Developmental neurobiology (DENE)
ions | Bruxelles Woluwe, Louvain-la-Neuve
Research
How neurons are specified during development and how they connect to each other to shape thoughts and behaviour are fascinating questions in neuroscience. The overall aim of our research is to understand the mechanisms that govern the development of the nervous system in physiological and pathological conditions, using a combination of molecular, cellular, and genetic approaches. Our studies emphasize in the role of Planar Cell Polarity (PCP) genes and cytoskeletal associated proteins such as the formin protein DIAPH3 and the microtubule binding protein KIF2A, in brain development and diseases. We uncovered key functions for these proteins in cell division, polarity, migration, and axon guidance; and linked their dysfunctions to several neurological disorders such as microcephaly, epilepsy, autism, and primary brain tumours.
Video DENE
Fadel TISSIR, Principal Investigator
Nuria RUIZ REIG, Postdoctoral researcher
Irene DURA ESTEVE, Postdoctoral researcher
Sanaa AHERDAN, Research technician
Sayed JREIGE, Research technician
Iliam AOMAR EL KARMOUDI, Research Technician
Publications
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2025
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2024
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2023
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2022
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2021
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2020
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2019
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2018
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2017
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1994
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Article de journalRuiz Reig, N., Virosztek, M., Chehade, G., Suelves Caballol, N., Zola, N. K. N., Salman, Y., Schakman, O., Kienlen-Campard, P., Hanseeuw, B., & Tissir, F. (2025). KIF2A downregulation links amyloid-β to Tau phosphorylation in Alzheimer’s disease. Brain : a journal of neurology. Accepted/in-press. https://doi.org/10.1093/brain/awaf382 (Original work published 2025)
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Boucherie, C., Alkailani, M., Jossin, Y., Ruiz Reig, N., Mahdi, A., Aldaalis, A., Aittaleb, M., & Tissir, F. (2025). Auts2 enhances neurogenesis and promotes expansion of the cerebral cortex. Journal of advanced research, 72, 151-163. https://doi.org/10.1016/j.jare.2024.07.012 (Original work published 2025)
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Article de journalChehade, G., El Hajj, N., Aittaleb, M., Alkailani, M. I., Bejaoui, Y., Mahdi, A., Aldaalis, A. A. H., Verbiest, M., Lelotte, J., Ruiz Reig, N., Durá Esteve, I., Raftopoulos, C., Tajeddine, N., & Tissir, F. (2024). DIAPH3 predicts survival of patients with -methylated glioblastoma. Frontiers in Oncology, 14, 1359652 [1-11]. https://doi.org/10.3389/fonc.2024.1359652 (Original work published 2024)
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Ruiz Reig, N., Chehade, G., Yerna, X., Durá Esteve, I., Gailly, P., & Tissir, F. (2024). Aberrant generation of dentate gyrus granule cells is associated with epileptic susceptibility in p53 conditional knockout mice. Frontiers in neuroscience, 18, 1418973 [1-10]. https://doi.org/10.3389/fnins.2024.1418973 (Original work published 2024)
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Ruiz Reig, N., Hakanen, J. T., & Tissir, F. (2024). Connecting neurodevelopment to neurodegeneration: a spotlight on the role of kinesin superfamily protein 2A (KIF2A). Neural Regeneration Research, 19(2), 375-379. https://doi.org/10.4103/1673-5374.375298 (Original work published 2024)
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Article de journalRuiz Reig, N., García-Sánchez, D., Schakman, O., Gailly, P., & Tissir, F. (2023). Inhibitory synapse dysfunction and epileptic susceptibility associated with KIF2A deletion in cortical interneurons. Frontiers in Molecular Neuroscience, 15, 1110986 [1-9]. https://doi.org/10.3389/fnmol.2022.1110986 (Original work published 2023)
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Liu, A., Yu, L., Li, X., Zhang, K., Zhang, W., So, K.-F., Tissir, F., Qu, Y., & Zhou, L. (2023). Celsr2-mediated morphological polarization and functional phenotype of reactive astrocytes in neural repair. Glia, 71(8), 1985-2004. https://doi.org/10.1002/glia.24378 (Original work published 2023)
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Chehade, G., Lawson, T. M., Lelotte, J., Daoud, L., Di Perri, D., Whenham, N., Duprez, T., Tajeddine, N., Tissir, F., & Raftopoulos, C. (2023). Long-term survival in patients with IDH-wildtype glioblastoma: clinical and molecular characteristics. Acta Neurochirurgica : the European journal of neurosurgery, 165(4), 1075-1085. https://doi.org/10.1007/s00701-023-05544-3 (Original work published 2023)
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Article de journalLi, C., Wei, J.-A., Wang, D., Luo, Z., Pang, C., Chen, K., Duan, J., Chen, B., Zhou, L., Tissir, F., Shi, L., So, K.-F., Zhang, L., & Qu, Y. (2022). Planar cell polarity protein Celsr2 maintains structural and functional integrity of adult cortical synapses. Progress in Neurobiology, 219, 102352 [1-14]. https://doi.org/10.1016/j.pneurobio.2022.102352 (Original work published 2022)
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Alkailani, M. I., Aittaleb, M., & Tissir, F. (2022). WNT signaling at the intersection between neurogenesis and brain tumorigenesis. Frontiers in Molecular Neuroscience, 15, 1017568 [1-17]. https://doi.org/10.3389/fnmol.2022.1017568 (Original work published 2022)
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Wen, Q., Weng, H., Liu, T., Yu, L., Zhao, T., Qin, J., Li, S., Wu, Q., Tissir, F., Qu, Y., & Zhou, L. (2022). Inactivating Celsr2 promotes motor axon fasciculation and regeneration in mouse and human. Brain : a journal of neurology, 145(2), 670-683. https://doi.org/10.1093/brain/awab317 (Original work published 2022)
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Hakanen, J. T., Parmentier, N., Sommacal, L., Garcia Sanchez, D., Aittaleb, M., Vertommen, D., Zhou, L., Ruiz Reig, N., & Tissir, F. (2022). The Celsr3-Kif2a axis directs neuronal migration in the postnatal brain. Progress in Neurobiology, 208(1), 102177. https://doi.org/10.1016/j.pneurobio.2021.102177 (Original work published 2022)
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Ruiz Reig, N., Chehade, G., Hakanen, J. T., Aittaleb, M., Wierda, K., De Wit, J., Nguyen, L., Gailly, P., & Tissir, F. (2022). KIF2A deficiency causes early-onset neurodegeneration. Proceedings of the National academy of sciences of the United States of America, 119(46), e2209714119 [1-11]. https://doi.org/10.1073/pnas.2209714119 (Original work published 2022)
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Article de journalEzan, J., Moreau, M. M., Mamo, T. M., Shimbo, M., Decroo, M., Richter, M., Peyroutou, R., Rachel, R., Tissir, F., de Anda, F. C., Sans, N., & Montcouquiol, M. (2021). Early loss of Scribble affects cortical development, interhemispheric connectivity and psychomotor activity. Scientific Reports, 11(1), 9106 [1-17]. https://doi.org/10.1038/s41598-021-88147-1 (Original work published 2021)
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Lau, E. O.-C., Damiani, D., Chehade, G., Ruiz-Reig, N., Saade, R., Jossin, Y., Aittaleb, M., Schakman, O., Tajeddine, N., Gailly, P., & Tissir, F. (2021). DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction. eLife, 10(10), 61974. https://doi.org/10.7554/eLife.61974 (Original work published 2021)
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Zhou, Q., Qin, J., Liang, Y., Zhang, W., He, S., Tissir, F., Qu, Y., & Zhou, L. (2021). Celsr3 is required for Purkinje cell maturation and regulates cerebellar postsynaptic plasticity. iScience, 24(7), 102812 [1-17]. https://doi.org/10.1016/j.isci.2021.102812 (Original work published 2021)
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Article de journalGualdani, R., Seghers, F., Yerna, X., Schakman, O., Tajeddine, N., Achouri, Y., Tissir, F., Devuyst, O., & Gailly, P. (2020). Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells. Science Signaling, 13(653), eabc6967. https://doi.org/10.1126/scisignal.abc6967 (Original work published 2020)
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Toch, M., Harris, A., Schakman, O., Kondratskaya, E., Boulland, J.-L., Dauguet, N., Debrulle, S., Baudouin, C., Hidalgo-Figueroa, M., Gow, A., Glover, J. C., Tissir, F., & Clotman, F. (2020). Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits. Scientific Reports, 10(1), 996 [1-17]. https://doi.org/10.1038/s41598-020-57945-4 (Original work published 2020)
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Aragona, M., Sifrim, A., Malfait, M., Song, Y., Van Herck, J., Dekoninck, S., Gargouri, S., Lapouge, G., Swedlund, B., Dubois, C., Baatsen, P., Vints, K., Han, S., Tissir, F., Voet, T., Simons, B. D., & Blanpain, C. (2020). Mechanisms of stretch-mediated skin expansion at single-cell resolution. Nature, 584(7820), 268-273. https://doi.org/10.1038/s41586-020-2555-7 (Original work published 2020)
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Yerna, X., Schakman, O., Ratbi, I., Kreis, A., Lepannetier, S., De Clippele, M., Achouri, Y., Tajeddine, N., Tissir, F., Gualdani, R., & Gailly, P. (2020). Role of the TRPC1 Channel in Hippocampal Long-Term Depression and in Spatial Memory Extinction. International Journal of Molecular Sciences, 21(5). https://doi.org/10.3390/ijms21051712 (Original work published 2020)
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Article de journalDebrulle, S., Baudouin, C., Hidalgo-Figueroa, M., Pelosi, B., Francius, C., Rucchin, V., Ronellenfitch, K., Chow, R. L., Tissir, F., Lee, S.-K., & Clotman, F. (2019). Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development. Cellular and Molecular Life Sciences. Accepted/in-press. https://doi.org/10.1007/s00018-019-03408-7 (Original work published 2019)
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Lindenmaier, L. B., Parmentier, N., Guo, C., Tissir, F., & Wright, K. M. (2019). Dystroglycan is a scaffold for extracellular axon guidance decisions. eLife, 8 (2019). https://doi.org/10.7554/eLife.42143 (Original work published 2019)
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Meyer, G., González-Arnay, E., Moll, U., Nemajerova, A., Tissir, F., & González-Gómez, M. (2019). Cajal-Retzius neurons are required for the development of the human hippocampal fissure. Journal of anatomy. Published. https://doi.org/10.1111/joa.12947 (Original work published 2019)
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Hakanen, J., Ruiz-Reig, N., & Tissir, F. (2019). Linking Cell Polarity to Cortical Development and Malformations. Frontiers in Cellular Neuroscience, 13, 244. https://doi.org/10.3389/fncel.2019.00244 (Original work published 2019)
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Article de journalBoucherie, C., Boutin, C., Jossin, Y., Schakman, O., Goffinet, A., Ris, L., Gailly, P., & Tissir, F. (2018). Neural progenitor fate decision defects, cortical hypoplasia and behavioral impairment in Celsr1-deficient mice. Molecular Psychiatry, 23(3), 723-734. https://doi.org/10.1038/mp.2017.236 (Original work published 2018)
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Clotman, F., & Tissir, F. (2018). Guidance of motor axons: where do we stand? Current Opinion in Physiology, 4, 76-81. https://doi.org/10.1016/j.cophys.2018.06.004 (Original work published 2018)
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Fuertes-Alvarez, S., Maeso-Alonso, L., Villoch-Fernandez, J., Wildung, M., Martin-Lopez, M., Marshall, C., Villena-Cortes, A. J., Diez-Prieto, I., Pietenpol, J. A., Tissir, F., Lizé, M., Marques, M. M., & Marin, M. C. (2018). p73 regulates ependymal planar cell polarity by modulating actin and microtubule cytoskeleton. Cell Death & Disease, 9(1183). https://doi.org/10.1038/s41419-018-1205-6 (Original work published 2018)
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Lepannetier, S., Gualdani, R., Tempesta, S., Schakman, O., Seghers, F., Kreis, A., Yerna, X., Slimi, A., De Clippele, M., Tajeddine, N., Voets, T., Bon, R. S., Beech, D. J., Tissir, F., & Gailly, P. (2018). Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory. Frontiers in Cellular Neuroscience, 12, 318. https://doi.org/10.3389/fncel.2018.00318 (Original work published 2018)
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Papier de conférenceArgyropoulou, V., Goemaere Julie, Lefort, C., Tissir, F., Huaux, F., Guiot, Y., Marbaix, E., Galant, C., & Knoops, B. (2018). Role of peroxiredoxin-5 in inflammation and tumor suppression. Groupe de contact FNRS “Oxidative Processes and Antioxidants” meeting on “Oxidative Stress in Subcellular Compartments”, Namur, Belgium.
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Article de journalMesséant, J., Ezan, J., Delers, P., Glebov, K., Marchiol, C., Lager, F., Renault, G., Tissir, F., Montcouquiol, M., Sans, N., Legay, C., & Strochlic, L. (2017). Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways. Development (Cambridge), 144, 1712-1724. https://doi.org/10.1242/dev.146167 (Original work published 2017)
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Duncan, J. S., Stoller, M. L., Francl, A. F., Tissir, F., Devenport, D., & Deans, M. R. (2017). Celsr1 coordinates the planar polarity of vestibular hair cells during inner ear development. Developmental Biology, 423, 126-137. https://doi.org/10.1016/j.ydbio.2017.01.020 (Original work published 2017)
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Goffinet, A., & Tissir, F. (2017). Seven pass Cadherins CELSR1-3. Seminars in Cell and Developmental Biology, 69, 102-110. https://doi.org/10.1016/j.semcdb.2017.07.014 (Original work published 2017)
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Article de journalLedonne, F., Orduz, D., Mercier, J., Vigier, L., Grove, E. A., Tissir, F., Angulo, M. C., Pierani, A., & Coppola, E. (2016). Targeted Inactivation of Bax Reveals a Subtype-Specific Mechanism of Cajal-Retzius Neuron Death in the Postnatal Cerebral Cortex. Cell Reports, 17(12), 3133-3141. https://doi.org/10.1016/j.celrep.2016.11.074 (Original work published 2016)
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de Frutos, C. A., Bouvier, G., Arai, Y., Thion, M. S., Lokmane, L., Keita, M., Garcia-Dominguez, M., Charnay, P., Hirata, T., Riethmacher, D., Grove, E. A., Tissir, F., Casado, M., Pierani, A., & Garel, S. (2016). Reallocation of Olfactory Cajal-Retzius Cells Shapes Neocortex Architecture. Neuron, 92(2), 435-448. https://doi.org/10.1016/j.neuron.2016.09.020 (Original work published 2016)
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Wang, W., Jossin, Y., Chai, G., Lien, W.-H., Tissir, F., & Goffinet, A. (2016). Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling. Nature Communications, 7, 10936. https://doi.org/10.1038/ncomms10936 (Original work published 2016)
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Janas, S., Seghers, F., Schakman, O., Alsady, M., Deen, P., Vriens, J., Tissir, F., Nilius, B., Loffing, J., Gailly, P., & Devuyst, O. (2016). TRPV4 is associated with central rather than nephrogenic osmoregulation. Pflügers Archiv - European journal of physiology, 468(9), 1595-1607. https://doi.org/10.1007/s00424-016-1850-5 (Original work published 2016)
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Glasco, D. M., Pike, W., Qu, Y., Reustle, L., Misra, K., Di Bonito, M., Studer, M., Fritzsch, B., Goffinet, A., Tissir, F., & Chandrasekhar, A. (2016). The atypical cadherin Celsr1 functions non-cell autonomously to block rostral migration of facial branchiomotor neurons in mice. Developmental Biology, 417(1), 40-49. https://doi.org/10.1016/j.ydbio.2016.07.004 (Original work published 2016)
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Damiani, D., Goffinet, A., Alberts, A., & Tissir, F. (2016). Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors. Nature Communications, 7, 13509. https://doi.org/10.1038/ncomms13509 (Original work published 2016)
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Ruiz-Reig, N., Andrés, B., Huilgol, D., Grove, E. A., Tissir, F., Tole, S., Theil, T., Herrera, E., & Fairén, A. (2016). Lateral Thalamic Eminence: A Novel Origin for mGluR1/Lot Cells. Cerebral Cortex, bhw126. https://doi.org/10.1093/cercor/bhw126 (Original work published 2016)
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Article de journalChai, G., Goffinet, A., & Tissir, F. (2015). Celsr3 and Fzd3 in axon guidance. The International Journal of Biochemistry & Cell Biology, 64, 11-14. https://doi.org/10.1016/j.biocel.2015.03.013 (Original work published 2015)
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Morello, F., Prasad, A. A., Rehberg, K., Vieira de Sá, R., Antón-Bolaños, N., Leyva-Diaz, E., Adolfs, Y., Tissir, F., López-Bendito, G., & Pasterkamp, R. J. (2015). Frizzled3 Controls Axonal Polarity and Intermediate Target Entry during Striatal Pathway Development. The Journal of Neuroscience, 35(42), 14205-14219. https://doi.org/10.1523/JNEUROSCI.1840-15.2015 (Original work published 2015)
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Barber, M., Arai, Y., Morishita, Y., Vigier, L., Causeret, F., Borello, U., Ledonne, F., Coppola, E., Contremoulins, V., Pfrieger, F. W., Tissir, F., Govindan, S., Jabaudon, D., Proux-Gillardeaux, V., Galli, T., & Pierani, A. (2015). Migration Speed of Cajal-Retzius Cells Modulated by Vesicular Trafficking Controls the Size of Higher-Order Cortical Areas. Current Biology, 25(19), 2466-2478. https://doi.org/10.1016/j.cub.2015.08.028 (Original work published 2015)
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Article de journalBoutin, C., Labedan, P., Dimidschstein, J., Richard, F., Cremer, H., André, P., Yang, Y., Montcouquiol, M., Goffinet, A., & Tissir, F. (2014). A dual role for planar cell polarity genes in ciliated cells. Proceedings of the National academy of sciences of the United States of America, 111(30), E3129-E3138. https://doi.org/10.1073/pnas.1404988111 (Original work published 2014)
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Chai, G., Zhou, L., Manto, M., Helmbacher, F., Clotman, F., Goffinet, A., & Tissir, F. (2014). Celsr3 is required in motor neurons to steer their axons in the hindlimb. Nature Neuroscience, 17(9), 1171-1179. https://doi.org/10.1038/nn.3784 (Original work published 2014)
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Qu, Y., Huang, Y., Feng, J., Alvarez-Bolado, G., Grove, E. A., Yang, Y., Tissir, F., Zhou, L., & Goffinet, A. (2014). Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner. Proceedings of the National academy of scinces of the United States of America, 111(29), E2996-E3004. https://doi.org/10.1073/pnas.1402105111 (Original work published 2014)
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Shi, D., Komatsu, K., Hirao, M., Toyooka, Y., Koyama, H., Tissir, F., Goffinet, A., Uemura, T., & Fujimori, T. (2014). Celsr1 is required for the generation of polarity at multiple levels of the mouse oviduct. Development (Cambridge), 141(23), 4558-4568. https://doi.org/10.1242/dev.115659 (Original work published 2014)
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Article de journalOnishi, K., Shafer, B., Lo, C., Tissir, F., Goffinet, A., & Zou, Y. (2013). Antagonistic Functions of Dishevelleds Regulate Frizzled3 Endocytosis via Filopodia Tips in Wnt-Mediated Growth Cone Guidance. The Journal of Neuroscience, 33(49), 19071-19085. https://doi.org/10.1523/JNEUROSCI.2800-13.2013 (Original work published 2013)
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Tissir, F., & Goffinet, A. (2013). Shaping the nervous system: role of the core planar cell polarity genes. Nature Reviews. Neuroscience, 14, 525-535. https://doi.org/10.1038/nrn3525 (Original work published 2013)
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Tatin, F., Taddei, A., Weston, A., Fuchs, E., Davenport, D., Tissir, F., & Makinen, T. (2013). Planar cell polarity protein Celsr1 regulates endothelial adherens junctionsand directed cell rearrangements during lymphatic valve morphogenesis. Developmental Cell, 26(1), 31-44. https://doi.org/10.1016/j.devcel.2013.05.015 (Original work published 2013)
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Tissir, F., & Goffinet, A. (2013). Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts. Molecular Neurodegeneration, 8(10). https://doi.org/10.1186/1750-1326-8-10 (Original work published 2013)
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Sasselli, V., Boesmans, W., Vanden Berghe, P., Tissir, F., Goffinet, A., & Pachnis, V. (2013). Planar cell polarity genes control the connectivity of enteric neurons. Journal of Clinical Investigation, 123(4), 1763-1772. https://doi.org/10.1172/JCI66759 (Original work published 2013)
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Chapitre de livreTissir, F., & Goffinet, A. (2013). Atypical cadherins Celsr1-3 and planar cell polarity in vertebrates. In “The Molecular Biology of Cadherins”. https://doi.org/10.1016/B978-0-12-394311-8.00009-1
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Article de journalFeng, J., Xu, Y., Wang, M., Ruan, Y., So, K.-F., Tissir, F., Goffinet, A., & Zhou, L. (2012). A role for atypical cadherin Celsr3 in hippocampal maturation and connectivity. The Journal of Neuroscience, 32(40), 13729-13743. https://doi.org/10.1523/JNEUROSCI.1965-12.2012 (Original work published 2012)
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Tissir, F., & Goffinet, A. (2012). Cilia: conductors’ batons of neuronal maturation. Nature Neuroscience, 15(3), 344-345. https://doi.org/10.1038/nn.3050 (Original work published 2012)
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Cortijo, C., Gouzi, M., Tissir, F., & Grapin-Botton, A. (2012). Planar cell polarity controls pancreatic Beta cell differentiation and glucose homeostasis. Cell Reports, 2(6), 1593-1606. https://doi.org/10.1016/j.celrep.2012.10.016 (Original work published 2012)
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Boutin, C., Goffinet, A., & Tissir, F. (2012). Celsr1-3 Cadherins in PCP and Brain Development. Current Topics in Developmental Biology, 101, 161-183. https://doi.org/10.1016/B978-0-12-394592-1.00010-7 (Original work published 2012)
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Pietri, S., Dimidschstein, J., Tiberi, L., Sotiropoulou, P. A., Bilheu, A., Goffinet, A., Achouri, Y., Tissir, F., Blanpain, C., Jacquemin, P., & Vanderhaeghen, P. (2012). Transcriptional mechanisms of EphA7 gene expression in the developing cerebral cortex. Cerebral Cortex, 22(7), 1678-1689. https://doi.org/10.1093/cercor/bhr245 (Original work published 2012)
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Article de journalTissir, F., & Goffinet, A. (2011). p73 and p63: Estranged relatives? Cell Cycle, 10(9), 1352-1351. https://doi.org/10.4161/cc.10.9.15383 (Original work published 2011)
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Article de journalZhou, L., Gall, D., Qu, Y., Prigogine, C., Cheron, G., Tissir, F., Schiffmann, S. N., & Goffinet, A. (2010). Maturation of “neocortex isole” in vivo in mice. The Journal of Neuroscience, 30(23), 7928-7939. https://doi.org/10.1523/JNEUROSCI.6005-09.2010 (Original work published 2010)
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Qu, Y., Glasco, D. M., Zhou, L., Sawant, A., Ravni, A., Fritzsch, B., Damrau, C., Murdoch, J. N., Evans, S., Pfaff, S. L., Formstone, C., Goffinet, A., Chandrasekhar, A., & Tissir, F. (2010). Atypical Cadherins Celsr1-3 Differentially Regulate Migration of Facial Branchiomotor Neurons in Mice. The Journal of Neuroscience, 30(28), 9392-9401. https://doi.org/10.1523/JNEUROSCI.0124-10.2010 (Original work published 2010)
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Tissir, F., & Goffinet, A. (2010). Planar cell polarity signaling in neural development. Current Opinion in Neurobiology, 20(5), 572-577. https://doi.org/10.1016/j.conb.2010.05.006 (Original work published 2010)
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Ravni, A., Goffinet, A., & Tissir, F. (2010). DeltaNp73 transcription factors modulate cell survival and tumor development. Cell Cycle, 9(8), 1523-1527. https://doi.org/10.4161/cc.9.8.11291 (Original work published 2010)
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Tissir, F., Qu, Y., Montcouquiol, M., Zhou, L., Komatsu, K., Shi, D., Fujimori, T., Labeau, J., Tyteca, D., Courtoy, P., Poumay, Y., Uemura, T., & Goffinet, A. (2010). Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nature Neuroscience, 13(6), 700-707. https://doi.org/10.1038/nn.2555 (Original work published 2010)
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Fenstermaker, A. G., Prasad, A. A., Bechara, A., Adolfs, Y., Tissir, F., Goffinet, A., Zou, Y., & Pasterkamp, R. J. (2010). Wnt/Planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem. The Journal of Neuroscience, 30(47), 16053-16064. https://doi.org/10.1523/JNEUROSCI.4508-10.2010 (Original work published 2010)
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Griveau, A., Borello, U., Causeret, F., Tissir, F., Boggetto, N., Karaz, S., & Pierani, A. (2010). A Novel Role for Dbx1-Derived Cajal-Retzius Cells in Early Regionalization of the Cerebral Cortical Neuroepithelium. PLoS Biology, 8(7), e1000440. https://doi.org/10.1371/journal.pbio.1000440 (Original work published 2010)
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Article de journalRavni, A., Qu, Y., Goffinet, A., & Tissir, F. (2009). Planar Cell Polarity Cadherin Celsr1 Regulates Skin Hair Patterning in the Mouse. The Journal of Investigative Dermatology, 129(10), 2507-2509. https://doi.org/10.1038/jid.2009.84 (Original work published 2009)
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Tissir, F., Ravni, A., Achouri, Y., Riethmacher, D., Meyer, G., & Goffinet, A. (2009). DeltaNp73 regulates neuronal survival in vivo. Proceedings of the National Academy of Sciences of the United States of America, 106(39), 16871-16876. https://doi.org/10.1073/pnas.0903191106 (Original work published 2009)
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Zhou, L., Qu, Y., Tissir, F., & Goffinet, A. (2009). Role of the Atypical Cadherin Celsr3 during Development of the Internal Capsule. Cerebral cortex (New York, N.Y. : 1991), 19 Suppl 1, i114-9. https://doi.org/10.1093/cercor/bhp032 (Original work published 2009)
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Article de journalZhou, L., Goffinet, A., & Tissir, F. (2008). Rôle de la cadhérine Celsr3 dans la connectivité du cortex cérébral. M/S : médecine sciences, 24(12), 1025-1027. https://doi.org/10.1051/medsci/200824121025 (Original work published 2008)
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Zhou, L., Bar, I., Achouri, Y., Campbell, K., De Backer, O., Hebert, J. M., Jones, K., Kessaris, N., de Rouvroit, C. L., O’Leary, D., Richardson, W. D., Goffinet, A., & Tissir, F. (2008). Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice. Science, 320(5878), 946-949. https://doi.org/10.1126/science.1155244 (Original work published 2008)
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Article de journalZhou, L., Tissir, F., & Goffinet, A. (2007). The atypical cadherin Celsr3 regulates the development of the axonal blueprint. Novartis Foundation Symposium, 288, 130-4; discussion 134-40. (Original work published 2007)
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Article de journalPrice, D. J., Kennedy, H., Dehay, C., Zhou, L., Mercier, M., Jossin, Y., Goffinet, A., Tissir, F., Blakey, D., & Molnár, Z. (2006). The development of cortical connections. European Journal of Neuroscience, 23(4), 910-920. https://doi.org/10.1111/j.1460-9568.2006.04620.x (Original work published 2006)
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Tissir, F., & Goffinet, A. (2006). Expression of planar cell polarity genes during development of the mouse CNS. European Journal of Neuroscience, 23(3), 597-607. https://doi.org/10.1111/j.1460-9568.2006.04596.x (Original work published 2006)
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Article de journalTissir, F., Bar, I., Jossin, Y., & Goffinet, A. (2005). Protocadherin Celsr3 is crucial in axonal tract development. Nature Neuroscience, 8(4), 451-457. https://doi.org/10.1038/nn1428 (Original work published 2005)
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Article de journalPerez-Garcia, C., Tissir, F., Goffinet, A., & Meyer, G. (2004). Reelin receptors in developing laminated brain structures of mouse and human. European Journal of Neuroscience, 20(10), 2827-2832. https://doi.org/10.1111/j.1460-9568.2004.03733.x (Original work published 2004)
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Kuvbachieva, A., Bestel, A.-M., Tissir, F., Maloum, I., Guimiot, F., Ramoz, N., Bourgeois, F., Moalic, J.-M., Goffinet, A., & Simonneau, M. (2004). Identification of a novel brain-specific and Reelin-regulated gene that encodes a protein colocalized with synapsin. European Journal of Neuroscience, 20(3), 603-610. https://doi.org/10.1111/j.1460-9568.2004.03473.x (Original work published 2004)
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Tissir, F., Wang, C.-E., & Goffinet, A. (2004). Expression of the chemokine receptor Cxcr4 mRNA during mouse brain development. Developmental Brain Research, 149(1), 63-71. https://doi.org/10.1016/j.devbrainres.2004.01.002 (Original work published 2004)
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Article de journalJossin, Y., Bar, I., Ignatova, N., Tissir, F., De Rouvroit, C. L., & Goffinet, A. (2003). The reelin signaling pathway: some recent developments. Cerebral cortex (New York, N.Y. : 1991), 13(6), 627-633. https://doi.org/10.1093/cercor/13.6.627 (Original work published 2003)
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Tissir, F., & Goffinet, A. (2003). Reelin and brain development. Nature Reviews. Neuroscience, 4(6), 496-505. https://doi.org/10.1038/nrn1113 (Original work published 2003)
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Tissir, F., Goffinet, A., Lambert De Rouvroit, C., Sire, J.-Y., & Meyer, G. (2003). Reelin expression during embryonic brain development in Crocodylus niloticus. The Journal of Comparative Neurology, 457(3), 250-262. https://doi.org/10.1002/cne.10573 (Original work published 2003)
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Jossin, Y., Ogawa, M., Metin, C., Tissir, F., & Goffinet, A. (2003). Inhibition of SRC family kinases and non-classical protein kinases C induce a reeler-like malformation of cortical plate development. The Journal of Neuroscience, 23(30), 9953-9959. (Original work published 2003)
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Bar, I., Tissir, F., Lambert de Rouvroit, C., De Backer, O., & Goffinet, A. (2003). The gene encoding disabled-1 (DAB1), the intracellular adaptor of the Reelin pathway, reveals unusual complexity in human and mouse. Journal of Biological Chemistry, 278(8), 5802-5812. https://doi.org/10.1074/jbc.M207178200 (Original work published 2003)
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Article de journalTissir, F., Bar, I., Goffinet, A., & Lambert De Rouvroit, C. (2002). Expression of the ankyrin repeat domain 6 gene (Ankrd6) during mouse brain development. Developmental Dynamics, 224(4), 465-469. https://doi.org/10.1002/dvdy.10126 (Original work published 2002)
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Tissir, F., Lambert de Rouvroit, C., & Goffinet, A. (2002). The role of reelin in the development and evolution of the cerebral cortex. Brazilian Journal of Medical and Biological Research, 35(12), 1473-1484. https://doi.org/10.1590/S0100-879X2002001200007 (Original work published 2002)
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Tissir, F., De-Backer, O., Goffinet, A., & Lambert de Rouvroit, C. (2002). Developmental expression profiles of Celsr (Flamingo) genes in the mouse. Mechanisms of Development, 112(1-2), 157-160. https://doi.org/10.1016/S0925-4773(01)00623-2 (Original work published 2002)
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Article de journalGoossens, D., Villafuerte, S., Tissir, F., Van Gestel, S., Claes, S., Souery, D., Massat, I., Van den Bossche, D., Van Zand, K., Mendlewicz, J., Van Broeckhoven, C., & Del-Favero, J. (2000). No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder. European Journal of Human Genetics, 8(5), 385-388. https://doi.org/10.1038/sj.ejhg.5200469 (Original work published 2000)
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Irobi, J., Tissir, F., De Jonghe, P., De Vriendt, E., Van Broeckhoven, C., Timmerman, V., & Beuten, J. (2000). A clone contig of 12q24.3 encompassing the distal hereditary motor neuropathy type II gene. Genomics, 65(1), 34-43. https://doi.org/10.1006/geno.2000.6149 (Original work published 2000)
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Article de journalSzpirer, C., Tissir, F., & et al. (1999). Rat chromosome 2 : Assignment of the genes encoding cyclin B1, interleukin 6 signal transducer, and protein convertase 1 to the Mcs1-containing region and identification of new microsatellite markers. Mammalian Genome, 10(1), 30-34. (Original work published 1999)
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Kuhlenbäumer, G., Schirmacher, A., Meuleman, J., Tissir, F., Del-Favero, J., Stögbauer, F., Young, P., Ringelstein, B., Van Broeckhoven, C., & Timmerman, V. (1999). A sequence-ready BAC/PAC contig and partial transcript map of approximately 1.5 Mb in human chromosome 17q25 comprising multiple disease genes. Genomics, 62(2), 242-250. https://doi.org/10.1006/geno.1999.5991 (Original work published 1999)
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Wang, S., Crutz, M., Del Favero, J., Zhang, Tissir, F., & et al. (1999). A high resolution physical map of human chromosome 21p using yeast artificial chromosomes. Genome Research, 9(11), 1059-1073. (Original work published 1999)
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Article de journalSzpirer, C., Szpirer, J., Van Vooren, P., Tissir, F., Simon, J. S., Koike, G., Jacob, H. J., Lander, E. S., Helou, K., Klinga-Levan, K., & Levan, G. (1998). Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Mammalian Genome, 9, 721-734. (Original work published 1998)
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Article de journalCourvoisier, H., Tissir, F., Vanvooren, P., Voigt, M. M., Szpirer, J., Szpirer, C., Mormède, P., & Moisan, M.-P. (1997). Assignment of the gene encoding the serotonin 5HT1B receptor to rat chromosome 8q31 by fluorescence in situ hybridization. Mammalian Genome, 8(10), 792-793. https://doi.org/10.1007/s003359900575 (Original work published 1997)
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Szpirer, C., Szpirer, J., Tissir, F., & et al. (1997). Rat chromosome 1 : Regional localization of seven genes (Slc9a3, Srd5a1, Esr, Tcp1, Grik5, Tnnt3, Jak2) and anchoring of the genetic linkage map to the cytogenetic map. Mammalian Genome, 8(9), 657-660. (Original work published 1997)
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Article de journalStephanova, E., Tissir, F., Dusetti, N., Iovanna, J., Szpirer, J., & Szpirer, C. (1996). The rat genes encoding the pancreatitis-associated proteins I, II and III (Pap1, Pap2, Pap3), and the lithostathin/pancreatic stone protein/regeneration protein (Reg) colocalize at 4q33-->q34. Cytogenetics and Cell Genetics, 72(1), 83-85. (Original work published 1996)
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Tissir, F., Champagne, B., & et al. (1996). Regional localization of the rat genes encoding the cAMP-specific phosphodiesterases 3 (Pde4d) and 4 (Pde4b) and the tyrosinase-related protein 1 (Tyrp1). Mammalian Genome, 7(3), 222-223. (Original work published 1996)
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Larsson, M., Tissir, F., & et al. (1996). Mapping of the rat ribosomal protein S18 gene (Rps 18) to chromosome 20p12. Mammalian Genome, 7(1), 90-91. (Original work published 1996)
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Article de journalTissir, F., Rivière, M., Guo, D., Tsuzuki, S., Inagami, T., Levan, G., Szpirer, J., & Szpirer, C. (1995). Localization of the genes encoding the three rat angiotensin II receptors, Agtr1a, Agtr1b, Agtr2, and the human AGTR2 receptor respectively to rat chromosomes 17q12, 2q24 and Xq34, and the human Xq22. Cytogenetics and Cell Genetics, 71(1), 77-80. (Original work published 1995)
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Article de journalSzpirer, c., Tissir, F., & et al. (1994). Assignment of rat Jun family genes to chromosome 19 (Junb), chromosome 5q31-33 (Jun), and chromosome 16 (Jund). Mammalian Genome, 5(6), 361-364. (Original work published 1994)
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Szpirer, C., Tissir, F., Rivière, M., Levan, G., & Szpirer, J. (1994). Assignment of rat Jun family genes to chromosome 19 (Junb), chromosome 5q31-33 (Jun), and chromosome 16 (Jund). Mammalian Genome, 5(6), 361-364. https://doi.org/10.1007/BF00356555 (Original work published 1994)
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