Research
libst | Louvain-la-Neuve
The Functional and Reproductive Morphology (FORM) group has recently been established within the AMCB, with the goal of exploring the detailed morphological features of female reproductive tissues, focusing on the breast and ovaries. In addition, we aim to understand how endocrine-disrupting chemicals impact these tissues and alter reproductive function.
Our primary focus is to describe the morphological characteristics of cells and their surrounding environment—the extracellular matrix, which is composed of a complex mix of fibers, proteoglycans, and glycosaminoglycans. To create a precise map of these components, we use advanced techniques like microscopy (Figure 1, showing collagen fibers within human breast tissue in reproductive age) and proteomics, considering the dynamic changes of the female reproductive tissues. Their structure and function change in response to the organism's hormonal milieu. By studying these tissues in different physiological conditions, we can better understand how their molecular context shifts.

This is a key knowledge for developing tailored in vitro models, such as organoids, that accurately mimic the natural environment of female reproductive tissues. These models hold significant potential for toxicological and pharmacological studies, allowing us to investigate how common endocrine disruptors—such as phthalates, bisphenols, and organochlorines—affect reproductive health. Creating an in vitro environment that closely mirrors the natural biological conditions is essential for obtaining reliable results that can guide future research and interventions.