Publications

Ameraoui, H., Bestard-Escalas, J., Roumain, M., Laghouati, A., Bottemanne, P., Al Houayek, M., & Muccioli, G. (2025). Oxysterol-mediated modulation of intestinal inflammation: insights into sex differences and GPR183 signaling. Cellular and Molecular Life Sciences. Accepted/in-press. https://doi.org/10.1007/s00018-025-05981-6 (Original work published 2025)

Labrak, Y., Al Houayek, M., Mwema, A., d’Auria, L., Ucakar, B., Van Pesch, V., Muccioli, G., & des Rieux, A. (2024). The combined administration of LNC-encapsulated retinoic acid and calcitriol stimulates oligodendrocyte progenitor cell differentiation in vitro and in vivo after intranasal administration. International Journal of Pharmaceutics, 659, 124237 [1-9]. https://doi.org/10.1016/j.ijpharm.2024.124237 (Original work published 2024)

Marotti, V., Xu, Y., Bohns Michalowski, C., Zhang, W., Ladeiro Domingues, I., Ameraoui, H., Moreels, T., Baatsen, P., Van Hul, M., Muccioli, G., Cani, P., Al Houayek, M., Malfanti, A., & Beloqui Garcia, A. (2024). A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment. Bioactive materials, 32, 206-221. https://doi.org/10.1016/j.bioactmat.2023.09.014 (Original work published 2024)

Roumain, M., Guillemot-Legris, O., Ameraoui, H., Al Houayek, M., & Muccioli, G. (2023). Identification and in vivo detection of side-chain hydroxylated metabolites of 4β-hydroxycholesterol. The Journal of Steroid Biochemistry and Molecular Biology, 234, 106376. https://doi.org/10.1016/j.jsbmb.2023.106376 (Original work published 2023)

Moens de Hase, E., Petitfils, C., Al Houayek, M., Depommier, C., Le Faouder, P., Delzenne, N., Van Hul, M., Muccioli, G., Cenac, N., & Cani, P. (2023). Dysosmobacter welbionis effects on glucose, lipid, and energy metabolism are associated with specific bioactive lipids. Journal of Lipid Research, 64(10), 100437 [1-14]. https://doi.org/10.1016/j.jlr.2023.100437 (Original work published 2023)

Mwema, A., Bottemanne, P., Paquot, A., Ucakar, B., Vanvarenberg, K., Al Houayek, M., Muccioli, G., & des Rieux, A. (2023). Lipid nanocapsules for the nose-to-brain delivery of the anti-inflammatory bioactive lipid PGD-G. Nanomedicine : nanotechnology, biology, and medicine, 48, 102633. https://doi.org/10.1016/j.nano.2022.102633 (Original work published 2023)

Abdul Khaliq, H., Al Houayek, M., Leclercq, J., & Muccioli, G. (2022). 5’AMP-activated protein kinase: an emerging target of phytochemicals to treat chronic inflammatory diseases. Critical Reviews in Food Science and Nutrition, 1-26. https://doi.org/10.1080/10408398.2022.2145264 (Original work published 2022)

Abdul Khaliq, H., Ortiz Aguirre, S. E., Al Houayek, M., Neyts, T., Muccioli, G., & Leclercq, J. (2022). Effect of a methanolic extract of Salvadora oleoides Decne. on LPS-activated J774 macrophages, its in vitro and in vivo toxicity study and dereplication of its chemical constituents. Toxicology Reports, 9, 1742-1753. https://doi.org/10.1016/j.toxrep.2022.09.004 (Original work published 2022)

Abdul Khaliq, H., Ortiz Aguirre, S. E., Al Houayek, M., Muccioli, G., & Leclercq, J. (2022). Dereplication and Quantification of Major Compounds of L. Extracts and Assessment of Their Effect on LPS-Activated J774 Macrophages. Molecules (Basel, Switzerland), 27(3), 963 [1-19]. https://doi.org/10.3390/molecules27030963 (Original work published 2022)

Bottemanne, P., Guillemot-Legris, O., Paquot, A., Masquelier, J., Malamas, M., Makriyannis, A., Al Houayek, M., & Muccioli, G. (2021). N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibition, but Not Fatty Acid Amide Hydrolase Inhibition, Prevents the Development of Experimental Autoimmune Encephalomyelitis in Mice. Neurotherapeutics, 1-19. https://doi.org/10.1007/s13311-021-01074-x (Original work published 2021)

Buisseret, B., Guillemot-Legris, O., Ben Kouidar, Y., Paquot, A., Muccioli, G., & Al Houayek, M. (2021). Effects of R-flurbiprofen and the oxygenated metabolites of endocannabinoids in inflammatory pain mice models. The FASEB Journal, 35(4), e21411 [1-16]. https://doi.org/10.1096/fj.202002468R (Original work published 2021)

Al Houayek, M., Ameraoui, H., & Muccioli, G. (2021). Bioactive lipids in inflammatory bowel diseases - From pathophysiological alterations to therapeutic opportunities. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1866(2), 158854 [1-18]. https://doi.org/10.1016/j.bbalip.2020.158854 (Original work published 2021)

Bottemanne, P., Paquot, A., Ameraoui, H., Guillemot-Legris, O., Al Houayek, M., & Muccioli, G. (2021). 25-Hydroxycholesterol metabolism is altered by lung inflammation, and its local administration modulates lung inflammation in mice. FASEB journal, 35(4), e21514 [1-19]. https://doi.org/10.1096/fj.202002555R (Original work published 2021)

Orefice, N. S., Guillemot-Legris, O., Capasso, R., Bottemanne, P., Hantraye, P., Caraglia, M., Orefice, G., Al Houayek, M., & Muccioli, G. (2020). miRNA profile is altered in a modified EAE mouse model of multiple sclerosis featuring cortical lesions. eLife, 9, e56916 [1-25]. https://doi.org/10.7554/eLife.56916 (Original work published 2020)

Al Houayek, M., Bannenberg, G., Muccioli, G., Norel, X., Yao, C., & Schebb, N. H. (2020). Editorial-Special issue of the 7 European workshop on lipid mediators. Prostaglandins & Other Lipid Mediators, 148, 106421 [1-3]. https://doi.org/10.1016/j.prostaglandins.2020.106421 (Original work published 2020)

Al Houayek, M., Stafberg, L., Karlsson, J., Bergström, S. H., & Fowler, C. J. (2020). Effects of orthotopic implantation of rat prostate tumour cells upon components of the N-acylethanolamine and monoacylglycerol signalling systems: an mRNA study. Scientific Reports, 10(1), 6314. https://doi.org/10.1038/s41598-020-63198-y (Original work published 2020)

Auquière, M., Terrasi, R., Gratpain, V., Vanderstraeten, J., Cronemberger-Andrade, A., Mozaheb, N., Mingeot-Leclercq, M.-P., des Rieux, A., & Muccioli, G. (2025). Critical evaluation of saponin as a permeabilizer for anandamide encapsulation in extracellular vesicles. Drug Delivery and Translational Research. Accepted/in-press. https://doi.org/10.1007/s13346-025-01951-4 (Original work published 2025)

Sun, M., Garnier, L., Chevalier, R., Roumain, M., Wang, C., Angelillo, J., Montorfani, J., Pick, R., Brighouse, D., Fournier, N., Tarussio, D., Tissot, S., Lobaccaro, J.-M., Petrova, T. V., Jandus, C., Speiser, D. E., Kopf, M., Pot, C., Scheiermann, C., et al. (2025). Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-55969-w (Original work published 2025)

Thibaut, M., Roumain, M., Piron, E., Gillard, J., Loriot, A., Neyrinck, A., Rodriguez, J., Massart, I., Thissen, J.-P., Huot, J. R., Pin, F., Bonetto, A., Delzenne, N., Muccioli, G., & Bindels, L. (2025). The microbiota-derived bile acid taurodeoxycholic acid improves hepatic cholesterol levels in mice with cancer cachexia. Gut microbes, 17(1), 2449586 [1-26]. https://doi.org/10.1080/19490976.2025.2449586 (Original work published 2025)

Ameraoui, H., Bestard-Escalas, J., Roumain, M., Laghouati, A., Bottemanne, P., Al Houayek, M., & Muccioli, G. (2025). Oxysterol-mediated modulation of intestinal inflammation: insights into sex differences and GPR183 signaling. Cellular and Molecular Life Sciences. Accepted/in-press. https://doi.org/10.1007/s00018-025-05981-6 (Original work published 2025)

Auquière, M., Muccioli, G., & des Rieux, A. (2025). Methods and Challenges in Purifying Drug‐Loaded Extracellular Vesicles. Journal of Extracellular Vesicles, 14(6), 1-20. https://doi.org/10.1002/jev2.70097 (Original work published 2025)

Hoste, E., Deldicque, L., Muccioli, G., Panin, N., Terrasi, R., Paquot, A., Lingurski, M., Pyr dit Ruys, S., Haufroid, V., & Elens, L. (2025). Silencing drug transporters in human primary muscle cells modulates atorvastatin pharmacokinetics: A pilot study. British Journal of Pharmacology, 1-18. https://doi.org/10.1111/bph.17449 (Original work published 2025)

Roumain, M., & Muccioli, G. (2025). Development and application of an LC-MS/MS method for the combined quantification of oxysterols and bile acids. Journal of Lipid Research, 66(1), 100697. https://doi.org/10.1016/j.jlr.2024.100697 (Original work published 2025)

Gratpain, V., Loriot, A., d’Auria, L., Bottemanne, P., Payen, V., Terrasi, R., Van Pesch, V., Muccioli, G., & des Rieux, A. (2024). Influence of a pro-inflammatory stimulus on the miRNA and lipid content of human dental stem cell-derived extracellular vesicles and their impact on microglial activation. Heliyon, 10(5), e27025 [1-14]. https://doi.org/10.1016/j.heliyon.2024.e27025 (Original work published 2024)

Labrak, Y., Al Houayek, M., Mwema, A., d’Auria, L., Ucakar, B., Van Pesch, V., Muccioli, G., & des Rieux, A. (2024). The combined administration of LNC-encapsulated retinoic acid and calcitriol stimulates oligodendrocyte progenitor cell differentiation in vitro and in vivo after intranasal administration. International Journal of Pharmaceutics, 659, 124237 [1-9]. https://doi.org/10.1016/j.ijpharm.2024.124237 (Original work published 2024)

Gillard, J., Roumain, M., Picalausa, C., Thibaut, M., Clerbaux, L.-A., Tailleux, A., Staels, B., Muccioli, G., Bindels, L., & Leclercq, I. (2024). A gut microbiota-independent mechanism shapes the bile acid pool in mice with MASH. JHEP Reports, 6(11), 101148 [1-11]. https://doi.org/10.1016/j.jhepr.2024.101148 (Original work published 2024)

Paone, P., Latousakis, D., Terrasi, R., Vertommen, D., Jian, C., Borlandelli, V., Suriano, F., Johansson, M. E. V., Puel, A., Bouzin, C., Delzenne, N., Salonen, A., Juge, N., Florea, B. I., Muccioli, G., Overkleeft, H., Van Hul, M., & Cani, P. (2024). Human milk oligosaccharide 2′-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice. Gut, X(1), 18. https://doi.org/10.1136/gutjnl-2023-330301 (Original work published 2024)

Mwema, A., Gratpain, V., Ucakar, B., Vanvarenberg, K., Perdaens, O., Van Pesch, V., Muccioli, G., & des Rieux, A. (2024). Impact of calcitriol and PGD2-G-loaded lipid nanocapsules on oligodendrocyte progenitor cell differentiation and remyelination. Drug Delivery and Translational Research, 14(11), 3128-3146. https://doi.org/10.1007/s13346-024-01535-8 (Original work published 2024)

Marotti, V., Xu, Y., Bohns Michalowski, C., Zhang, W., Ladeiro Domingues, I., Ameraoui, H., Moreels, T., Baatsen, P., Van Hul, M., Muccioli, G., Cani, P., Al Houayek, M., Malfanti, A., & Beloqui Garcia, A. (2024). A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment. Bioactive materials, 32, 206-221. https://doi.org/10.1016/j.bioactmat.2023.09.014 (Original work published 2024)

Dalle, S., Poffé, C., Lauriks, W., Robberechts, R., Stalmans, M., Terrasi, R., Muccioli, G., & Koppo, K. (2024). Circulating Endocannabinoids Are Associated with Mental Alertness During Ultra-Endurance Exercise. Cannabis and Cannabinoid Research, 10(2). https://doi.org/10.1089/can.2024.0169 (Original work published 2024)

Muccioli, G., & Bannenberg, G. (2024). Editorial – Special issue of the 8th European Workshop on Lipid Mediators. Prostaglandins & Other Lipid Mediators, 172, 106835. https://doi.org/10.1016/j.prostaglandins.2024.106835 (Original work published 2024)

Ruiz, F., Peter, B., Rebeaud, J., Vigne, S., Bressoud, V., Roumain, M., Wyss, T., Yersin, Y., Wagner, I., Kreutzfeldt, M., Pimentel Mendes, M., Kowalski, C., Boivin, G., Roth, L., Schwaninger, M., Merkler, D., Muccioli, G., Hugues, S., Petrova, T. V., & Pot, C. (2023). Endothelial cell-derived oxysterol ablation attenuates experimental autoimmune encephalomyelitis. EMBO reports, 24(3), e55328 [1-20]. https://doi.org/10.15252/embr.202255328 (Original work published 2023)

Karemera, M., Verce, M., Roumain, M., Muccioli, G., Cani, P., Everard, A., Stephenne, X., & Sokal, E. (2023). Pediatric Autoimmune or Primary Sclerosing Cholangitis: Metronidazole Effectiveness on Biochemical Data, Bile Acid Profile, and Gut Microbiota: A Pilot Study. JPGN reports, 4(3), e334 [1-8]. https://doi.org/10.1097/pg9.0000000000000334 (Original work published 2023)

Roumain, M., Guillemot-Legris, O., Ameraoui, H., Al Houayek, M., & Muccioli, G. (2023). Identification and in vivo detection of side-chain hydroxylated metabolites of 4β-hydroxycholesterol. The Journal of Steroid Biochemistry and Molecular Biology, 234, 106376. https://doi.org/10.1016/j.jsbmb.2023.106376 (Original work published 2023)

Moens de Hase, E., Petitfils, C., Al Houayek, M., Depommier, C., Le Faouder, P., Delzenne, N., Van Hul, M., Muccioli, G., Cenac, N., & Cani, P. (2023). Dysosmobacter welbionis effects on glucose, lipid, and energy metabolism are associated with specific bioactive lipids. Journal of Lipid Research, 64(10), 100437 [1-14]. https://doi.org/10.1016/j.jlr.2023.100437 (Original work published 2023)

Cloos, A.-S., Rab, M. A., Van Der Smissen, P., van Oirschot, B. A., Mignolet, E., van der Net, J. B., Koster, A., Kleinen, K., Larondelle, Y., Terrasi, R., Muccioli, G., van Wijk, R., & Tyteca, D. (2023). Red blood cells from patients with sitosterolemia exhibit impaired membrane lipid composition and distribution and decreased deformability. Frontiers in Hematology. Red Cells, Iron and Erythropoiesis, 2, 055086 [1-14]. https://doi.org/10.3389/frhem.2023.1055086 (Original work published 2023)

Hoste, E., Paquot, A., Panin, N., Horion, S., El-Hamdaoui, H., Muccioli, G., Haufroid, V., & Elens, L. (2023). Genetic polymorphisms in SLCO2B1 and ABCC1 conjointly modulate atorvastatin intracellular accumulation in HEK293 recombinant cell lines. Therapeutic Drug Monitoring, 45(3), 400-408. https://doi.org/10.21203/rs.3.rs-1520877/v1 (Original work published 2023)

Mwema, A., Bottemanne, P., Paquot, A., Ucakar, B., Vanvarenberg, K., Al Houayek, M., Muccioli, G., & des Rieux, A. (2023). Lipid nanocapsules for the nose-to-brain delivery of the anti-inflammatory bioactive lipid PGD-G. Nanomedicine : nanotechnology, biology, and medicine, 48, 102633. https://doi.org/10.1016/j.nano.2022.102633 (Original work published 2023)

Régnier, M., Van Hul, M., Roumain, M., Paquot, A., de Wouters d’Oplinter, A., Suriano, F., Everard, A., Delzenne, N., Muccioli, G., & Cani, P. (2023). Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota. Gut microbes, 15(1), 20 [1-19]. https://doi.org/10.1080/19490976.2023.2178796 (Original work published 2023)

Mwema, A., Muccioli, G., & des Rieux, A. (2023). Innovative drug delivery strategies to the CNS for the treatment of multiple sclerosis. Journal of controlled release : official journal of the Controlled Release Society, 364, 435-457. https://doi.org/10.1016/j.jconrel.2023.10.052 (Original work published 2023)

van Doorslaer de ten Ryen, S., Dalle, S., Terrasi, R., Koppo, K., Muccioli, G., & Deldicque, L. (2023). Regulation of the endocannabinoid system by endurance and resistance exercise in hypoxia in human skeletal muscle. Journal of Applied Physiology, 134(3), 569-580. https://doi.org/10.1152/japplphysiol.00645.2022 (Original work published 2023)

Romano, A., Friuli, M., Eramo, B., Gallelli, C. A., Koczwara, J. B., Azari, E. K., Paquot, A., Arnold, M., Langhans, W., Muccioli, G., Lutz, T. A., & Gaetani, S. (2023). “To brain or not to brain”: evaluating the possible direct effects of the satiety factor oleoylethanolamide in the central nervous system. Frontiers in Endocrinology, 14, 1158287 [1-12]. https://doi.org/10.3389/fendo.2023.1158287 (Original work published 2023)

Paquot, A., Bestard-Escalas, J., & Muccioli, G. (2023). Set up and validation of a sensitive method to quantify prostaglandins, prostaglandin-glycerol esters and prostaglandin-ethanolamides, as well as their respective precursors. Prostaglandins & Other Lipid Mediators, 106763. https://doi.org/10.1016/j.prostaglandins.2023.106763 (Original work published 2023)

van Dijk, M. J., van Oirschot, B. A., Harrison, A. N., Recktenwald, S. M., Qiao, M., Stommen, A., Cloos, A.-S., Vanderroost, J., Terrasi, R., Dey, K., Bos, J., Rab, M. A. E., Bogdanova, A., Minetti, G., Muccioli, G., Tyteca, D., Egée, S., Kaestner, L., Molday, R. S., et al. (2023). A novel missense variant in ATP11C is associated with reduced red blood cell phosphatidylserine flippase activity and mild hereditary hemolytic anemia. American journal of hematology, 98(12), 1877-1887. https://doi.org/10.1002/ajh.27088 (Original work published 2023)

Mozaheb, N., Van Der Smissen, P., Opsomer, T., Mignolet, E., Terrasi, R., Paquot, A., Larondelle, Y., Dehaen, W., Muccioli, G., & Mingeot-Leclercq, M.-P. (2022). Contribution of Membrane Vesicle to Reprogramming of Bacterial Membrane Fluidity in Pseudomonas aeruginosa. mSphere, 7(3), e0018722 [1-13]. https://doi.org/10.1128/msphere.00187-22 (Original work published 2022)

Barington, L., Christensen, L. v. V., Pedersen, K. K., Niss Arfelt, K., Roumain, M., Jensen, K. H. R., Kjær, V. M. S., Daugvilaite, V., Kearney, J. F., Christensen, J. P., Hjortø, G. M., Muccioli, G., Holst, P. J., & Rosenkilde, M. M. (2022). GPR183 Is Dispensable for B1 Cell Accumulation and Function, but Affects B2 Cell Abundance, in the Omentum and Peritoneal Cavity. Cells, 11(3), 494 [1-18]. https://doi.org/10.3390/cells11030494 (Original work published 2022)

Le Roy, T., Moens De Hase, E., Van Hul, M., Paquot, A., Pelicaen, R., Régnier, M., Depommier, C., Druart, C., Everard, A., Maiter, D., Delzenne, N., Bindels, L., de Barsy, M., Loumaye, A., Hermans, M., Thissen, J.-P., Vieira-Silva, S., Falony, G., Raes, J., et al. (2022). Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice. Gut, 71, 534-543. https://doi.org/10.1136/gutjnl-2020-323778 (Original work published 2022)

Abdul Khaliq, H., Al Houayek, M., Leclercq, J., & Muccioli, G. (2022). 5’AMP-activated protein kinase: an emerging target of phytochemicals to treat chronic inflammatory diseases. Critical Reviews in Food Science and Nutrition, 1-26. https://doi.org/10.1080/10408398.2022.2145264 (Original work published 2022)

De Berdt, P., Vanvarenberg, K., Ucakar, B., Bouzin, C., Paquot, A., Gratpain, V., Loriot, A., Payen, V., Bearzatto, B., Muccioli, G., Gatto, L., Diogenes, A., & des Rieux, A. (2022). The human dental apical papilla promotes spinal cord repair through a paracrine mechanism. Cellular and molecular life sciences : CMLS, 79(5), 252. https://doi.org/10.1007/s00018-022-04210-8 (Original work published 2022)

Yelek, C., Mignion, L., Paquot, A., Bouzin, C., Corbet, C., Muccioli, G., Cani, P., & Jordan, B. (2022). Tumor Metabolism Is Affected by Obesity in Preclinical Models of Triple-Negative Breast Cancer. Cancers, 14(3), 562 [1-16]. https://doi.org/10.3390/cancers14030562 (Original work published 2022)

Abdul Khaliq, H., Ortiz Aguirre, S. E., Al Houayek, M., Neyts, T., Muccioli, G., & Leclercq, J. (2022). Effect of a methanolic extract of Salvadora oleoides Decne. on LPS-activated J774 macrophages, its in vitro and in vivo toxicity study and dereplication of its chemical constituents. Toxicology Reports, 9, 1742-1753. https://doi.org/10.1016/j.toxrep.2022.09.004 (Original work published 2022)

Bozzato, E., Tsakiris, N., Paquot, A., Muccioli, G., Bastiancich, C., & Préat, V. (2022). Dual-drug loaded nanomedicine hydrogel as a therapeutic platform to target both residual glioblastoma and glioma stem cells. International Journal of Pharmaceutics, 628, 122341 [1-12]. https://doi.org/10.1016/j.ijpharm.2022.122341 (Original work published 2022)

Ranaivo, H., Zhang, Z., Alligier, M., Van Den Berghe, L., Sothier, M., Lambert-Porcheron, S., Feugier, N., Cuerq, C., Machon, C., Neyrinck, A., Seethaler, B., Rodriguez, J., Roumain, M., Muccioli, G., Maquet, V., Laville, M., Bischoff, S. C., Walter, J., Delzenne, N., & Nazare, J.-A. (2022). Chitin-glucan supplementation improved postprandial metabolism and altered gut microbiota in subjects at cardiometabolic risk in a randomized trial. Scientific Reports, 12(1), 8830 [1-14]. https://doi.org/10.1038/s41598-022-12920-z (Original work published 2022)

Copperi, F., Schleis, I., Roumain, M., Muccioli, G., Casola, S., Klingenspor, M., Pfeifer, A., & Gnad, T. (2022). EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes. Communications biology, 5(1), 280 [1-9]. https://doi.org/10.1038/s42003-022-03201-6 (Original work published 2022)

Berland, C., Castel, J., Terrasi, R., Montalban, E., Foppen, E., Martin, C., Muccioli, G., Luquet, S., & Gangarossa, G. (2022). Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis. Molecular Psychiatry, 27(4), 2340-2354. https://doi.org/10.1038/s41380-021-01428-z (Original work published 2022)

Abdul Khaliq, H., Ortiz Aguirre, S. E., Al Houayek, M., Muccioli, G., & Leclercq, J. (2022). Dereplication and Quantification of Major Compounds of L. Extracts and Assessment of Their Effect on LPS-Activated J774 Macrophages. Molecules (Basel, Switzerland), 27(3), 963 [1-19]. https://doi.org/10.3390/molecules27030963 (Original work published 2022)

Valderrama, J. A., Pérez-Herrera, A., Muccioli, G., Venegas-Casanova, E. A., Jara-Aguilar, R., Calderon, P. B., Benites, J., & Mitu, L. (2022). On the Reaction of 2-Alkanoylnaphthohydroquinones with Hydroxylamine: Access to Cytotoxic 2-(Hydroxyamino)-1,4-naphthoquinone and Their 3-(Hydroxyimino)alkyl Analogous. Journal of Chemistry, 2022, 1-8. https://doi.org/10.1155/2022/7664037 (Original work published 2022)

Labrak, Y., Heurtault, B., Frisch, B., Saulnier, P., Lepeltier, E., Miron, V. E., Muccioli, G., & des Rieux, A. (2022). Impact of anti-PDGFRα antibody surface functionalization on LNC uptake by oligodendrocyte progenitor cells. International Journal of Pharmaceutics, 618, 121623. https://doi.org/10.1016/j.ijpharm.2022.121623 (Original work published 2022)

Perez, L., Scarcello, E., Ibouraadaten, S., Yakoub, Y., Leinardi, R., Ambroise, J., Bearzatto, B., Gala, J.-L., Paquot, A., Muccioli, G., Bouzin, C., Van Den Brûle, S., & Lison, D. (2021). Dietary nanoparticles alter the composition and function of the gut microbiota in mice at dose levels relevant for human exposure. Food and Chemical Toxicology, 154, 112352 [1-13]. https://doi.org/10.1016/j.fct.2021.112352 (Original work published 2021)

Lison, D., Ambroise, J., Leinardi, R., Ibouraadaten, S., Yakoub, Y., Deumer, G., Haufroid, V., Paquot, A., Muccioli, G., & Van Den Brûle, S. (2021). Systemic effects and impact on the gut microbiota upon subacute oral exposure to silver acetate in rats. Archives of toxicology, 95(4), 1251-1266. https://doi.org/10.1007/s00204-021-02998-1 (Original work published 2021)

Gratpain, V., Mwema, A., Labrak, Y., Muccioli, G., Van Pesch, V., & des Rieux, A. (2021). Extracellular vesicles for the treatment of central nervous system diseasesExtracellular vesicles for the treatment of central nervous system diseases. Advanced Drug Delivery Reviews, 174, 535-552. https://doi.org/10.1016/j.addr.2021.05.006 (Original work published 2021)

Bottemanne, P., Guillemot-Legris, O., Paquot, A., Masquelier, J., Malamas, M., Makriyannis, A., Al Houayek, M., & Muccioli, G. (2021). N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibition, but Not Fatty Acid Amide Hydrolase Inhibition, Prevents the Development of Experimental Autoimmune Encephalomyelitis in Mice. Neurotherapeutics, 1-19. https://doi.org/10.1007/s13311-021-01074-x (Original work published 2021)

Buisseret, B., Guillemot-Legris, O., Ben Kouidar, Y., Paquot, A., Muccioli, G., & Al Houayek, M. (2021). Effects of R-flurbiprofen and the oxygenated metabolites of endocannabinoids in inflammatory pain mice models. The FASEB Journal, 35(4), e21411 [1-16]. https://doi.org/10.1096/fj.202002468R (Original work published 2021)

Buya, A., Terrasi, R., Mbinze, J. K., Muccioli, G., Beloqui Garcia, A., Memvanga, P. B., & Préat, V. (2021). Quality-by-Design-Based Development of a Voxelotor Self-Nanoemulsifying Drug-Delivery System with Improved Biopharmaceutical Attributes. Pharmaceutics, 13(9), 1388 [1-20]. https://doi.org/10.3390/pharmaceutics13091388 (Original work published 2021)

Thibaut, M., Gillard, J., Dolly, A., Roumain, M., Leclercq, I., Delzenne, N., Muccioli, G., & Bindels, L. (2021). Bile Acid Dysregulation Is Intrinsically Related to Cachexia in Tumor-Bearing Mice. Cancers, 13(24), 6389 [1-17]. https://doi.org/10.3390/cancers13246389 (Original work published 2021)

Cloos, A.-S., Daenen, L. G. M., Maja, M., Stommen, A., Vanderroost, J., Van Der Smissen, P., Rab, M., Westerink, J., Mignolet, E., Larondelle, Y., Terrasi, R., Muccioli, G., Dumitru, A.-C., Alsteens, D., van Wijk, R., & Tyteca, D. (2021). Impaired Cytoskeletal and Membrane Biophysical Properties of Acanthocytes in Hypobetalipoproteinemia – A Case Study. Frontiers in Physiology, 12(2), 638027 [1-22]. https://doi.org/10.3389/fphys.2021.638027 (Original work published 2021)

Suriano, F., Vieira-Silva, S., Falony, G., Roumain, M., Paquot, A., Pelicaen, R., Régnier, M., Delzenne, N., Raes, J., Muccioli, G., Van Hul, M., & Cani, P. (2021). Novel insights into the genetically obese (ob/ob) and diabetic (db/db) mice: two sides of the same coin. Microbiome, 9(1), 147. https://doi.org/10.1186/s40168-021-01097-8 (Original work published 2021)

Bottemanne, P., Paquot, A., Ameraoui, H., Guillemot-Legris, O., Al Houayek, M., & Muccioli, G. (2021). 25-Hydroxycholesterol metabolism is altered by lung inflammation, and its local administration modulates lung inflammation in mice. FASEB journal, 35(4), e21514 [1-19]. https://doi.org/10.1096/fj.202002555R (Original work published 2021)

Guillemot-Legris, O., & Muccioli, G. (2021). The oxysterome and its receptors as pharmacological targets in inflammatory diseases. British Journal of Pharmacology. Accepted/in-press. https://doi.org/10.1111/bph.15479 (Original work published 2021)

Genton, L., Pruijm, M., Teta, D., Bassi, I., Cani, P., Gaïa, N., Herrmann, F. R., Marangon, N., Mareschal, J., Muccioli, G., Stoermann, C., Suriano, F., Wurzner-Ghajarzadeh, A., Lazarevic, V., & Schrenzel, J. (2021). Gut barrier and microbiota changes with glycine and branched-chain amino acid supplementation in chronic haemodialysis patients. Journal of Cachexia, Sarcopenia and Muscle, 1-13. https://doi.org/10.1002/jcsm.12781 (Original work published 2021)

Abot, A., Wemelle, E., Laurens, C., Paquot, A., Pomie, N., Carper, D., Bessac, A., Mas Orea, X., Fremez, C., Fontanie, M., Lucas, A., Lesage, J., Everard, A., Meunier, E., Dietrich, G., Muccioli, G., Moro, C., Cani, P., & Knauf, C. (2021). Identification of new enterosynes using prebiotics: roles of bioactive lipids and mu-opioid receptor signalling in humans and mice. Gut, 70(6), 1078-1087. https://doi.org/10.1136/gutjnl-2019-320230 (Original work published 2021)

Al Houayek, M., Ameraoui, H., & Muccioli, G. (2021). Bioactive lipids in inflammatory bowel diseases - From pathophysiological alterations to therapeutic opportunities. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1866(2), 158854 [1-18]. https://doi.org/10.1016/j.bbalip.2020.158854 (Original work published 2021)

Van Den Brûle, S., Rappe, M., Ambroise, J., Bouzin, C., Dessy, C., Paquot, A., Muccioli, G., & Lison, D. (2021). Diesel exhaust particles alter the profile and function of the gut microbiota upon subchronic oral administration in mice. Particle and Fibre Toxicology, 18(1), 7 [1-15]. https://doi.org/10.1186/s12989-021-00400-7 (Original work published 2021)

Ange, M., De Poortere, J., Ginion, A., Battault, S., Dechamps, M., Muccioli, G., Roumain, M., Morelle, J., Druart, S., Mathivet, T., Bertrand, L., Castanares Zapatero, D., Horman, S., & Beauloye, C. (2021). Canagliflozin protects against sepsis capillary leak syndrome by activating endothelial α1AMPK. Scientific Reports, 11(1), 13700 [1-13]. https://doi.org/10.1038/s41598-021-93156-1 (Original work published 2021)

Stillemans, G., Paquot, A., Muccioli, G., Hoste, E., Panin, N., Åsberg, A., Balligand, J.-L., Haufroid, V., & Elens, L. (2021). Atorvastatin population pharmacokinetics in a real‐life setting: Influence of genetic polymorphisms and association with clinical response. Clinical and Translational Science (Print). Published. https://doi.org/10.1111/cts.13185 (Original work published 2021)

Neyrinck, A., Rodriguez, J., Zhang, Z., Seethaler, B., Robles Sanchez, C., Roumain, M., Hiel, S., Bindels, L., Cani, P., Paquot, N., Cnop, M., Nazare, J.-A., Laville, M., Muccioli, G., Bischoff, S. C., Walter, J., Thissen, J.-P., & Delzenne, N. (2021). Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial. European Journal of Nutrition, 60(6), 3159-3170. https://doi.org/10.1007/s00394-021-02484-5 (Original work published 2021)

Thibaut, M., Sboarina, M., Roumain, M., Pötgens, S., Neyrinck, A., Destrée, F., Gillard, J., Leclercq, I., Dachy, G., Demoulin, J. B., Tailleux, A., Lestavel, S., Rastelli, M., Everard, A., Cani, P., Porporato, P. E., Loumaye, A., Thissen, J.-P., Muccioli, G., et al. (2021). Inflammation-induced cholestasis in cancer cachexia. Journal of Cachexia, Sarcopenia and Muscle, 12(1), 70-20. https://doi.org/10.1002/jcsm.12652 (Original work published 2021)

Yelek, C., Mignion, L., Joudiou, N., Terrasi, R., Gourgue, F., Van Hul, M., Delzenne, N., Gallez, B., Corbet, C., Muccioli, G., Feron, O., Cani, P., & Jordan, B. (2020). Acetate: Friend or foe against breast tumour growth in the context of obesity? Journal of Cellular and Molecular Medicine (Print) : a journal of translational medicine, 24(24), 14195-14204. https://doi.org/10.1111/jcmm.16034 (Original work published 2020)

Manca, C., Boubertakh, B., Leblanc, N., Deschênes, T., Lacroix, S., Martin, C., Houde, A., Veilleux, A., Flamand, N., Muccioli, G., Raymond, F., Cani, P., Di Marzo, V., & Silvestri, C. (2020). Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling. Journal of Lipid Research, 61(1), 70-85. https://doi.org/10.1194/jlr.RA119000424 (Original work published 2020)

Diermeier, T., Meredith, S. J., Irrgang, J. J., Zaffagnini, S., Kuroda, R., Hochino, Y., Samuelsson, K., Smith, C. N., Popchak, A., Musahl, V., Sheean, A., Burnham, J. M., Lian, J., Smith, C., Popchak, A., Herbst, E., Pfeiffer, T., Araujo, P., Oostdyk, A., et al. (2020). Patient-Reported and Quantitative Outcomes of Anatomic Anterior Cruciate Ligament Reconstruction With Hamstring Tendon Autografts. Orthopaedic Journal of Sports Medicine, 8(7), 1-7. https://doi.org/10.1177/2325967120926159 (Original work published 2020)

Briand-Mésange, F., Pons, V., Allart, S., Masquelier, J., Chicanne, G., Beton, N., Payrastre, B., Muccioli, G., Ausseil, J., Davignon, J.-L., Salles, J.-P., & Chap, H. (2020). Glycerophosphodiesterase 3 (GDE3) is a lysophosphatidylinositol-specific ectophospholipase C acting as an endocannabinoid signaling switch. Journal of Biological Chemistry, 295(46), 15767-15781. https://doi.org/10.1074/jbc.RA120.015278 (Original work published 2020)

Phung, A. S., Bannenberg, G., Vigor, C., Reversat, G., Oger, C., Roumain, M., Galano, J.-M., Durand, T., Muccioli, G., Ismail, A., & Wang, S. C. (2020). Chemical Compositional Changes in Over-Oxidized Fish Oils. Foods, 9(10), 1501. https://doi.org/10.3390/foods9101501 (Original work published 2020)

Tsakiris, N., Fauvet, F., Ruby, S., Puisieux, A., Paquot, A., Muccioli, G., Vigneron, A. M., & Préat, V. (2020). Combined nanomedicines targeting colorectal cancer stem cells and cancer cells. Journal of Controlled Release, 326, 387-395. https://doi.org/10.1016/j.jconrel.2020.07.025 (Original work published 2020)

Lefort, C., Roumain, M., Van Hul, M., Rastelli, M., Manco, R., Leclercq, I., Delzenne, N., Di Marzo, V., Flamand, N., Luquet, S., Silvestri, C., Muccioli, G., & Cani, P. (2020). Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism. Cells, 9(5), 1247 [1-23]. https://doi.org/10.3390/cells9051247 (Original work published 2020)

Morelle, A., Caruano, J., Feledziak, M., Michaux, C., Perpète, E., Muccioli, G., Marchand-Brynaert, J., & Robiette, R. (2020). β-lactams to act on the endocannabinoid system. Chimie Nouvelle, 134, 41. (Original work published 2020)

Van Hul, M., Le Roy, T., Prifti, E., Dao, M. C., Paquot, A., Zucker, J.-D., Delzenne, N., Muccioli, G., Clément, K., & Cani, P. (2020). From correlation to causality: the case of Subdoligranulum. Gut Microbes, 12(1), 1-13. https://doi.org/10.1080/19490976.2020.1849998 (Original work published 2020)

Pollet, H., Cloos, A.-S., Stommen, A., Vanderroost, J., Conrard, L., Paquot, A., Ghodsi, M., Carquin, M., Léonard, A.-C., Guthmann, M., Lingurski, M., Vermylen, C., Killian, T., Gatto, L., Rider, M. H., Pyr dit Ruys, S., Vertommen, D., Vikkula, M., Brouillard, P., et al. (2020). Aberrant Membrane Composition and Biophysical Properties Impair Erythrocyte Morphology and Functionality in Elliptocytosis. Biomolecules, 10(8), 1120 [1-25]. https://doi.org/10.3390/biom10081120 (Original work published 2020)

Ríos, D., Valderrama, J. A., Cautin, M., Tapia, M., Salas, F., Guerrero-Castilla, A., Muccioli, G., Buc Calderon, P., & Benites, J. (2020). New 2-Acetyl-3-aminophenyl-1,4-naphthoquinones: Synthesis and Antiproliferative Activities on Breast and Prostate Human Cancer Cells. Oxidative Medicine and Cellular Longevity, 2020, 8939716 [1-11]. https://doi.org/10.1155/2020/8939716 (Original work published 2020)

Orefice, N. S., Guillemot-Legris, O., Capasso, R., Bottemanne, P., Hantraye, P., Caraglia, M., Orefice, G., Al Houayek, M., & Muccioli, G. (2020). miRNA profile is altered in a modified EAE mouse model of multiple sclerosis featuring cortical lesions. eLife, 9, e56916 [1-25]. https://doi.org/10.7554/eLife.56916 (Original work published 2020)

Demaret, T., Evraerts, J., Ravau, J., Roumain, M., Muccioli, G., Najimi, M., & Sokal, E. (2020). High Dose Versus Low Dose Syngeneic Hepatocyte Transplantation in -G844D NMRI Mouse Model is Safe but Does Not Achieve Long Term Engraftment. Cells, 10(1), 40 [1-12]. https://doi.org/10.3390/cells10010040 (Original work published 2020)

Valderrama, J. A., Ríos, D., Muccioli, G., Buc Calderon, P., & Benites, J. (2020). In Vitro Inhibition of Hsp90 Protein by Benzothiazoloquinazolinequinones Is Enhanced in The Presence of Ascorbate. A Preliminary In Vivo Antiproliferative Study. Molecules, 25(4), 953. https://doi.org/10.3390/molecules25040953 (Original work published 2020)

Al Houayek, M., Bannenberg, G., Muccioli, G., Norel, X., Yao, C., & Schebb, N. H. (2020). Editorial-Special issue of the 7 European workshop on lipid mediators. Prostaglandins & Other Lipid Mediators, 148, 106421 [1-3]. https://doi.org/10.1016/j.prostaglandins.2020.106421 (Original work published 2020)

Rastelli, M., Van Hul, M., Terrasi, R., Lefort, C., Régnier, M., Beiroa, D., Delzenne, N., Everard, A., Nogueiras, R., Luquet, S., Muccioli, G., & Cani, P. (2020). Intestinal NAPE-PLD contributes to short-term regulation of food intake via gut-to-brain axis. American journal of physiology. Endocrinology and metabolism, 319(3), E647-E657. https://doi.org/10.1152/ajpendo.00146.2020 (Original work published 2020)

Le Roy, T., Van Der Smissen, P., Paquot, A., Delzenne, N., Muccioli, G., Collet, J.-F., & Cani, P. (2020). Dysosmobacter welbionis gen. nov., sp. nov., isolated from human faeces and emended description of the genus Oscillibacter. International journal of systematic and evolutionary microbiology, 70(9), 4851-4858. https://doi.org/10.1099/ijsem.0.003547 (Original work published 2020)

Demaret, T., Roumain, M., Ambroise, J., Evraerts, J., Ravau, J., Bouzin, C., Bearzatto, B., Gala, J.-L., Stepman, H., Marie, S., Vincent, M.-F., Muccioli, G., Najimi, M., & Sokal, E. (2020). Longitudinal study of Pex1-G844D NMRI mouse model: A robust pre-clinical model for mild Zellweger spectrum disorder. BBA - Molecular Basis of Disease, 1866(11), 165900 [1-18]. https://doi.org/10.1016/j.bbadis.2020.165900 (Original work published 2020)

Rodriguez, J., Neyrinck, A., Zhang, Z., Seethaler, B., Nazare, J.-A., Robles Sanchez, C., Roumain, M., Muccioli, G., Bindels, L., Cani, P., Maquet, V., Laville, M., Bischoff, S. C., Walter, J., & Delzenne, N. (2020). Metabolite profiling reveals the interaction of chitin-glucan with the gut microbiota. Gut microbes, 12(1), 1810530 [1-15]. https://doi.org/10.1080/19490976.2020.1810530 (Original work published 2020)

Cloos, A.-S., Ghodsi, M., Stommen, A., Vanderroost, J., Dauguet, N., Pollet, H., D’Auria, L., Mignolet, E., Larondelle, Y., Terrasi, R., Muccioli, G., Van Der Smissen, P., & Tyteca, D. (2020). Interplay Between Plasma Membrane Lipid Alteration, Oxidative Stress and Calcium-Based Mechanism for Extracellular Vesicle Biogenesis From Erythrocytes During Blood Storage. Frontiers in Physiology, 11, 712 [1-23]. https://doi.org/10.3389/fphys.2020.00712 (Original work published 2020)