SpacePain Lab
ions | Bruxelles Woluwe, Louvain-la-Neuve
The ability to perceive pain is crucial for survival, it can indeed be seen as a warning signal allowing to detect and to react against stimuli that have the potential to inflict tissue damages. But pain is also a major healthcare issue as its treatment constitutes a very problematic challenge for physicians. Because of its aversive quality and its high prevalence, chronic pain affects the quality of life of millions of individuals and imposes a severe financial burden upon our societies. Therefore, progress in understanding the biological, psychological and social mechanisms of pain in humans is not only important for basic research, but also critical for the development of effective strategies for the diagnosis and management of pathological pain conditions.
The objective of our group is to study the neurophysiological mechanisms underlying the cognitive aspects of pain. More specifically, we study the ability of the brain to prioritize the processing of painful stimuli (selective attention), to locate (spatial perception, body representation, multisensory interaction) and to plan actions against them in order to protect the body against physical damages (motor control, nociceptive reflexes). We also investigate how cognitive factors can modulate pain, induce analgesia (hypnosis, cognitive control) and influence nociceptive brain plasticity (central sensitization), in both healthy volunteers and patients (complex regional pain syndrome, fibromyalgia).
Several techniques are used: neurophysiology (electroencephalography, evoked potentials, electromyography, transcranial magnetic stimulation), psychophysics (threshold measurement, mental chronometry) and neuropsychology (congenital blindness, chronic pain, hemispatial neglect, etc.).
Publications
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2026
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2025
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2024
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2023
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2022
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2021
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2020
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2019
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2018
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2017
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2016
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2015
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2014
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2013
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2012
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2011
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2005
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2003
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2002
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2001
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2000
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1999
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Article de journalLeu, C., Herbillon, G., Liberati, G., & Legrain, V. (2026). Frequency‐Tagging Captures Distinct Neural Responses Elicited by Bilateral Periodic Thermonociceptive Stimulation. European Journal of Neuroscience, 63(9), e70539. https://doi.org/10.1111/ejn.70539 (Original work published 2026)
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Louis, M.-H., Legrain, V., Aron, V., Filbrich, L., Mouraux, A., Henrard, S., Guillaume, L., Mouraux, D., Barbier, O., Libouton, X., & Berquin, A. (2026). Complex regional pain syndrome evolution is determined by both biological and psychosocial factors: a 1-year prospective observational study. PAIN®, 167(2), 396-431. https://doi.org/10.1097/j.pain.0000000000003815 (Original work published 2026)
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Manfron, L., Filbrich, L., Della Porta, D., Mouraux, A., & Legrain, V. (2026). Multisensory impact of visual stimuli on detection thresholds of thermo-nociceptive inputs conveyed by Aδ and C fibers. Behavioural Brain Research, 496, 115846. https://doi.org/10.1016/j.bbr.2025.115846 (Original work published 2026)
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Johnson, A., Bourgy, C., Dupuis, M., Herbillon, G., Vanhaudenhuyse, A., Rainville, P., Watremez, C., & Legrain, V. (2026). Investigating pain perception under focused hypnotic analgesia: Local and remote effects. International Journal of Clinical and Experimental Hypnosis. Accepted/in-press. (Original work published 2026)
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Louis, M.-H., Legrain, V., Aron, V., Filbrich, L., Henrard, S., Mouraux, A., & Berquin, A. (2026). CRPS evolution is determined by both biological and psychosocial factors – a 1-Year prospective observational study. PAIN®, 167(4), 991-992. https://doi.org/10.1097/j.pain.0000000000003877 (Original work published 2026)
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Article de journalDella Porta, D., Scheirman, E., & Legrain, V. (2025). The effect of top-down attention on secondary mechanical hyperalgesia: a reply to Torta and Meyers. PAIN®, 166, 225-227. https://doi.org/10.1097/j.pain.0000000000003465 (Original work published 2025)
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Leu, C., Forest, S., Legrain, V., & Liberati, G. (2025). The effect of stimulus saliency on the modulation of ongoing neural oscillations related to thermonociception: A registered report. Cortex, 185, 316-335. https://doi.org/10.1016/j.cortex.2025.02.009 (Original work published 2025)
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Louis, M.-H., Mouraux, D., Aron, V., Filbrich, L., Legrain, V., Henrard, S., Barbier, O., Libouton, X., Berquin, A., & Lambert, J. (2025). Early CRPS Is a Heterogeneous Condition: Results From a Latent Class Analysis. European Journal of Pain, 29(2), e4785. https://doi.org/10.1002/ejp.4785 (Original work published 2025)
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Papier de conférenceLouis, M.-H., Legrain, V., & Berquin, A. (2025). Facteurs pronostiques précoces dans le SDRC : vers une approche stratifiée potentielle. IVe SYMPOSIUM FRANCOPHONE DE RECHERCHE SUR LA DOULEUR, Lyon.
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Legrain, V. (2025). Controlling pain and its sensitization through cognitive load. 14th Congress of the European Federation of IASP Chapters (EFIC), Lyon.
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Louis, M.-H., Legrain, V., Aron, V., Filbrich, L., Berquin, A., & et al. (2025). Psychosocial prognostic factors in CRPS. 14th Congress of the European Pain Federation EFIC, Lyon.
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Legrain, V. (2025). To see or not to see your pain. Impact of blindness on intensity perception and spatial representation of pain. 21ème Symposium du Réseau Français de Recherche sur la Douleur, Lyon.
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Article de journalDella Porta, D., Scheirman, E., & Legrain, V. (2024). Top-down attention does not modulate mechanical hypersensitivity consecutive to central sensitization: Insights from an experimental analysis. PAIN®, 165((9)), 2098-2110. https://doi.org/10.1097/j.pain.0000000000003225 (Original work published 2024)
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Papier de conférenceLouis, M.-H., Legrain, V., Aron, V., Filbrich, L., Henrard, S., & Berquin, A. (2024). Early CRPS is not a homogeneous group: a cluster analysis. IASP World Congress on Pain 2024, Amsterdam.
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Article de journalFilbrich, L., Kuzminova, A., Molitor, V., Mouraux, D., Berquin, A., Barbier, O., Libouton, X., & Legrain, V. (2023). Characterizing biased visuospatial perception in complex regional pain syndrome. European Journal of Pain, 27(7), 871-883. https://doi.org/10.1002/ejp.2118 (Original work published 2023)
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Filbrich, L., Verfaille, C., Vannuscorps, G., Berquin, A., Barbier, O., Libouton, X., Fraselle, V., Mouraux, D., & Legrain, V. (2023). Atypical influence of biomechanical knowledge in Complex Regional Pain Syndrome-towards a different perspective on body representation. Scientific Reports, 13(1), 520 [1-14]. https://doi.org/10.1038/s41598-023-27733-x (Original work published 2023)
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Manfron, L., Filbrich, L., Molitor, V., Farnè, A., Mouraux, A., & Legrain, V. (2023). Perceptual simultaneity between nociceptive and visual stimuli depends on their spatial congruence. Experimental Brain Research, 241(7), 1785-1796. https://doi.org/10.1007/s00221-023-06637-2 (Original work published 2023)
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Legrain, V., Filbrich, L., & Vanderclausen, C. (2023). Letter on the pain of blind people for the use of those who can see their pain. PAIN®, 164(7), 1451-1456. https://doi.org/10.1097/j.pain.0000000000002862 (Original work published 2023)
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Louis, M.-H., Meyer, C., Legrain, V., Berquin, A., & et al. (2023). Biological and psychological early prognostic factors in complex regional pain syndrome : a systematic review. European Journal of Pain, 27(3), 338-352. https://doi.org/10.1002/ejp.2068 (Original work published 2023)
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Louis, M.-H., Meyer, C., Legrain, V., & Berquin, A. (2023). Facteurs pronostiques précoces dans le syndrome douloureux régional complexe : une revue systématique. Douleur et Analgésie, 36(3), 133-147. https://doi.org/10.3166/dea-2022-0267 (Original work published 2023)
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Papier de conférenceLouis, M.-H., Legrain, V., Filbrich, L., Halicka, M., & Berquin, A. (2023). [Preliminary results] Early prognostic factors in complex regional pain syndrome: a 1-year Belgian prospective longitudinal observational study (NCT05337501). IoNS Young Researcher Day 2023, UCLouvain Woluwé.
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Kuzminova, A., & et al. (2023). Investigating event-related brain potentials elicited by high-speed heating using a contact thermode.
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Louis, M.-H., Legrain, V., Filbrich, L., Halicka, M., & Berquin, A. (2023). [Preliminary results] Early prognostic factors in complex regional pain syndrome: a 1-year Belgian prospective longitudinal observational study (NCT05337501). 2nd BPS Young Researchers Day 2023, Gand.
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Kuzminova, A., & et al. (2023). Multisensory interactions between nociception and vision through the looking glass.
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Kuzminova, A., & et al. (2023). Multisensory interactions between nociception and vision through the looking glass.
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Papier de conférenceLouis, M.-H., Meyer, C., Legrain, V., Berquin, A., & et al. (2022). Syndrome Douloureux Régional Complexe (SDRC) : Quels sont les facteurs pronostiques précoces ? Une revue systématique de la littérature. 22ème Congrès national de la Société Française d’Etude et du Traitement de la Douleur, Lille.
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Kuzminova, A., & et al. (2022). Multisensory interactions between nociception and vision.
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Article de journalDella Porta, D., Vilz, M.-L., Kuzminova, A., Filbrich, L., Mouraux, A., & Legrain, V. (2022). No evidence for an effect of selective spatial attention on the development of secondary hyperalgesia: A replication study. Frontiers in Human Neuroscience, 16, 997230. https://doi.org/10.3389/fnhum.2022.997230 (Original work published 2022)
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Papier de conférenceKuzminova, A., & et al. (2021). Multisensory interactions between nociception and vision.
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Article de journalVanderclausen, C., Filbrich, L., De Volder, A., & Legrain, V. (2021). Measuring the sensitivity of tactile temporal order judgments in sighted and blind participants using the adaptive psi method. Attention, Perception & Psychophysics, 83, 2995-3007. (Original work published 2021)
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Verfaille, C., Filbrich, L., Rossetti, Y., Berquin, A., Mouraux, D., Barbier, O., Libouton, X., Fraselle, V., & Legrain, V. (2021). Visuomotor impairments in Complex Regional Pain Syndrome during pointing tasks. PAIN®, 162(3), 811-822. https://doi.org/10.1097/j.pain.0000000000002068 (Original work published 2021)
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Manfron, L., Vanderclausen, C., & Legrain, V. (2021). No evidence for an effect of the distance between the hands on tactile temporal order judgments. Perception, 50, 294-307. (Original work published 2021)
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Article de journalFilbrich, L., van den Broeke, E., Legrain, V., & Mouraux, A. (2020). The focus of spatial attention during the induction of central sensitization can modulate the subsequent development of secondary hyperalgesia. Cortex, 124, 193-203. https://doi.org/10.1016/j.cortex.2019.11.014 (Original work published 2020)
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Vanderclausen, C., Manfron, L., De Volder, A., & Legrain, V. (2020). The influence of visual experience and cognitive goals on the spatial representations of nociceptive stimuli. PAIN®, 161(2), 328-337. https://doi.org/10.1097/j.pain.0000000000001721 (Original work published 2020)
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De Paepe, A. L., Legrain, V., Van der Biest, L., Hollevoet, N., Van Tongel, A., De Wilde, L., Jacobs, H., & Crombez, G. (2020). An investigation of perceptual biases in complex regional pain syndrome. PeerJ, 8, e8819. https://doi.org/10.7717/peerj.8819 (Original work published 2020)
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Manfron, L., Legrain, V., & Filbrich, L. (2020). Seeing or not Seeing Where Your Hands Are. The Influence of Visual Feedback About Hand Position on the Interaction Between Nociceptive and Visual Stimuli. Multisensory Research, 33, 457-478. https://doi.org/10.1163/22134808-20191448 (Original work published 2020)
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Vanderclausen, C., Bourgois, M., De Volder, A., & Legrain, V. (2020). Testing the exteroceptive function of nociception: The role of visual experience in shaping the spatial representations of nociceptive inputs. Cortex, 126, 26-38. https://doi.org/10.1016/j.cortex.2019.12.024 (Original work published 2020)
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Torta, D., Ninghetto, M., Ricci, R., & Legrain, V. (2020). Rating the Intensity of a Laser Stimulus, but Not Attending to Changes in Its Location or Intensity Modulates the Laser-Evoked Cortical Activity. Frontiers in Human Neuroscience, 14, 120. https://doi.org/10.3389/fnhum.2020.00120 (Original work published 2020)
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Manfron, L., Filbrich, L., Nijs, E., Mouraux, A., & Legrain, V. (2020). Investigating perceptual simultaneity between nociceptive and visual stimuli by means of temporal order judgments. Neuroscience Letters, 735, 135156. https://doi.org/10.1016/j.neulet.2020.135156 (Original work published 2020)
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Papier de conférenceLegrain, V. (2020). Where is my pain? Spatial representation and perception of nociceptive and painful stimuli. Department of Cognitive and Affective Sciences, University of Lille, Lille.
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Legrain, V. (2020). Where is my pain? Spatial representation and perception of nociceptive and painful stimuli. Department of Cognitive Psychology and Neuroscience, University of Liège, Liège.
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Papier de conférenceLegrain, V. (2019). Where is my pain? Neuropsychological investigations of the spatial perception of pain. ImpAct Team, Centre de Recherche en Neuroscience de Lyon (INSERM-CNRS-Lyon 1), Lyon.
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Vanderclausen, C., & Legrain, V. (2019). Spatial representations of nociceptive stimuli. Laser Talks in Lyon. Laser Talks in Lyon (Laser talks in Europe 8th edition), Lyon.
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Legrain, V. (2019). Spatial representation and perception of nociceptive and painful stimuli in the human brain. Body Representation Network (BRNet) meeting, Milan.
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Manfron Louise, & Legrain, V. (2019). Multisensory interaction between nociceptive and visual stimuli. Laser Talks in Lyon (Laser talks in Europe 8th edition), Lyon.
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Article de journalFilbrich, L., Blandiaux, S., Manfron, L., Farnè, A., De Keyser, R., & Legrain, V. (2019). Unimodal and crossmodal extinction of nociceptive stimuli in healthy volunteers. Behavioural Brain Research, 362, 114-121. https://doi.org/10.1016/j.bbr.2019.01.002 (Original work published 2019)
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Verfaille, C., Filbrich, L., Cordova Bulens, D., Lefèvre, P., Berquin, A., Barbier, O., Libouton, X., Fraselle, V., Mouraux, D., & Legrain, V. (2019). Robot-assisted line bisection in patients with Complex Regional Pain Syndrome. PLoS One, 14(5), e0213732 [1-30]. https://doi.org/10.1371/journal.pone.0213732 (Original work published 2019)
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Papier de conférenceMouraux, A., Filbrich, L., Legrain, V., & van den Broeke, E. (2018). The induction of secondary hyperalgesia can be modulated by spatial attention. Pain Mechanisms and Therapeutics Conference, Toarmina.
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Vanderclausen, C., De Volder, A., & Legrain, V. (2018). Danger in the dark! Localization of nociceptive stimuli in normally sighted and congenitally blind people. Neuronus 2018 IBRO neuroscience forum, Krakow, Poland.
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Filbrich, L., Legrain, V., & Mouraux, A. (2018). Impaired visual perception in complex regional pain syndrome. Pain Mechanisms and Therapeutics Conference June 2018, Taormina, Italy.
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Article de journalFilbrich, L., Halicka, M., Alamia, A., & Legrain, V. (2018). Investigating the spatial characteristics of the crossmodal interaction between nociception and vision using gaze direction. Consciousness and Cognition, 57, 106-115. https://doi.org/10.1016/j.concog.2017.11.011 (Original work published 2018)
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Torta, D., Filbrich, L., van den Broeke, E., & Legrain, V. (2018). No perceptual prioritization of non-nociceptive vibrotactile and visual stimuli presented on a sensitized body part. Scientific Reports, 8(1), 5359. https://doi.org/10.1038/s41598-018-23135-6 (Original work published 2018)
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De Keyser, R., Mouraux, A., Quek, G., Torta, D., & Legrain, V. (2018). Fast periodic visual stimulation to study tool-selective processing in the human brain. Experimental Brain Research, 236(10), 2751-2763. https://doi.org/10.1007/s00221-018-5331-2 (Original work published 2018)
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Legrain, V., Manfron, L., Garcia, M., & Filbrich, L. (2018). Does body perception shape visuospatial perception? Perception, 47, 507-520. https://doi.org/10.1177/0301006618763269 (Original work published 2018)
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Papier de conférenceVanderclausen, C., & Legrain, V. (2017). Measuring the sensitivity of nociceptive temporal order judgment in sighted and early blind participants using the PSI method. Pain research meeting, Anvers.
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Legrain, V. (2017). Where is my pain? Neuropsychological investigations of the spatial perception of pain. University of Bath, Department of Psychology, Bath.
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Legrain, V., Vanderclausen, C., Bourgois, M., & Filbrich, L. (2017). Two lasers are better than one! Exploring the spatial perception of laser stimuli by means of temporal order judgment. Laser Talks in Brussels (Laser talks in Europe 8th edition), Brussels.
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Legrain, V. (2017). Investigating the spatial dimension of nociception and pain using temporal order judgment. Health Psychology Research Group, University of Leuven, Leuven.
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Filbrich, L., Verfaille, C., Berquin, A., Barbier, O., Libouton, X., Fraselle, V., Mouraux, D., & Legrain, V. (2017). Does CRPS Impair The Perception of Somatosensory and Non-somatosensory Stimuli? Pain Research Meeting 2017, Antwerp.
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Article de journalFilbrich, L., Alamia, A., Burns, S., & Legrain, V. (2017). Erratum to: Orienting attention in visual space by nociceptive stimuli: investigation with a temporal order judgment task based on the adaptive PSI method. Experimental Brain Research, 235(9), 2901. https://doi.org/10.1007/s00221-017-5020-6 (Original work published 2017)
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Filbrich, L., Alamia, A., Burns, S., & Legrain, V. (2017). Orienting attention in visual space by nociceptive stimuli: investigation with a temporal order judgment task based on the adaptive PSI method. Experimental Brain Research, 235(7), 2069-2079. https://doi.org/10.1007/s00221-017-4951-2 (Original work published 2017)
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Filbrich, L., Alamia, A., Blandiaux, S., Burns, S., & Legrain, V. (2017). Shaping visual space perception through bodily sensations: testing the impact of nociceptive stimuli on visual perception in the peripersonal space with temporal order judgments. PLoS One, 12(8), e0182634. https://doi.org/10.1371/journal.pone.0182634 (Original work published 2017)
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Orban de Xivry, J.-J., Legrain, V., & Lefèvre, P. (2017). Overlap of movement planning and movement execution reduces reaction time by up to 100ms. Journal of Neurophysiology, 117, 117-122. https://doi.org/10.1101/039842 (Original work published 2017)
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De Paepe, A. L., Crombez, G., & Legrain, V. (2017). Remapping nociceptive stimuli into a peripersonal reference frame is spatially locked to the stimulated limb. Neuropsychologia, 101, 121-131. https://doi.org/10.1016/j.neuropsychologia.2017.05.015 (Original work published 2017)
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Filbrich, L., Alamia, A., Verfaille, C., Berquin, A., Barbier, O., Libouton, X., Fraselle, V., Mouraux, D., & Legrain, V. (2017). Biased visuospatial perception in complex regional pain syndrome. Scientific Reports, 7(1), 9712 [1-12]. https://doi.org/10.1038/s41598-017-10077-8 (Original work published 2017)
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Legrain, V. (2017). Lost in space: do somatic symptoms affect the perception of extra-somatic stimuli? Brain : a journal of neurology, 140, 2254-2256. https://doi.org/10.1093/brain/awx188 (Original work published 2017)
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Guillery, E., Mouraux, A., Thonnard, J.-L., & Legrain, V. (2017). Mind Your Grip: Even Usual Dexterous Manipulation Requires High Level Cognition. Frontiers in Behavioral Neuroscience, 11, 220 [1-11]. https://doi.org/10.3389/fnbeh.2017.00220 (Original work published 2017)
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Torta, D., Legrain, V., Mouraux, A., & Valentini, E. (2017). Attention to pain! A neurocognitive perspective on attentional modulation of pain in neuroimaging studies. Cortex, 89, 120-134. https://doi.org/10.1016/j.cortex.2017.01.010 (Original work published 2017)
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Orban de Xivry, J.-J., Legrain, V., & Lefèvre, P. (2017). Overlap of movement planning and movement execution reduces reaction time. Journal of Neurophysiology, 117(1), 117-122. https://doi.org/10.1152/jn.00728.2016 (Original work published 2017)
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Vanderclausen, C., Filbrich, L., Alamia, A., & Legrain, V. (2017). Investigating peri-limb interaction between nociception and vision using spatial depth. Neuroscience Letters, 654, 111-116. https://doi.org/10.1016/j.neulet.2017.05.060 (Original work published 2017)
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Chapitre de livreLegrain, V. (2017). Neurosciences cognitives et douleur. In Encyclopaedia Universalis. Encyclopaedia Universalis SA.
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Papier de conférenceLegrain, V. (2016). Characterizing spatial cognition impairments in CRPS patients. Satellite symposium of the 16th World Congress on Pain, Tokyo.
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Legrain, V. (2016). Mapping pain in a multisensory space. Neuronus 2016 IBRO & IRUN Neuroscience Forum, Krakow.
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Legrain, V., Vanderclausen, C., Blandiaux, S., & Filbrich, L. (2016). Neuropsychology of body perception: insights from the study of hemispatial neglect and extinction. 24th Brussels Hand/Upper Limb International Symposium, Genval, Belgium.
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Verfaille, C., Cordova Bulens, D., Filbrich, L., Barbier, O., Libouton, X., Fraselle, V., Mouraux, D., Berquin, A., & Legrain, V. (2016). Does CRPS impair visuo-motor coordination in peripersonal space? Pain Research Meeting, Rauischholzhausen, Germany.
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Mouraux, A., Torta, D., & Legrain, V. (2016). Pain, neglect and the central representation of the body in CRPS. 24th Brussels Hand/Upper Limb International Symposium, Genval Belgium. 24th Brussels Hand/Upper Limb International Symposium, Genval, Belgium. (Original work published 2016)
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Article de journalVan der Biest, L., Legrain, V., Paepe, A. D., & Crombez, G. (2016). Watching what’s coming near increases tactile sensitivity: An experimental investigation. Behavioural Brain Research, 297, 307-314. https://doi.org/10.1016/j.bbr.2015.10.028 (Original work published 2016)
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De Paepe, A. L., Crombez, G., & Legrain, V. (2016). What’s Coming Near? The Influence of Dynamical Visual Stimuli on Nociceptive Processing. PLoS One, 11(5), e0155864. https://doi.org/10.1371/journal.pone.0155864 (Original work published 2016)
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Filbrich, L., Torta, D., Vanderclausen, C., Azanon, E., & Legrain, V. (2016). Using temporal order judgments to investigate attention bias toward pain and threat-related information. Methodological and theoretical issues. Consciousness and Cognition, 41, 135-138. https://doi.org/10.1016/j.concog.2016.02.008 (Original work published 2016)
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Torta, D., Legrain, V., Rossetti, Y., & Mouraux, A. (2016). Prisms for pain. Can visuo-motor rehabilitation strategies alleviate chronic pain ? European Journal of Pain, 20(1), 64-69. https://doi.org/10.1002/ejp.723 (Original work published 2016)
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Article de journalTorta, D., Legrain, V., & Mouraux, A. (2015). Looking at the hand modulates the brain responses to nociceptive and non-nociceptive somatosensory stimuli but does not necessarily modulate their perception. Psychophysiology : an international journal, 52, 1010-1018. https://doi.org/10.1111/psyp.12439 (Original work published 2015)
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Colon, E., Legrain, V., Huang, G., & Mouraux, A. (2015). Frequency-tagging of steady-state evoked potentials to explore the crossmodal links in spatial attention between vision and touch. Psychophysiology : an international journal, 52(11), 1498-1510. https://doi.org/10.1111/psyp.12511 (Original work published 2015)
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Riquelme, I., Henne, C., Flament, B., Legrain, V., Bleyenheuft, Y., & Hatem, S. (2015). Use of prism adaptation in children with unilateral brain lesion: Is it feasible? Research in Developmental Disabilities, 43-44, 61-71. https://doi.org/10.1016/j.ridd.2015.06.009 (Original work published 2015)
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De Paepe, A. L., Crombez, G., & Legrain, V. (2015). From a Somatotopic to a Spatiotopic Frame of Reference for the Localization of Nociceptive Stimuli. PLoS One, 10(8), e0137120. https://doi.org/10.1371/journal.pone.0137120 (Original work published 2015)
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Papier de conférenceColon, E., Legrain, V., & Mouraux, A. (2015). EEG frequency-tagging to explore the crossmodal links in spatial attention between vision and touch. Neuronus, IBRO & IRUN Neuroscience Forum, Krakow, Poland.
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De Paepe, A., Crombez, G., & Legrain, V. (2015). Localizing nociceptive stimuli in peripersonal space: the role of spatial perception in pain. 4th ARPH (Association for Researchers in Psychology and Health) Conference, Ghent, Belgium.
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Legrain, V. (2015). Aspects neuropsychologiques de la nociception et de la douleur. Centre hospitalier neurologique William Lennox, Ottignies.
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Guillery, E., Mouraux, A., Thonnard, J.-L., & Legrain, V. (2015). Assessing cognitive interference on motor control. Frontiers in Neuroscience, 9. (Original work published 2015)
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Chapitre de livreLegrain, V., & Torta, D. (2015). Cognitive psychology and neuropsychology of nociception and pain. In Pickering G. & Gibson S. (ed.), Pain, Emotion and Cognition: a Complex Nexus (pp. 2-20). Springer. https://doi.org/10.1007/978-3-319-12033-1_1
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Article de journalFavril, L., Sambo, C. F., Mouraux, A., & Legrain, V. (2014). Shifting attention between the space of the body and external space: Electrophysiological correlates of visual-nociceptive crossmodal spatial attention. Psychophysiology : an international journal, 51(5), 464-477. https://doi.org/10.1111/psyp.12157 (Original work published 2014)
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Colon, E., Legrain, V., & Mouraux, A. (2014). EEG frequency-tagging to dissociate the cortical responses to nociceptive and non-nociceptive stimuli. Journal of Cognitive Neuroscience, 26(10), 2262-2274. https://doi.org/10.1162/jocn_a_00648 (Original work published 2014)
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Mouraux, A., Marot, E., & Legrain, V. (2014). Short trains of intra-epidermal electrical stimulation to elicit reliable behavioral and electrophysiological responses to the selective activation of nociceptors in humans. Neuroscience Letters, 561(21), 69-73. https://doi.org/10.1016/j.neulet.2013.12.017 (Original work published 2014)
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De Paepe, A. L., Crombez, G., Spence, C., & Legrain, V. (2014). Mapping nociceptive stimuli in a peripersonal frame of reference: Evidence from a temporal order judgment task. Neuropsychologia, 56, 219-228. https://doi.org/10.1016/j.neuropsychologia.2014.01.016 (Original work published 2014)
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Papier de conférenceTorta, D., Legrain, V., & Mouraux, A. (2014). The effect of direct or mirror vision of the hand on the processing of nociceptive and non-nociceptive somatosensory inputs: an ERP study. 30th International Congress of Clinical Neurophysiology (ICCN), Berlin, Germany.
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Papier de conférenceLegrain, V., & Annick De Paepe. (2013). Localizing nociceptive stimuli in peripersonal space: behavioral and electrophysiological evidence. Laser Talks in Lecce (Laser talks in Europe 6th edition), Lecce.
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Legrain, V. (2013). Hemispatial neglect in complex regional pain syndrome. Theoretical and clinical implications. 1st Meeting of the Belgian Neurorehabilitation Society, Brussels.
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Colon, E., Legrain, V., & Mouraux, A. (2013). EEG frequency-tagging to dissociate the cortical responses to nociceptive and non-nociceptive stimuli. Laser Talks, Lecce.
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Legrain, V. (2013). Pain, body, and space. Neuropsychological approach of the spatial perception of pain. ImpAct Team, Centre de Recherche en Neuroscience de Lyon (INSERM-CNRS-Lyon 1), Lyon.
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Legrain, V. (2013). Visuospatial influences of nociception. A cognitive approach of pain processing. International Congress on Neuropathic Pain, Toronto.
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Article de journalMouraux, A., De Paepe, A., Marot, E., Plaghki, L., & Legrain, V. (2013). Unmasking the obligatory components of nociceptive event-related brain potentials. Journal of Neurophysiology, 110, 2312-2324. https://doi.org/10.1152/jn.00137.2013 (Original work published 2013)
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Van Ryckeghem, D. M. L., Crombez, G., Eccleston, C., Legrain, V., & Van Damme, S. (2013). Keeping pain out of your mind: The role of attentional set in pain. European Journal of Pain, 17(3), 402-411. https://doi.org/10.1002/j.1532-2149.2012.00195.x (Original work published 2013)
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Caty, G., Hu, L., Legrain, V., Plaghki, L., & Mouraux, A. (2013). Psychophysical and electrophysiological evidence for nociceptive dysfunction in CRPS. PAIN®, 154(11), 2521-2528. https://doi.org/10.1016/j.pain.2013.07.038 (Original work published 2013)
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Legrain, V., & Mouraux, A. (2013). Activating selectively and reliably nociceptive afferents with concentric electrode stimulation: Yes we can! Provided that low stimulus intensities are used! Clinical Neurophysiology, 124(2), 424. https://doi.org/10.1016/j.clinph.2012.05.026 (Original work published 2013)
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Torta, D., Legrain, V., Algoet, M., Olivier, E., Duque, J., & Mouraux, A. (2013). Theta burst stimulation applied over primary motor and somatosensory cortices produces analgesia unrelated to the changes in nociceptive event-related potentials. PLoS One, 8(8), e73263. https://doi.org/10.1371/journal.pone.0073263 (Original work published 2013)
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Legrain, V. (2013). Une approche cognitive de la nociception et de la douleur – Een cognitieve benaderingswijze van nociceptie en pijn. Neurone, 18, 1-5. (Original work published 2013)
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Legrain, V., Crombez, G., Plaghki, L., & Mouraux, A. (2013). Shielding cognition from nociception with working memory. Cortex, 49(7), 1922-1934. https://doi.org/10.1016/j.cortex.2012.08.014 (Original work published 2013)
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Chapitre de livreRossetti, Y., Jacquin-Courtois, S., Legrain, V., & et al. (2013). Le syndrome douloureux régional chronique à la lumière des troubles de la cognition spatiale: des opportunités physiopathologiques et thérapeutiques? In Ribnik P., Genty. (Eds). (ed.), Syndrome douloureux chroniques en médecine physique et de réadaptation (pp. 99-109). Springer-Verlag.
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Article de journalChuryukanov, M., Plaghki, L., Legrain, V., & Mouraux, A. (2012). Thermal detection thresholds of Aδ- and C-fibre afferents activated by brief CO2 laser pulses applied onto the human hairy skin. PLoS One, 7(4), e35817 [1-9]. https://doi.org/10.1371/journal.pone.0035817 (Original work published 2012)
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Legrain, V., Bultitude, J. H., De Paepe, A. L., & Rossetti, Y. (2012). Pain, body, and space : what do patients with complex regional pain syndrome really neglect? PAIN®. Published. https://doi.org/10.1016/j.pain.2011.12.010 (Original work published 2012)
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Colon, E., Nozaradan, S., Legrain, V., & Mouraux, A. (2012). Steady-state evoked potentials to tag specific components of nociceptive cortical processing. NeuroImage, 60(1), 571-581. https://doi.org/10.1016/j.neuroimage.2011.12.015 (Original work published 2012)
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Van Damme, S., & Legrain, V. (2012). How efficient is the orienting of spatial attention to pain? An experimental investigation. PAIN®, 153(6), 1226-1231. https://doi.org/10.1016/j.pain.2012.02.027 (Original work published 2012)
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Huart, C., Legrain, V., Hummel, T., Rombaux, P., & Mouraux, A. (2012). Time-Frequency Analysis of Chemosensory Event-Related Potentials to Characterize the Cortical Representation of Odors in Humans. PLoS One, 7(3), e33221. https://doi.org/10.1371/journal.pone.0033221 (Original work published 2012)
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Colon, E., Legrain, V., & Mouraux, A. (2012). Steady-state evoked potentials to study the processing of tactile and nociceptive somatosensory input in the human brain. Neurophysiologie Clinique, 42(5), 315-523. https://doi.org/10.1016/j.neucli.2012.05.005 (Original work published 2012)
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Jacquin-Courtois, S., Rossetti, Y., Legrain, V., Sumitani, M., & Miyauchi, S. (2012). Adaptation visuomotrice et représentations corporelles: de la négligence au syndrome douloureux régional complexe. La Lettre de Médecine Physique et de Réadaptation, 28(2), 93-98. https://doi.org/10.1007/s11659-012-0315-2 (Original work published 2012)
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Papier de conférenceLegrain, V. (2012). Shielding cognition form nociception with working memory. Annual Scientific Meeting of the Belgian Pain Society, Leuven.
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Legrain, V. (2012). The salience detection hypothesis: a brain that protects its body. 14th World Congress on Pain, Milan.
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Article de journalRyckeghem, D. M. L., Damme, S., Crombez, G., Eccleston, C., Verhoeven, K., & Legrain, V. (2011). The role of spatial attention in attentional control over pain: an experimental investigation. Experimental Brain Research, 208(2), 269-275. https://doi.org/10.1007/s00221-010-2477-y (Original work published 2011)
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Legrain, V., Crombez, G., & Mouraux, A. (2011). Controlling attention to nociceptive stimuli with working memory. PLoS One, 6(6), e20926 [1-9]. https://doi.org/10.1371/journal.pone.0020926 (Original work published 2011)
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Verhoeven, K., Stefaanl, V. D., Christopherl, E., Dimitri, M. L. R., Legrain, V., & Geertl, C. (2011). Distraction from pain and executive functioning: An experimental investigation of the role of inhibition, task switching and working memory. European Journal of Pain, 15(8), 866-873. https://doi.org/10.1016/j.ejpain.2011.01.009 (Original work published 2011)
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Legrain, V., Crombez, G., Verhoeven, K., & Mouraux, A. (2011). The role of working memory in the attentional control of pain. PAIN®, 152(2), 453-459. https://doi.org/10.1016/j.pain.2010.11.024 (Original work published 2011)
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Legrain, V. (2011). Where is my pain? PAIN®, 152(3), 467-468. https://doi.org/10.1016/j.pain.2010.11.011 (Original work published 2011)
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Mouraux, A., Iannetti, G. D., Colon, E., Nozaradan, S., Legrain, V., & Plaghki, L. (2011). Nociceptive steady-state evoked potentials elicited by rapid periodic thermal stimulation of cutaneous nociceptors. The Journal of Neuroscience, 31(16), 6079-6087. https://doi.org/10.1523/JNEUROSCI.3977-10.2011 (Original work published 2011)
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Chouchoul, F., Pichotl, V., Perchetl, C., Legrain, V., Garcia-Larreal, L., Rochel, F., & Bastujil, H. (2011). Autonomic pain responses during sleep: A study of heart rate variability. European Journal of Pain, 15(6), 554-560. https://doi.org/10.1016/j.ejpain.2010.11.011 (Original work published 2011)
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Legrain, V., Iannetti, G. D., Plaghki, L., & Mouraux, A. (2011). The pain matrix reloaded : a salience detection system for the body. Progress in Neurobiology, 93(1), 111-124. https://doi.org/10.1016/j.pneurobio.2010.10.005 (Original work published 2011)
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Papier de conférenceMouraux, A., GianDominico Iannetti, Colon, E., Nozaradan, S., Legrain, V., & Plaghki, L. (2011). Nociceptive steady-state evoked potentials. 20th Neuromeeting Burgundy, Beaune.
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Mouraux, A., Colon, E., Legrain, V., & et al. (2011). Novel approaches to characterize the cortical representation of pain in the brain. Acta Neurologica Belgica 110th Anniversary Symposium, special meeting of the Belgian Neurological Society, Brussels.
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Colon, E., Nozaradan, S., Legrain, V., & Mouraux, A. (2011). Nociceptive and non-nociceptive steady-state evoked potentials tag distinct cortical network. Laser Talks, Alborg, Denmark.
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Legrain, V. (2011). Shielding cognitive processing from distraction from pain with working memory. Laser Talks in Aalborg (Laser talks in Europe 5th edition), Aalborg.
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Torta, D., Legrain, V., & Mouraux, A. (2011). A multimodal imaging study for the investigation of the neural mechanisms of the TMS induced analgesia. Societa’ italiana di psicofisiologia (SIPF). 19th Congress of the Italian Psychophysiological Society (SIPF), Brescia, Italy. (Original work published 2011)
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Legrain, V. (2011). Obligatory and non-obligatory components of nociceptive event-related brain potentials. 20th Neuromeeting Burgundy, Beaune.
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Article de journalVan Damme, S., Legrain, V., Vogt, J., & Crombez, G. (2010). Keeping pain in mind: A motivational account of attention to pain. Neuroscience & Biobehavioral Reviews, 34(2), 204-213. https://doi.org/10.1016/j.neubiorev.2009.01.005 (Original work published 2010)
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Pollok, B., Krause, V., Legrain, V., Ploner, M., Freynhagen, R., Melchior, I., Schnitzler, A., & Sugihara, I. (2010). Differential Effects of Painful and Non-Painful Stimulation on Tactile Processing in Fibromyalgia Syndrome and Subjects with Masochistic Behaviour. PLoS One, 5(12), e15804. https://doi.org/10.1371/journal.pone.0015804 (Original work published 2010)
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Article de journalVan Damme, S., Crombez, G., Wiech, K., Legrain, V., Peters, M. L., & Eccleston, C. (2009). Why become more general when we can be more specific? Comment on Hollins et al. “Perceived intensity and unpleasantness of cutaneous and auditory stimuli: an evaluation of the generalized hypervigilance hypothesis” [Pain 2009;141:215-221], and on Rollman “Perspectives on hypervigilance” [Pain 2009;141:183-184]. PAIN®, 144(3), 342-3; author reply 343-4. https://doi.org/10.1016/j.pain.2009.04.035 (Original work published 2009)
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Legrain, V., VAN Damme, S., Eccleston, C., Davis, K. D., Seminowicz, D. A., & Crombez, G. (2009). A neurocognitive model of attention to pain: Behavioral and neuroimaging evidence. PAIN®, 144(3), 230-232. https://doi.org/10.1016/j.pain.2009.03.020 (Original work published 2009)
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Legrain, V., Perchet, C., & Garcia-Larrea, L. (2009). INVOLUNTARY ORIENTING OF ATTENTION TO NOCICEPTIVE EVENTS. NEURAL AND BEHAVIORAL SIGNATURES. Journal of Neurophysiology, 102(4), 2423-2434. https://doi.org/10.1152/jn.00372.2009 (Original work published 2009)
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Papier de conférenceLegrain, V. (2009). Cognitive and attentional modulation of LEPs: novelty effects and orienting attention. Laser Talks in Mannheim (Laser talks in Europe 4th edition), Mannheim.
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Article de journalBastuji, H., Perchet, C., Legrain, V., Montes, C., & García-Larrea, L. (2008). Laser evoked responses to painful stimulation persist during sleep and predict subsequent arousals. PAIN®, 137(3), 589-599. https://doi.org/10.1016/j.pain.2007.10.027 (Original work published 2008)
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Perchet, C., Godinho, F., Mazza, S., Frot, M., Legrain, V., Magnin, M., & Garcia-Larrea, L. (2008). Evoked potentials to nociceptive stimuli delivered by CO2 or Nd:YAP lasers. Clinical Neurophysiology, 119(11), 2615-2622. https://doi.org/10.1016/j.clinph.2008.06.021 (Original work published 2008)
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Legrain, V. (2008). La modulation de la douleur par l’attention. Les apports de la neurophysiologie. Douleur et Analgésie, 21(2), 99-107. https://doi.org/10.1007/s11724-008-0089-0 (Original work published 2008)
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Papier de conférenceGarcia-Larrea Luis, Godinho Fabio, Frot Maud, Legrain, V., & Peyron Roland. (2008). Attention and emotion modify pain perception through different neurophysiological mechanisms. Clinical Neurophysiology, 119, S52. (Original work published 2008)
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Plaghki, L., & Legrain, V. (2008). High-order nociceptive processing anomalies in chronic pain syndromes. 16th European Congress of Physical Medicine and Rehabilitation, Bruges.
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Bastuji Hélène, Perchet Caroline, Mazza Stéphanie, & Legrain, V. (2008). Brain processing of nociceptive stimulation during sleep in humans: surface and intracortical responses. Clinical Neurophysiology, 40, S32. (Original work published 2008)
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Legrain, V. (2008). Interaction between top-down and bottom-up attention attentional processes in pain modulation. Special Interest Meeting “Symptom Perception and Illness Behaviour”, Bellem.
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Bastuji Hélène, Perchet Caroline, Mazza Stéphanie, Legrain, V., & et al. (2008). Traitement cortical de l’information nociceptive au cours du sommeil chez l’Homme : Réponses intra-cérébrales et de surface. 4ème Symposium National du Réseau Recherche sur la Douleur, Strasbourg.
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Hélène Bastuji, Caroline Perchet, Stéphanie Mazza, Legrain, V., & et al. (2008). Brain processing of nociceptive stimulation during sleep in humans: surface and intracortical responses. 19th Congress of the European Sleep Research Society, Glasgow.
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Papier de conférenceLegrain, V. (2007). Traitement cérébral de l’information nociceptive au cours du sommeil. Etude neurophysiologique au moyen des potentiels évoqués laser. Congrès de la Société de Neurophysiologie Clinique de Langue Française, Bordeaux.
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Legrain, V. (2007). Attentional modulations of nociception and pain perception. Neurophysiological studies with laser-evoked potentials. Lab of Magnetoencephalography, Heinrich Heine Universität, Düsseldorf, Düsseldorf.
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Papier de conférenceBastuji Hélène, Perchet Caroline, Legrain, V., & Garcia-Larrea Luis. (2006). Laser evoked responses to painful stimulation during sleep. 18th Congress of the European Sleep Research Society, Innsbruck.
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Article de journalLegrain, V., Plaghki, L., & García-Larrea, L. (2005). Cognitive modulation of pain-related brain responses. Comments on Seminowicz et al. (Pain 2004;112:48-58). PAIN®, 114(3), 524-6; author reply 526-7. https://doi.org/10.1016/j.pain.2005.01.025 (Original work published 2005)
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Legrain, V., Bruyer, R., Guerit, J.-M., & Plaghki, L. (2005). Involuntary orientation of attention to unattended deviant nociceptive stimuli is modulated by concomitant visual task difficulty. Evidence from laser evoked potentials. Clinical Neurophysiology, 116(9), 2165-2174. https://doi.org/10.1016/j.clinph.2005.05.019 (Original work published 2005)
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Papier de conférenceLegrain, V. (2005). Attentional modulations of the nociceptive processing in the human brain as revealed by laser-evoked potentials (LEPs) and magnetic fields (LEFs). Laser Talks in Brussels (Laser talks in Europe 2nd edition), Brussels.
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Legrain, V. (2005). EP assessment of pain. Functional aspects: studies of attentional modulations with laser-evoked potientials (LEPs) and magnetic fields (LEFs). 14th Neuromeeting Burgundy, Beaune.
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Article de journalLegrain, V., Guerit, J.-M., Bruyer, R., & Plaghki, L. (2003). Electrophysiological correlates of attentional orientation in humans to strong intensity deviant nociceptive stimuli, inside and outside the focus of spatial attention. Neuroscience Letters, 339(2), 107-110. https://doi.org/10.1016/S0304-3940(02)01485-4 (Original work published 2003)
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Legrain, V., Bruyer, R., Guerit, J.-M., & Plaghki, L. (2003). Nociceptive processing in the human brain of infrequent task-relevant and task-irrelevant noxious stimuli. A study with event-related potentials evoked by CO2 laser radiant heat stimuli. PAIN®, 103(3), 237-248. https://doi.org/10.1016/S0304-3959(02)00451-7 (Original work published 2003)
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Papier de conférenceLegrain, V. (2003). Evoked potential mapping of human pain: attention and distraction effects. Pain in Europe IV, EFIC Triennal Congress, Prague.
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Legrain, V., & Guérit Jean-Michel. (2003). Réponses nociceptives au laser enregistrées en mode “oddball”. 12th Neuromeeting Burgundy, Nuits Saint-Georges.
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Article de journalLegrain, V., Guerit, J.-M., Bruyer, R., & Plaghki, L. (2002). Attentional modulation of the nociceptive processing into the human brain: selective spatial attention, probability of stimulus occurrence, and target detection effects on laser evoked potentials. PAIN®, 99(1-2), 21-39. https://doi.org/10.1016/S0304-3959(02)00051-9 (Original work published 2002)
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Papier de conférenceLegrain, V. (2001). Attentional modulation of the nociceptive processing into the human brain: selective spatial attention, probability of stimulus occurrence, and target detection. Fall Meeting of the Belgian Society of Clinical Neurophysiology, Brussels.
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Article de journalLegrain, V., Janne, P., Laloux, P., Ossemann, M., Dupuis, M., & Reynaert, C. (2001). Intérêts clinique et physiopathologique des potentiels évoqués cognitifs dans la migraine. Revue Neurologique, 157(4), 365-375. (Original work published 2001)
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Article de journalLegrain, V. (2000). L’apport des potentiels évoqués cognitifs à l’étude de la migraine: une approche psychophysiologique – Het belang van de cognitieve opgewekte potentialen bij de studie van migraine : een psychofysiologische benadering. Neurone/Neuron, 5, 73-78. (Original work published 2000)
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Papier de conférenceLegrain, V., & Ophoven Eric. (1999). Evaluation des facteurs psychologiques liés aux céphalées de tension: revue des instruments psychométriques. 23ème réunion annuelle de la Société Française de la Douleur, Lille.
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Article de journalLegrain, V., & Ophoven, E. (1999). Evaluation des facteurs psychologiques liés aux céphalées de tension: revue des instruments psychométriques. Douleur et Analgésie, 12(1), 101-110. https://doi.org/10.1007/BF03007064 (Original work published 1999)
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