Publications

Cerckel, G., Dereinne, D., Ledesma-García, L., Meuric, V., Desguin, B., Mignolet, J., Soumillion, P., & Hols, P. (2026). Non-peptide dysbiosis metabolites reprogram a peptide quorum-sensing receptor to induce sustained predation in beneficial streptococci. PLoS Biology, 24(3), e3003718. https://doi.org/10.1371/journal.pbio.3003718 (Original work published 2026)

Revilla-Guarinos, A., Camelo Castillo, A., Cebrián, R., Ferrer, M. D., López-López, A., Adrados-Planell, A., Lahoz Oliva, S., Ledesma, L., Hols, P., & Mira, Á. (2026). Streptococcus dentisani 7746 encodes a cocktail of 14 bacteriocins associated with Com and Blp-like quorum sensing regulatory systems. Journal of Oral Microbiology, 18(1), 1-22. https://doi.org/10.1080/20002297.2026.2633915 (Original work published 2026)

Damoczi, J., Pigeolet, L., Cassiers, C., Mignolet, J., & Hols, P. (2026). A streamlined ABC extruder-repressor module drives multi-bacteriocin resistance in streptococci. BIORXIV. Submitted. https://doi.org/10.64898/2026.02.18.706565 (Original work published 2026)

Quintero-Yanes, A., Petit, K., Rodriguez-Villalobos, H., Vande Capelle, H., De Veirman, O., Gerstmans, H., Masschelein, J., Borrero, J., Hols, P., & Gabant, P. (2025). Multiplexed bacteriocin synthesis to combat and prevent antimicrobial resistance. Communications biology, 8(1), 1246. https://doi.org/10.1038/s42003-025-08639-y (Original work published 2025)

Damoczi, J., Knoops, A., Martou, M.-S., Jaumaux, F., Gabant, P., Mahillon, J., Veening, J.-W., Mignolet, J., & Hols, P. (2024). Uncovering the arsenal of class II bacteriocins in salivarius streptococci. Communications biology, 7(1), 1511. https://doi.org/10.1038/s42003-024-07217-y (Original work published 2024)

Toussaint, F., Henry de Frahan, M., Poncelet, F., Ladrière, J.-M., Horvath, P., Fremaux, C., & Hols, P. (2024). Unveiling the regulatory network controlling natural transformation in lactococci. PLoS genetics, 20(7), e1011340. https://doi.org/10.1371/journal.pgen.1011340 (Original work published 2024)

Di Giacomo, S., Toussaint, F., Ledesma-García, L., Knoops, A., Vande Capelle, F., Fremaux, C., Horvath, P., Ladrière, J.-M., Ait-Abderrahim, H., Hols, P., & Mignolet, J. (2022). Expanding natural transformation to improve beneficial lactic acid bacteria. FEMS microbiology reviews, 46(4), 1-15. https://doi.org/10.1093/femsre/fuac014 (Original work published 2022)

Knoops, A., Vande Capelle, F., Fontaine, L., Verhaegen, M., Mignolet, J., Goffin, P., Mahillon, J., Sass, A., Coenye, T., Ledesma-García, L., & Hols, P. (2022). The CovRS Environmental Sensor Directly Controls the ComRS Signaling System To Orchestrate Competence Bimodality in Salivarius Streptococci. mBio, 13(1), e03125-21. https://doi.org/10.1128/mbio.03125-21 (Original work published 2022)

Knoops, A., Ledesma-García, L., Waegemans, A., Lamontagne, M., Decat, B., Degand, H., Morsomme, P., Soumillion, P., Delvigne, F., & Hols, P. (2022). Competence shut-off by intracellular pheromone degradation in salivarius streptococci. PLOS Genetics, 18(5), e1010198. https://doi.org/10.1371/journal.pgen.1010198 (Original work published 2022)

Knoops, A., Waegemans, A., Lamontagne, M., Decat, B., Mignolet, J., Veening, J.-W., & Hols, P. (2022). A Genome-Wide CRISPR Interference Screen Reveals an StkP-Mediated Connection between Cell Wall Integrity and Competence in Streptococcus salivarius. mSystems, 7(6), e0073522. https://doi.org/10.1128/msystems.00735-22 (Original work published 2022)

Ledesma-García, L., Ensinck, I., Dereinne, D., Viela Bovio, F., Mignolet, J., Dufrêne, Y., Soumillion, P., Nessler, S., & Hols, P. (2021). Co-evolution of the bacterial pheromone ComS and sensor ComR fine-tunes natural transformation in streptococci. Journal of Biological Chemistry, 101346. https://doi.org/10.1016/j.jbc.2021.101346 (Original work published 2021)

Desguin, B., Urdiain-Arraiza, J., Da Costa, M., Fellner, M., Hu, J., Hausinger, R. P., Desmet, T., Hols, P., & Soumillion, P. (2020). Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases. Scientific Reports, 10(1), 18123. https://doi.org/10.1038/s41598-020-74802-6 (Original work published 2020)

Ledesma-García, L., Thuillier, J., Guzman-Espinola, A., Ensinck, I., Li de la Sierra-Gallay, I., Lazar, N., Aumont-Nicaise, M., Mignolet, J., Soumillion, P., Nessler, S., & Hols, P. (2020). Molecular dissection of pheromone selectivity in the competence signaling system ComRS of streptococci. Proceedings of the National Academy of Sciences, 117(14), 201916085. https://doi.org/10.1073/pnas.1916085117 (Original work published 2020)