Publications

Wen, T., Robeyns, K., Collard, L., Leyssens, T., & Leng, F. (2026). Chiral resolution of racemic ibuprofen sodium via diastereomeric ionic cocrystallization with proline. Chemical Communications, 62(32), 8280-8283. https://doi.org/10.1039/D6CC01175F (Original work published 2026)

Nikonovich, T., Chatzigiannis, C. M., Bordier, C., Solorzano-Rodriguez, R., Baier, D. M., Ort, F. F., Aav, R., Leyssens, T., Blanco-Ania, D., Rutjes, F. P. J. T., Kananovich, D., & Colacino, E. (2026). Mechanochemical Methods for Amide Bond Formation. Chemical Reviews. Published. https://doi.org/10.1021/acs.chemrev.5c00534 (Original work published 2026)

Wery, G., Gieling, J., El Kaderi, Z., Hendrickx, L., Wiegand, T., Bolm, C., Leyssens, T., & Baier, D. M. (2026). Scalable and sustainable mechanochemical deracemisation by resonant acoustic mixing. Green Chemistry. Published. https://doi.org/10.1039/D5GC06927K (Original work published 2026)

Carvalho, A. C. S., Duarte, M. T., Gomes, C. S. B., Sarraguça, M., Bacchi, A., Prencipe, M., Gieling, J., Shemchuk, N., Baier, D. M., Robeyns, K., Polyzois, H., Tajber, L., Chatzigiannis, C. M., Colacino, E., Leyssens, T., & André, V. (2026). Mechanochemically Driven Synthesis of Anticancer Cocrystals: A Case Study of Lenalidomide. Chemistry–Methods, 6(5). https://doi.org/10.1002/cmtd.70092 (Original work published 2026)

Jiang, Y., Souare, S., Robeyns, K., Leng, F., Collard, L., & Leyssens, T. (2026). Solvent-triggered breakdown of solid solution behaviour enables direct enantioselective crystallization of RS-phenprocoumon. Chemical Communications, 62(24), 6613-6616. https://doi.org/10.1039/D6CC00933F (Original work published 2026)

Poljanic, L., Leyssens, T., Collard, L., & Baier, D. M. (2026). When chirality breaks: mechanochemical degradation of biaryl atropisomers. RSC Mechanochemistry, 3(2), 218-223. https://doi.org/10.1039/d5mr00132c (Original work published 2026)

Meersseman Arango, H., Luis Alconero, P., Leyssens, T., & Debecker, D. (2025). Enzyme-membrane reactors: recent trends and applications for the production of fine chemicals and pharmaceutical building blocks. Comptes rendus. Chimie, 28(G1), 151-170. https://doi.org/10.5802/crchim.378 (Original work published 2025)

Wen, T., Robeyns, K., Tumanov, N., Wouters, J., Baier, D., Wang, T., Miao, S., Liu, X., Sun, G., Leyssens, T., & Leng, F. (2025). Combining Sodium Profen Salts with Carbohydrates through Ionic Cocrystallization. Crystal Growth & Design, 25(17), 7208-7215. https://doi.org/10.1021/acs.cgd.5c00762 (Original work published 2025)

Meersseman Arango, H., Bachus, N., Nguyen, X. D. L., Bredun, B., Luis Alconero, P., Leyssens, T., Roura Padrosa, D., Paradisi, F., & Debecker, D. (2025). Crystallization-assisted asymmetric synthesis of enantiopure amines using membrane-immobilized transaminase. Chem & Bio Engineering, 2(4), 272-282. https://doi.org/10.1021/cbe.4c00186 (Original work published 2025)

Esser, G., Crits, R., de Meester, J., Robeyns, K., Leyssens, T., Chernyshov Dmitry, Graversen, L. G., Sapnik, A. F., Jensen, K. M. Ø., Dejoie, C., He, M., Filinchuk, Y., Hermans, S., & Steenhaut, T. (2025). Toward Reversible Crystalline-to-Amorphous Guest-Induced Transitions in Manganese(III) Carboxylate Metal–Organic Frameworks. Inorganic Chemistry, 64(9), 4491-4500. https://doi.org/10.1021/acs.inorgchem.4c05337 (Original work published 2025)

Steenhaut, T., Li, X., Zhou, F., Robeyns, K., Leyssens, T., Filinchuk, Y., & Shemchuk, O. (2025). A hydrogen-bonded organic framework with ultramicroporous channels based on proline and DL-2-phenoxypropionic acid. CrystEngComm, 27(23), 3887-3890. https://doi.org/10.1039/d5ce00357a (Original work published 2025)

Chen, D., Robeyns, K., Leyssens, T., Saikia, B., & Van Cleuvenbergen, S. (2025). Polymorphic Control in Pharmaceutical Gel-Mediated Crystallization: Exploiting Solvent–Gelator Synergy in FmocFF Organogels. Gels, 11(7), 509. https://doi.org/10.3390/gels11070509 (Original work published 2025)

Lopes, C., Casali, L., Emmerling, F., Leyssens, T., Dupray, V., Brandel, C., & Cartigny, Y. (2025). Efficient racemization of the pharmaceutical compound Levetiracetam using solvent-free mechanochemistry. RSC Mechanochemistry, 2(1), 83-90. https://doi.org/10.1039/d4mr00103f (Original work published 2025)

Chergaoui, S., Tocci, E., Rizzuto, C., Prenesti, G., Debecker, D., Leyssens, T., & Luis, P. (2025). Modulating crystal polymorphism via membrane-regulated supersaturation: an experimental and molecular dynamics simulation study. Journal of Colloid and Interface Science, 708, 139803. https://doi.org/10.1016/j.jcis.2025.139803 (Original work published 2026)

de Meester, J., Shemchuk, O., Collard, L., Wouters, J., Robeyns, K., & Leyssens, T. (2025). Solvent selection as a major determinant of chiral resolution outcomes: the BINOL–DACH case study. CrystEngComm, 27(48), 7826-7833. https://doi.org/10.1039/d5ce00706b (Original work published 2025)

Meersseman Arango, H., Leyssens, T., Luis Alconero, P., & Debecker, D. (2025). Enzyme-membrane-reactors: recent trends and applications for the production of fine chemicals and pharmaceutical building-blocks. Comptes rendus. Chimie, 1(1), 1. (Original work published 2025)

Spoletti, E., Wen, T., Leng, F., Boukioud, N., Lacey, J. C., Darwish, S., Shemchuk, O., Robeyns, K., Leyssens, T., & Lusi, M. (2025). Piracetam and Oxiracetam Afford Molecular, Cocrystalline, and Ionic Cocrystalline Solid Solutions. Crystal Growth & Design, 25(16), 6754-6763. https://doi.org/10.1021/acs.cgd.5c00735 (Original work published 2025)

Gieling, J., Wery, G., Lopes, C., de Meester, J., Brandel, C., Cartigny, Y., Leyssens, T., & Baier, D. (2025). Mechanochemical Deracemization: A Sustainable Approach to Enantiopurity. Chemistry: A European Journal, 31(15). https://doi.org/10.1002/chem.202404120 (Original work published 2025)

Songsermsawad, S., Boonpalit, K., Shemchuk, O., Robeyns, K., Leyssens, T., & Flood, A. E. (2025). Stereochemical Control of Cocrystal and Hybrid Salt–Cocrystal Formation in the Baclofen–Mandelic Acid System. Crystal Growth & Design, 25(16), 6830-6836. https://doi.org/10.1021/acs.cgd.5c00779 (Original work published 2025)

Wery, G., Pastucha, K., Robeyns, K., & Leyssens, T. (2024). The Inability of Metal Coordination to Control the Regioselectivity of Dimerization of Trans-Cinnamic Acid Derivatives. Crystals, 14(6), 530. https://doi.org/10.3390/cryst14060530 (Original work published 2024)

Songsermsawad, S., Shemchuk, O., Robeyns, K., Zhou, F., Flood, A. E., & Leyssens, T. (2024). Double Trouble: A Peculiar Case of Solid Solution Cocrystals Involving Two Chiral Compounds. Crystal Growth & Design, 24(7), 2977-2984. https://doi.org/10.1021/acs.cgd.4c00074 (Original work published 2024)

Robeyns, K., Debecker, D., Luis Alconero, P., Caro Garrido, C., vandooren, m., Leyssens, T., & et al. (2024). Combining a Drug and a Nutraceutical: A New Cocrystal of Praziquantel and Curcumin. Crystals, Feature Papers in Crystals 2023(14), 181. https://doi.org/10.3390/cryst14020181 (Original work published 2024)

Meersseman Arango, H., Nguyen, X. D. L., Luis Alconero, P., Leyssens, T., Roura Padrosa, D., Paradisi, F., & Debecker, D. (2024). Membrane-immobilized transaminases for the synthesis of enantiopure amines. RSC Sustainability, 10(2), 3139-3152. https://doi.org/10.1039/d4su00293h (Original work published 2024)

Chergaoui, S., Lauzer, J., Debecker, D., Leyssens, T., & Luis Alconero, P. (2024). Tuning membrane properties to control supersaturation of antisolvent crystallization. Journal of Membrane Science, 694, 122415. https://doi.org/10.1016/j.memsci.2024.122415 (Original work published 2024)

Songsermsawad, S., Shemchuk, O., Robeyns, K., Collard, L., E. Flood, A., & Leyssens, T. (2024). Simultaneously resolving BINOL and proline using a stoichiometric cocrystal switch. Chemical Communications. Published. https://doi.org/10.1039/d4cc02180k (Original work published 2024)

Body, C., Wery, G., Gubbels, L., Robeyns, K., & Leyssens, T. (2024). Control of Regioselectivity in the Dimerization of trans-Cinnamic Acid and Its Derivatives Using Cocrystal Engineering. Crystal Growth & Design, 24(5), 2117-2125. https://doi.org/10.1021/acs.cgd.3c01449 (Original work published 2024)

de Meester, J., Layrisse, P., Marchivie, M., Collard, L., Wery, G., Brandel, C., Cartigny, Y., Subra-Paternault, P., Leyssens, T., & Harscoat-Schiavo, C. (2024). Towards a new approach in chiral resolution: Pressurized-CO2 assisted preferential cocrystallization. The Journal of Supercritical Fluids, 212, 106339. https://doi.org/10.1016/j.supflu.2024.106339 (Original work published 2024)

de Meester, J., Shemchuk, O., Collard, L., Wouters, J., Baillieux, S., Robeyns, K., & Leyssens, T. (2024). Using the nature of the achiral solvent to orient chiral resolution. CrystEngComm, 26(15), 2056-2059. https://doi.org/10.1039/d4ce00124a (Original work published 2024)

Chergaoui, S., Debecker, D., Leyssens, T., & Luis Alconero, P. (2023). Key Parameters Impacting the Crystal Formation in Antisolvent Membrane-Assisted Crystallization. Membranes, 13(2), 140. https://doi.org/10.3390/membranes13020140 (Original work published 2023)

Caro Garrido, C., Robeyns, K., Leyssens, T., & et al. (2023). Pentapotassium Bis(hydrogenphospate) Dihydrogenphospate Monohydrate. Pentapotassium Bis(hydrogenphospate) Dihydrogenphospate Monohydrate, M1711(2023), 3. https://doi.org/10.3390/M1711 (Original work published 2023)

Lopes, C., Cartigny, Y., Brandel, C., Dupray, V., Body, C., Shemchuk, O., & Leyssens, T. (2023). A Greener Pathway to Enantiopurity: Mechanochemical Deracemization through Abrasive Grinding. Chemistry: A European Journal. Published. https://doi.org/10.1002/chem.202300585 (Original work published 2023)

Chergaoui, S., Debecker, D., Leyssens, T., & Luis Alconero, P. (2023). Control of Antisolvent Mass Transfer through Porous Membranes for the Crystallization of Organic Compounds. Crystal Growth & Design, 23(9), 6418-6430. https://doi.org/10.1021/acs.cgd.3c00408 (Original work published 2023)

Caro Garrido, C., Robeyns, K., Debecker, D., Luis Alconero, P., & Leyssens, T. (2023). From Liquid to Solid: Cocrystallization as an Engineering Tool for the Solidification of Pyruvic Acid. Crystals, 13(5), 808. https://doi.org/10.3390/cryst13050808 (Original work published 2023)

Meersseman Arango, H., van den Biggelaar, L., Soumillion, P., Luis Alconero, P., Leyssens, T., Paradisi, F., & Debecker, D. (2023). Continuous flow-mode synthesis of (chiral) amines with transaminase: a strategic biocatalytic approach to essential building blocks. Reaction Chemistry & Engineering, 8, 1505-1544. https://doi.org/10.1039/d3re00210a (Original work published 2023)

Kumar, S., Body, C., Leyssens, T., Van Hecke, K., Berger, G., Van der Lee, A., Laurencin, D., Richeter, S., Clément, S., & Meyer, F. (2023). Halogen-Bonded Thiophene Derivatives Prepared by Solution and/or Mechanochemical Synthesis. Evidence of N···S Chalcogen Bonds in Homo- and Cocrystals. Crystal Growth & Design, 23(4), 2442-2454. https://doi.org/10.1021/acs.cgd.2c01402 (Original work published 2023)

Bodart, L., Body, J., Tumanov, N., Leyssens, T., & Wouters, J. (2023). Salt and Cocrystals Combining Sulfathiazole with Pyrimethamine. Crystal Growth & Design, 23(11), 7811-7820. https://doi.org/10.1021/acs.cgd.3c00626 (Original work published 2023)

Zhou, F., Body, C., Robeyns, K., Leyssens, T., & Shemchuk, O. (2023). On the pairwise cocrystallization of racemic compounds. CrystEngComm, 25(20), 3060-3065. https://doi.org/10.1039/d3ce00226h (Original work published 2023)

Leng, F., Robeyns, K., Leyssens, T., & Shemchuk, O. (2022). Combining Racetams with a Sweetener through Complexation. Crystal Growth & Design, 22(5), 3016-3023. https://doi.org/10.1021/acs.cgd.1c01462 (Original work published 2022)

Zhou, F., Collard, L., Robeyns, K., Leyssens, T., & Shemchuk, O. (2022). <scp>l</scp>-Proline, a resolution agent able to target both enantiomers of mandelic acid: an exciting case of stoichiometry controlled chiral resolution. Chemical Communications, 58(61), 8560-8563. https://doi.org/10.1039/d2cc02942a (Original work published 2022)

Charpentier, M. D., Venkatramanan, R., Rougeot, C., Leyssens, T., Johnston, K., & ter Horst, J. H. (2022). Multicomponent Chiral Quantification with Ultraviolet Circular Dichroism Spectroscopy: Ternary and Quaternary Phase Diagrams of Levetiracetam. Molecular Pharmaceutics, 20(1), 616-629. https://doi.org/10.1021/acs.molpharmaceut.2c00825 (Original work published 2022)

Leng, F., Shemchuk, O., Robeyns, K., & Leyssens, T. (2022). Complexation: An Interesting Pathway for Combining Two APIs at the Solid State. Pharmaceutics, 14(9), 1960. https://doi.org/10.3390/pharmaceutics14091960 (Original work published 2022)

Zhou, F., Shemchuk, O., Charpentier, M. D., Matheys, C., Collard, L., ter Horst, J. H., & Leyssens, T. (2021). Simultaneous Chiral Resolution of Two Racemic Compounds by Preferential Cocrystallization**. Angewandte Chemie (International Edition), 60(37), 20264-20268. https://doi.org/10.1002/anie.202107804 (Original work published 2021)

Guillot, M., de Meester, J., Collard, L., Riant, O., & Leyssens, T. (2021). Co-Crystallization-Induced Spontaneous Deracemization: An Optimization Study. Organic Process Research and Development, 25(4), 884-891. https://doi.org/10.1021/acs.oprd.0c00538 (Original work published 2021)

Fucheng, L., Robeyns, K., & Leyssens, T. (2021). Urea as a Cocrystal Former—Study of 3 Urea Based Pharmaceutical Cocrystals. Pharmaceutics, 13(5), 671. https://doi.org/10.3390/pharmaceutics13050671 (Original work published 2021)

Shemchuk, O., Grepioni, F., Leyssens, T., & Braga, D. (2021). Chiral Resolution via Cocrystallization with Inorganic Salts. Israel Journal of Chemistry, 61(9-10), 563-572. https://doi.org/10.1002/ijch.202100049 (Original work published 2021)

Song, L., Robeyns, K., Tumanov, N., Wouters, J., & Leyssens, T. (2020). Combining API in a dual-drug ternary cocrystal approach. Chemical Communications, 56(86), 13229-13232. https://doi.org/10.1039/d0cc05788f (Original work published 2020)

De Maere D’aertrycke, J.-B., Morlot, J., Robeyns, K., Filinchuk, Y., & Leyssens, T. (2020). Exploring the solid-state phases and thermodynamics of calcium l-lactate. Food Chemistry, 325(1), 126884. https://doi.org/10.1016/j.foodchem.2020.126884 (Original work published 2020)

Seiler, V. K., TUMANOV, N., Robeyns, K., Champagne, B., Wouters, J., & Leyssens, T. (2020). Merocyanines in a Halogen-Bonded Network Involving Inorganic Building Blocks. Crystal Growth & Design, 20(2), 608-616. https://doi.org/10.1021/acs.cgd.9b00903 (Original work published 2020)

Song, L., Leng, F., Robeyns, K., & Leyssens, T. (2020). Quaternary phase diagrams as a tool for ionic cocrystallization: the case of a solid solution between a racemic and enantiopure ionic cocrystal. CrystEngComm, 22(14), 2537-2542. https://doi.org/10.1039/d0ce00179a (Original work published 2020)

Guillot, M., de Meester, J., Huynen, S., Collard, L., Robeyns, K., Riant, O., & Leyssens, T. (2020). Cocrystallization-Induced Spontaneous Deracemization: A General Thermodynamic Approach to Deracemization. Angewandte Chemie (International Edition). Accepted/in-press. https://doi.org/10.1002/anie.202002464 (Original work published 2020)

Xu, G., Leloux, S., Zhang, P., Meijide Suárez, J., Zhang, Y., Derat, E., Ménand, M., Bistri‐Aslanoff, O., Roland, S., Leyssens, T., Riant, O., & Sollogoub, M. (2020). Capturing the Monomeric (L)CuH in NHC‐Capped Cyclodextrin: Cavity‐Controlled Chemoselective Hydrosilylation of α,β‐Unsaturated Ketones. Angewandte Chemie (International Edition), 59(19), 7591-7597. https://doi.org/10.1002/anie.202001733 (Original work published 2020)

Kovalenko, V., TUMANOV, N., Vasiutovich, K., & Leyssens, T. (2020). Ethoxycarbonyl functionalized Tröger’s base alongside its congener dihydroquinazoline: A trick with crystallization. Chemical Data Collections, 25, 100339. https://doi.org/10.1016/j.cdc.2020.100339 (Original work published 2020)

Buol, X., Robeyns, K., Caro Garrido, C., TUMANOV, N., Collard, L., Wouters, J., & Leyssens, T. (2020). Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach. Pharmaceutics, 12(7), 653. https://doi.org/10.3390/pharmaceutics12070653 (Original work published 2020)

BODART, L., DERLET, A., Buol, X., Leyssens, T., TUMANOV, N., & Wouters, J. (2020). Combining Two Antitubercular Drugs, Clofazimine and 4-Aminosalicylic Acid, in Order to Improve Clofazimine Aqueous Solubility and 4-Aminosalicylic Acid Thermal Stability. Journal of Pharmaceutical Sciences, 109(12), 3645-3652. https://doi.org/10.1016/j.xphs.2020.09.024 (Original work published 2020)

Buol, X., Caro Garrido, C., Robeyns, K., Tumanov, N., Collard, L., Wouters, J., & Leyssens, T. (2020). Chiral Resolution of Mandelic Acid through Preferential Cocrystallization with Nefiracetam. Crystal Growth & Design, 20(12), 7979-7988. https://doi.org/10.1021/acs.cgd.0c01236 (Original work published 2020)

de Maere d’Aertrycke, J.-B., Payen, R., Collard, L., Robeyns, K., Croker, D., & Leyssens, T. (2020). Enabling Cocrystallization of Challenging Systems: Passing through a Stable Cocrystal Solvate as a Pathway to Strenuous Cocrystal Forms. Crystal Growth & Design, 20(3), 2035-2043. https://doi.org/10.1021/acs.cgd.9b01691 (Original work published 2020)

QUERTINMONT, J., Leyssens, T., Wouters, J., & Champagne, B. (2020). Unraveling the Effects of Co-Crystallization on the UV/Vis Absorption Spectra of an N-Salicylideneaniline Derivative. A Computational RI-CC2 Investigation. Molecules, 25(19), 4512. https://doi.org/10.3390/molecules25194512 (Original work published 2020)

Shemchuk, O., Song, L., TUMANOV, N., Wouters, J., Braga, D., Grepioni, F., & Leyssens, T. (2020). Chiral Resolution of RS-Oxiracetam upon Cocrystallization with Pharmaceutically Acceptable Inorganic Salts. Crystal Growth & Design, 20(4), 2602-2607. https://doi.org/10.1021/acs.cgd.9b01725 (Original work published 2020)

Guillot, M., De Meester, J., ter Horst, J. H., Riant, O., & Leyssens, T. (2020). Fungicide Precursor Racemization Kinetics for Deracemization in Complex Systems. European Journal of Organic Chemistry, 2021(3), 473-482. https://doi.org/10.1002/ejoc.202001402 (Original work published 2020)

Song, L., Shemchuk, O., Robeyns, K., Dario Braga, Fabrizia Grepioni, & Leyssens, T. (2019). Ionic cocrystals of etiracetam and levetiracetam: the importance of chirality for ionic cocrystals. Crystal Growth & Design, 19, 2446-2454. (Original work published 2019)

Tumanova, N., Seiler, V. K., Tumanov, N., Robeyns, K., Filinchuk, Y., Wouters, J., & Leyssens, T. (2019). Structural Analysis of d-Phenylglycinamide Salts Uncovers Potential Pitfalls in Chiral Resolution via Diastereomeric Salt Formation. Crystal Growth & Design, 19(7), 3652-3659. https://doi.org/10.1021/acs.cgd.8b01769 (Original work published 2019)

QUERTINMONT, J., Leyssens, T., Wouters, J., & Champagne, B. (2019). Periodic DFT Study of the Effects of Co‐Crystallization on a N‐Salicylideneaniline Molecular Switch. ChemPhysChem : a European journal of chemical physics and physical chemistry, 20(19), 2434-2442. https://doi.org/10.1002/cphc.201900463 (Original work published 2019)

Mercier, G., Robeyns, K., TUMANOV, N., Champagne, B., Wouters, J., & Leyssens, T. (2019). New Insights into Photochromic Properties of N-Salicylideneaniline Derivatives Using a Cocrystal Engineering Approach. Crystal Growth & Design, 19(10), 5544-5556. https://doi.org/10.1021/acs.cgd.9b00363 (Original work published 2019)

Liu, X., Depaifve, S., Leyssens, T., Hermans, S., & Vlad, A. (2019). Versatile Synthesis of Vanadium(III, IV, V) Oxides@Reduced Graphene Oxide Nanocomposites and Evaluation of their Lithium and Sodium Storage Performances. Batteries & Supercaps, 2(12), 1016-1025. https://doi.org/10.1002/batt.201900113 (Original work published 2019)

Seiler, V. K., Robeyns, K., TUMANOV, N., Cinčić, D., Wouters, J., Champagne, B., & Leyssens, T. (2019). A coloring tool for spiropyrans: solid state metal–organic complexation versus salification. CrystEngComm, 21(33), 4925-4933. https://doi.org/10.1039/c9ce00805e (Original work published 2019)

Buol, X., Robeyns, K., TUMANOV, N., Wouters, J., & Leyssens, T. (2019). Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms: A Potential Antidementia Drug. Journal of Pharmaceutical Sciences, 108(11), 3616-3622. https://doi.org/10.1016/j.xphs.2019.07.010 (Original work published 2019)

Nagy, A., Collard, L., Indukuri, K., Leyssens, T., & Riant, O. (2019). Enantio‐, Regio‐ and Chemoselective Copper‐Catalyzed 1,2‐Hydroborylation of Acylsilanes. Chemistry: A European Journal. Accepted/in-press. https://doi.org/10.1002/chem.201901785 (Original work published 2019)