Louvain Aging Brain Lab
ions | Bruxelles Woluwe, Louvain-la-Neuve
The Louvain Aging Brain LAB aims to study the manifestations related to normal and pathological aging, including those caused by Alzheimer's disease and other related diseases. Our research tools include neuropsychological tests (e.g., memory, language tests), imaging techniques (MRI/PET) that measure brain lesions or their effects on the brain, biological analyses of the cerebrospinal fluid (CSF) and plasma, the analysis of genetic risk factors, and post-mortem analyses of human brain samples using both high-field neuroimaging and mass spectrometry for biochemical characterization of brain proteins. Our populations of interest include patients with cognitive impairment who visit the memory clinic, asymptomatic people with a family risk of developing Alzheimer's disease, and both young and old clinically normal individuals.
The Louvain Aging Brain is also interested in exploring the cognitive difficulties that are encountered in other neurodegenerative diseases, such as frontotemporal lobe degeneration (FTLD), cerebral amyloid angiopathy (CAA), and parkinsonian syndromes. Through this spectrum of diseases, our aim is to better understand the links between the biochemical alterations observed on some proteins, the regional distribution of various neuropathologies in the brain, and cognitive symptoms.
Bernard Hanseeuw (Principal Investigator)
Adrian Ivanoiu (Principal Investigator)
Clémence Balty (Postdoctoral researcher)
Flo Blondiaux Pirson (Postdoctoral researcher)
Nicolas Delinte (Postdoctoral researcher)
Thomas Gérard (MD, Postdoctoral researcher)
Vincent Malotaux (Postdoctoral researcher)
Lisa Quenon (Postdoctoral researcher)
Jean-Louis Bayart (PhD student)
Graziella de Broqueville (MD, PhD student)
Paul Dulieu (PhD Student)
Guy Gikelekele (MD, PhD student)
Julia Goloubeva (PhD Student)
Lara Huyghe (PhD student)
Adrien Kirsh (MD, PhD student)
Amina Sellimi (MD, PhD student)
Axelle A.T. Vanparys (PhD student)
Youssef Bellaali (Alumni)
Emilien Boyer (Alumni)
Lise Colmant (Alumni)
Nathalie Kyalu Ngoie Zola (Alumni)
Mélina Regy (Alumni)
Yasmine Salman (Alumni)
Publications
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Article de journalSalman, Y., Gérard, T., Malotaux, V., Huyghe, L., Colmant, L., Bayart, J.-L., Boyer, E., Blondiaux Pirson, F., Kienlen-Campard, P., Dricot, L., Lhommel, R., Ivanoiu, A., Quenon, L., & Hanseeuw, B. (2026). Amygdala shows heterogeneous atrophy and tauopathy patterns across the AD continuum. Alzheimer’s Research & Therapy. Published. https://doi.org/10.1186/s13195-026-02172-8 (Original work published 2026)
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Bouchoucha, K., Collin, L., Coquette, C., Colmant, L., Boyer, E., Huyghe, L., Quenon, L., Gerard, T., Salman, Y., Hox, V., Kienlen-Campard, P., Hanseeuw, B., Decottignies, A., & Huart, C. (2026). Olfactory decline tracks central‐to‐peripheral spread of tau pathology in Alzheimer’s disease. Alzheimer’s & Dementia, 22(4), 16. https://doi.org/10.1002/alz.71402 (Original work published 2026)
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Bellaali, Y., Sulcova, D., Salatino, A., Dricot, L., Hanseeuw, B., Woodard, J., & Ivanoiu, A. (2026). Modulating the default mode network with deep TMS: a proof-of-concept framework with potential relevance to circuits implicated in lack of awareness of cognitive decline. Frontiers in Aging Neuroscience, 18, 9. https://doi.org/10.3389/fnagi.2026.1742759 (Original work published 2026)
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Tort-Colet, N., Stankeviciute, L., Fernández-Arcos, A., Soldevila-Domenech, N., Sánchez-Benavides, G., Shekari, M., Vállez García, D., Altomare, D., Barkhof, F., Boada, M., Buckley, C., Collij, L., Den Braber, A., Farrar, G., Ford, L., Frisoni, G., Gismondi, R., Gispert, J., Grootoonk, S., et al. (2026). Self-reported sleep quality and longitudinal amyloid burden in clinically unimpaired adults from the AMYPAD PNHS study. Alzheimer’s Research & Therapy, 18(1), 11. https://doi.org/10.1186/s13195-026-02049-w (Original work published 2026)
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Hanseeuw, B., Quenon, L., Bayart, J.-L., Boyer, E., Colmant, L., Salman, Y., Gérard, T., Huyghe, L., Malotaux, V., Kienlen-Campard, P., Blondiaux Pirson, F., Lhommel, R., Dricot, L., Ivanoiu, A., Shamsundar, K., Pak, W., Soldo, J., Iqbal, K., & et al. (2026). Tau pathological activity in plasma before the onset of symptomatic Alzheimer’s disease. medRxiv, 48. https://doi.org/10.64898/2026.04.03.26350110 (Original work published 2026)
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Villain, N., Hanseeuw, B., Planche, V., & Paretsky, M. (2026). Author Response: The Great Debate in Diagnosing Alzheimer Disease: More Than Just a β Test. Neurology, 106(6), 1. https://doi.org/10.1212/wnl.0000000000210240 (Original work published 2026)
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Thibault, E., Del Carmen Montenegro, G., Becker, J., Price, J., Healy, B., Hanseeuw, B., Buckley, R., Jacobs, H., Properzi, M., Sperling, R., Johnson, K., & Farrell, M. (2026). Amyloid spatial extent with florbetapir-PET for early detection of preclinical Alzheimer’s disease. The Journal of Prevention of Alzheimer’s Disease, 13(5), 100529. https://doi.org/10.1016/j.tjpad.2026.100529 (Original work published 2026)
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Van Langenhove, T., Van Mossevelde, S., Miatton, M., De Lepeleire, J., Bruffaerts, R., Bier, J., Segers, K., Verschraegen, J., Petrovic, M., Ventura, M., Jedidi, H., Beyer, I., Mormont, E., Vandenberghe, R., Delva, A., Gilles, C., Van Weehaeghe, D., Picard, G., De Deyn, P., et al. (2026). Biomarker‐Based Diagnosis and Care Pathways for Alzheimer’s Disease in the Era of Disease‐Modifying Treatments: A Consensus Statement by Belgian Experts. European Journal of Neurology, 33(8), e70668. https://doi.org/10.1111/ene.70668 (Original work published 2026)
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Yurtsever, Z., Capuani, S., Fratini, M., Nicaise, C., Salman, Y., Hanseeuw, B., Carlesimo, G., Latagliata, E., & Coccurello, R. (2026). Norepinephrine and dopamine Imbalance in the medial frontal gyrus from patients with Alzheimer’s disease. IBRO Neuroscience Reports, 20, 94-100. https://doi.org/10.1016/j.ibneur.2026.01.001 (Original work published 2026)
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Tristão-Pereira, C., Langella, S., Baena, A., Londono, N., Sanchez, J., Martinez, L., Alvarez, S., Vidal, M., Aguillon, D., Su, Y., Protas, H., Properzi, M., Malotaux, V., He, B., Giudicessi, A., Reiman, E., Hanseeuw, B., & Quiroz, Y. (2026). Contribution of local amyloid-β and tau burden to hypometabolism in autosomal-dominant Alzheimer’s disease. Brain Communications, 8(1), 15. https://doi.org/10.1093/braincomms/fcaf508 (Original work published 2026)
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Hendrickx Van De Craen, E., Bossaerts, L., Sieben, A., Van Den Bossche, T., Bjerke, M., Hanseeuw, B., Bergmans, B., Vandenberghe, R., De Deyn, P., Cras, P., Sleegers, K., Engelborghs, S., Van Broeckhoven, C., & Van Der Zee, J. (2026). Rare ABCA7 mutations in Alzheimer’s disease and cerebral amyloid angiopathy pathology. Neurobiology of Aging, 160, 33-46. https://doi.org/10.1016/j.neurobiolaging.2025.12.010 (Original work published 2026)
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Fathi, Y., Boutachkourt, A., Joris, V., Onofrj, V., Dricot, L., Behets, C., Hanseeuw, B., & Liberati, G. (2026). Focal and Steerable Temporal Interference Stimulation of the Human Left Posterior Insula: A Proof-of-Concept Validation Using Intracranial Recordings in a Human Cadaver. Bioengineering, 13(9), 1050. https://doi.org/10.3390/xxxxx (Original work published 2026)
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Article de journalHuyghe, L., Quenon, L., Bayart, J.-L., Colmant, L., Boyer, E., Gérard, T., Salman, Y., Besson, G., Dricot, L., Lhommel, R., Ivanoiu, A., Bastin, C., Delhaye, E., & Hanseeuw, B. (2025). Discrimination tasks increase the value of plasma p‐tau217 to predict presymptomatic Alzheimer’s disease. Alzheimer’s & Dementia, 21(Suppl 8), e109967. https://doi.org/10.1002/alz70862_109967 (Original work published 2025)
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Huyghe, L., Quenon, L., Bayart, J.-L., Colmant, L., Boyer, E., Gérard, T., Salman, Y., Besson, G., Dricot, L., Lhommel, R., Ivanoiu, A., Bastin, C., Delhaye, E., & Hanseeuw, B. (2025). Discrimination tasks increase the value of plasma p-tau217 topredict presymptomatic Alzheimer’s disease. Alzheimer’s & Dementia, 21(Suppl 3), e102899 [1-5]. https://doi.org/10.1002/alz70857_102899 (Original work published 2025)
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Quenon, L., Huyghe, L., Bayart, J.-L., Boyer, E., Colmant, L., Salman, Y., Gérard, T., Malotaux, V., Delhaye, E., Besson, G., Dricot, L., Lhommel, R., Ivanoiu, A., Bastin, C., & Hanseeuw, B. (2025). Targeting pre‐symptomatic AD individuals: Deep cognitive assessment and plasma biomarkers to predict tau aggregation. Alzheimer’s & Dementia, 21(S2), e098968 [1-4]. https://doi.org/10.1002/alz70856_098968 (Original work published 2025)
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Pieperhoff, L., Lorenzini, L., Mastenbroek, S., Tranfa, M., Shekari, M., Wink, A., Wolz, R., Grootoonk, S., Ritchie, C., Boada, M., Marquié, M., Van Der Flier, W., Vandenberghe, R., Hanseeuw, B., Martínez-Lage, P., Payoux, P., Visser, P., Schöll, M., Frisoni, G., et al. (2025). Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History study. NeuroImage: Clinical, 48, 103912. https://doi.org/10.1016/j.nicl.2025.103912 (Original work published 2025)
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Huyghe, L., Salman, Y., Colmant, L., Gérard, T., Malotaux, V., Besson, G., Delhaye, E., Bastin, C., Dessain, Q., Dricot, L., Lhommel, R., Ivanoiu, A., Quenon, L., & Hanseeuw, B. (2025). Preclinical detection of Alzheimer’s disease pathology using conceptual discrimination abilities. The Journal of Prevention of Alzheimer’s Disease, 12(9), 100332. https://doi.org/10.1016/j.tjpad.2025.100332 (Original work published 2025)
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Lorenzini, L., Tranfa, M., Pieperhoff, L., Masserini, F., Ten Kate, M., Collij, L., Pontillo, G., Luckett, E., Wink, A., Mutsaerts, H., Oliveira, T., Altomare, D., Boada, M., Den Braber, A., Birck, C., Buckley, C., Farrar, G., Van Der Flier, W., Frisoni, G., et al. (2025). Cortical thickness subtypes in cognitively unimpaired individuals: Differential network and transcriptomic vulnerability to cortical thinning. Alzheimer’s & Dementia, 21(10), e70762 [1-16]. https://doi.org/10.1002/alz.70762 (Original work published 2025)
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Dobbels, L., Hanseeuw, B., Vanopdenbosch, L., Sieben, A., & Cras, P. (2025). Nervous system tumors as subject of multidisciplinary oncological consult. Acta Neurologica Belgica, 125(5), 1155-1156. https://doi.org/10.1007/s13760-025-02847-3 (Original work published 2025)
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Colmant, L., Quenon, L., Huyghe, L., Ivanoiu, A., Gérard, T., Lhommel, R., Coppens, P., Salman, Y., Malotaux, V., Kunz, L., Axmacher, N., Dricot, L., Lefèvre, P., & Hanseeuw, B. (2025). Rotation errors in path integration are associated with Alzheimer’s disease tau pathology: a cross-sectional study. Alzheimer’s research & therapy, 17(1), 34 [1-16]. https://doi.org/10.1186/s13195-025-01679-w (Original work published 2025)
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Dessain, Q., Delinte, N., Hanseeuw, B., Dricot, L., & Macq, B. (2025). Leveraging Swin Transformer for enhanced diagnosis of Alzheimer’s disease using multi-shell diffusion MRI. IEEE Transactions on Biomedical Engineering, 1-10. https://doi.org/10.1109/tbme.2025.3636745 (Original work published 2025)
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Ruiz Reig, N., Virosztek, M., Chehade, G., Suelves Caballol, N., Zola, N. K. N., Salman, Y., Schakman, O., Kienlen-Campard, P., Hanseeuw, B., & Tissir, F. (2025). KIF2A downregulation links amyloid-β to Tau phosphorylation in Alzheimer’s disease. Brain : a journal of neurology. Accepted/in-press. https://doi.org/10.1093/brain/awaf382 (Original work published 2025)
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Malotaux, V., Salman, Y., & Hanseeuw, B. (2025). Wherever tau pathology starts, propagation will follow brain connections. Brain, 148(11), 3787-3788. https://doi.org/10.1093/brain/awaf350 (Original work published 2025)
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Koops, E. A., Dutta, J., Hanseeuw, B., Becker, J. A., Van Egroo, M., Prokopiou, P. C., Price, J. C., Arnold, S. E., Sperling, R. A., Johnson, K. A., & Jacobs, H. I. L. (2025). Elevated locus coeruleus metabolism provides resilience against cognitive decline in preclinical Alzheimer’s disease. Alzheimer’s & Dementia, 21(1), e14385 [1-14]. https://doi.org/10.1002/alz.14385 (Original work published 2025)
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Huyghe, L., Quenon, L., Salman, Y., Colmant, L., Gérard, T., Malotaux, V., Boyer, E., Dricot, L., Lhommel, R., Woodard, J. L., Ivanoiu, A., & Hanseeuw, B. (2025). Entorhinal tau impairs short-term memory binding in preclinical Alzheimer’s disease. Journal of the International Neuropsychological Society, 1-12. https://doi.org/10.1017/s1355617725000165 (Original work published 2025)
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David, J., Quenon, L., Hanseeuw, B., Ivanoiu, A., Volfart, A., Koessler, L., & Rossion, B. (2025). An objective and sensitive electrophysiological marker of word semantic categorization impairment in Alzheimer’s disease. Clinical Neurophysiology, 170, 98-109. https://doi.org/10.1016/j.clinph.2024.12.018 (Original work published 2025)
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Xia, Y., Dhaynaut, M., Chemli, Y., Lois, C., Hanseeuw, B., Thibault, E., Groot, C., Ossenkoppele, R., Johnson, K., El Fakhri, G., Normandin, M. D., & Guehl, N. J. (2025). Quantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [<sup>18</sup>F]MK6240. The Journal of Nuclear Medicine, jnumed. https://doi.org/10.2967/jnumed.125.270165 (Original work published 2025)
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Cacciamani, F., Nielson, K. A., Hanseeuw, B., Gagliardi, G. P., & Vannini, P. (2025). Editorial: To Know or Not to Know: causes and evolution of lack of awareness of cognitive decline in neurodegenerative diseases, volume II. Frontiers in Aging Neuroscience, 17. https://doi.org/10.3389/fnagi.2025.1568173 (Original work published 2025)
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Townsend, D. L., Properzi, M. J., Betthauser, T. J., Klinger, H. M., Boyle, R., Coughlan, G., Hanseeuw, B., Yang, H.-S., Cody, K. A., Amariglio, R. E., Farrell, M., Jacobs, H. I. L., Shirzadi, Z., Yau, W.-Y., Price, J. C., Chhatwal, J., Rentz, D. M., Johnson, K. A., Sperling, R. A., et al. (2025). Estimating the preclinical Alzheimer’s disease course with multimodal data. Alzheimer’s & Dementia, 21(9), e70658 [1-10]. https://doi.org/10.1002/alz.70658 (Original work published 2025)
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Salman, Y., Huyghe, L., Quenon, L., Ghysens, O., Malotaux, V., Tomé, S. O., Thal, D. R., & Hanseeuw, B. (2025). Autopsy-proven patient with corticobasal degeneration presenting with visuo-constructive disorders as initial symptoms: How advanced MRI sequences can help clinical practice. Journal of Alzheimer’s Disease, 104(1), 158-172. https://doi.org/10.1177/13872877251314199 (Original work published 2025)
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Gérard, T., Colmant, L., Malotaux, V., Salman, Y., Huyghe, L., Quenon, L., Boyer, E., Dricot, L., Ivanoiu, A., Lhommel, R., & Hanseeuw, B. (2025). Tau PET Imaging With [18F]MK-6240: Limited Affinity for Primary Tauopathies and High Specificity for Alzheimer’s Disease. European Journal of Neurology, 32(2), e70068. https://doi.org/10.1111/ene.70068 (Original work published 2025)
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Coughlan, G. T., Klinger, H. M., Boyle, R., Betthauser, T. J., Binette, A. P., Christenson, L., Chadwick, T., Hansson, O., Harrison, T. M., Healy, B., Jacobs, H. I. L., Hanseeuw, B., Jonaitis, E., Jack, C. R., Johnson, K. A., Langhough, R. E., Properzi, M. J., Rentz, D. M., Schultz, A. P., et al. (2025). Sex Differences in Longitudinal Tau-PET in Preclinical Alzheimer Disease : A Meta-Analysis. JAMA Neurology, 82(4), 364. https://doi.org/10.1001/jamaneurol.2025.0013 (Original work published 2025)
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Jessen, F., Arbizu, J., Boada, M., Balasa, M., Bennys, K., Boban, M., Bürger, K., Chincarini, A., Cagnin, A., De Deyn, P. P., Düzel, E., Engelborghs, S., Ewers, M., Exalto, L. G., van der Flier, W. M., Fortea, J., Frederiksen, K. S., Frisoni, G. B., Frölich, L., et al. (2025). Comment by European Alzheimer’s Disease Consortium (EADC) investigators on the negative recommendation of the CHMP on the marketing authorization of donanemab for early Alzheimer’ s disease. The Journal of Prevention of Alzheimer’s Disease, 12(8), 100259. https://doi.org/10.1016/j.tjpad.2025.100259 (Original work published 2025)
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Dourte, M., Paître, E., Bouchoucha, M., Boyer, E., Tomé, S. O., Doeraene, E., Huart, C., Leroy, K., Thal, D. R., Decottignies, A., Hanseeuw, B., Suelves Caballol, N., & Kienlen-Campard, P. (2025). The olfactory epithelium: a critical gateway for pathological tau propagation and a target for mitigating tauopathy in the central nervous system. Acta Neuropathologica, 149(1), 64 [1-25]. https://doi.org/10.1007/s00401-025-02902-6 (Original work published 2025)
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Khalifa, C., Grisart, B., Mabille, F., Hanseeuw, B., Ivanoiu, A., & Momeni, M. (2025). Assessment of indirect effects of apolipoprotein Ee4 carrier status on postoperative delirium incidence in cardiac surgery – A preplanned secondary analysis of a prospective cohort study. Delirium Communications, 1-11. https://doi.org/10.56392/001c.136823 (Original work published 2025)
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Salman, Y., Goloubeva, J., Huyghe, L., Quenon, L., Tomé, S. O., & Hanseeuw, B. (2025). Specific atrophy patterns distinguish tau and TDP-43 pathology: a longitudinal MRI ante-mortem study. Acta Neuropathologica Communications. Accepted/in-press. https://doi.org/10.1186/s40478-025-02200-y (Original work published 2025)
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Ossenkoppele, R., Coomans, E. M., Apostolova, L. G., Baker, S. L., Barthel, H., Beach, T. G., Benzinger, T. L. S., Betthauser, T., Bischof, G. N., Bottlaender, M., Bourgeat, P., den Braber, A., Brendel, M., Brickman, A. M., Cash, D. M., Carrillo, M. C., Coath, W., Christian, B. T., Dickerson, B. C., et al. (2025). Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex. Nature Neuroscience, 28(8), 1610-1621. https://doi.org/10.1038/s41593-025-02000-6 (Original work published 2025)
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Quenon, L., Rossion, B., Huyghe, L., David, J., Woodard, J. L., Dricot, L., Lhommel, R., Hanseeuw, B., & Ivanoiu, A. (2025). Unfamiliar facial identity discrimination and recognition impairment in prodromal Alzheimer’s disease: A behavioral pattern separation and completion study. Neuropsychologia, 215, 109179. https://doi.org/10.1016/j.neuropsychologia.2025.109179 (Original work published 2025)
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Wittens, M. M. J., Sima, D. M., Brys, A., Struyfs, H., Niemantsverdriet, E., De Roeck, E., Bastin, C., Benoit, F., Bergmans, B., Bier, J.-C., de Deyn, P. P., Deryck, O., Hanseeuw, B., Ivanoiu, A., Picard, G., Salmon, E., Segers, K., Sieben, A., Thiery, E., et al. (2025). Independent validation and outlier analysis of EuroPOND alzheimer’s disease staging model using ADNI and real-world clinical data. Alzheimer’s Research & Therapy, 17(1). https://doi.org/10.1186/s13195-025-01788-6 (Original work published 2025)
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Gawor, K., Verrept, S., Arekatla, G., Wouters, D., Ronisz, A., Hecht, M., Laureyssen, C., Donck, H. V., Lahaije, B., Ospitalieri, S., Vandenbulcke, M., Otto, M., von Arnim, C. A. F., Ghebremedhin, E., Hanseeuw, B., Vandenberghe, R., Blaschko, M., Sifrim, A., Sleegers, K., et al. (2025). Alzheimer’s disease and its co-pathologies: Implications for hippocampal degeneration, cognitive decline, and the role of APOE ε4. Alzheimer’s & Dementia, 21(7), e70483 [1-18]. https://doi.org/10.1002/alz.70483 (Original work published 2025)
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Papier de conférenceSalman, Y., Goloubeva, J., Huyghe, L., Quenon, L., Tomé, S. O., & Hanseeuw, B. (2025). Specific atrophy patterns distinguish tau and TDP‐43 pathology: a longitudinal MRI ante‐mortem study. Alzheimer’s & Dementia, 21(S2), 1-5. https://doi.org/10.1002/alz70856_098328 (Original work published 2025)
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Article de journalColmant, L., Boyer, E., Gerard, T., Sleegers, K., Lhommel, R., Ivanoiu, A., Lefèvre, P., Kienlen-Campard, P., & Hanseeuw, B. (2024). Definition of a Threshold for the Plasma Aβ42/Aβ40 Ratio Measured by Single-Molecule Array to Predict the Amyloid Status of Individuals without Dementia. International journal of molecular sciences, 25(2), 1173 [1-17]. https://doi.org/10.3390/ijms25021173 (Original work published 2024)
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Farrell, M. E., Thibault, E. G., Becker, J. A., Price, J. C., Healy, B. C., Hanseeuw, B., Buckley, R. F., Jacobs, H. I. L., Schultz, A. P., Chen, C. D., Sperling, R. A., & Johnson, K. A. (2024). Spatial extent as a sensitive amyloid‐PET metric in preclinical Alzheimer’s disease. Alzheimer’s & Dementia, 20(8), 5434-5449. https://doi.org/10.1002/alz.14036 (Original work published 2024)
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Engels-Domínguez, N., Koops, E. A., Hsieh, S., Wiklund, E. E., Schultz, A. P., Riphagen, J. M., Prokopiou, P. C., Hanseeuw, B., Rentz, D. M., Sperling, R. A., Johnson, K. A., & Jacobs, H. I. L. (2024). Lower in vivo locus coeruleus integrity is associated with lower cortical thickness in older individuals with elevated Alzheimer’s pathology: a cohort study. Alzheimer’s research & therapy, 16(1), 129 [1-14]. https://doi.org/10.1186/s13195-024-01500-0 (Original work published 2024)
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Blondiaux Pirson, F., Colmant, L., Lebrun, L., Hanseeuw, B., & Crevecoeur, F. (2024). Erroneous Compensation for Long-Latency Feedback Delays as Origin of Essential Tremor. The Journal of Neuroscience, 44(25), e0069242024 [1-10]. https://doi.org/10.1523/JNEUROSCI.0069-24.2024 (Original work published 2024)
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Langella, S., Lopera, F., Baena, A., Fox‐Fuller, J. T., Munera, D., Martinez, J. E., Giudicessi, A., Vannini, P., Hanseeuw, B., Marshall, G. A., Quiroz, Y. T., & Gatchel, J. R. (2024). Depressive symptoms and hippocampal volume in autosomal dominant Alzheimer’s disease. Alzheimer’s & Dementia, 20(2), 986-994. https://doi.org/10.1002/alz.13501 (Original work published 2024)
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Scott, M. R., Edwards, N. C., Properzi, M. J., Jacobs, H. I., Price, J. C., Lois, C., Farrell, M. E., Hanseeuw, B., Thibault, E. G., Rentz, D. M., Johnson, K. A., Sperling, R. A., Schultz, A. P., & Buckley, R. F. (2024). Contribution of extracerebral tracer retention and partial volume effects to sex differences in Flortaucipir-PET signal. Journal of cerebral blood flow and metabolism, 44(1), 131-141. https://doi.org/10.1177/0271678X231196978 (Original work published 2024)
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Regy, M., Dugravot, A., Sabia, S., Helmer, C., Tzourio, C., Hanseeuw, B., Singh-Manoux, A., & Dumurgier, J. (2024). The role of dementia in the association between APOE4 and all-cause mortality: pooled analyses of two population-based cohort studies. The lancet. Healthy longevity, 5(6), e422-e430. https://doi.org/10.1016/s2666-7568(24)00066-7 (Original work published 2024)
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Gérard, T., Colmant, L., Malotaux, V., Salman, Y., Huyghe, L., Quenon, L., Dricot, L., Ivanoiu, A., Lhommel, R., & Hanseeuw, B. (2024). The spatial extent of tauopathy on [18F]MK-6240 tau PET shows stronger association with cognitive performances than the standard uptake value ratio in Alzheimer’s disease. European Journal of Nuclear Medicine and Molecular Imaging, 51(6), 1662-1674. https://doi.org/10.1007/s00259-024-06603-2 (Original work published 2024)
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Salman, Y., Gérard, T., Huyghe, L., Colmant, L., Quenon, L., Malotaux, V., Ivanoiu, A., Lhommel, R., Dricot, L., & Hanseeuw, B. (2024). Amygdala atrophies in specific subnuclei in preclinical Alzheimer’s disease. Alzheimer’s & Dementia, 20(10), 7205-7219. https://doi.org/10.1002/alz.14235 (Original work published 2024)
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Boyer, E., Deltenre, L., Dourte, M., Colmant, L., Paître, E., Sleegers, K., Suelves Caballol, N., Hanseeuw, B., & Kienlen-Campard, P. (2024). Comparison of plasma soluble and extracellular vesicles-associated biomarkers in Alzheimer’s disease patients and cognitively normal individuals. Alzheimer’s research & therapy, 6(1), 141 [1-14]. https://doi.org/10.1186/s13195-024-01508-6 (Original work published 2024)
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Munro, C. E., Farrell, M., Hanseeuw, B., Rentz, D. M., Buckley, R., Properzi, M., Yuan, Z., Vannini, P., Amariglio, R. E., Quiroz, Y. T., Blacker, D., Sperling, R. A., Johnson, K. A., Marshall, G. A., & Gatchel, J. R. (2024). Change in Depressive Symptoms and Longitudinal Regional Amyloid Accumulation in Unimpaired Older Adults. JAMA Network Open, 7(8), e2427248 [1-14]. https://doi.org/10.1001/jamanetworkopen.2024.27248 (Original work published 2024)
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Wittens, M. M. J., Denissen, S., Sima, D. M., Fransen, E., Niemantsverdriet, E., Bastin, C., Benoit, F., Bergmans, B., Bier, J.-C., de Deyn, P. P., Deryck, O., Hanseeuw, B., Ivanoiu, A., Picard, G., Ribbens, A., Salmon, E., Segers, K., Sieben, A., Struyfs, H., et al. (2024). Brain age as a biomarker for pathological versus healthy ageing – a REMEMBER study. Alzheimer’s research & therapy, 16(1), 128 [1-18]. https://doi.org/10.1186/s13195-024-01491-y (Original work published 2024)
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Bollack, A., Collij, L. E., García, D. V., Shekari, M., Altomare, D., Payoux, P., Dubois, B., Grau‐Rivera, O., Boada, M., Marquié, M., Nordberg, A., Walker, Z., Scheltens, P., Schöll, M., Wolz, R., Schott, J. M., Gismondi, R., Stephens, A., Buckley, C., et al. (2024). Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study. Alzheimer’s & Dementia, 20(5), 3429-3441. https://doi.org/10.1002/alz.13761 (Original work published 2024)
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Huszár, Z., Engh, M. A., Pavlekovics, M., Sato, T., Steenkamp, Y., Hanseeuw, B., Terebessy, T., Molnár, Z., Hegyi, P., & Csukly, G. (2024). Risk of conversion to mild cognitive impairment or dementia among subjects with amyloid and tau pathology: a systematic review and meta-analysis. Alzheimer’s research & therapy, 16(1), 81 [1-19]. https://doi.org/10.1186/s13195-024-01455-2 (Original work published 2024)
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David, J., Quenon, L., Hanseeuw, B., Ivanoiu, A., Volfart, A., Koessler, L., & Rossion, B. (2024). An objective and sensitive electrophysiological marker of word semantic categorization impairment in Alzheimer’s disease. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 170, 98-109. https://doi.org/10.1016/j.clinph.2024.12.018 (Original work published 2024)
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Kyalu Ngoie Zola, N., Balty, C., Vertommen, D., & Hanseeuw, B. (2024). Des modifications post-traductionnelles de la protéine tau soluble distinguent la maladie d’Alzheimer des autres tauopathies. Médecine sciences : M/S, 40(4), 328-331. https://doi.org/10.1051/medsci/2024032 (Original work published 2024)
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Klinger, H. M., Healy, B. C., Hanseeuw, B., Jones, R. N., Boyle, R., Townsend, D. L., Properzi, M. J., Coughlan, G. T., Seto, M., Birkenbihl, C., Farrell, M. E., Papp, K. V., Chhatwal, J. P., Yang, H.-S., Schultz, A. P., Amariglio, R. E., Jacobs, H. I. L., Price, J. C., Johnson, K. A., et al. (2024). Latent change‐on‐change between amyloid accumulation and cognitive decline. Alzheimer’s & Dementia, 20(12), 8728-8738. https://doi.org/10.1002/alz.14326 (Original work published 2024)
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Quenon, L., Collij, L. E., Garcia, D. V., Lopes Alves, I., Gérard, T., Malotaux, V., Huyghe, L., Gispert, J. D., Jessen, F., Visser, P. J., den Braber, A., Ritchie, C. W., Boada, M., Marquié, M., Vandenberghe, R., Luckett, E. S., Schöll, M., Frisoni, G. B., Buckley, C., et al. (2024). Amyloid-PET imaging predicts functional decline in clinically normal individuals. Alzheimer’s research & therapy, 16(1), 130 [1-13]. https://doi.org/10.1186/s13195-024-01494-9 (Original work published 2024)
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Ikanga, J., Jean, K., Medina, P., Patel Sundaram, S., Schwinne, M., Epenge, E., Gikelekele, G., Tshengele, N., Kavugho, I., Mampunza, S., Mananga, L., Teunissen E., C., Stringer, A., Rojas C., J., Chan, B., Lago Lario, A., Kramer H., J., Boxer L., A., Jeromin, A., et al. (2024). Neurodegenerative Plasma Biomarkers for Prediction of Hippocampal Atrophy in Older Adults with Suspected Alzheimer’s Disease in Kinshasa, Democratic Republic of Congo. MedRxiv. Submitted. https://doi.org/10.1101/2024.09.03.24313019 (Original work published 2024)
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Burling, J. E., Katz, Z., Yuan, Z., Munro, C., Mimmack, K., Ma, G., Hanseeuw, B., Papp, K. V., Amariglio, R. E., Vannini, P., Rentz, D. M., Quiroz, Y. T., Johnson, K. A., Sperling, R. A., Blacker, D., Marshall, G. A., Yang, H.-S., & Gatchel, J. R. (2024). Study Partner Report of Apathy in Older Adults is Associated with AD Biomarkers: Findings from the Harvard Aging Brain Study. American Journal of Geriatric Psychiatry, 32(8), 909-919. https://doi.org/10.1016/j.jagp.2024.01.020 (Original work published 2024)
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Boyle, R., Townsend, D. L., Klinger, H. M., Scanlon, C. E., Yuan, Z., Coughlan, G. T., Seto, M., Shirzadi, Z., Yau, W.-Y. W., Jutten, R. J., Schneider, C., Farrell, M. E., Hanseeuw, B., Mormino, E. C., Yang, H.-S., Papp, K. V., Amariglio, R. E., Jacobs, H. I. L., Price, J. C., et al. (2024). Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration. Alzheimer’s research & therapy, 16(1), 148 [1-16]. https://doi.org/10.1186/s13195-024-01510-y (Original work published 2024)
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Dubois, B., Villain, N., Schneider, L., Fox, N., Campbell, N., Galasko, D., Kivipelto, M., Jessen, F., Hanseeuw, B., Boada, M., Barkhof, F., Nordberg, A., Froelich, L., Waldemar, G., Frederiksen, K. S., Padovani, A., Planche, V., Rowe, C., Bejanin, A., et al. (2024). Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation. JAMA Neurology, 81(12), 1304-1311. https://doi.org/10.1001/jamaneurol.2024.3770 (Original work published 2024)
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Jessen, F., Kramberger, M. G., Angioni, D., Aarsland, D., Balasa, M., Bennys, K., Boada, M., Boban, M., Chincarini, A., Exalto, L., Felbecker, A., Fliessbach, K., Frisoni, G. B., Garza-Martínez, A. J., Grimmer, T., Hanseeuw, B., Hort, J., Ivanoiu, A., Klöppel, S., et al. (2024). Progress in the Treatment of Alzheimer’s Disease Is Needed – Position Statement of European Alzheimer’s Disease Consortium (EADC) Investigators. The journal of prevention of Alzheimer’s disease, 11(5), 1212-1218. https://doi.org/10.14283/jpad.2024.153 (Original work published 2024)
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Malotaux, V., Colmant, L., Quenon, L., Huyghe, L., Gérard, T., Dricot, L., Lhommel, R., Ivanoiu, A., & Hanseeuw, B. (2024). Suspecting Non-Alzheimer’s Pathologies and Mixed Pathologies: A Comparative Study Between Brain Metabolism and Tau Images. Journal of Alzheimer’s Disease, 97(1), 421-433. https://doi.org/10.3233/jad-230696 (Original work published 2024)
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Article de journalHanseeuw, B., Jacobs, H. I. L., Schultz, A. P., Buckley, R. F., Farrell, M. E., Guehl, N. J., Becker, J. A., Properzi, M., Sanchez, J. S., Quiroz, Y. T., Vannini, P., Sepulcre, J., Yang, H.-S., Chhatwal, J. P., Gatchel, J., Marshall, G. A., Amariglio, R., Papp, K., Rentz, D. M., et al. (2023). Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults : Harvard Aging Brain Study. Neurology, 101(24), e2533-e2544. https://doi.org/10.1212/wnl.0000000000207962 (Original work published 2023)
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Kyalu Ngoie Zola, N., Balty, C., Pyr dit Ruys, S., Vanparys, A., Huyghe, N., Herinckx, G., Johanns, M., Boyer, E., Kienlen-Campard, P., Rider, M. H., Vertommen, D., & Hanseeuw, B. (2023). Specific post-translational modifications of soluble tau protein distinguishes Alzheimer’s disease and primary tauopathies. Nature Communications, 14(1), 3706 [1-17]. https://doi.org/10.1038/s41467-023-39328-1 (Original work published 2023)
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Collij, L. E., Farrar, G., Valléz García, D., Bader, I., Shekari, M., Lorenzini, L., Pemberton, H., Altomare, D., Pla, S., Loor, M., Markiewicz, P., Yaqub, M., Buckley, C., Frisoni, G. B., Nordberg, A., Payoux, P., Stephens, A., Gismondi, R., Visser, P. J., et al. (2023). The amyloid imaging for the prevention of Alzheimer’s disease consortium: A European collaboration with global impact. Frontiers in Neurology, 13, 1063598 [1-15]. https://doi.org/10.3389/fneur.2022.1063598 (Original work published 2023)
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Colmant, L., Bierbrauer, A., Bellaali, Y., Kunz, L., Van Dongen, J., Sleegers, K., Axmacher, N., Lefèvre, P., Hanseeuw, B., & et al. (2023). Dissociating effects of aging and genetic risk of sporadic Alzheimer’s disease on path integration. Neurobiology of Aging, 131, 170-181. https://doi.org/10.1016/j.neurobiolaging.2023.07.025 (Original work published 2023)
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Hanseeuw, B., & Johnson, K. A. (2023). Preclinical Alzheimer’s disease: how to predict who will decline next year? Brain communications, 5(2), fcad079 [1-3]. https://doi.org/10.1093/braincomms/fcad079 (Original work published 2023)
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Bader, I., Bader, I., Lopes Alves, I., Vállez García, D., Vellas, B., Dubois, B., Boada, M., Marquié, M., Altomare, D., Scheltens, P., Vandenberghe, R., Hanseeuw, B., Schöll, M., Frisoni, G. B., Jessen, F., Nordberg, A., Kivipelto, M., Ritchie, C. W., Grau-Rivera, O., et al. (2023). Recruitment of pre-dementia participants: main enrollment barriers in a longitudinal amyloid-PET study. Alzheimer’s research & therapy, 15(1), 189 [1-14]. https://doi.org/10.1186/s13195-023-01332-4 (Original work published 2023)
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Blondiaux Pirson, F., Lebrun, L., Hanseeuw, B., & Crevecoeur, F. (2023). Impairments of saccadic and reaching adaptation in Essential Tremor are linked to movement execution. Journal of Neurophysiology, 130(5), 1092-1102. https://doi.org/10.1152/jn.00165.2023 (Original work published 2023)
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Coughlan, G. T., Betthauser, T. J., Boyle, R., Koscik, R. L., Klinger, H. M., Chibnik, L. B., Jonaitis, E. M., Yau, W.-Y. W., Wenzel, A., Christian, B. T., Gleason, C. E., Saelzler, U. G., Properzi, M. J., Schultz, A. P., Hanseeuw, B., Manson, J. E., Rentz, D. M., Johnson, K. A., Sperling, R., et al. (2023). Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography. JAMA Neurology, 80(5), 462-473. https://doi.org/10.1001/jamaneurol.2023.0455 (Original work published 2023)
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Guehl, N. J., Dhaynaut, M., Hanseeuw, B., Moon, S.-H., Lois, C., Thibault, E., Fu, J. F., Price, J. C., Johnson, K. A., El Fakhri, G., & Normandin, M. D. (2023). Measurement of Cerebral Perfusion Indices from the Early Phase of [18F]MK6240 Dynamic Tau PET Imaging. The Journal of Nuclear Medicine, 64(6), 968-975. https://doi.org/10.2967/jnumed.122.265072 (Original work published 2023)
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Schultz, S. A., Shirzadi, Z., Schultz, A. P., Liu, L., Fitzpatrick, C. D., McDade, E., Barthelemy, N. R., Renton, A., Esposito, B., Joseph‐Mathurin, N., Cruchaga, C., Chen, C. D., Goate, A., Allegri, R. F., Benzinger, T. L. S., Berman, S., Chui, H. C., Fagan, A. M., Farlow, M. R., et al. (2023). Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer’s disease. Aging Cell, 22(8), e13871 [1-13]. https://doi.org/10.1111/acel.13871 (Original work published 2023)
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Regy, M., Dugravot, A., Sabia, S., Bouaziz-Amar, E., Paquet, C., Hanseeuw, B., Singh-Manoux, A., & Dumurgier, J. (2023). Association between ATN profiles and mortality in a clinical cohort of patients with cognitive disorders. Alzheimer’s research & therapy, 15(1), 77 [1-11]. https://doi.org/10.1186/s13195-023-01220-x (Original work published 2023)
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Lebrun, L., Hanseeuw, B., Van Pesch, V., & Ivanoiu, A. (2023). Alzheimer disease’s cerebrospinal fluid biomarkers differences between immigrants and natives in a Belgian memory clinic. Acta Neurologica Belgica, 123(2), 537-544. https://doi.org/10.1007/s13760-022-02143-4 (Original work published 2023)
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Malotaux, V., Dricot, L., Quenon, L., Lhommel, R., Ivanoiu, A., & Hanseeuw, B. (2023). Default-Mode Network Connectivity Changes During the Progression Toward Alzheimer’s Dementia: A Longitudinal Functional Magnetic Resonance Imaging Study. Brain Connectivity, 13(5), 287-296. https://doi.org/10.1089/brain.2022.0008 (Original work published 2023)
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Papier de conférence
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Quenon, L., Collij, L., Vallez Garcia, D., Lopes Alves, I., Bader, I., Iidow, I. N., Gérard, T., Gispert, J. D., Jessen, F., Visser, P. J., Herholz, K., Ritchie, C. W., Boada, M., Marquie, M., Vandenberghe, R., Schöll, M., Frisoni, G. B., Ford, L., Wolz, R., et al. (2023). Evaluating the global Centiloid value for predicting functional decline. Alzheimer’s Association International Conference, Amsterdam.
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Article de journalVan Wambeke, É., Gérard, T., Lhommel, R., & Hanseeuw, B. (2022). Disclosing tau tangles using PET imaging: a pharmacological review of the radiotracers available in 2021. Acta Neurologica Belgica, 122(2), 263-272. https://doi.org/10.1007/s13760-021-01797-w (Original work published 2022)
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Mossakowski, M., Jacobs, S., Hanseeuw, B., Duprez, T., & van Marcke de Lummen, C. J. (2022). Acute leukoencephalopathy and thyroiditis induced by capecitabine. Acta Neurologica Belgica, 122(5), 1373-1375. https://doi.org/10.1007/s13760-022-01893-5 (Original work published 2022)
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Van Schoor, E., Vandenbulcke, M., Bercier, V., Vandenberghe, R., van der Zee, J., Van Broeckhoven, C., Otto, M., Hanseeuw, B., Van Damme, P., Van Den Bosch, L., & Thal, D. R. (2022). Frontotemporal Lobar Degeneration Case with an N-Terminal TUBA4A Mutation Exhibits Reduced TUBA4A Levels in the Brain and TDP-43 Pathology. Biomolecules, 12(3), 440 [1-13]. https://doi.org/10.3390/biom12030440 (Original work published 2022)
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Jacobs, H. I. L., O’Donnell, A., Satizabal, C. L., Lois, C., Kojis, D., Hanseeuw, B., Thibault, E., Sanchez, J. S., Buckley, R. F., Yang, Q., DeCarli, C., Killiany, R., Sargurupremraj, M., Sperling, R. A., Johnson, K. A., Beiser, A. S., & Seshadri, S. (2022). Associations Between Brainstem Volume and Alzheimer’s Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study. Journal of Alzheimer’s Disease, 86(4), 1603-1609. https://doi.org/10.3233/JAD-215372 (Original work published 2022)
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Farrell, M. E., Papp, K. V., Buckley, R. F., Jacobs, H. I. L., Schultz, A. P., Properzi, M. J., Vannini, P., Hanseeuw, B., Rentz, D. M., Johnson, K. A., & Sperling, R. A. (2022). Association of Emerging β-Amyloid and Tau Pathology With Early Cognitive Changes in Clinically Normal Older Adults. Neurology, 98(15), e1512-e1524. https://doi.org/10.1212/wnl.0000000000200137 (Original work published 2022)
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Chhatwal, J. P., Schultz, S. A., McDade, E., Schultz, A. P., Liu, L., Hanseeuw, B., Joseph-Mathurin, N., Feldman, R., Fitzpatrick, C. D., Sparks, K. P., Levin, J., Berman, S. B., Renton, A. E., Esposito, B. T., Fernandez, M. V., Sung, Y. J., Lee, J. H., Klunk, W. E., Hofmann, A., et al. (2022). Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer’s disease: cross-sectional and longitudinal analyses of an observational study. The Lancet Neurology, 21(2), 140-152. https://doi.org/10.1016/s1474-4422(21)00375-6 (Original work published 2022)
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Dumurgier, J., Sabia, S., Zetterberg, H., Teunissen, C. E., Hanseeuw, B., Orellana, A., Schraen, S., Gabelle, A., Boada, M., Lebouvier, T., Willemse, E. A. J., Cognat, E., Ruiz, A., Hourregue, C., Lilamand, M., Bouaziz-Amar, E., Laplanche, J.-L., Pasquier, F., Scheltens, P., et al. (2022). A Pragmatic, Data-Driven Method to Determine Cutoffs for CSF Biomarkers of Alzheimer Disease Based on Validation Against PET Imaging. Neurology, 99(7), e669-e678. https://doi.org/10.1212/wnl.0000000000200735 (Original work published 2022)
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Régy, M., Dugravot, A., Sabia, S., Fayosse, A., Mangin, J.-F., Chupin, M., Fischer, C., Bouteloup, V., Dufouil, C., Chêne, G., Paquet, C., Hanseeuw, B., Singh-Manoux, A., & Dumurgier, J. (2022). Association of APOE ε4 with cerebral gray matter volumes in non-demented older adults: The MEMENTO cohort study. NeuroImage, 250(1), 118966 [1-8]. https://doi.org/10.1016/j.neuroimage.2022.118966 (Original work published 2022)
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Article de journalLodder, C., Scheyltjens, I., Stancu, I. C., Botella Lucena, P., Gutiérrez de Ravé, M., Vanherle, S., Vanmierlo, T., Cremers, N., Vanrusselt, H., Brône, B., Hanseeuw, B., Octave, J.-N., Bottelbergs, A., Movahedi, K., & Dewachter, I. (2021). CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia. Acta Neuropathologica Communications, 9(1), 108 [1-21]. https://doi.org/10.1186/s40478-021-01204-8 (Original work published 2021)
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Bossaerts, L., Hens, E., Hanseeuw, B., Vandenberghe, R., Cras, P., De Deyn, P. P., Engelborghs, S., & Van Broeckhoven, C. (2021). Premature termination codon mutations in ABCA7 contribute to Alzheimer’s disease risk in Belgian patients. Neurobiology of Aging, 106, 307. https://doi.org/10.1016/j.neurobiolaging.2021.04.023 (Original work published 2021)
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Farrell, M. E., Jiang, S., Schultz, A. P., Properzi, M. J., Price, J. C., Becker, J. A., Jacobs, H. I. L., Hanseeuw, B., Rentz, D. M., Villemagne, V. L., Papp, K. V., Mormino, E. C., Betensky, R. A., Johnson, K. A., Sperling, R. A., & Buckley, R. F. (2021). Defining the Lowest Threshold for Amyloid-PET to Predict Future Cognitive Decline and Amyloid Accumulation. Neurology, 96(4), e619-e631. https://doi.org/10.1212/WNL.0000000000011214 (Original work published 2021)
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Gagliardi, G., Kuppe, M., Lois, C., Hanseeuw, B., & Vannini, P. (2021). Pathological correlates of impaired self-awareness of memory function in Alzheimer’s disease. Alzheimer’s research & therapy, 13(1), 118 [1-11]. https://doi.org/10.1186/s13195-021-00856-x (Original work published 2021)
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Mayblyum, D. V., Becker, J. A., Jacobs, H. I. L., Buckley, R. F., Schultz, A. P., Sepulcre, J., Sanchez, J. S., Rubinstein, Z. B., Katz, S. R., Moody, K. A., Vannini, P., Papp, K. V., Rentz, D. M., Price, J. C., Sperling, R. A., Johnson, K. A., & Hanseeuw, B. (2021). Comparing PET and MRI Biomarkers Predicting Cognitive Decline in Preclinical Alzheimer Disease. Neurology, 96(24), e2933-e2943. https://doi.org/10.1212/WNL.0000000000012108 (Original work published 2021)
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Babulal, G. M., Torres, V. L., Acosta, D., Agüero, C., Aguilar-Navarro, S., Amariglio, R., Ussui, J. A., Baena, A., Bocanegra, Y., Brucki, S. M. D., Bustin, J., Cabrera, D. M., Custodio, N., Diaz, M. M., Peñailillo, L. D., Franco, I., Gatchel, J. R., Garza-Naveda, A. P., González Lara, M., et al. (2021). The impact of COVID-19 on the well-being and cognition of older adults living in the United States and Latin America. EClinicalMedicine, 35, 100848 [1-9]. https://doi.org/10.1016/j.eclinm.2021.100848 (Original work published 2021)
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Guilmot, A., Maldonado Slootjes, S. I., Sellimi, A., Bronchain, M., Hanseeuw, B., Belkhir, L., Yombi, J. C., De Greef, J., Pothen, L., Yildiz, H., Duprez, T., Fillee, C., Anantharajah, A., Capes, A., Hantson, P., Jacquerye, P., Raymackers, J.-M., London, F., El Sankari, S., et al. (2021). Immune-mediated neurological syndromes in SARS-CoV-2-infected patients. Journal of neurology, 268(3), 751-757. https://doi.org/10.1007/s00415-020-10108-x (Original work published 2021)
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Sanchez, J. S., Becker, J. A., Jacobs, H. I. L., Hanseeuw, B., Jiang, S., Schultz, A. P., Properzi, M. J., Katz, S. R., Beiser, A., Satizabal, C. L., O’Donnell, A., DeCarli, C., Killiany, R., El Fakhri, G., Normandin, M. D., Gómez-Isla, T., Quiroz, Y. T., Rentz, D. M., Sperling, R. A., et al. (2021). The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography. Science Translational Medicine, 13(577), eabc0655 [1-12]. https://doi.org/10.1126/scitranslmed.abc0655 (Original work published 2021)
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Sanchez, J. S., Hanseeuw, B., Lopera, F., Sperling, R. A., Baena, A., Bocanegra, Y., Aguillon, D., Guzmán-Vélez, E., Pardilla-Delgado, E., Ramirez-Gomez, L., Vila-Castelar, C., Martinez, J. E., Fox-Fuller, J. T., Ramos, C., Ochoa-Escudero, M., Alvarez, S., Jacobs, H. I. L., Schultz, A. P., Gatchel, J. R., et al. (2021). Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer’s disease: findings from the Colombia-Boston (COLBOS) biomarker study. Alzheimer’s research & therapy, 13(1), 27 [1-14]. https://doi.org/10.1186/s13195-020-00765-5 (Original work published 2021)
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Frederiksen, K. S., Nielsen, T. R., Appollonio, I., Andersen, B. B., Riverol, M., Boada, M., Ceccaldi, M., Dubois, B., Engelborghs, S., Frölich, L., Hausner, L., Gabelle, A., Gabryelewicz, T., Grimmer, T., Hanseeuw, B., Hort, J., Hugon, J., Jelic, V., Koivisto, A., et al. (2021). Biomarker counselling, disclosure of diagnosis and follow-up in patients with mild cognitive impairment: A European Alzheimer´s Disease Consortium survey. International Journal of Geriatric Psychiatry, 36(2), 324-333. https://doi.org/10.1002/gps.5427 (Original work published 2021)
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Wittens, M. M. J., Sima, D. M., Houbrechts, R., Ribbens, A., Niemantsverdriet, E., Fransen, E., Bastin, C., Benoit, F., Bergmans, B., Bier, J.-C., De Deyn, P. P., Deryck, O., Hanseeuw, B., Ivanoiu, A., Lemper, J.-C., Mormont, E., Picard, G., de la Rosa, E., Salmon, E., et al. (2021). Diagnostic Performance of Automated MRI Volumetry by icobrain dm for Alzheimer’s Disease in a Clinical Setting: A REMEMBER Study. Journal of Alzheimer’s Disease, 83(2), 623-639. https://doi.org/10.3233/JAD-210450 (Original work published 2021)
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Bucci, M., Savitcheva, I., Farrar, G., Salvadó, G., Collij, L., Doré, V., Gispert, J. D., Gunn, R., Hanseeuw, B., Hansson, O., Shekari, M., Lhommel, R., Molinuevo, J. L., Rowe, C., Sur, C., Whittington, A., Buckley, C., & Nordberg, A. (2021). A multisite analysis of the concordance between visual image interpretation and quantitative analysis of [F]flutemetamol amyloid PET images. European Journal of Nuclear Medicine and Molecular Imaging, 48(7), 2183-2199. https://doi.org/10.1007/s00259-021-05311-5 (Original work published 2021)
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Heeren, A., Hanseeuw, B., Cougnon, L.-A., & Lits, G. (2021). Excessive Worrying as a Central Feature of Anxiety during the First COVID-19 Lockdown-Phase in Belgium: Insights from a Network Approach. Psychologica Belgica, 61(1), 401. https://doi.org/10.5334/pb.1069 (Original work published 2021)
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Bellaali, Y., Woodard, J. L., Hanseeuw, B., & Ivanoiu, A. (2021). Spouse-Appraised Memory Functioning Predicts Memory Decline Better Than Subjective Memory Complaints in Community Dwelling Older Adults at Genetic Risk for Alzheimer’s Disease. Frontiers in Psychiatry, 12, 633102 [1-9]. https://doi.org/10.3389/fpsyt.2021.633102 (Original work published 2021)
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Vrancx, C., Vadukul, D. M., Suelves Caballol, N., Contino, S., D’Auria, L., Perrin, F., Van Pesch, V., Hanseeuw, B., Quinton, L., & Kienlen-Campard, P. (2021). Mechanism of Cellular Formation and In Vivo Seeding Effects of Hexameric β-Amyloid Assemblies. Molecular Neurobiology : a review journal. Accepted/in-press. https://doi.org/10.1007/s12035-021-02567-8 (Original work published 2021)
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Rodriguez-Vieitez, E., Montal, V., Sepulcre, J., Lois, C., Hanseeuw, B., Vilaplana, E., Schultz, A. P., Properzi, M. J., Scott, M. R., Amariglio, R., Papp, K. V., Marshall, G. A., Fortea, J., Johnson, K. A., Sperling, R. A., & Vannini, P. (2021). Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults. Molecular Psychiatry, 26(12), 7813-7822. https://doi.org/10.1038/s41380-021-01290-z (Original work published 2021)
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Article de journalHanseeuw, B., Malotaux, V., Dricot, L., Quenon, L., Sznajer, Y., Cerman, J., Woodard, J., Buckley, C., Farrar, G., Ivanoiu, A., & Lhommel, R. (2020). Defining a Centiloid scale threshold predicting long-term progression to dementia in patients attending the memory clinic: an [18F] flutemetamol amyloid PET study. European Journal of Nuclear Medicine and Molecular Imaging, 48(1), 302-310. https://doi.org/10.1007/s00259-020-04942-4 (Original work published 2021)
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d’Oleire Uquillas, F., Jacobs, H. I. L., Schultz, A. P., Hanseeuw, B., Buckley, R. F., Sepulcre, J., Pascual-Leone, A., Donovan, N. J., Johnson, K. A., Sperling, R. A., & Vannini, P. (2020). Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults. Cerebral Cortex, 30(3), 1974-1983. https://doi.org/10.1093/cercor/bhz217 (Original work published 2020)
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Bierbrauer, A., Kunz, L., Gomes, C. A., Luhmann, M., Deuker, L., Getzmann, S., Wascher, E., Gajewski, P. D., Hengstler, J. G., Fernandez-Alvarez, M., Atienza, M., Cammisuli, D. M., Bonatti, F., Pruneti, C., Percesepe, A., Bellaali, Y., Hanseeuw, B., Strange, B. A., Cantero, J. L., & Axmacher, N. (2020). Unmasking selective path integration deficits in Alzheimer’s disease risk carriers. Science advances, 6(35), eaba1394 [1-21]. https://doi.org/10.1126/sciadv.aba1394 (Original work published 2020)
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Buckley, R. F., Scott, M. R., Jacobs, H. I. L., Schultz, A. P., Properzi, M. J., Amariglio, R. E., Hohman, T. J., Mayblyum, D. V., Rubinstein, Z. B., Manning, L., Hanseeuw, B., Mormino, E. C., Rentz, D. M., Johnson, K. A., & Sperling, R. A. (2020). Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline. Annals of Neurology, 88(5), 921-932. https://doi.org/10.1002/ana.25878 (Original work published 2020)
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Rodriguez (Then), F. S., Jackson, J., Ware, C., Churchyard, R., & Hanseeuw, B. (2020). Interdisciplinary and Transdisciplinary Perspectives: On the Road to a Holistic Approach to Dementia Prevention and Care. Journal of Alzheimer’s Disease Reports, 4(1), 39-48. https://doi.org/10.3233/adr-180070 (Original work published 2020)
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Jacobs, H. I. L., Augustinack, J. C., Schultz, A. P., Hanseeuw, B., Locascio, J., Amariglio, R. E., Papp, K. V., Rentz, D. M., Sperling, R. A., & Johnson, K. A. (2020). The presubiculum links incipient amyloid and tau pathology to memory function in older persons. Neurology, 94(18), e1916-e1928. https://doi.org/10.1212/wnl.0000000000009362 (Original work published 2020)
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Vannini, P., Hanseeuw, B., Gatchel, J. R., Sikkes, S. A. M., Alzate, D., Zuluaga, Y., Moreno, S., Mendez, L., Baena, A., Ospina-Lopera, P., Tirado, V., Henao, E., Acosta-Baena, N., Giraldo, M., Lopera, F., & Quiroz, Y. T. (2020). Trajectory of Unawareness of Memory Decline in Individuals With Autosomal Dominant Alzheimer Disease. JAMA Network Open, 3(12), e2027472 [1-14]. https://doi.org/10.1001/jamanetworkopen.2020.27472 (Original work published 2020)
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Scott, M. R., Hampton, O. L., Buckley, R. F., Chhatwal, J. P., Hanseeuw, B., Jacobs, H. IL., Properzi, M. J., Sanchez, J. S., Johnson, K. A., Sperling, R. A., & Schultz, A. P. (2020). Inferior temporal tau is associated with accelerated prospective cortical thinning in clinically normal older adults. NeuroImage, 220, 116991 [1-10]. https://doi.org/10.1016/j.neuroimage.2020.116991 (Original work published 2020)
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Hanseeuw, B., Scott, M. R., Sikkes, S., Properzi, M., Gatchel, J., Salmon, E., Marshall, G. A., & Vannini, P. (2020). Evolution of anosognosia in Alzheimer’s disease and its relationship to amyloid. Annals of Neurology, 87(2), 267-280. https://doi.org/10.1002/ana.25649 (Original work published 2020)
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Hanseeuw, B., & Lhommel, R. (2020). Utilisation de la TEP-amyloïde pour prédire l’évolution à long terme des patients non déments consultant à la Clinique de la Mémoire : intérêt de la quantification Centiloïde, une échelle internationale standardisée. Medecine Nucleaire : imagerie fonctionelle et metabolique, 44(2), 138-139. https://doi.org/10.1016/j.mednuc.2020.01.131 (Original work published 2020)
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Mormont, E., Bier, J.-C., Bruffaerts, R., Cras, P., De Deyn, P., Deryck, O., Engelborghs, S., Petrovic, M., Picard, G., Segers, K., Thiery, E., Versijpt, J., & Hanseeuw, B. (2020). Practices and opinions about disclosure of the diagnosis of Alzheimer’s disease to patients with MCI or dementia: a survey among Belgian medical experts in the field of dementia. Acta Neurologica Belgica, 120(5), 1157-1163. https://doi.org/10.1007/s13760-020-01448-6 (Original work published 2020)
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Riphagen, J. M., Ramakers, I. H. G. M., Freeze, W. M., Pagen, L. H. G., Hanseeuw, B., Verbeek, M. M., Verhey, F. R. J., & Jacobs, H. I. L. (2020). Linking APOE-ε4, blood-brain barrier dysfunction, and inflammation to Alzheimer’s pathology. Neurobiology of Aging, 85, 96-103. https://doi.org/10.1016/j.neurobiolaging.2019.09.020 (Original work published 2020)
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Papier de conférence
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Seminck, O., Cougnon, L.-A., Hanseeuw, B., & Fairon, C. (2020). The Mind-It Corpus: a Longitudinal Corpus of Electronic Messages Written by Older Adults with Incipient Alzheimer’s Disease and Clinically Normal Volunteers. In Dimitrios Kokkinakis, Kristina Lundholm Fors, Charalambos Themistocleous,Malin Antonsson, Marie Eckerström (ed.), Proceedings of the LREC 2020 Workshop on:Resources and Processing of Linguistic, Para-linguisticand Extra-linguistic Data from P (p. p. 108-115). European Language Resources Association (ELRA).
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Woodard, J., Bellaali, Y., Dricot, L., Lhommel, R., Malotaux, V., Quenon, L., Hanseeuw, B., & Ivanoiu, A. (2020). Multivariate prediction of rate of decline in memory functioning over six years using imaging biomarkers : Neuroimaging / Optimal neuroimaging measures for tracking disease progression. Alzheimer’s & Dementia, 16(Suppl 4), e045645 [1-2]. https://doi.org/10.1002/alz.045645 (Original work published 2020)
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Article de journalVannini, P., Uquillas, F. d., Jacobs, H. I. L., Sepulcre, J., Gatchel, J., Amariglio, R. E., Hanseeuw, B., Papp, K. V., Hedden, T., Rentz, D. M., Pascual-Leone, A., Johnson, K. A., & Sperling, R. A. (2019). Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults. NeuroImage: Clinical, 24, 102097 [1-8]. https://doi.org/10.1016/j.nicl.2019.102097 (Original work published 2019)
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Fuller, J. T., Cronin-Golomb, A., Gatchel, J. R., Norton, D. J., Guzmán-Vélez, E., Jacobs, H. I. L., Hanseeuw, B., Pardilla-Delgado, E., Artola, A., Baena, A., Bocanegra, Y., Kosik, K. S., Chen, K., Tariot, P. N., Johnson, K., Sperling, R. A., Reiman, E. M., Lopera, F., & Quiroz, Y. T. (2019). Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer’s Disease: A Comprehensive Review of the Colombian Kindred. The journal of prevention of Alzheimer’s disease, 6(2), 112-120. https://doi.org/10.14283/jpad.2019.6 (Original work published 2019)
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Sperling, R. A., Mormino, E. C., Schultz, A. P., Betensky, R. A., Papp, K. V., Amariglio, R. E., Hanseeuw, B., Buckley, R., Chhatwal, J., Hedden, T., Marshall, G. A., Quiroz, Y. T., Donovan, N. J., Jackson, J., Gatchel, J. R., Rabin, J. S., Jacobs, H., Yang, H.-S., Properzi, M., et al. (2019). The impact of Aβ and tau on prospective cognitive decline in older individuals. Annals of Neurology, 85(2), 181-193. https://doi.org/10.1002/ana.25395 (Original work published 2019)
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Picard, G., Bier, J.-C., Capron, I., De Deyn, P. P., Deryck, O., Engelborghs, S., Hanseeuw, B., Lemper, J.-C., Mormont, E., Petrovic, M., Salmon, E., Segers, K., Sieben, A., Thiery, E., Ventura, M., Versijpt, J., & Ivanoiu, A. (2019). Dementia, End of Life, and Euthanasia: A Survey Among Dementia Specialists Organized by the Belgian Dementia Council. Journal of Alzheimer’s Disease, 69(4), 989-1001. https://doi.org/10.3233/JAD-181277 (Original work published 2019)
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Fichou, Y., Al-Hilaly, Y. K., Devred, F., Smet-Nocca, C., Tsvetkov, P. O., Verelst, J., Winderickx, J., Geukens, N., Vanmechelen, E., Perrotin, A., Serpell, L., Hanseeuw, B., Medina, M., Buée, L., & Landrieu, I. (2019). The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention? Acta Neuropathologica Communications, 7(1), 31 [1-17]. https://doi.org/10.1186/s40478-019-0682-x (Original work published 2019)
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Buckley, R. F., Mormino, E. C., Rabin, J. S., Hohman, T. J., Landau, S., Hanseeuw, B., Jacobs, H. I., Papp, K. V., Amariglio, R. E., Properzi, M. J., Schultz, A. P., Kirn, D., Scott, M. R., Hedden, T., Farrell, M., Price, J., Chhatwal, J., Rentz, D. M., Villemagne, V. L., et al. (2019). Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured By Positron Emission Tomography in Clinically Normal Older Adults. JAMA Neurology, 76(5), 542-551. https://doi.org/10.1001/jamaneurol.2018.4693. (Original work published 2019)
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Huijbers, W., Schultz, A. P., Papp, K. V., LaPoint, M. R., Hanseeuw, B., Chhatwal, J. P., Hedden, T., Johnson, K. A., & Sperling, R. A. (2019). Tau accumulation in clinically normal older adults is associated with hippocampal hyperactivity. The Journal of Neuroscience, 39(3), 548-556. https://doi.org/10.1523/JNEUROSCI.1397-18.2018 (Original work published 2019)
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Bayart, J.-L., Hanseeuw, B., Ivanoiu, A., & Van Pesch, V. (2019). Analytical and clinical performances of the automated Lumipulse cerebrospinal fluid Aβ and T-Tau assays for Alzheimer’s disease diagnosis. Journal of neurology, 266(9), 2304-2311. https://doi.org/10.1007/s00415-019-09418-6 (Original work published 2019)
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Buckley, R. F., Mormino, E. C., Chhatwal, J., Schultz, A. P., Rabin, J. S., Rentz, D. M., Acar, D., Properzi, M. J., Dumurgier, J., Jacobs, H., Gomez-Isla, T., Johnson, K. A., Sperling, R. A., & Hanseeuw, B. (2019). Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid. Neurobiology of Aging, 78, 178-185. https://doi.org/10.1016/j.neurobiolaging.2019.02.019 (Original work published 2019)
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Hanseeuw, B., Lopera, F., Sperling, R. A., Norton, D. J., Guzman-Velez, E., Baena, A., Pardilla-Delgado, E., Schultz, A. P., Gatchel, J., Jin, D., Chen, K., Reiman, E. M., Johnson, K. A., Quiroz, Y. T., & et al. (2019). Striatal amyloid is associated with tauopathy and memory decline in familial Alzheimer’s disease. Alzheimer’s research & therapy, 11(1), 17 [1-6]. https://doi.org/10.1186/s13195-019-0468-1 (Original work published 2019)
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Hanseeuw, B., Betensky, R. A., Jacobs, H. I. L., Schultz, A. P., Sepulcre, J., Becker, J. A., Cosio, D. M. O., Farrell, M., Quiroz, Y. T., Mormino, E. C., Buckley, R. F., Papp, K. V., Amariglio, R. A., Dewachter, I., Ivanoiu, A., Huijbers, W., Hedden, T., Marshall, G. A., Chhatwal, J. P., et al. (2019). Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study. JAMA Neurology, 76(8), 915-924. https://doi.org/10.1001/jamaneurol.2019.1424 (Original work published 2019)
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Marshall, G. A., Gatchel, J. R., Donovan, N. J., Muniz, M. C., Schultz, A. P., Becker, J. A., Chhatwal, J. P., Hanseeuw, B., Papp, K. V., Amariglio, R. E., Rentz, D. M., Sperling, R. A., & Johnson, K. A. (2019). Regional Tau Correlates of Instrumental Activities of Daily Living and Apathy in Mild Cognitive Impairment and Alzheimer’s Disease Dementia. Journal of Alzheimer’s Disease, 67(2), 757-768. https://doi.org/10.3233/JAD-170578 (Original work published 2019)
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Yang, H.-S., Chhatwal, J. P., Xu, J., White, C. C., Hanseeuw, B., Rabin, J. S., Papp, K. V., Buckley, R. F., Schultz, A. P., Properzi, M. J., Gatchel, J. R., Amariglio, R. E., Donovan, N. J., Mormino, E. C., Hedden, T., Marshall, G. A., Rentz, D. M., Johnson, K. A., De Jager, P. L., & Sperling, R. A. (2019). An UNC5C Allele Predicts Cognitive Decline and Hippocampal Atrophy in Clinically Normal Older Adults. Journal of Alzheimer’s Disease, 68(3), 1161-1170. https://doi.org/10.3233/JAD-180788 (Original work published 2019)
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Rabin, J. S., Yang, H.-S., Schultz, A. P., Hanseeuw, B., Hedden, T., Viswanathan, A., Gatchel, J. R., Marshall, G. A., Kilpatrick, E., Klein, H., Rao, V., Buckley, R. F., Yau, W.-Y. W., Kirn, D. R., Rentz, D. M., Johnson, K. A., Sperling, R. A., & Chhatwal, J. P. (2019). Vascular risk and β-amyloid are synergistically associated with cortical tau. Annals of Neurology, 85(2), 272-279. https://doi.org/10.1002/ana.25399 (Original work published 2019)
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Article de journald’Oleire Uquillas, F., Jacobs, H. I. L., Biddle, K. D., Properzi, M., Hanseeuw, B., Schultz, A. P., Rentz, D. M., Johnson, K. A., Sperling, R. A., & Donovan, N. J. (2018). Regional tau pathology and loneliness in cognitively normal older adults. Translational psychiatry, 8(1), 282 [1-9]. https://doi.org/10.1038/s41398-018-0345-x (Original work published 2018)
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Donovan, N. J., Locascio, J. J., Marshall, G. A., Gatchel, J., Hanseeuw, B., Rentz, D. M., Johnson, K. A., & Sperling, R. A. (2018). Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults. American Journal of Psychiatry, 175(6), 530-537. https://doi.org/10.1176/appi.ajp.2017.17040442 (Original work published 2018)
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d’Oleire Uquillas, F., Jacobs, H. I. L., Hanseeuw, B., Marshall, G. A., Properzi, M., Schultz, A. P., LaPoint, M. R., Johnson, K. A., Sperling, R. A., & Vannini, P. (2018). Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals. NeuroImage: Clinical, 17, 388-396. https://doi.org/10.1016/j.nicl.2017.10.034 (Original work published 2018)
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Hanseeuw, B., Jonas, V., Jackson, J., Betensky, R. A., Rentz, D. M., Johnson, K. A., Sperling, R. A., & Donovan, N. J. (2018). Association of anxiety with subcortical amyloidosis in cognitively normal older adults. Molecular Psychiatry. Accepted/in-press. https://doi.org/10.1038/s41380-018-0214-2 (Original work published 2018)
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Orlovsky, I., Huijbers, W., Hanseeuw, B., Mormino, E. C., Hedden, T., Buckley, R. F., LaPoint, M., Rabin, J. S., Rentz, D. M., Johnson, K. A., Sperling, R. A., & Papp, K. V. (2018). The relationship between recall of recently versus remotely encoded famous faces and amyloidosis in clinically normal older adults. Alzheimer’s & dementia (Amsterdam, Netherlands), 10, 121-129. https://doi.org/10.1016/j.dadm.2017.11.003 (Original work published 2018)
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Buckley, R. F., Mormino, E. C., Amariglio, R. E., Properzi, M. J., Rabin, J. S., Lim, Y. Y., Papp, K. V., Jacobs, H. I. L., Burnham, S., Hanseeuw, B., Doré, V., Dobson, A., Masters, C. L., Waller, M., Rowe, C. C., Maruff, P., Donohue, M. C., Rentz, D. M., Kirn, D., et al. (2018). Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer’s disease: Findings from three well-characterized cohorts. Alzheimer’s & Dementia, 14(9), 1193-1203. https://doi.org/10.1016/j.jalz.2018.04.010 (Original work published 2018)
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Niemantsverdriet, E., Ribbens, A., Bastin, C., Benoit, F., Bergmans, B., Bier, J.-C., Bladt, R., Claes, L., De Deyn, P. P., Deryck, O., Hanseeuw, B., Ivanoiu, A., Lemper, J.-C., Mormont, E., Picard, G., Salmon, E., Segers, K., Sieben, A., Smeets, D., et al. (2018). A Retrospective Belgian Multi-Center MRI Biomarker Study in Alzheimer’s Disease (REMEMBER). Journal of Alzheimer’s Disease, 63(4), 1509-1522. https://doi.org/10.3233/JAD-171140 (Original work published 2018)
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Hanseeuw, B., Jonas, V., Jackson, J., Betensky, R. A., Rentz, D. M., Johnson, K. A., Sperling, R. A., & Donovan, N. J. (2018). Correction: Association of anxiety with subcortical amyloidosis in cognitively normal older adults. Molecular Psychiatry. Accepted/in-press. https://doi.org/10.1038/s41380-018-0323-y (Original work published 2018)
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Sepulcre, J., Grothe, M. J., d’Oleire Uquillas, F., Ortiz-Terán, L., Diez, I., Yang, H.-S., Jacobs, H. I. L., Hanseeuw, B., Li, Q., El-Fakhri, G., Sperling, R. A., & Johnson, K. A. (2018). Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nature Medicine, 24(12), 1910-1918. https://doi.org/10.1038/s41591-018-0206-4 (Original work published 2018)
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Hanseeuw, B., Betensky, R. A., Mormino, E. C., Schultz, A. P., Sepulcre, J., Becker, J. A., Jacobs, H. I. L., Buckley, R. F., LaPoint, M. R., Vanini, P., Donovan, N. J., Chhatwal, J. P., Marshall, G. A., Papp, K. V., Amariglio, R. E., Rentz, D. M., Sperling, R. A., & Johnson, K. A. (2018). PET staging of amyloidosis using striatum. Alzheimer’s & Dementia, S1552-5260(18), 30133-3013X. https://doi.org/10.1016/j.jalz.2018.04.011 (Original work published 2018)
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Article de journalVannini, P., Hanseeuw, B., Munro, C. E., Amariglio, R. E., Marshall, G. A., Rentz, D. M., Pascual-Leone, A., Johnson, K. A., & Sperling, R. A. (2017). Anosognosia for memory deficits in mild cognitive impairment: Insight into the neural mechanism using functional and molecular imaging. NeuroImage: Clinical, 15, 408-414. https://doi.org/10.1016/j.nicl.2017.05.020 (Original work published 2017)
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Mormino, E. C., Papp, K. V., Rentz, D. M., Donohue, M. C., Amariglio, R., Quiroz, Y. T., Chhatwal, J., Marshall, G. A., Donovan, N., Jackson, J., Gatchel, J. R., Hanseeuw, B., Schultz, A. P., Aisen, P. S., Johnson, K. A., & Sperling, R. A. (2017). Early and late change on the preclinical Alzheimer’s cognitive composite in clinically normal older individuals with elevated amyloid β. Alzheimer’s & Dementia, 13(9), 1004-1012. https://doi.org/10.1016/j.jalz.2017.01.018 (Original work published 2017)
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Dumurgier, J., Hanseeuw, B., Hatling, F. B., Judge, K. A., Schultz, A. P., Chhatwal, J. P., Blacker, D., Sperling, R. A., Johnson, K. A., Hyman, B. T., & Gómez-Isla, T. (2017). Alzheimer’s Disease Biomarkers and Future Decline in Cognitive Normal Older Adults. Journal of Alzheimer’s Disease, 60(4), 1451-1459. https://doi.org/10.3233/jad-170511 (Original work published 2017)
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Sepulcre, J., Grothe, M. J., Sabuncu, M., Chhatwal, J., Schultz, A. P., Hanseeuw, B., El Fakhri, G., Sperling, R., & Johnson, K. A. (2017). Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurology, 74(7), 813-820. https://doi.org/10.1001/jamaneurol.2017.0263 (Original work published 2017)
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Vannini, P., Amariglio, R., Hanseeuw, B., Johnson, K. A., McLaren, D. G., Chhatwal, J., Pascual-Leone, A., Rentz, D., & Sperling, R. A. (2017). Memory self-awareness in the preclinical and prodromal stages of Alzheimer’s disease. Neuropsychologia, 99, 343-349. https://doi.org/10.1016/j.neuropsychologia.2017.04.002 (Original work published 2017)
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Hanseeuw, B., Betensky, R. A., Schultz, A. P., Papp, K. V., Mormino, E. C., Sepulcre, J., Bark, J. S., Cosio, D. M., LaPoint, M., Chhatwal, J. P., Rentz, D. M., Sperling, R. A., & Johnson, K. A. (2017). Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline : Tau, Amyloid, FDG, and Memory in Normal Aging. Annals of Neurology, 81(4), 583-596. https://doi.org/10.1002/ana.24910 (Original work published 2017)
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Versijpt, J., Tant, M., Beyer, I., Bier, J.-C., Cras, P., De Deyn, P. P., De Wit, P., Deryck, O., Hanseeuw, B., Lambert, M., Lemper, J.-C., Mormont, E., Petrovic, M., Picard, G., Salmon, E., Segers, K., Sieben, A., Thiery, E., Tournoy, J., et al. (2017). Alzheimer’s disease and driving: review of the literature and consensus guideline from Belgian dementia experts and the Belgian road safety institute endorsed by the Belgian Medical Association. Acta Neurologica Belgica, 117(4), 811-819. https://doi.org/10.1007/s13760-017-0840-5 (Original work published 2017)
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Vannini, P., Hanseeuw, B., Munro, C. E., Amariglio, R. E., Marshall, G. A., Rentz, D. M., Pascual-Leone, A., Johnson, K. A., & Sperling, R. A. (2017). Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden. Neurology, 88(18), 1759-1767. https://doi.org/10.1212/wnl.0000000000003889 (Original work published 2017)
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Schultz, A. P., Chhatwal, J. P., Hedden, T., Mormino, E. C., Hanseeuw, B., Sepulcre, J., Huijbers, W., LaPoint, M., Buckley, R. F., Johnson, K. A., & Sperling, R. A. (2017). Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals. The Journal of Neuroscience, 37(16), 4323-4331. https://doi.org/10.1523/jneurosci.3263-16.2017 (Original work published 2017)
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Buckley, R. F., Schultz, A. P., Hedden, T., Papp, K. V., Hanseeuw, B., Marshall, G., Sepulcre, J., Smith, E. E., Rentz, D. M., Johnson, K. A., Sperling, R. A., & Chhatwal, J. P. (2017). Functional network integrity presages cognitive decline in preclinical Alzheimer disease. Neurology, 89(1), 29-37. https://doi.org/10.1212/wnl.0000000000004059 (Original work published 2017)
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Buckley, R. F., Hanseeuw, B., Schultz, A. P., Vannini, P., Aghjayan, S. L., Properzi, M. J., Jackson, J. D., Mormino, E. C., Rentz, D. M., Sperling, R. A., Johnson, K. A., & Amariglio, R. E. (2017). Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden. JAMA Neurology, 74(12), 1455-1463. https://doi.org/10.1001/jamaneurol.2017.2216 (Original work published 2017)
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Article de journalQuenon, L., Dricot, L., Woodard, J., Hanseeuw, B., Gilis, N., Lhommel, R., & Ivanoiu, A. (2016). Prediction of Free and Cued Selective Reminding Test Performance Using Volumetric and Amyloid-Based Biomarkers of Alzheimer’s Disease. Journal of the International Neuropsychological Society, 22(10), 991-1004. https://doi.org/10.1017/S1355617716000813 (Original work published 2016)
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Hanseeuw, B., Dricot, L., Lhommel, R., Quenon, L., & Ivanoiu, A. (2016). Patients with Amyloid-Negative Mild Cognitive Impairment have Cortical Hypometabolism but the Hippocampus is Preserved. Journal of Alzheimer’s Disease, 53(2), 651-660. https://doi.org/10.3233/JAD-160204 (Original work published 2016)
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Mormino, E. C., Papp, K. V., Rentz, D. M., Schultz, A. P., LaPoint, M., Amariglio, R., Hanseeuw, B., Marshall, G. A., Hedden, T., Johnson, K. A., & Sperling, R. A. (2016). Heterogeneity in Suspected Non-Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals. JAMA Neurology, 73(10), 1185-1191. https://doi.org/10.1001/jamaneurol.2016.2237 (Original work published 2016)
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Hanseeuw, B., Schultz, A., Sperling, R., & Johnson, K. (2016). Hippocampal metabolism is decreased in high-amyloid mild cognitive impairment. Alzheimer’s & Dementia, 12(12), 1288-1296. https://doi.org/10.1016/j.jalz.2016.06.2357 (Original work published 2016)
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Pierrot, N., Lhommel, R., Quenon, L., Hanseeuw, B., Dricot, L., Sindic, C., Maloteaux, J.-M., Octave, J.-N., & Ivanoiu, A. (2016). Targretin Improves Cognitive and Biological Markers in a Patient with Alzheimer’s Disease. Journal of Alzheimer’s Disease, 49(2), 271-276. https://doi.org/10.3233/JAD-150405 (Original work published 2016)
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Article de journalQuenon, L., de Xivry, J.-J. O., Hanseeuw, B., & Ivanoiu, A. (2015). Investigating Associative Learning Effects in Patients with Prodromal Alzheimer’s Disease Using the Temporal Context Model. Journal of the International Neuropsychological Society, 21(9), 699-708. https://doi.org/10.1017/S1355617715000855 (Original work published 2015)
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Ivanoiu, A., Dricot, L., Gilis, N., Grandin, C., Lhommel, R., Quenon, L., & Hanseeuw, B. (2015). Classification of Non-Demented Patients Attending a Memory Clinic using the New Diagnostic Criteria for Alzheimer’s Disease with Disease-Related Biomarkers. Journal of Alzheimer’s Disease, 43(3), 835-847. https://doi.org/10.3233/JAD-140651 (Original work published 2015)
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Huart, C., Rombaux, P., Gérard, T., Hanseeuw, B., Lhommel, R., Quenon, L., Ivanoiu, A., & Mouraux, A. (2015). Unirhinal Olfactory Testing for the Diagnostic Workup of Mild Cognitive Impairment. Journal of Alzheimer’s Disease, 47(1), 253-270. https://doi.org/10.3233/JAD-141494 (Original work published 2015)
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Papier de conférenceHanseeuw, B., Dricot, L., Gilis, N., Grandin, C., Lhommel, R., Quenon, L., & Ivanoiu, A. (2013). Hippocampus subfields atrophy in preclinical and predemential Alzheimer’s disease is different from atrophy observed in patients suffering from non-Alzheimer pathology. Alzheimer’s Association International Conference (AAIC), Boston, USA.
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Ivanoiu, A., Dricot, L., Gilis, N., Grandin, C., Lhommel, R., Quenon, L., & Hanseeuw, B. (2013). The classification of non demented patients attending a Memory Clinic according to the NIA&AA guidelines on Alzheimer’s disease related biomarkers. Alzheimer’s Association International Conference (AAIC), Boston, USA.
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Article de journalBukowski, H., Dricot, L., Hanseeuw, B., & Rossion, B. (2013). Cerebral lateralization of face-sensitive areas in left-handers : only the FFA does not get it right. Cortex, 49(9), 2583-2589. https://doi.org/10.1016/j.cortex.2013.05.002 (Original work published 2013)
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Article de journalHanseeuw, B., Seron, X., & Ivanoiu, A. (2012). Increased sensitivity to proactive and retroactive interference in amnestic mild cognitive impairment: New insights. Brain and Cognition, 80(1), 104-110. https://doi.org/10.1016/j.bandc.2012.04.002 (Original work published 2012)
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Rossion, B., Hanseeuw, B., & Dricot, L. (2012). Defining face perception areas in the human brain : a large-scale factorial fMRI face localizer analysis. Brain and Cognition, 79(2), 138-157. https://doi.org/10.1016/j.bandc.2012.01.001 (Original work published 2012)
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Papier de conférenceHanseeuw, B., Bastin, C., & Barbeau, E. (2012). Substrats neuronaux de la mémoire associative et de la mémoire d’item dans les troubles cognitifs légers. “ Familiarité et recollection dans la maladie d’Alzheimer: approches en neuro-imagerie ” - 11ème réunion francophone sur la maladie d’Alzheimer et les syndromes apparentés, Toulouse, France.
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Article de journalHanseeuw, B., Dricot, L., Kavec, M., Grandin, C., Seron, X., & Ivanoiu, A. (2011). Associative encoding deficits in amnestic mild cognitive impairment : a volumetric and functional MRI study. NeuroImage, 56(3), 1743-1748. https://doi.org/10.1016/j.neuroimage.2011.03.034 (Original work published 2011)
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Hanseeuw, B., Van Leemput, K., Kavec, M., Grandin, C., Seron, X., & Ivanoiu, A. (2011). Mild cognitive impairment : differential atrophy in the hippocampal subfields. American Journal of Neuroradiology, 32(9), 1658-1661. https://doi.org/10.3174/ajnr.A2589 (Original work published 2011)
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Hanseeuw, B., & Ivanoiu, A. (2011). Performance on the RI-48 Cued Recall Test Best Predicts Conversion to Dementia at the 5- and 10-Year Follow-Ups. Dementia and Geriatric Cognitive Disorders. Extra, 1(1), 258-266. https://doi.org/10.1159/000330097 (Original work published 2011)
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Papier de conférence
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Article de journalHanseeuw, B., Seron, X., & Ivanoiu, A. (2010). Increased sensitivity to proactive interference in amnestic mild cognitive impairment is independent of associative and semantic impairment. Brain and Cognition, 72(2), 325-331. https://doi.org/10.1016/j.bandc.2009.10.004 (Original work published 2010)
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