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Aromatic Oligoamide Foldamers: Towards Secondary Structure-Driven Self-Assembly by Louis SMAL -
Jeudi 9 octobre 2025 à 11h00 - Auditoire SUD01 - Croix du Sud - 1348 Louvain-la-Neuve -
Self-assembly is a powerful strategy for designing large, organized molecular structures. In biology, extensive surface interactions enable self-assembly to achieve high selectivity and precision, producing stable, asymmetric assemblies. Mimicking these extensive surface interactions seen in biological systems could enhance synthetic self-assembly methods, and foldamers are a promising tool for this purpose. Aromatic Oligoamide Foldamers (AOF), known for their high stability, predictable folding, and ability to form multi-stranded helical assemblies, are particularly well-suited for this purpose, as they rely on extensive aromatic surface interactions. These folding molecules could be of interest in designing synthetic assembled systems. This PhD thesis aims to develop a new methodology based on AOF self-assembly, leveraging its capacity to form double helices as a new approach to connect molecular components and ultimately create assembled supramolecular structures.
Jury members :
Prof. Michael Singleton (UCLouvain) (Supervisor)
Prof. Charles-André Fustin (UCLouvain) (Co-supervisor)
Prof. Yann Garcia (UCLouvain) (Chairperson)
Prof. Raphaël Robiette (UCLouvain) (Secretary)
Dr. Gabriella Barozzino Consiglio (UClouvain)
Prof. David Canevet (Université d’Angers)
Prof. Peter Knipe (Queen's University Belfast)
Pay attention : the public defense of Louis SMAL will also take place in the form of a videoconference
