Dr Alexandre GOBERT
Postdoctoral researcher - CMFA, LDRI, UCLouvain
Investigating ACSL4 inhibition and substrate specificity: a pathway to targeting ferroptosis-related neurodegenerative diseases
Related publications:
- Charnelle E, Gobert A, Marteau R, et al. Discovery of Potent Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) Inhibitors with Antiferroptotic Properties. J Med Chem. 2025;68(15):15766-15784. doi:10.1021/acs.jmedchem.5c00739
- Mazhari Dorooee D, Ravez S, Vertommen D, et al. LIBX-A401: A Novel Selective Inhibitor of Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) and Its Binding Mode. Angew Chem Int Ed Engl. 2025;64(19):e202500518. doi:10.1002/anie.202500518
- Doll, S., Proneth, B., Tyurina, Y. et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol 13, 91–98 (2017). https://doi.org/10.1038/nchembio.2239
Info: quentin.spillier@uclouvain.be
