Gwenaëlle MAHIEU - LDRI / TFAR FACM and PMGK

An integrated pharmacokinetic, pharmacogenomic and pharmacodynamic study of fluoroquinolones in the context of intracellular infections

Promotor: Prof Françoise Van Bambeke – Co-Promotor: Prof Laure Elens

Related publications: 

• Mahieu, G., Elens, L., Prebonnaud, N., Chauzy, A., & Van Bambeke, F. (2025). A hollow fiber infection model to study intracellular and extracellular antibiotic activity against Staphylococcus aureus. iScience, 28(3), 112076. https://doi.org/10.1016/j.isci.2025.112076
• Mahieu, G., Haufroid, V., Van Bambeke, F., & Elens, L. (2025). In vitro assessment of ATP-binding cassette transporters and their functional genetic polymorphisms on fluoroquinolone accumulation in human embryonic kidney 293 recombinant cell lines. Drug Metabolism and Disposition, 100063. https://doi.org/10.1016/j.dmd.2025.100063
• Mahieu, G., Sennesael, A.-L., Pochet, L., Haufroid, V., Van Bambeke, F., Spinewine, A., & Elens, L. (2024). In vitro assessment of the risk of ABCB1-mediated drug–drug interaction between rivaroxaban and tacrolimus in human embryonic kidney 293 recombinant cell lines. Research and Practice in Thrombosis and Haemostasis, 8(5), 102521. (Collaborative work). https://doi.org/10.1016/j.rpth.2024.102521 

Info: françoise.vanbambeke@uclouvain.be