Prof. Tom Leyssens

The main focus of our research group lies in the field of crystal engineering and crystallization process development, with a strong emphasis on designing and understanding multi-component solid forms. By combining principles of crystal engineering, crystallization, and mechanochemistry, we explore the solid-state landscape to uncover novel routes for material synthesis. Our research aims not only at the discovery of new crystalline systems but also at developing practical processes - optimisation, resolution, and purification - based on the intrinsic properties of these new-found solid forms.

A particular area of interest is the development of solvent-free, mechanochemical approaches, as part of our ongoing efforts to reduce solvent usage and translate solution-based crystallization strategies into sustainable solid-state methodologies. Recently, special emphasis is placed on chiral aspects, including resolution and deracemization, where we exploit the synergy between mechanochemistry and crystal engineering for the efficient preparation of enantiopure compounds.

Our group is highly application-driven, with projects spanning from fundamental solid-state studies to industrial process development. We collaborate with partners in the pharmaceutical and agrochemical industries to address pressing challenges such as solubility enhancement, control of hygroscopicity, alternative formulations, and purification via co-crystallization. By tailoring the design of multi-component systems, we aim to create innovative solutions that improve the performance and stability of active compounds.

Current projects focus on compounds of pharmaceutical relevance and those important to the food industry, where crystallization plays a crucial role in quality, functionality, and stability. Our collaborative efforts with companies including Callebaut, Aevigenomics, Citribel, Futerro, Nutreco, Givaudon, UCB, and Umicore highlight the translational impact of our work, bridging academic research and industrial needs.

Through this integrated approach, we advance the understanding of crystalline materials and develop novel, sustainable strategies for solid-state process design, resolution, and purification.