Publications

Meersseman Arango, Hippolyte ; Luis Alconero, Patricia ; Leyssens, Tom ; Debecker, Damien P..

Enzyme-membrane reactors: recent trends and applications for the production of fine chemicals and pharmaceutical building blocks. In: Comptes Rendus. Chimie, Vol. 28, no.G1, p. 151-170 (2025). doi:10.5802/crchim.378.

Meersseman Arango, Hippolyte ; Leyssens, Tom ; Luis Alconero, Patricia ; Debecker, Damien P..

Enzyme-membrane-reactors: recent trends and applications for the production of fine chemicals and pharmaceutical building-blocks. In: Comptes rendus. Chimie, Vol. 1, no.1, p. 1 (2025) (Accepté/Sous presse).

Esser, Guillaume ; Crits, Robin ; de Meester, Joséphine ; Robeyns, Koen ; Leyssens, Tom ; Chernyshov Dmitry ; Graversen, Laura G. ; Sapnik, Adam F. ; Jensen, Kirsten M. Ø. ; Dejoie, Catherine ; He, Meng ; Filinchuk, Yaroslav ; Hermans, Sophie ; Steenhaut, Timothy.

Toward Reversible Crystalline-to-Amorphous Guest-Induced Transitions in Manganese(III) Carboxylate Metal–Organic Frameworks. In: Inorganic Chemistry, Vol. XXXX, no.XXX, p. XXX-XXX (2025). doi:10.1021/acs.inorgchem.4c05337.

Caro Garrido, Camila ; Leyssens, Tom.

Combining a Drug and a Nutraceutical: A New Cocrystal of Praziquantel and Curcumin. In: Combining a Drug and a Nutraceutical: A New Cocrystal of Praziquantel and Curcumin, Vol. Feature Papers in Crystals 2023, no.14, p. 181 (2024). doi:10.3390/cryst14020181.

Body, Carole ; Wery, Guillaume ; Gubbels, Lisa ; Robeyns, Koen ; Leyssens, Tom.

Control of Regioselectivity in the Dimerization of trans-Cinnamic Acid and Its Derivatives Using Cocrystal Engineering. In: Crystal Growth & Design, Vol. 24, no.5, p. 2117-2125 (2024). doi:10.1021/acs.cgd.3c01449.

Songsermsawad, Sarita ; Shemchuk, Oleksii ; Robeyns, Koen ; Zhou, Fuli ; Flood, Adrian E. ; Leyssens, Tom.

Double Trouble: A Peculiar Case of Solid Solution Cocrystals Involving Two Chiral Compounds. In: Crystal Growth & Design, Vol. 24, no. 7, p. 2977-2984 (2024). doi:10.1021/acs.cgd.4c00074.

Meersseman Arango, Hippolyte ; Nguyen, Xuan Dieu Linh ; Luis Alconero, Patricia ; Leyssens, Tom ; Roura Padrosa, David ; Paradisi, Francesca ; Debecker, Damien P..

Membrane-immobilized transaminases for the synthesis of enantiopure amines. In: RSC Sustainability, Vol. 10, no.2, p. 3139-3152 (2024). doi:10.1039/d4su00293h.

Songsermsawad, Sarita ; Shemchuk, Oleksii ; Robeyns, Koen ; Collard, Laurent ; E. Flood, Adrian ; Leyssens, Tom.

Simultaneously resolving BINOL and proline using a stoichiometric cocrystal switch. In: Chemical Communications, (2024). doi:10.1039/d4cc02180k.

Wéry, Guillaume ; Pastucha, Karol ; Robeyns, Koen ; Leyssens, Tom.

The Inability of Metal Coordination to Control the Regioselectivity of Dimerization of Trans-Cinnamic Acid Derivatives. In: Crystals, Vol. 14, no.6, p. 530 (2024). doi:10.3390/cryst14060530.

de Meester, Joséphine ; Layrisse, Patrick ; Marchivie, Mathieu ; Collard, Laurent ; Wéry, Guillaume ; Brandel, Clément ; Cartigny, Yohann ; Subra-Paternault, Pascale ; Leyssens, Tom ; Harscoat-Schiavo, Christelle.

Towards a new approach in chiral resolution: Pressurized-CO2 assisted preferential cocrystallization. In: The Journal of Supercritical Fluids, Vol. 212, p. 106339 (2024). doi:10.1016/j.supflu.2024.106339.

Chergaoui, Sara ; Lauzer, Jimmy ; Debecker, Damien P. ; Leyssens, Tom ; Luis Alconero, Patricia.

Tuning membrane properties to control supersaturation of antisolvent crystallization. In: Journal of Membrane Science, Vol. 694, p. 122415 (2024). doi:10.1016/j.memsci.2024.122415.

de Meester, Joséphine ; Shemchuk, Oleksii ; Collard, Laurent ; Wouters, Johan ; Baillieux, Simon ; Robeyns, Koen ; Leyssens, Tom.

Using the nature of the achiral solvent to orient chiral resolution. In: CrystEngComm, Vol. 26, no.15, p. 2056-2059 (2024). doi:10.1039/d4ce00124a.

Lopes, Chrystal ; Cartigny, Yohann ; Brandel, Clément ; Dupray, Valérie ; Body, Carole ; Shemchuk, Oleksii ; Leyssens, Tom.

A Greener Pathway to Enantiopurity: Mechanochemical Deracemization through Abrasive Grinding. In: Chemistry – A European Journal, (2023). doi:10.1002/chem.202300585.

Meersseman Arango, Hippolyte ; van den Biggelaar, Ludivine ; Soumillion, Patrice ; Luis Alconero, Patricia ; Leyssens, Tom ; Paradisi, Francesca ; Debecker, Damien P..

Continuous flow-mode synthesis of (chiral) amines with transaminase: a strategic biocatalytic approach to essential building blocks. In: Reaction Chemistry & Engineering, Vol. 8, p. 1505–1544 (2023). doi:10.1039/d3re00210a.

Chergaoui, Sara ; Debecker, Damien P. ; Leyssens, Tom ; Luis Alconero, Patricia.

Control of Antisolvent Mass Transfer through Porous Membranes for the Crystallization of Organic Compounds. In: Crystal Growth & Design, Vol. 23, no. 9, p. 6418-6430 (2023). doi:10.1021/acs.cgd.3c00408.

Caro Garrido, Camila ; Robeyns, Koen ; Debecker, Damien P. ; Luis Alconero, Patricia ; Leyssens, Tom.

From Liquid to Solid: Cocrystallization as an Engineering Tool for the Solidification of Pyruvic Acid. In: Crystals, Vol. 13, no.5, p. 808 (2023). doi:10.3390/cryst13050808.

Kumar, Shiv ; Body, Carole ; Leyssens, Tom ; Van Hecke, Kristof ; Berger, Gilles ; Van der Lee, Arie ; Laurencin, Danielle ; Richeter, Sébastien ; Clément, Sébastien ; Meyer, Franck.

Halogen-Bonded Thiophene Derivatives Prepared by Solution and/or Mechanochemical Synthesis. Evidence of N···S Chalcogen Bonds in Homo- and Cocrystals. In: Crystal Growth & Design, Vol. 23, no.4, p. 2442-2454 (2023). doi:10.1021/acs.cgd.2c01402.

Chergaoui, Sara ; Debecker, Damien P. ; Leyssens, Tom ; Luis Alconero, Patricia.

Key Parameters Impacting the Crystal Formation in Antisolvent Membrane-Assisted Crystallization. In: Membranes, Vol. 13, no.2, p. 140 (2023). doi:10.3390/membranes13020140.

Zhou, Fuli ; Body, Carole ; Robeyns, Koen ; Leyssens, Tom ; Shemchuk, Oleksii.

On the pairwise cocrystallization of racemic compounds. In: CrystEngComm, Vol. 25, no.20, p. 3060-3065 (2023). doi:10.1039/d3ce00226h.

Caro Garrido, Camila ; Robeyns, Koen ; Leyssens, Tom.

Pentapotassium Bis(hydrogenphospate) Dihydrogenphospate Monohydrate. In: Pentapotassium Bis(hydrogenphospate) Dihydrogenphospate Monohydrate, Vol. M1711, no.2023, p. 3 (2023). doi:10.3390/M1711.

Bodart, Laurie ; Body, Jeanne ; Tumanov, Nikolay ; Leyssens, Tom ; Wouters, Johan.

Salt and Cocrystals Combining Sulfathiazole with Pyrimethamine. In: Crystal Growth & Design, Vol. 23, no.11, p. 7811-7820 (2023). doi:10.1021/acs.cgd.3c00626.

Zhou, Fuli ; Collard, Laurent ; Robeyns, Koen ; Leyssens, Tom ; Shemchuk, Oleksii.

<scp>l</scp>-Proline, a resolution agent able to target both enantiomers of mandelic acid: an exciting case of stoichiometry controlled chiral resolution. In: Chemical Communications, Vol. 58, no.61, p. 8560-8563 (2022). doi:10.1039/d2cc02942a.

Leng, Fucheng ; Robeyns, Koen ; Leyssens, Tom ; Shemchuk, Oleksii.

Combining Racetams with a Sweetener through Complexation. In: Crystal Growth &amp; Design, Vol. 22, no.5, p. 3016-3023 (2022). doi:10.1021/acs.cgd.1c01462.

Leng, Fucheng ; Shemchuk, Oleksii ; Robeyns, Koen ; Leyssens, Tom.

Complexation: An Interesting Pathway for Combining Two APIs at the Solid State. In: Pharmaceutics, Vol. 14, no.9, p. 1960 (2022). doi:10.3390/pharmaceutics14091960.

Charpentier, Maxime D. ; Venkatramanan, Raghunath ; Rougeot, Céline ; Leyssens, Tom ; Johnston, Karen ; ter Horst, Joop H..

Multicomponent Chiral Quantification with Ultraviolet Circular Dichroism Spectroscopy: Ternary and Quaternary Phase Diagrams of Levetiracetam. In: Molecular Pharmaceutics, Vol. 20, no.1, p. 616-629 (2022). doi:10.1021/acs.molpharmaceut.2c00825.

Shemchuk, Oleksii ; Grepioni, Fabrizia ; Leyssens, Tom ; Braga, Dario.

Chiral Resolution via Cocrystallization with Inorganic Salts. In: Israel Journal of Chemistry, Vol. 61, no.9-10, p. 563-572 (2021). doi:10.1002/ijch.202100049.

Guillot, Michael ; de Meester, Joséphine ; Collard, Laurent ; Riant, Olivier ; Leyssens, Tom.

Co-Crystallization-Induced Spontaneous Deracemization: An Optimization Study. In: Organic Process Research & Development, Vol. 25, no.4, p. 884-891 (2021). doi:10.1021/acs.oprd.0c00538.

Zhou, Fuli ; Shemchuk, Oleksii ; Charpentier, Maxime D. ; Matheys, Chloé ; Collard, Laurent ; ter Horst, Joop H. ; Leyssens, Tom.

Simultaneous Chiral Resolution of Two Racemic Compounds by Preferential Cocrystallization**. In: Angewandte Chemie International Edition, Vol. 60, no.37, p. 20264-20268 (2021). doi:10.1002/anie.202107804.

Fucheng, Leng ; Robeyns, Koen ; Leyssens, Tom.

Urea as a Cocrystal Former—Study of 3 Urea Based Pharmaceutical Cocrystals. In: Pharmaceutics, Vol. 13, no.5, p. 671 (2021). doi:10.3390/pharmaceutics13050671.

Xu, Guangcan ; Leloux, Sébastien ; Zhang, Pinglu ; Meijide Suárez, Jorge ; Zhang, Yongmin ; Derat, Etienne ; Ménand, Mickaël ; Bistri‐Aslanoff, Olivia ; Roland, Sylvain ; Leyssens, Tom ; Riant, Olivier ; Sollogoub, Matthieu.

Capturing the Monomeric (L)CuH in NHC‐Capped Cyclodextrin: Cavity‐Controlled Chemoselective Hydrosilylation of α,β‐Unsaturated Ketones. In: Angewandte Chemie International Edition, Vol. 59, no.19, p. 7591-7597 (2020). doi:10.1002/anie.202001733.

Buol, Xavier ; Caro Garrido, Camila ; Robeyns, Koen ; Tumanov, Nikolay ; Collard, Laurent ; Wouters, Johan ; Leyssens, Tom.

Chiral Resolution of Mandelic Acid through Preferential Cocrystallization with Nefiracetam. In: Crystal Growth & Design, Vol. 20, no.12, p. 7979-7988 (2020). doi:10.1021/acs.cgd.0c01236.

Shemchuk, Oleksii ; Song, Lixing ; TUMANOV, Nikolay ; Wouters, Johan ; Braga, Dario ; Grepioni, Fabrizia ; Leyssens, Tom.

Chiral Resolution of RS-Oxiracetam upon Cocrystallization with Pharmaceutically Acceptable Inorganic Salts. In: Crystal Growth & Design, Vol. 20, no.4, p. 2602-2607 (2020). doi:10.1021/acs.cgd.9b01725.

Guillot, Michael ; de Meester, Joséphine ; Huynen, Sarah ; Collard, Laurent ; Robeyns, Koen ; Riant, Olivier ; Leyssens, Tom.

Cocrystallization-Induced Spontaneous Deracemization: A General Thermodynamic Approach to Deracemization. In: Angewandte Chemie International Edition, (2020). doi:10.1002/anie.202002464 (Accepté/Sous presse).

Song, Lixing ; Robeyns, Koen ; Tumanov, Nikolay ; Wouters, Johan ; Leyssens, Tom.

Combining API in a dual-drug ternary cocrystal approach. In: Chemical Communications, Vol. 56, no.86, p. 13229-13232 (2020). doi:10.1039/d0cc05788f.

BODART, Laurie ; DERLET, Amélie ; Buol, Xavier ; Leyssens, Tom ; TUMANOV, Nikolay ; Wouters, Johan.

Combining Two Antitubercular Drugs, Clofazimine and 4-Aminosalicylic Acid, in Order to Improve Clofazimine Aqueous Solubility and 4-Aminosalicylic Acid Thermal Stability. In: Journal of Pharmaceutical Sciences, Vol. 109, no.12, p. 3645-3652 (2020). doi:10.1016/j.xphs.2020.09.024.

de Maere d'Aertrycke, J-B. ; Payen, Ricky ; Collard, Laurent ; Robeyns, Koen ; Croker, Denise ; Leyssens, Tom.

Enabling Cocrystallization of Challenging Systems: Passing through a Stable Cocrystal Solvate as a Pathway to Strenuous Cocrystal Forms. In: Crystal Growth & Design, Vol. 20, no.3, p. 2035-2043 (2020). doi:10.1021/acs.cgd.9b01691.

Kovalenko, Vitaly ; TUMANOV, Nikolay ; Vasiutovich, Kiryl ; Leyssens, Tom.

Ethoxycarbonyl functionalized Tröger's base alongside its congener dihydroquinazoline: A trick with crystallization. In: Chemical Data Collections, Vol. 25, p. 100339 (2020). doi:10.1016/j.cdc.2020.100339.

De Maere D'aertrycke, Jean-Baptiste ; Morlot, Julien ; Robeyns, Koen ; Filinchuk, Yaroslav ; Leyssens, Tom.

Exploring the solid-state phases and thermodynamics of calcium l-lactate. In: Food Chemistry, Vol. 325, no.1, p. 126884 (2020). doi:10.1016/j.foodchem.2020.126884.

Guillot, Michael ; De Meester, Joséphine ; ter Horst, Joop H. ; Riant, Olivier ; Leyssens, Tom.

Fungicide Precursor Racemization Kinetics for Deracemization in Complex Systems. In: European Journal of Organic Chemistry, Vol. 2021, no.3, p. 473-482 (2020). doi:10.1002/ejoc.202001402.

Buol, Xavier ; Robeyns, Koen ; Caro Garrido, Camila ; TUMANOV, Nikolay ; Collard, Laurent ; Wouters, Johan ; Leyssens, Tom.

Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach. In: Pharmaceutics, Vol. 12, no.7, p. 653 (2020). doi:10.3390/pharmaceutics12070653.

Seiler, Vanessa Kristina ; TUMANOV, Nikolay ; Robeyns, Koen ; Champagne, Benoit ; Wouters, Johan ; Leyssens, Tom.

Merocyanines in a Halogen-Bonded Network Involving Inorganic Building Blocks. In: Crystal Growth & Design, Vol. 20, no. 2, p. 608-616 (2020). doi:10.1021/acs.cgd.9b00903.

Song, Lixing ; Leng, Fucheng ; Robeyns, Koen ; Leyssens, Tom.

Quaternary phase diagrams as a tool for ionic cocrystallization: the case of a solid solution between a racemic and enantiopure ionic cocrystal. In: CrystEngComm, Vol. 22, no.14, p. 2537-2542 (2020). doi:10.1039/d0ce00179a.

QUERTINMONT, Jean ; Leyssens, Tom ; Wouters, Johan ; Champagne, Benoit.

Unraveling the Effects of Co-Crystallization on the UV/Vis Absorption Spectra of an N-Salicylideneaniline Derivative. A Computational RI-CC2 Investigation. In: Molecules, Vol. 25, no.19, p. 4512 (2020). doi:10.3390/molecules25194512.

Seiler, Vanessa Kristina ; Robeyns, Koen ; TUMANOV, Nikolay ; Cinčić, Dominik ; Wouters, Johan ; Champagne, Benoit ; Leyssens, Tom.

A coloring tool for spiropyrans: solid state metal–organic complexation versus salification. In: CrystEngComm, Vol. 21, no.33, p. 4925-4933 (2019). doi:10.1039/c9ce00805e.

Nagy, Audric ; Collard, Laurent ; Indukuri, Kiran ; Leyssens, Tom ; Riant, Olivier.

Enantio‐, Regio‐ and Chemoselective Copper‐Catalyzed 1,2‐Hydroborylation of Acylsilanes. In: Chemistry – A European Journal, (2019). doi:10.1002/chem.201901785 (Accepté/Sous presse).

Buol, Xavier ; Robeyns, Koen ; TUMANOV, Nikolay ; Wouters, Johan ; Leyssens, Tom.

Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms: A Potential Antidementia Drug. In: Journal of Pharmaceutical Sciences, Vol. 108, no. 11, p. 3616-3622 (2019). doi:10.1016/j.xphs.2019.07.010.

Song, Lixing ; Shemchuk, Oleksii ; Robeyns, Koen ; Dario Braga ; Fabrizia Grepioni ; Leyssens, Tom.

Ionic cocrystals of etiracetam and levetiracetam: the importance of chirality for ionic cocrystals . In: Crystal Growth & Design, Vol. 19, p. 2446-2454 (2019).

Mercier, Gabriel ; Robeyns, Koen ; TUMANOV, Nikolay ; Champagne, Benoit ; Wouters, Johan ; Leyssens, Tom.

New Insights into Photochromic Properties of N-Salicylideneaniline Derivatives Using a Cocrystal Engineering Approach. In: Crystal Growth & Design, Vol. 19, no. 10, p. 5544-5556 (2019). doi:10.1021/acs.cgd.9b00363.

QUERTINMONT, Jean ; Leyssens, Tom ; Wouters, Johan ; Champagne, Benoit.

Periodic DFT Study of the Effects of Co‐Crystallization on a N‐Salicylideneaniline Molecular Switch. In: ChemPhysChem, Vol. 20, no. 19, p. 2434-2442 (2019). doi:10.1002/cphc.201900463.

Tumanova, Natalia ; Seiler, Vanessa Kristina ; Tumanov, Nikolay ; Robeyns, Koen ; Filinchuk, Yaroslav ; Wouters, Johan ; Leyssens, Tom.

Structural Analysis of d-Phenylglycinamide Salts Uncovers Potential Pitfalls in Chiral Resolution via Diastereomeric Salt Formation. In: Crystal Growth & Design, Vol. 19, no. 7, p. 3652-3659 (2019). doi:10.1021/acs.cgd.8b01769 (Accepté/Sous presse).

Liu, Xuelian ; Depaifve, Sébastien ; Leyssens, Tom ; Hermans, Sophie ; Vlad, Alexandru.

Versatile Synthesis of Vanadium(III, IV, V) Oxides@Reduced Graphene Oxide Nanocomposites and Evaluation of their Lithium and Sodium Storage Performances. In: Batteries & Supercaps, Vol. 2, no. 12, p. 1016-1025 (2019). doi:10.1002/batt.201900113.