Seminars and thesis defences

Antoine GLORIEUX – TFAR FACM
Phages as innovative adjuvant of antibiotic therapy versus lung infections in patients with Cystic Fibrosis 

Alice BARBÉ – TFAR PMGK and FACM – MNUT
Impact of antibiotic treatments on tacrolimus pharmacokinetics in renal transplant patients - potential influence of gut microbiota

Info: mireille.alhouayek@uclouvain.be
 

LDRI Seminar - Group Leader Series - Prof. Nathalie DELZENNE

Feeding the gut microbiota for health: from basic science to clinical relevance

Related publications:

• Delzenne, Nathalie M., Bindels, Laure B., Neyrinck, Audrey M. & Walter, Jens (2024). The gut microbiome and dietary fibres: implications in obesity, cardiometabolic diseases and cancer. Nature reviews. Microbiology, [1-14].
• Neyrinck, Audrey M., Rodriguez, Julie, Zhang, Zhengxiao, Nazare, Julie-Anne, Bindels, Laure B., Cani, Patrice D., Maquet, Véronique, Laville, Martine, Bischoff, Stephan C, Walter, Jens & Delzenne, Nathalie M. (2022). Breath volatile metabolome reveals the impact of dietary fibres on the gut microbiota: Proof of concept in healthy volunteers. EBioMedicine, 80, 104051 [1-13]. 
• Rodriguez, Julie, Hiel, Sophie, Neyrinck, Audrey M., Le Roy, Tiphaine, Pötgens, Sarah, Leyrolle, Quentin, Pachikian, Barbara D., Gianfrancesco, Marco A, Cani, Patrice D., Paquot, Nicolas, Cnop, Miriam, Lanthier, Nicolas, Thissen, Jean-Paul, Bindels, Laure B. & Delzenne, Nathalie M. (2020). Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients. Gut, 69(11), 1975-1987. 
• Leclercq, Sophie, Le Roy, Tiphaine, Furgiuele, Sonia, Coste, Valentin, Bindels, Laure B., Leyrolle, Quentin, Neyrinck, Audrey M., Quoilin, Caroline, Amadieu, Camille, Petit, Géraldine, Dricot, Laurence, Tagliatti, Vanessa, Cani, Patrice D., Verbeke, Kristin, Colet, Jean-Marie, Starkel, Peter, de Timary, Philippe & Delzenne, Nathalie M. (2020). Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder. Cell reports, 33, 108238 [1-24]. 

Info: president-LDRI@uclouvain.be


 

Prof. Sylvain GOUTELLE - Laboratoire de Biométrie et Biologie Evolutive - Université Lyon 1 - Faculté de Pharmacie de Lyon - France

Pharmacokinetic Modeling of Antibiotics in Populations and Individuals
 

Related publications:

• Goutelle et al. Defining standard and high dosages for β-lactam agents administered by intermittent, prolonged or continuous infusion: a PK/PD simulation study.  J. Antimicrob. Chemother 2023 Nov 6;78(11):2762-2769.
• Goutelle et al. AUC-based monitoring and model-informed precision dosing of vancomycin in critically ill patients: why and how?  Anaesth Crit Care Pain Med. 2023 Dec;42(6):101286
• Tulopu et al. Evaluation of Limited Sampling Strategies for Bayesian Estimation of Daptomycin Area Under the Concentration-Time Curve: A Short Communication. Ther Drug Monit. 2023 Aug 1;45(4):562-565. 

Info: francoise.vanbambeke@uclouvain.be and laure.elens@uclouvain.be
 

Mélina CARBONE - REMA

Cocktails of fungicides targeting cellular respiration: which benefits to counteract resistance to cryptogamic diseases for which risks for human cells exposed?

Claire CAUWELIER - MNUT

Studying the effetc of hydrolysates contianing bioactive peptides, in murine models of intestinal inflammation and obesity

Auditoire Maisin

Info: mireille.alhouayek@uclouvain.be

Laurie HOFLACK -  ADDB and BPBL

Development and pharmacological assessment of a dual nanocarrier containing pro-resolutive drugs in models of rheumatoid arthritis

Clémence FAYT – MNUT

Roles of gut microbes in inter-individual reward dysregulations during obesity

Info : mireille.alhouayek@uclouvain.be

Monday, February 17, 2025 - 1pm - Auditoire Maisin 
 

Membrane lipids as potential biomarkers and therapeutical targets
 

Selected publications
•    Maja M*, Verfaillie M*, Van Der Smissen P, Henriet P, Pierreux C, Sounni NE, Tyteca D. Targeting cholesterol impairs cell invasion of all breast cancer types. Cancer cell international. 2024; 24:27 [1-18].
•    Maja M, Mohammed D, Dumitru A-C, Verstraeten S, Lingurski M, Mingeot-Leclercq M-P, Alsteens D, Tyteca D. Surface cholesterol-enriched domains specifically promote invasion of breast cancer cell lines by controlling invadopodia and extracellular matrix degradation. Cell Mol Life Sci. 2022; 79:417.
•    Ghodsi M, Cloos A-S, Lotens A, De Bueger M, Van Der Smissen P, Henriet P, Cellier N, Pierreux CE, Najdovski T, Tyteca D. Development of an easy non-destructive particle isolation protocol for quality control of red blood cell concentrates. Journal of Extracellular Biology. 2025; e70028.
•    Ghodsi M*, Cloos A-S*, Mozaheb N, Van Der Smissen P, Henriet P, Pierreux CE, Cellier N, Mingeot-Leclercq M-P, Najdovski T, Tyteca D. Variability of extracellular vesicle release during storage of red blood cell concentrates is associated with differential membrane alterations, including loss of cholesterol-enriched domains. Front Physiol. 2023; 14:1205493. 

Info: giulio.muccioli@uclouvain.be

Monday, February 10, 2025 - 1pm - Auditoire Maisin 
 

Elsa TEMPERMAN (BPBL) - Inhibiting ABHD6 as anti-inflammatory strategy in the context of chronic lung inflammation
Marie-Sophie MARTOU (CMFA/FATH) - Creating anti-angiogenic miniproteins targeting protein-protein interactions as a new strategy in anticancer therapy
Edwige PIRON (MNUT) - Targeting bacterial metabolites to tackle muscle wasting in colorectal cancer-associated cachexia: toward a mechanistic understanding
Lisa FLASSE (LTAP) - Study of the adverse mechanisms associated with low toxicity, persistent particles
Paul PARRENS (ADDB/FACM) - Engineering bacterocin-based nanomedicines for the eradication of Staphylococcus aureus intracellular reservoirs in the context of skin chronic infections
Yasmine VANDENSANDE (REMA/FATH) - Induction of a mitochondrial oxidative stress in cholangiocarcinoma to boost the sensitivity to targeted therapy
William VAN den BOSSCHE (ADDB) - Gas-promoted microbubbles-based drug delivery systems for the delivery of biologics in inflammatory bowel disease treatment

Info : mireille.alhouayek@uclouvain.be

Monday, February 3, 2025 - 1pm - Auditoire Maisin 
 

Gas-promoted in situ bioadhesive foam platform for efficient macromolecule delivery in the treatment of inflammatory bowel disease

Promotor: Prof. Ana Beloqui

Related publications :
•    Zhang W., Van den Bossche W., Yagoubi H., Kambale E.K., Whani K., Saxena T., Guilbaud L., Moreels T.G., Messens J., Beloqui A. Glepaglutide-loaded foam for the induction of mucosal healing in the treatment of inflammatory bowel disease. Advanced Healthcare Materials (2025) Accepted.
•    Zhang W., McCartney F., Xu Y., Bohns Michalowski C., Domingues I., Kambale E.K., Moreels T.G., Guilbaud L., Chen C., Marotti V., Brayden D.J., Beloqui A. An in situ bioadhesive foam as a large intestinal delivery platform for antibody fragment to treat inflammatory bowel disease. Journal of Controlled Release 374 (2024) 254-266.
•    Zhang W., Bohns Michalowski C., Beloqui A. Oral delivery of biologics in inflammatory bowel disease treatment. Frontiers in Bioengineering and Biotechnology Nanobiotechnology 9 (2021) 675194

Info: ana.beloqui@uclouvain.be

Friday January 31, 2025 – 4pm – Auditoire Maisin
 

Transforming the oral route for drug delivery
 
Selected publications:
•    Arrick G, Sticker D, Chazal A, Lu Y, Duncombe T, Gwynee D, Mouridsen B, Wainer J, Jepsen JPH et al. Cephalopod-inspired jetting devices for gastrointestinal drug delivery. Nature. 2024 doi.org/10.1038/s41586-024-08202-5
•    Ramadi KB, McRae JC, Selsing G, Su A, Fernandes R, Hickling M, Rios B, Babaee S, Min S, Gwynne D, Jia NZ, Aragon A, Ishida K, Kuosmanen J, Jenkins J, Hayward A, Kamrin K, Traverso G. Bioinspired, ingestible electroceutical capsules for hunger-regulating hormone modulation. Sci Robot. 2023 Apr 26;8(77):eade9676. doi: 10.1126/scirobotics.ade9676. 
•    Srinivasan SS, Alshareef A, Hwang AV, Kang Z, Kuosmanen J, Ishida K, Jenkins J, Liu S, Madani WAM, Lennerz J, Hayward A, Morimoto J, Fitzgerald N, Langer R, Traverso G. RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract. Sci Robot. 2022 Sep 28;7(70):eabp9066. doi: 10.1126/scirobotics.abp9066.

Full list of publications:  https://www.ncbi.nlm.nih.gov/myncbi/carlo.traverso.1/bibliography/public/

Info: ana.beloqui@uclouvain.be

Friday, January 24, 2025 – 1pm – Salle Couvreur