Giuditta LEONE - Thesis public defence

Giuditta LEONE – ADDB/CMFA

Development of PEG-treprostinil conjugates for sustained local delivery in pulmonary arterial hypertension

Promotor: Prof. Rita Vanbever
Co-promotor: Prof. Raphaël Frédérick

Related publications :

•    Leone, G., Ucakar, B., Perros, F., Frédérick, R., & Vanbever, R. (2025). Synthesis and in vitro evaluation of polyethylene glycol-treprostinil conjugates for sustained local delivery in pulmonary arterial hypertension. European Journal of Pharmaceutical Sciences, 214, 107287. https://doi.org/10.1016/j.ejps.2025.107287 
•    Leone, G., Frédérick, R., & Vanbever, R. Prodrug approaches for sustained small-molecule drug delivery to the lungs. Submitted.
•    Leone, G., Akoumia, KKF., Ucakar, B., Esfahani, H., Perros, F., Frédérick, R., Dessy, C., Vanbever, R. Polyethylene glycol double prodrug increases treprostinil lung retention in the treatment of pulmonary arterial hypertension. In preparation.
 

This thesis defence took place on November 21, 2025.