecut transcription factor hepatocyte nuclear factor-6 controls B lymphopoiesis in fetal liver. Journal of Immunology, 171(3), 1297-1303. https://doi.org/10.4049/jimmunol.171.3.1297 (Original work published 2003)
Journal article
Clotman, F., Lannoy, V. J., Reber, M., Cereghini, S., Cassiman, D., Jacquemin, P., Roskams, T., Rousseau, G., & Lemaigre, F. (2002). The onecut transcription factor HNF6 is required for normal development of the biliary tract. Development (Cambridge, England), 129(8), 1819-1828. (Original work published 2002)
Journal article
Clotman, F., De Backer, O., Boon, T., De Plaen, E., & Picard, J. (2000). Cell- and stage-specific expression of mage genes during mouse spermatogenesis. Mammalian Genome, 11(8), 696-699. https://doi.org/10.1007/s003350010116 (Original work published 2000)
Journal article
Carmeliet, P., Moons, L., Lampugnani, M. G., Breviario, F., Compernolle, V., Bono, F., Balconi, G., Spagnuolo, R., Oosthuyse, B., Dewerchin, M., Zanetti, A., Angellilo, A., Mattot, V., Nuyens, D., Lutgens, E., Clotman, F., de Ruiter, M. C., Gittenberger-de Groot, A., Poelmann, R., et al. (1999). Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell, 98(2), 147-157. (Original work published 1999)
Gofflot, F., Kolf-Clauw, M., Clotman, F., Roux, C., & Picard, J. (1999). Absence of ventral cell populations in the developing brain in a rat model of the Smith-Lemli-Opitz syndrome. American Journal of Medical Genetics, 87(3), 207-216. https://doi.org/10.1002/(SICI)1096-8628(19991126)87:3<207::AID-AJMG3>3.0.CO;2-5 (Original work published 1999)
Journal article
Clotman, F., Van Maele, G., Chu-Wu, L., & Picard, J. (1998). Structural and gene expression abnormalities induced by retinoic acid in the forebrain. Reproductive Toxicology, 12(2), 169-176. https://doi.org/10.1016/S0890-6238(97)00151-2 (Original work published 1998)
Clotman, F., Van Maele, G., & Picard, JJ. (1998). All-trans-retinoic acid upregulates the expression of COUP-TFI in early-somite mouse embryos cultured in vitro. Neurotoxicology and Teratology, 20(6), 591-599. https://doi.org/10.1016/S0892-0362(98)00018-X (Original work published 1998)
Journal article
Clotman, F., Van Maele, G., & Picard, J. (1997). Retinoic acid induces a tissue-specific deletion in the expression domain of Otx2. Neurotoxicology and Teratology, 19(3), 163-169. https://doi.org/10.1016/S0892-0362(97)00017-2 (Original work published 1997)
Landry, C., Clotman, F., Hioki, T., Oda, H., Picard, J., Lemaigre, F., & Rousseau, G. (1997). HNF-6 is expressed in endoderm derivatives and nervous system of the mouse embryo and participates to the cross-regulatory network of liver-enriched transcription factors. Developmental Biology Journal, 192(2), 247-257. https://doi.org/10.1006/dbio.1997.8757 (Original work published 1997)
Rosen, E., Chan, J., Idusogie, E., Clotman, F., Vlasuk, G., Luther, T., Jalbert, L., Albrecht, S., Zhong, L., Lissens, A., Schoonjans, L., Moons, L., Collen, D., Castellino, F., & Carmeliet, P. (1997). Mice lacking factor VII develop normally but suffer fatal perinatal bleeding. Nature : international weekly journal of science, 390(6657), 290-294. https://doi.org/10.1038/36862 (Original work published 1997)
Van Maele, G., Clotman, F., Gofflot, F., Bosschaert, J., & Picard, J. (1997). Postimplantation mouse embryos cultured in vitro : Assessment with whole-mount immunostaining and in situ hybridization. The International Journal of Developmental Biology, 41(2), 365-374. (Original work published 1997)
Conference paper
Clotman, F., Vanmaelefabry, G., & Picard, JJ. (1997). Deletion of a specific region of the expression domain of Otx2 in early mouse embryos exposed in vitro to AT-retinoic acid. Developmental Biology, 186(2), B185-B185. (Original work published 1997)
Journal article
Van Maele, G., Clotman, F., & Picard, J. (1996). Exogenously added retinoic acid effects on expression of Otx2 and on morphology in early mouse embryos. Hunan Shifan Daxue Xuebao (Ziran Kexue Ban), 19(3), 47-53. (Original work published 1996)
Dissertation
Clotman, F. (1996). Modifications des domaines d’expression de gènes du développement induites par l’acide rétinoïque sous la forme all-trans chez des embryons de souris cultivés in vitro.
Journal article
Van Maele, G., Gofflot, F., Clotman, F., & Picard, J. (1995). Alterations of mouse embryonic branchial nerves and ganglia induced by ethanol. Neurotoxicology and Teratology, 17(4), 497-506. https://doi.org/10.1016/0892-0362(95)00009-G (Original work published 1995)
