Mammalian Development & Cell Biology (MACE Lab)
ions | Bruxelles Woluwe, Louvain-la-Neuve
Research
The mammalian cerebral cortex plays key roles in learning and memory, the control of sensory and motor functions or of our emotions. The proper execution of these tasks depends on a long process of embryonic and postnatal development which relies on the production by neural stem cells of the appropriate number of neurons with proper identities that migrate to their specific location and make connections with each other. Defective signaling pathways during development are the causes of human brain disorders such as lissencephalies and heterotopias, mental retardation, dyslexia, schizophrenia, autism, epilepsy and many others. The goal of our laboratory is to better define the mechanisms of neural cell proliferation, migration, differentiation and synaptogenesis.
A better understanding of how the brain develops in normal conditions and in disease will provide new concepts for therapeutic approaches to improve diagnosis and to treat and prevent neurodevelopmental disorders.
video MACE
Publications
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Article de journalCalvo-Jiménez, E., Stam, K., Jossi, A., & Jossin, Y. (2025). GRASPs link Reelin to the Golgi during neocortical development to control neuronal migration and dendritogenesis. Communications Biology, 8(1), 1-14. https://doi.org/10.1038/s42003-025-08014-x (Original work published 2025)
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Article de journalBoucherie, C., Alkailani, M., Jossin, Y., Ruiz Reig, N., Mahdi, A., Aldaalis, A., Aittaleb, M., & Tissir, F. (2024). Auts2 enhances neurogenesis and promotes expansion of the cerebral cortex. Journal of Advanced Research. Accepted/in-press. https://doi.org/10.1016/j.jare.2024.07.012 (Original work published 2024)
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Article de journalCossard, A., Stam, K., Smets, A., & Jossin, Y. (2023). MKL/SRF and Bcl6 mutual transcriptional repression safeguards the fate and positioning of neocortical progenitor cells mediated by RhoA. Science advances, 9(46), eadd0676 [1-20]. https://doi.org/10.1126/sciadv.add0676 (Original work published 2023)
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Article de journalJossin, Y. (2020). Molecular mechanisms of cell polarity in a range of model systems and in migrating neurons. Molecular and Cellular Neuroscience, 106, 103503 [1-23]. https://doi.org/10.1016/j.mcn.2020.103503 (Original work published 2020)
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Article de journalKon, E., Calvo Jimenez, E., Cossard, A., Na, Y., Cooper, J. A., & Jossin, Y. (2019). N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration. eLife, 8. https://doi.org/10.7554/eLife.47673 (Original work published 2019)
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Article de journalKon, E., Cossard, A., & Jossin, Y. (2017). Neuronal Polarity in the Embryonic Mammalian Cerebral Cortex. Frontiers in Cellular Neuroscience, 11. https://doi.org/10.3389/fncel.2017.00163 (Original work published 2017)
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Article de journalDimidschstein, J., Passante, L., Dufour, A., van den Ameele, J., Tiberi, L., Hrechdakian, T., Adams, R., Klein, R., Lie, D., Jossin, Y., & Vanderhaeghen, P. (2013). Ephrin-B1 Controls the Columnar Distribution of Cortical Pyramidal Neurons by Restricting Their Tangential Migration. Neuron, 79(6), 1123-1135. https://doi.org/10.1016/j.neuron.2013.07.015 (Original work published 2013)
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Article de journalJossin, Y. (2011). Polarization of migrating cortical neurons by Rap1 and N-cadherin: Revisiting the model for the Reelin signaling pathway. Small GTPases, 2(6), 322-328. https://doi.org/10.4161/sgtp.18283 (Original work published 2011)
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Jossin, Y., & Cooper, J. A. (2011). Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex. Nature Neuroscience, 14(6), 697-703 (2011 juin). https://doi.org/10.1038/nn.2816 (Original work published 2011)
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Article de journalFörster, E., Jossin, Y., Zhao, S., Chai, X., Frotscher, M., & Goffinet, A. (2006). Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus. European Journal of Neuroscience, 23(4), 901-909. https://doi.org/10.1111/j.1460-9568.2006.04612.x (Original work published 2006)
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Article de journalBock, H. H., Jossin, Y., Liu, P., Förster, E., May, P., Goffinet, A., & Herz, J. (2003). Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. Journal of Biological Chemistry, 278(40), 38772-38779. https://doi.org/10.1074/jbc.M306416200 (Original work published 2003)
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Jossin, Y., Bar, I., Ignatova, N., Tissir, F., De Rouvroit, C. L., & Goffinet, A. (2003). The reelin signaling pathway: some recent developments. Cerebral cortex (New York, N.Y. : 1991), 13(6), 627-633. https://doi.org/10.1093/cercor/13.6.627 (Original work published 2003)
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Article de journalGilot, P., Jossin, Y., & Content, J. (2000). Cloning, sequencing and characterisation of a Listeria monocytogenes gene encoding a fibronectin-binding protein. Journal of Medical Microbiology, 49(10), 887-896. https://hdl.handle.net/2078.5/231972 (Original work published 2000)
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