Publications
ldri | Bruxelles Woluwe
Joelle Leclercq
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Article de journalMamede, L., Rangel, G. W., Schmitt, M., Albrecht, S., Spichty, M., Bero, J., Beaufay, C., Florent, I., Llinás, M., Frédérich, M., & Leclercq, J. (2026). Natural triterpenic phenolic esters target PfA-M17 in Plasmodium falciparum. Malaria Journal, 25(1), 74 [1-11]. https://doi.org/10.1186/s12936-025-05762-3 (Original work published 2026)
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Article de journalCoelho Cristino Mamede, L., Fall, F., Vast, M., Hughes, K., Martelli, G., Caligiore, F., Govaerts, B., Michels, P. A. M., Frédérich, M., & Leclercq, J. (2025). Metabolomics study of 3-O-p-(Z/E)-coumaroyltormentic acid-treated Trypanosoma brucei brucei. International journal for parasitology. Drugs and drug resistance, 100595. https://doi.org/10.1016/j.ijpddr.2025.100595 (Original work published 2025)
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Ba, A., Roumy, V., Hughes, K., Samaillie, J., Bourlet, M., Hennebelle, T., Ndoye, S. F., Herent, M.-F., Leclercq, J., Seck, M., & Rivière, C. (2025). Antiparasitic Activities of Plants From the Traditional Senegalese Pharmacopoeia: Isolation of Antitrypanosomal and Antileishmanial Ellagic Acid Derivatives From Terminalia Avicennioides. Chemistry & Biodiversity, e202403320 [1-14]. https://doi.org/10.1002/cbdv.202403320 (Original work published 2025)
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Coelho Cristino Mamede, L., Rangel, G. W., Shinyuy, L. M., Boussif, N., Herent, M.-F., Govaerts, B., Jansen, O., Ledoux, A., De Tullio, P., Leclercq, J., Llinás, M., & Frédérich, M. (2025). Metabolite profiling of Artemisia afra and Artemisia annua extracts reveals divergent effects on Plasmodium falciparum. Phytomedicine, 136, 156361 [1-9]. https://doi.org/10.1016/j.phymed.2025.156361 (Original work published 2025)
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Article de journalMamede, L., Fall, F., Schoumacher, M., Ledoux, A., Bugli, C., De Tullio, P., Leclercq, J., Govaerts, B., & Frédérich, M. (2024). Comparison of extraction methods in vitro Plasmodium falciparum: A1H NMR and LC-MS joined approach. Biochemical and Biophysical Research Communications, 703, 149684 [1-9]. https://doi.org/10.1016/j.bbrc.2024.149684 (Original work published 2024)
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Tchetan, E., Houehanou, T. D., Olounlade, A. P., Azando, E. V. B., Quinet, M., Houinato, M. R. B., Hounzangbe-Adote, S. M., Leclercq, J., & Gbaguidi, F. A. (2024). Stands diversity and population structure of five ethnoveterinary woody species according to climatic zone and human disturbance in Benin (West Africa). Discover Conservation, 1(1), 9 [1-23]. https://doi.org/10.1007/s44353-024-00006-y (Original work published 2024)
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Fall, F., Desmet, L., Mamede, L., Schioppa, L., de Tullio, P., Frédérich, M., Govaerts, B., & Leclercq, J. (2024). Comparison of Three Widely Employed Extraction Methods for Metabolomic Analysis of Trypanosoma brucei. Current protocols, 4(5), e1043. https://doi.org/10.1002/cpz1.1043 (Original work published 2024)
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Prieto, J. M., Barker, A. M., Schaffner, U., Leclercq, J., Braca, A., & Boevé, J.-L. (2024). Furostanol Saponins and Ecdysteroids from Plants of the Genus Helleborus as Phagostimulants and Predator Deterrents for Larvae of Two Monophadnus Sawfly Species. Plants, 13(16), 2230 [1-19]. https://doi.org/10.3390/plants13162230 (Original work published 2024)
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Tchetan, E., Ortiz Aguirre, S. E., Olounladé, P. A., Azando, E. V. B., Avril, C., Demblon, D., Hounzangbe-Adote, S. M., Gbaguidi, F. A., & Leclercq, J. (2024). Antitrypanosomal activity of Crossopteryx febrifuga and phytochemical profiling using LC-MS/MS analysis coupled to molecular network and SIRIUS. Fitoterapia, 179, 106255 [1-12]. https://doi.org/10.1016/j.fitote.2024.106255 (Original work published 2024)
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Kambale Kavungere, E., Ladeiro Domingues, I., Zhang, W., Marotti, V., Chen, C., Hughes, K., Leclercq, J., Memvanga, P. B., & Beloqui Garcia, A. (2024). “Green” synthesized versus chemically synthesized zinc oxide nanoparticles: In vivo antihyperglycemic activity and pharmacokinetics. International Journal of Pharmaceutics, 650, 123701 [1-8]. https://doi.org/10.1016/j.ijpharm.2023.123701 (Original work published 2024)
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Fall, F., Coelho Cristino Mamede, L., Vast, M., De Tullio, P., Hayette, M.-P., Michels, P. A. M., Frédérich, M., Govaerts, B., & Leclercq, J. (2024). First comprehensive untargeted metabolomics study of suramin-treated Trypanosoma brucei: an integrated data analysis workflow from multifactor data modelling to functional analysis. Metabolomics, 20, 25 [1-17]. https://doi.org/10.1007/s11306-024-02094-2 (Original work published 2024)
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Ba, A., Roumy, V., Al Ibrahim, M., Hughes, K., Hennebelle, T., Samaillie, J., Sahpaz, S., Beniddir, M. A., Herent, M.-F., Séron, K., Leclercq, J., Seck, M., & Rivière, C. (2024). Antileishmanial, antitrypanosomal and anti-coronavirus activities of benzophenanthridine alkaloids and other specialized metabolites isolated from the root bark of Zanthoxylum zanthoxyloides (Lam.) B.Zepernick & Timler. Fitoterapia, 179, 106232 [1-13]. https://doi.org/10.1016/j.fitote.2024.106232 (Original work published 2024)
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Article de journalNhu, T. Q., Hang, B. T. B., Huong, D. T. T., Scippo, M.-L., Phuong, N. T., Leclercq, J., & Kestemont, P. (2023). Psidium guajava L.- dichloromethane and ethyl acetate fractions ameliorate striped catfish (Pangasianodon hypophthalmus) status via immune response, inflammatory, and apoptosis pathways. Fish and Shellfish Immunology, 138, 108851 [1-10]. https://doi.org/10.1016/j.fsi.2023.108851 (Original work published 2023)
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Tchetan, E., Ortiz, S., Olounladé, P. A., Hughes, K., Laurent, P., Azando, E. V. B., Hounzangbe-Adote, S. M., Gbaguidi, F. A., & Leclercq, J. (2023). Fractionation Coupled to Molecular Networking: Towards Identification of Anthelmintic Molecules in Terminalia leiocarpa (DC.) Baill. Molecules, 28(1), 76 [1-22]. https://doi.org/10.3390/molecules28010076 (Original work published 2023)
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Pannequin, A., Leclercq, J., Costa, J., Tintaru, A., & Muselli, A. (2023). First Phytochemical Profiling and In-Vitro Antiprotozoal Activity of Essential Oil and Extract of Plagiochila porelloides. Molecules, 28(2), 616 [1-17]. https://doi.org/10.3390/molecules28020616 (Original work published 2023)
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Hughes, K., Le, T. B., Van Der Smissen, P., Tyteca, D., Mingeot-Leclercq, M.-P., & Leclercq, J. (2023). The Antileishmanial Activity of Eugenol Associated with Lipid Storage Reduction Rather Than Membrane Properties Alterations. Molecules, 28(9), 3871 [1-17]. https://doi.org/10.3390/molecules28093871 (Original work published 2023)
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Zhao, Y., Cartabia, A., Garcés Ruiz, M. C., Herent, M.-F., Leclercq, J., Ortiz Aguirre, S. E., Stéphane Declerck, & Lalaymia, I. (2023). Arbuscular mycorrhizal fungi impact the production of alkannin/shikonin and their derivatives in Alkanna tinctoria Tausch. grown in semi-hydroponic and pot cultivation systems. Frontiers in Microbiology, 14(2023), 1216029. https://doi.org/10.3389/fmicb.2023.1216029 (Original work published 2023)
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Nguyen, P. D., Herent, M.-F., Le, T.-B., Bui, T.-B.-H., Bui, T.-B.-H., Do, T.-T.-H., Nguyen, T.-P., Scippo, M.-L., Kestemont, P., & Leclercq, J. (2023). Isolation of quercetin-3-O-sulfate and quantification of major compounds from Psidium guajava L. from Vietnam. Journal of Food Composition and Analysis, 115, 104928 [1-7]. https://doi.org/10.1016/j.jfca.2022.104928 (Original work published 2023)
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Ledoux, A., Hamann, C., Bonnet, O., Jullien, K., Leclercq, J., Tchinda, A., Smadja, J., Gauvin-Bialecki, A., Maquoi, E., & Frédérich, M. (2023). Bioactive Clerodane Diterpenoids from the Leaves of Casearia coriacea Vent. Molecules, 28(3), 1197 [1-10]. https://doi.org/10.3390/molecules28031197 (Original work published 2023)
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Zhao, Y., Cartabia, A., Mónica Garcés-Ruizk, Herent, M.-F., Leclercq, J., Sergio Ortiz, Stéphane Declerck, & Lalaymia, I. (2023). Arbuscular mycorrhizal fungi impact the production of alkannin/shikonin and their derivatives in Alkanna tinctoria Tausch. grown in semi-hydroponic and pot cultivation systems. Front. Microbiol., 10 August 2023 Sec. Microbe and Virus Interactions with Plants, 14(2023), 1216029. https://doi.org/10.3389/fmicb.2023.1216029 (Original work published 2023)
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Zhao, Y., Cartabia, A., Garcés Ruiz, M. C., Herent, M.-F., Leclercq, J., Ortiz Aguirre, S. E., & Declerck, S. (2023). Arbuscular mycorrhizal fungi impact the production of alkannin/shikonin and their derivatives in Alkanna tinctoria Tausch. grown in semi-hydroponic and pot cultivation systems. Frontiers in Microbiology, 14(1216029), 1-19. https://doi.org/10.3389/fmicb.2023.1216029 (Original work published 2023)
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Kambale Kavungere, E., Katemo, F. M., Leclercq, J., Memvanga, P. B., & Beloqui Garcia, A. (2023). “Green”-synthesized zinc oxide nanoparticles and plant extracts: A comparison between synthesis processes and antihyperglycemic activity. International Journal of Pharmaceutics, 635, 122715 [1-8]. https://doi.org/10.1016/j.ijpharm.2023.122715 (Original work published 2023)
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Article de journalKambale Kavungere, E., Leclercq, J., Memvanga, P. B., & Beloqui Garcia, A. (2022). An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations. Pharmaceutics, 14(10), 2135 [1-42]. https://doi.org/10.3390/pharmaceutics14102135 (Original work published 2022)
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Tchetan, E., Olounladé, P. A., Azando, E. V. B., Abdul Khaliq, H., Ortiz, S., Houngbeme, A., Alowanou, G. G., Koura, B. I., Akouedegni, G. C., Houinato, M. R. B., Hounzangbe-Adote, S. M., Gbaguidi, F. A., & Leclercq, J. (2022). Anthelmintic Activity, Cytotoxicity, and Phytochemical Screening of Plants Used to Treat Digestive Parasitosis of Small Ruminants in Benin (West Africa). Animals, 12(19), 2718 [1-18]. https://doi.org/10.3390/ani12192718 (Original work published 2022)
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Fall, F., Mamede, L., Schioppa, L., Ledoux, A., De Tullio, P., Michels, P., Frédérich, M., & Leclercq, J. (2022). Trypanosoma brucei: Metabolomics for analysis of cellular metabolism and drug discovery. Metabolomics, 18(4), 20 [1-18]. https://doi.org/10.1007/s11306-022-01880-0 (Original work published 2022)
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Nain, C. W., Mignolet, E., Herent, M.-F., Leclercq, J., Debier, C., Page, M., & Larondelle, Y. (2022). The Catechins Profile of Green Tea Extracts Affects the Antioxidant Activity and Degradation of Catechins in DHA-Rich Oil. Antioxidants, 11(9), 1844 [1-17]. https://doi.org/10.3390/antiox11091844 (Original work published 2022)
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Abdul Khaliq, H., Al Houayek, M., Leclercq, J., & Muccioli, G. (2022). 5’AMP-activated protein kinase: an emerging target of phytochemicals to treat chronic inflammatory diseases. Critical Reviews in Food Science and Nutrition, 1-26. https://doi.org/10.1080/10408398.2022.2145264 (Original work published 2022)
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Mamede, L., Fall, F., Schoumacher, M., Ledoux, A., De Tullio, P., Leclercq, J., & Frédérich, M. (2022). Recent metabolomic developments for antimalarial drug discovery. Parasitology Research, 121(12), 3351-3380. https://doi.org/10.1007/s00436-022-07673-7 (Original work published 2022)
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Abdul Khaliq, H., Ortiz Aguirre, S. E., Al Houayek, M., Neyts, T., Muccioli, G., & Leclercq, J. (2022). Effect of a methanolic extract of Salvadora oleoides Decne. on LPS-activated J774 macrophages, its in vitro and in vivo toxicity study and dereplication of its chemical constituents. Toxicology Reports, 9, 1742-1753. https://doi.org/10.1016/j.toxrep.2022.09.004 (Original work published 2022)
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Abdul Khaliq, H., Ortiz Aguirre, S. E., Al Houayek, M., Muccioli, G., & Leclercq, J. (2022). Dereplication and Quantification of Major Compounds of L. Extracts and Assessment of Their Effect on LPS-Activated J774 Macrophages. Molecules (Basel, Switzerland), 27(3), 963 [1-19]. https://doi.org/10.3390/molecules27030963 (Original work published 2022)
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Article de journalde Oliveira, A. C., Miyagawa, L. M., Monteiro, K. M., Dias, A. L. S., Longato, G. B., Spindola, H., Vendramini‐Costa, D. B., Leclercq, J., Carvalho, J. E., & Rogez, H. (2021). Phenolic composition, antiproliferative and antiulcerogenic activities of a polyphenol‐rich purified extract from açai ( Euterpe oleracea ) fruits. International Journal of Food Science & Technology (Print) : a leading international forum for high quality research with a practical application, 1-89. https://doi.org/10.1111/ijfs.15332 (Original work published 2021)
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Tchetan, E., Olounlade, A. P., Houehanou, T. D., Azando, E. V. B., Kaneho, J. A., Houinato, M. R. B., Hounzangbe-Adote, S. M., Leclercq, J., & Gbaguidi, F. A. (2021). Ethnoveterinary knowledge of sheep and goat farmers in Benin (West Africa): effect of socioeconomic and environmental factors. Heliyon, 7(7), e07656 [1-14]. https://doi.org/10.1016/j.heliyon.2021.e07656 (Original work published 2021)
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Muganga, R., Bero, J., Leclercq, J., Angenot, L., Tits, M., Mouithys-Mickalad, A., Franck, T., & Frédérich, M. (2021). In vitro Antileishmanial, Antitrypanosomal, and Anti-inflammatory-like Activity of Terminalia mollis Root Bark. Planta medica, 87(9), 724-731. https://doi.org/10.1055/a-1260-6382 (Original work published 2021)
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Nguyen, T. H., Nguyen, P. D., Leclercq, J., Muller, M., Ly Huong, D. T., Pham, H. T., & Kestemont, P. (2021). Developmental Toxicity of Clerodendrum cyrtophyllum Turcz Ethanol Extract in Zebrafish Embryo. Journal of Ethnopharmacology, 267, 113538 [1-15]. https://doi.org/10.1016/j.jep.2020.113538 (Original work published 2021)
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Sounouvou, H. T., Toukourou, K. H., Catteau, L., Toukourou, F., Evrard, B., Van Bambeke, F., Gbaguidi, F., & Leclercq, J. (2021). Antimicrobial potentials of essential oils extracted from West African aromatic plants on common skin infections. Scientific African, 11, e00706 [1-12]. https://doi.org/10.1016/j.sciaf.2021.e00706 (Original work published 2021)
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Catteau, L., Schioppa, L., Beaufay, C., Girardi, C., Herent, M.-F., Frédérich, M., & Leclercq, J. (2021). Antiprotozoal activities of Triterpenic Acids and Ester Derivatives Isolated from the Leaves of Vitellaria paradoxa. Planta medica, 87(10-11), 860-867. https://doi.org/10.1055/a-1286-1879 (Original work published 2021)
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Schioppa, L., Fall, F., Ortiz Aguirre, S. E., Poupaert, J., & Leclercq, J. (2021). A Validated HPLC-PDA-HRMS Method to Investigate the Biological Stability and Metabolism of Antiparasitic Triterpenic Esters. Molecules, 26(23), 7154 [1-13]. https://doi.org/10.3390/molecules26237154 (Original work published 2021)
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Sounouvou, H. T., Defourny, C., Gbaguidi, F., Ziemons, E., Piel, G., Leclercq, J., & Evrard, B. (2021). Development of a highly persistent silicone-based sprayable emulsion containing essential oils for treatment of skin infections. International Journal of Pharmaceutics, 596, 120214 [1-10]. https://doi.org/10.1016/j.ijpharm.2021.120214 (Original work published 2021)
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El-Hilaly, J., Amarouch, M.-Y., Morel, N., Lyoussi, B., & Leclercq, J. (2021). Ajuga iva water extract antihypertensive effect on stroke-prone spontaneously hypertensive rats, vasorelaxant effects ex vivo and in vitro activity of fractions. Journal of Ethnopharmacology, 270, 113791 [1-8]. https://doi.org/10.1016/j.jep.2021.113791 (Original work published 2021)
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Tchetan, E., Olounlade, A. P., Azando, E. V. B., Quinet, M., Marcotty, T., Hounzangbe-Adoté, S. M., Leclercq, J., & Gbaguidi, F. A. (2021). La médecine ethnovétérinaire à la croisée de la recherche scientifique : synthèse des connaissances et perspectives. Revue d’Elevage et de Medecine Veterinaire des Pays Tropicaux, 74(3), 167-175. https://doi.org/10.19182/remvt.36762 (Original work published 2021)
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Verstraeten, S., Catteau, L., Boukricha, L., Leclercq, J., & Mingeot-Leclercq, M.-P. (2021). Effect of Ursolic and Oleanolic Acids on Lipid Membranes: Studies on MRSA and Models of Membranes. Antibiotics, 10(11), 1381 [1-18]. https://doi.org/10.3390/antibiotics10111381 (Original work published 2021)
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Schioppa, L., Beaufay, C., Bonneau, N., Sanchez, M., Girardi, C., Leverrier, A., Ortiz Aguirre, S. E., Palermo, J., Poupaert, J., & Leclercq, J. (2021). Design, Synthesis and Biological Activity of C3 Hemisynthetic Triterpenic Esters as Novel Antitrypanosomal Hits. ChemistryOpen, 10(9), 896-903. https://doi.org/10.1002/open.202100159 (Original work published 2021)
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Article de journalZinsou, A., Assanhou, A. G., Ganfon, H., Sounouvou, H., Kassehin, U. C., Lawson, R. F., Medegan, S., Evrard, B., Leclercq, J., & Gbaguidi, F. A. (2020). Development of new dermatological formulations for the treatment of cutaneous candidiasis. Scientific African, 8, e00342 [1-8]. https://doi.org/10.1016/j.sciaf.2020.e00342 (Original work published 2020)
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Toukourou, K. H., Uwambayinema, F., Yakoub, Y., Mertens, B., Laleye, A., Lison, D., Leclercq, J., & Gbaguidi, F. (2020). In Vitro and In Vivo Toxicity Studies on Cymbopogon giganteus Chiov. Leaves Essential Oil From Benin. Journal of Toxicology, 2020, 8261058 [1-12]. https://doi.org/10.1155/2020/8261058 (Original work published 2020)
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Dori, D., Assanhou, G. A., Evrard, B., Leclercq, J., & Semdé, R. (2020). Evaluation of National Quality Control Capacity for Herbal Medicines in West Africa: the Case of Benin and Burkina Faso. Health Sciences and Disease, 21(11), 53-58. (Original work published 2020)
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Nhu, T. Q., Bich Hang, B. T., Cornet, V., Oger, M., Bach, L. T., Anh Dao, N. L., Thanh Huong, D. T., Leclercq, J., Scippo, M.-L., Phuong, N. T., & Kestemont, P. (2020). Single or Combined Dietary Supply of Psidium guajava and Phyllanthus amarus Extracts Differentially Modulate Immune Responses and Liver Proteome in Striped Catfish (Pangasianodon hyphophthalmus). Frontiers in Immunology, 11, 797 [1-22]. https://doi.org/10.3389/fimmu.2020.00797 (Original work published 2020)
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Dori, D., Méda, N., Gbaguidi, F. A., Leclercq, J., & Semdé, R. (2020). Distribution en gros et délivrance des médicaments à base de plantes à travers le circuit pharmaceutique du Burkina Faso. Annales Pharmaceutiques Francaises, 78(2), 179-188. https://doi.org/10.1016/j.pharma.2019.12.003 (Original work published 2020)
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Nhu, T. Q., Nguyen, P. D., Bich Hang, B. T., Bach, L. T., Thanh Huong, D. T., Buu Hue, B. T., Scippo, M.-L., Phuong, N. T., Leclercq, J., & Kestemont, P. (2020). Immunomodulatory potential of extracts, fractions and pure compounds from Phyllanthus amarus and Psidium guajava on striped catfish (Pangasianodon hypophthalmus) head kidney leukocytes. Fish and Shellfish Immunology, 104, 289-303. https://doi.org/10.1016/j.fsi.2020.05.051 (Original work published 2020)
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Landoulsi, A., Hennebelle, T., Bero, J., Rivière, C., Sahpaz, S., Leclercq, J., Neut, C., Benhamida, J., & Roumy, V. (2020). Antimicrobial and Light-Enhanced Antimicrobial Activities, Cytotoxicity and Chemical Variability of All Tunisian Eryngium Species. Chemistry & Biodiversity, 17(4), e1900543 [1-13]. https://doi.org/10.1002/cbdv.201900543 (Original work published 2020)
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Le Anh Dao, N., Phu, T. M., Douny, C., Leclercq, J., Hue, B. T. B., Bach, L. T., Quynh Nhu, T., Thi Bich Hang, B., Thi Thanh Huong, D., Thanh Phuong, N., Kestemont, P., & Scippo, M.-L. (2020). Screening and comparative study of in vitro antioxidant and antimicrobial activities of ethanolic extracts of selected Vietnamese plants. International Journal of Food Properties, 23(1), 481-496. https://doi.org/10.1080/10942912.2020.1737541 (Original work published 2020)
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Adjibodé, S. M., Kassehin, C. U., Médégan, S. F., Leclercq, J., Gbaguidi, F. A., & Poupaert, J. (2020). Solar light photo-catalyzed condensation of aldones with 4-phenylthiosemicarbazide, a green chemistry approach. Journal of Medicinal and Chemical Sciences, 3(3), 228-234. https://doi.org/10.26655/JMCHEMSCI.2020.3.4 (Original work published 2020)
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Sounouvou, H. T., Lechanteur, A., Leclercq, J., Piel, G., Donneau, A.-F., Gbaguidi, F., & Evrard, B. (2020). Chromametric assessment of drug skin tolerance: A comparative study between Africans and Caucasians skins. Skin Research and Technology, 26(3), 329-337. https://doi.org/10.1111/srt.12804 (Original work published 2020)
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Toukourou, K. H., Sounouvou, H., Catteau, L., Toukourou, F., Van Bambeke, F., Gbaguidi, F., & Leclercq, J. (2020). Cymbopogon giganteus Chiov. essential oil: Direct effects or activity in combination with antibiotics against multi-drug resistant bacteria. Journal of Applied Biology & Biotechnology, 8(1), 84-89. https://doi.org/10.7324/jabb.2020.80114 (Original work published 2020)
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