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Institute Of NeuroScience

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Institute Of NeuroScience

Neuroinflammation Imaging Lab (NIL)

ions | Bruxelles Woluwe, Louvain-la-Neuve

The standard MRI protocols routinely used for MS diagnosis have a limited specificity for the underlying brain pathology, possibly resulting in wrong diagnosis and incorrect treatments for patients. At the same time, using the same routine imaging protocols, the pathological heterogeneity of what is currently diagnosed as "MS" is probably underestimated, limiting the application of MRI as a tool to guide individually tailored treatment. The major goal of our research is to combine advanced and more established imaging, laboratory and clinical data in order i) to "dissect" the pathological heterogeneity between MS and mimicking disorders, ii) identify different pathological entities within the "MS spectrum" itself and, iii) evaluate clinical course and response-to-treatment based on the extracted multimodal features.

Thanks to the very productive collaboration between highly experienced clinicians (at Cliniques Universitaires Saint-Luc), talented neuroimaging scientists (NEUR, Institute of Neuroscience (IoNS), UCLouvain) and neuroimmunologists (CEMO, Institute of Neuroscience (IoNS), UCLouvain), we perform advanced MRI on neuroinflammatory patients, and we study the association between imaging, clinical and biological features.

Pietro Maggi
2021-present, principal investigator

Colin Vanden Bulke
2021-present, PhD student

Maxence Wynen
2021-present, PhD student

Anna Stölting
2022-present, PhD student

Serena Borrelli
2023-present, PhD student

François Guisset
2023-present, visiting fellow

 

NIL group picture

National

Vincent van Pesch, MD, PhD, Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium (BE)
Topic: Advanced soluble biomarkers of neuroinflammation.

Barbara Willekens, MD, PhD, Antwerp University Hospital, Antwerp, Belgium (BE)
Topic: Advanced MRI diagnostic biomarkers.

International

Renaud du Pasquier, MD, Head of the Department of Neurology, Lausanne University Hospital, Lausanne (CH)
Topic: neuroimmunology and biomarkers.

Meritxell Bach Cuadra, PhD, Director, Medical Image Analysis Laboratory, University of Lausanne, Lausanne (CH)
Topic: machine learning techniques.

Daniel S. Reich, MD, PhD Chief, Translational Neuroradiology Section/NINDS/NIH, Bethesda (US)
Topic: advanced MRI biomarkers.

Martina Absinta, MD, PhD, San Raffaele University Hospital, Milan (IT)
Topic: advanced MRI biomarkers.

Massimiliano Calabrese, MD, University Hospital of Verona, Verona (IT)
Topic: advanced MRI diagnostic biomarkers.

Andrew Solomon, MD, University of Vermont, VT (USA)
Topic: advanced MRI diagnostic biomarkers.

  • Unravelling MS lesion morphology and heterogeneity using advanced MRI metrics and their links to clinical scores and soluble biomarkers.
  • Treatment effects on chronic active MS lesions using advanced imaging and laboratory biomarkers.
  • Combination of advanced MRI biomarkers to improve the diagnostic and prognostic workup of MS patients.
  • Studying the role of small vessel disease in MS.
  • Study the interplay between neuroinflammation, glymphatic system disfunction and neurodegeneration and the role of lifestyle habits (e.g. diet) in MS.

Maggi P, Macri SM, Gaitán MI, Leibovitch E, Wholer JE, Knight HL, Ellis M, Wu T, Silva AC, Massacesi L, Jacobson S, Westmoreland S, Reich DS. The formation of inflammatory demyelinated lesions in cerebral white matter. Annals of neurology. 2014;76(4):594-608.

Maggi P, Absinta M, Grammatico M, Vuolo L, Emmi G, Carlucci G, Spagni G, Barilaro A, Repice AM, Emmi L, Prisco D, Martinelli V, Scotti R, Sadeghi N, Perrotta G, Sati P, Dachy B, Reich DS, Filippi M, Massacesi L. Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies. Annals of neurology. 2018;83(2):283-294. doi:10.1002/ana.25146.

Maggi P, Kuhle J, Schädelin S, van der Meer F, Weigel M, Mathias A, Lu PJ, Rahmanzadeh R, Benkert P, La Rosa F, Bach Cuadra M, Sati P, Théaudin M, Pot C, van Pesch V, Leppert D, Stadelmann C, Kappos L, Du Pasquier R, Reich DS, Absinta M, Granziera C. Association of chronic white matter inflammation and neurofilament levels in patients with multiple sclerosis. Neurology. 2021 Jun 4;10.1212/WNL.0000000000012326.

Maggi P, Sati P, Cortese I, Jacobson S, Smith BR, Nath A, Ohayon J, van Pesch V, Perrotta G, Pot C, Théaudin M, Martinelli V, Scotti R, Wu T, Du Pasquier R, Calabresi P, Filippi M, Reich DS, Absinta M. Paramagnetic rim lesions are specific to multiple sclerosis: an international multicenter 3-Tesla MRI study. Annals of neurology. 2020; 88(5):1034-1042. doi:10.1002/ana.25877.

Maggi P, Bulcke CV, Pedrini E, Bugli C, Sellimi A, Wynen M, et al. B cell depletion therapy does not resolve chronic active multiple sclerosis lesions. eBioMedicine. 2023 Aug;94:104701.

Colin Vanden Bulcke, Anna Stölting, Dragan Maric, Benoît Macq, Martina Absinta, Pietro Maggi. Comparative overview of multi-shell diffusion MRI models to characterize the microstructure of multiple sclerosis lesions and periplaques. NeuroImage: Clinical 2024. doi.org/10.1016/j.nicl.2024.103593.

Borrelli S, Guisset F, Vanden Bulcke C, Stölting A, Bugli C, Lolli V, et al. Enlarged perivascular spaces are associated with brain microangiopathy and aging in multiple sclerosis. Mult Scler. 2024 Jun 7;13524585241256881.

Borrelli S, Martire MS, Stölting A, Vanden Bulcke C, Pedrini E, Guisset F, et al. Central Vein Sign, Cortical Lesions, and Paramagnetic Rim Lesions for the Diagnostic and Prognostic Workup of Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2024 Jul;11(4):e200253.

  • Journal article
    • 2025
      Wynen, Maxence ; Gordaliza, Pedro M. ; Istasse, Maxime ; Stölting, Anna ; Maggi, Pietro ; Macq, Benoît ; Bach Cuadra, Meritxell. ConfLUNet: Multiple sclerosis lesion instance segmentation in presence of confluent lesions. In: Computers in Biology and Medicine, Vol. 197, no.A, p. 110919 (2025). doi:10.1016/j.compbiomed.2025.110919 (Accepté/Sous presse).
      http://hdl.handle.net/2078.1/306382
    • Deltombe, Matthieu ; Stölting, Anna ; Maggi, Pietro ; Van Pesch, Vincent. FCRL5, a B-Cell Marker With Novel Diagnostic and Prognostic Value for Multiple Sclerosis. In: Neurology(R) neuroimmunology & neuroinflammation, Vol. 12, no.6, p. 2332-7812 (2025). doi:10.1212/NXI.0000000000200485.
      http://hdl.handle.net/2078.1/306375
    • Van Boxstael, Elisabeth ; de Hennin, Alexia ; Vigneul, Eric ; Scoppettuolo, Pasquale ; El Sankari, Souraya ; Bocchio, Anna Paola ; Borrelli, Serena ; Lolli, Valentina ; Van Pesch, Vincent ; Slootjes, Sofia Maldonado ; Finet, Patrice ; Rovira, Àlex ; Reich, Daniel S ; Maggi, Pietro. Posterior fossa ring-enhancing lesions in the adult immunocompetent host: illustrative cases, systematic review, and proposed diagnostic algorithm.. In: AJNR. American journal of neuroradiology, (2025). doi:10.3174/ajnr.A8677 (Accepté/Sous presse).
      http://hdl.handle.net/2078.1/301072
    • Martire, Maria Sofia ; Moiola, Lucia ; Maggi, Pietro ; Borrelli, Serena ; Novati, Valentina ; Martinelli, Vittorio ; Rocca, Maria A ; Vezzulli, Paolo ; Falini, Andrea ; Filippi, Massimo ; Absinta, Martina. Reliability of paramagnetic rim lesion detection at 1.5T MRI in multiple sclerosis patients.. In: Multiple sclerosis (Houndmills, Basingstoke, England), Vol. 31, no.2, p. 13524585251314358 (2025). doi:10.1177/13524585251314358.
      http://hdl.handle.net/2078.1/303466
    • Fagiani, F. ; Pedrini, E. ; Martire, M.S. ; Gastoldi, G. ; Vanden Bulcke, Colin ; Lin, J.-P. ; Maric, D. ; Brambilla, E. ; Ruffini, F. ; Peri, C. ; Calabresi, P.A. ; Maggi, Pietro ; Panina-Bordignon, P. ; Martino, G. ; Reich, D.S. ; Absinta, M.. Spatially-restricted inflammation-induced senescent-like glia in multiple sclerosis and patient-derived organoids. In: Nature Communications, Vol. 16, no.1, p. 8477 (2025). doi:10.1038/s41467-025-63371-9.
      http://hdl.handle.net/2078.1/306374
    • Borrelli, Serena ; Maggi, Pietro. The combination of central vein sign, cortical lesions, and paramagnetic rim lesions for differentiating MOGAD from MS: a case report. In: Acta Neurologica Belgica, Vol. 125, no.1, p. 1-280 (2025). doi:10.1007/s13760-024-02717-4.
      http://hdl.handle.net/2078.1/303468
    • 2024
      Borrelli, Serena ; Martire, Maria Sofia ; Stölting, Anna ; Vanden Bulcke, Colin ; Pedrini, Edoardo ; Guisset, François ; Bugli, Céline ; Yildiz, Halil ; Pothen, Lucie ; Elands, Sophie ; Martinelli, Vittorio ; Smith, Bryan ; Jacobson, Steven ; Du Pasquier, Renaud A. ; Van Pesch, Vincent ; Filippi, Massimo ; Reich, Daniel S. ; Absinta, Martina ; Maggi, Pietro. Central Vein Sign, Cortical Lesions, and Paramagnetic Rim Lesions for the Diagnostic and Prognostic Workup of Multiple Sclerosis. In: Neurology Neuroimmunology & Neuroinflammation, Vol. 11, no. 4 (2024) (2024) (2024). doi:10.1212/nxi.0000000000200253.
      http://hdl.handle.net/2078.1/288701
    • Borrelli, Serena ; Leclercq, Sophie ; Pasi, Marco ; Maggi, Pietro. Cerebral small vessel disease and glymphatic system dysfunction in multiple sclerosis: A narrative review. In: Multiple Sclerosis and Related Disorders, Vol. 91, no.10, p. 105878 (2024). doi:10.1016/j.msard.2024.105878.
      http://hdl.handle.net/2078.1/291471
    • Stölting, Anna ; Vanden Bulcke, Colin ; Borrelli, Serena ; Bugli, Céline ; Du Pasquier, Renaud ; Van Pesch, Vincent ; Maggi, Pietro. Clinical relevance of paramagnetic rim lesion heterogeneity in multiple sclerosis. In: Annals of clinical and translational neurology, Vol. 11, no. 12, p. 3137-3151 (2024). doi:10.1002/acn3.52220.
      http://hdl.handle.net/2078.1/296905
    • Vanden Bulcke, Colin ; Stölting, Anna ; Maric, Dragan ; Macq, Benoît ; Absinta, Martina ; Maggi, Pietro. Comparative overview of multi-shell diffusion MRI models to characterize the microstructure of multiple sclerosis lesions and periplaques. In: NeuroImage: Clinical, Vol. 42, p. 103593 (2024). doi:10.1016/j.nicl.2024.103593.
      http://hdl.handle.net/2078.1/288630
    • Cagol, Alessandro ; Cortese, Rosa ; Barakovic, Muhamed ; Schaedelin, Sabine ; Ruberte, Esther ; Absinta, Martina ; Barkhof, Frederik ; Calabrese, Massimiliano ; Castellaro, Marco ; Ciccarelli, Olga ; Cocozza, Sirio ; De Stefano, Nicola ; Enzinger, Christian ; Filippi, Massimo ; Jurynczyk, Maciej ; Maggi, Pietro ; Mahmoudi, Nima ; Messina, Silvia ; Montalban, Xavier ; Palace, Jacqueline ; Pontillo, Giuseppe ; Pröbstel, Anne-Katrin ; Rocca, Maria A ; Ropele, Stefan ; Rovira, Àlex ; Schoonheim, Menno M ; Sowa, Piotr ; Strijbis, Eva ; Wattjes, Mike P ; Sormani, Maria Pia ; Kappos, Ludwig ; Granziera, Cristina. Diagnostic Performance of Cortical Lesions and the Central Vein Sign in Multiple Sclerosis.. In: JAMA neurology, Vol. 81, no. 2, p. 143-153 (2024). doi:10.1001/jamaneurol.2023.4737.
      http://hdl.handle.net/2078.1/285621
    • Maggi, Pietro ; Absinta, Martina. Emerging MRI biomarkers for the diagnosis of multiple sclerosis. In: Multiple sclerosis journal, Vol. 14, no. 30, p. 1704-1713 (2024). doi:10.1177/13524585241293.
      http://hdl.handle.net/2078.1/297457
    • Borrelli, Serena ; Guisset, François ; Vanden Bulcke, Colin ; Stölting, Anna ; Bugli, Céline ; Lolli, Valentina ; Du Pasquier, Renaud ; van Pesch, Vincent ; Absinta, Martina ; Pasi, Marco ; Maggi, Pietro. Enlarged perivascular spaces are associated with brain microangiopathy and aging in multiple sclerosis. In: Multiple Sclerosis Journal, (2024). doi:10.1177/13524585241256881.
      http://hdl.handle.net/2078.1/288104
    • 2023
      Maggi, Pietro ; Vanden Bulcke, Colin ; Pedrini, Edoardo ; Bugli, Céline ; Sellimi, Amina ; Wynen, Maxence ; Stölting, Anna ; Mullins, William ; Kalaitzidis, Grigorios ; Lolli, Valentina ; Perrotta, Gaetano ; El Sankari, Souraya ; Duprez, Thierry ; Li, Xu ; Calabresi, Peter ; Van Pesch, Vincent ; Reich, Daniel ; Absinta, Martina. B cell depletion therapy does not resolve chronic active multiple sclerosis lesions. In: EBioMedicine, Vol. 94, p. 104701 [1-15] (2023). doi:10.1016/j.ebiom.2023.104701.
      http://hdl.handle.net/2078.1/275856
    • Filippi, Massimo ; Preziosa, Paolo ; Arnold, Douglas L. ; Barkhof, Frederik ; Harrison, Daniel M. ; Maggi, Pietro ; Mainero, Caterina ; Montalban, Xavier ; Sechi, Elia ; Weinshenker, Brian G. ; Rocca, Maria A.. Present and future of the diagnostic work-up of multiple sclerosis: the imaging perspective. In: Journal of neurology, Vol. 270, no. 3, p. 1286-1299 (2023). doi:10.1007/s00415-022-11488-y.
      http://hdl.handle.net/2078.1/272774
    • 2022
      Vanden Bulcke, Colin ; Wynen, Maxence ; Debotel, Jules ; La Rosa, Francesco ; Absinta, Martina ; Dricot, Laurence ; Macq, Benoît ; Bach Cuadra, Meritxell ; Maggi, Pietro. BMAT: An open-source BIDS managing and analysis tool. In: NeuroImage. Clinical, Vol. 36, p. 103252 [1-8] (2022). doi:10.1016/j.nicl.2022.103252.
      http://hdl.handle.net/2078.1/270030
    • La Rosa, Francesco ; Wynen, Maxence ; Al-Louzi, Omar ; Beck, Erin S ; Huelnhagen, Till ; Maggi, Pietro ; Thiran, Jean-Philippe ; Kober, Tobias ; Shinohara, Russell T ; Sati, Pascal ; Reich, Daniel S ; Granziera, Cristina ; Absinta, Martina ; Bach Cuadra, Meritxell. Cortical lesions, central vein sign, and paramagnetic rim lesions in multiple sclerosis: Emerging machine learning techniques and future avenues. In: NeuroImage. Clinical, Vol. 36, p. 103205 [1-14] (2022). doi:10.1016/j.nicl.2022.103205.
      http://hdl.handle.net/2078.1/272773
    • Singh, Bhagteshwar ; Lant, Suzannah ; Cividini, Sofia ; Cattrall, Jonathan W S ; Goodwin, Lynsey C ; Benjamin, Laura ; Michael, Benedict D ; Khawaja, Ayaz ; Matos, Aline de Moura Brasil ; Alkeridy, Walid ; Pilotto, Andrea ; Lahiri, Durjoy ; Rawlinson, Rebecca ; Mhlanga, Sithembinkosi ; Lopez, Evelyn C ; Sargent, Brendan F ; Somasundaran, Anushri ; Tamborska, Arina ; Webb, Glynn ; Younas, Komal ; Al Sami, Yaqub ; Babu, Heavenna ; Banks, Tristan ; Cavallieri, Francesco ; Cohen, Matthew ; Davies, Emma ; Dhar, Shalley ; Fajardo Modol, Anna ; Farooq, Hamzah ; Harte, Jeffrey ; Hey, Samuel ; Joseph, Albert ; Karthikappallil, Dileep ; Kassahun, Daniel ; Lipunga, Gareth ; Mason, Rachel ; Minton, Thomas ; Mond, Gabrielle ; Poxon, Joseph ; Rabas, Sophie ; Soothill, Germander ; Zedde, Marialuisa ; Yenkoyan, Konstantin ; Brew, Bruce ; Contini, Erika ; Cysique, Lucette ; Zhang, Xin ; Maggi, Pietro ; Van Pesch, Vincent ; Lechien, Jérome ; Saussez, Sven ; Heyse, Alex ; Brito Ferreira, Maria Lúcia. Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis.. In: PloS one, Vol. 17, no.6, p. e0263595 (2022). doi:10.1371/journal.pone.0263595.
      http://hdl.handle.net/2078.1/279637
    • 2021
      Maggi, Pietro ; Kuhle, Jens ; Schädelin, Sabine ; van der Meer, Franziska ; Weigel, Matthias ; Galbusera, Riccardo ; Mathias, Amandine ; Lu, Po-Jui ; Rahmanzadeh, Reza ; Benkert, Pascal ; La Rosa, Francesco ; Bach Cuadra, Meritxell ; Sati, Pascal ; Théaudin, Marie ; Pot, Caroline ; Van Pesch, Vincent ; Leppert, David ; Stadelmann, Christine ; Kappos, Ludwig ; Du Pasquier, Renaud ; Reich, Daniel S ; Absinta, Martina ; Granziera, Cristina. Chronic White Matter Inflammation and Serum Neurofilament Levels in Multiple Sclerosis.. In: Neurology, Vol. 97, no. 6, p. e543-e553 (2021). doi:10.1212/WNL.0000000000012326.
      http://hdl.handle.net/2078.1/259263
    • Guilmot, Antoine ; Maldonado Slootjes, Sofia Ijke ; Sellimi, Amina ; Bronchain, Maroussia ; Hanseeuw, Bernard ; Belkhir, Leïla ; Yombi, Jean Cyr ; De Greef, Julien ; Pothen, Lucie ; Yildiz, Halil ; Duprez, Thierry ; Fillee, Catherine ; Anantharajah, Ahalieyah ; Capes, Antoine ; Hantson, Philippe ; Jacquerye, Philippe ; Raymackers, Jean-Marc ; London, Frédéric ; El Sankari, Souraya ; Ivanoiu, Adrian ; Maggi, Pietro ; Van Pesch, Vincent. Immune-mediated neurological syndromes in SARS-CoV-2-infected patients.. In: Journal of neurology, Vol. 268, no. 3, p. 751-757 (2021). doi:10.1007/s00415-020-10108-x.
      http://hdl.handle.net/2078.1/232183
    • Rahmanzadeh, Reza ; Lu, Po-Jui ; Barakovic, Muhamed ; Weigel, Matthias ; Maggi, Pietro ; Nguyen, Thanh D ; Schiavi, Simona ; Daducci, Alessandro ; La Rosa, Francesco ; Schaedelin, Sabine ; Absinta, Martina ; Reich, Daniel S ; Sati, Pascal ; Wang, Yi ; Bach Cuadra, Meritxell ; Radue, Ernst-Wilhelm ; Kuhle, Jens ; Kappos, Ludwig ; Granziera, Cristina. Myelin and axon pathology in multiple sclerosis assessed by myelin water and multi-shell diffusion imaging.. In: Brain, Vol. 144, no. 6, p. 1684-1696 (2021). doi:10.1093/brain/awab088.
      http://hdl.handle.net/2078.1/261565
    • 2020
      Maggi, Pietro ; Fartaria, Mário João ; Jorge, João ; La Rosa, Francesco ; Absinta, Martina ; Sati, Pascal ; Meuli, Reto ; Du Pasquier, Renaud ; Reich, Daniel S. ; Cuadra, Meritxell Bach ; Granziera, Cristina ; Richiardi, Jonas ; Kober, Tobias. CVSnet: A machine learning approach for automated central vein sign assessment in multiple sclerosis. In: NMR in Biomedicine, Vol. 33, no.5 (2020). doi:10.1002/nbm.4283.
      http://hdl.handle.net/2078.1/259265
    • Maggi, Pietro ; Guilmot, Antoine ; Maldonado Slootjes, Sofia ; Huart, Caroline ; Hanseeuw, Bernard ; Duprez, Thierry ; De Greef, Julien ; Belkhir, Leïla ; Yombi, Jean Cyr ; Ivanoiu, Adrian ; Van Pesch, Vincent. Implications neurologiques de l’infection à SARS-CoV-2. In: Louvain médical, Vol. 139, no.05-06, p. 312-314 (2020).
      http://hdl.handle.net/2078.1/302364
    • Maggi, Pietro ; Sati, Pascal ; Nair, Govind ; Cortese, Irene C M ; Jacobson, Steven ; Smith, Bryan R ; Nath, Avindra ; Ohayon, Joan ; Van Pesch, Vincent ; Perrotta, Gaetano ; Pot, Caroline ; Théaudin, Marie ; Martinelli, Vittorio ; Scotti, Roberta ; Wu, Tianxia ; Du Pasquier, Renaud ; Calabresi, Peter A ; Filippi, Massimo ; Reich, Daniel S ; Absinta, Martina. Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study.. In: Annals of Neurology, Vol. 88, no. 5, p. 1034-1042 (2020). doi:10.1002/ana.25877.
      http://hdl.handle.net/2078.1/239835
    • Barquero, Germán ; La Rosa, Francesco ; Kebiri, Hamza ; Lu, Po-Jui ; Rahmanzadeh, Reza ; Weigel, Matthias ; Fartaria, Mário João ; Kober, Tobias ; Théaudin, Marie ; Du Pasquier, Renaud ; Sati, Pascal ; Reich, Daniel S ; Absinta, Martina ; Granziera, Cristina ; Maggi, Pietro ; Bach Cuadra, Meritxell. RimNet: A deep 3D multimodal MRI architecture for paramagnetic rim lesion assessment in multiple sclerosis.. In: NeuroImage. Clinical, Vol. 28, p. 102412 [1-11] (2020). doi:10.1016/j.nicl.2020.102412.
      http://hdl.handle.net/2078.1/239129
    • Maggi, Pietro ; Absinta, Martina ; Sati, Pascal ; Perrotta, Gaetano ; Massacesi, Luca ; Dachy, Bernard ; Pot, Caroline ; Meuli, Reto ; Reich, Daniel S ; Filippi, Massimo ; Pasquier, Renaud Du ; Théaudin, Marie. The "central vein sign" in patients with diagnostic "red flags" for multiple sclerosis: A prospective multicenter 3T study.. In: Multiple Sclerosis : clinical and laboratory research, Vol. 26, no.4, p. 421-432 (2020). doi:10.1177/1352458519876031.
      http://hdl.handle.net/2078.1/259189
    • Guisset, François ; Lolli, Valentina ; Bugli, Céline ; Perrotta, Gaetano ; Absil, Julie ; Dachy, Bernard ; Pot, Caroline ; Théaudin, Marie ; Pasi, Marco ; Van Pesch, Vincent ; Maggi, Pietro. The central vein sign in multiple sclerosis patients with vascular comorbidities.. In: Multiple Sclerosis Journal, p. [1-9] (2020). doi:10.1177/1352458520943785 (Accepté/Sous presse).
      http://hdl.handle.net/2078.1/239849
    • 2019
      Lysandropoulos, Andreas P. ; Perrotta, Gaetano ; Billiet, Thibo ; Ribbens, Annemie ; Du Pasquier, Renaud ; Pot Kreis, Caroline ; Maggi, Pietro ; Théaudin, Marie. Human Leukocyte Antigen Genotype as a Marker of Multiple Sclerosis Prognosis. In: Canadian Journal of Neurological Sciences, Vol. 47, no.2, p. 189-196 (2019). doi:10.1017/cjn.2019.329.
      http://hdl.handle.net/2078.1/259163
    • 2018
      Maggi, Pietro ; Absinta, Martina ; Grammatico, Matteo ; Vuolo, Luisa ; Emmi, Giacomo ; Carlucci, Giovanna ; Spagni, Gregorio ; Barilaro, Alessandro ; Repice, Anna Maria ; Emmi, Lorenzo ; Prisco, Domenico ; Martinelli, Vittorio ; Scotti, Roberta ; Sadeghi, Niloufar ; Perrotta, Gaetano ; Sati, Pascal ; Dachy, Bernard ; Reich, Daniel S ; Filippi, Massimo ; Massacesi, Luca. Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies.. In: Annals of Neurology, Vol. 83, no.2, p. 283-294 (2018). doi:10.1002/ana.25146.
      http://hdl.handle.net/2078.1/259187
    • D'Elios, M. M. ; Aldinucci, A. ; Amoriello, R. ; Benagiano, M. ; Bonechi, E. ; Maggi, Pietro ; Flori, A. ; Ravagli, C. ; Saer, D. ; Cappiello, L. ; Conti, L. ; Valtancoli, B. ; Bencini, A. ; Menichetti, L. ; Baldi, G. ; Ballerini, C.. Myelin-specific T cells carry and release magnetite PGLA–PEG COOH nanoparticles in the mouse central nervous system. In: RSC Advances, Vol. 8, no.2, p. 904-913 (2018). doi:10.1039/c7ra11290d.
      http://hdl.handle.net/2078.1/259171
    • 2017
      Maggi, Pietro ; Sati, Pascal ; Massacesi, Luca. Magnetic resonance imaging of experimental autoimmune encephalomyelitis in the common marmoset.. In: Journal of Neuroimmunology, Vol. 304, p. 86-92 (2017). doi:10.1016/j.jneuroim.2016.09.016.
      http://hdl.handle.net/2078.1/259185
    • 2016
      Maggi, Pietro ; Bier, Jean Christophe ; De Breucker, Sandra. Massive subdural haematoma and dementia: a "yin and yang" paradigm.. In: The Medical journal of Australia, Vol. 204, no.3, p. 126-.e1 (2016). doi:10.5694/mja15.01043.
      http://hdl.handle.net/2078.1/275855
    • 2015
      Ballerini, Clara ; Baldi, Giovanni ; Aldinucci, Alessandra ; Maggi, Pietro. Nanomaterial Applications in Multiple Sclerosis Inflamed Brain. In: Journal of Neuroimmune Pharmacology, Vol. 10, no.1, p. 1-13 (2015). doi:10.1007/s11481-015-9588-y.
      http://hdl.handle.net/2078.1/259161
    • Maggi, Pietro ; Mazzoni, Lorenzo N ; Moretti, Marco ; Grammatico, Matteo ; Chiti, Stefano ; Massacesi, Luca. SWI enhances vein detection using gadolinium in multiple sclerosis.. In: Acta Radiologica Open, Vol. 4, no.3, p. 2047981614560938 (2015). doi:10.1177/2047981614560938.
      http://hdl.handle.net/2078.1/259191
    • 2014
      Gaitán, María I ; Maggi, Pietro ; Wohler, Jillian ; Leibovitch, Emily ; Sati, Pascal ; Calandri, Ismael L ; Merkle, Hellmut ; Massacesi, Luca ; Silva, Afonso C ; Jacobson, Steven ; Reich, Daniel S. Perivenular brain lesions in a primate multiple sclerosis model at 7-tesla magnetic resonance imaging. In: Multiple Sclerosis : clinical and laboratory research, Vol. 20, no.1, p. 64-71 (2013). doi:10.1177/1352458513492244.
      http://hdl.handle.net/2078.1/259173
    • Maggi, Pietro ; Macri, Sheila M Cummings ; Gaitán, María I ; Leibovitch, Emily ; Wholer, Jillian E ; Knight, Heather L ; Ellis, Mary ; Wu, Tianxia ; Silva, Afonso C ; Massacesi, Luca ; Jacobson, Steven ; Westmoreland, Susan ; Reich, Daniel S. The formation of inflammatory demyelinated lesions in cerebral white matter.. In: Annals of Neurology, Vol. 76, no.4, p. 594-608 (2014). doi:10.1002/ana.24242.
      http://hdl.handle.net/2078.1/259183
    • 2013
      Leibovitch, Emily ; Wohler, Jillian E ; Cummings Macri, Sheila M ; Motanic, Kelsey ; Harberts, Erin ; Gaitán, María I ; Maggi, Pietro ; Ellis, Mary ; Westmoreland, Susan ; Silva, Afonso ; Reich, Daniel S ; Jacobson, Steven. Novel marmoset (Callithrix jacchus) model of human Herpesvirus 6A and 6B infections: immunologic, virologic and radiologic characterization.. In: PLoS Pathogens, Vol. 9, no.1, p. e1003138 (2013). doi:10.1371/journal.ppat.1003138.
      http://hdl.handle.net/2078.1/259181
    • Absinta, Martina ; Sati, Pascal ; Gaitán, María I. ; Maggi, Pietro ; Cortese, Irene C. M. ; Filippi, Massimo ; Reich, Daniel S.. Seven-tesla phase imaging of acute multiple sclerosis lesions: A new window into the inflammatory process : MS Lesions at 7T Phase Imaging. In: Annals of Neurology, Vol. 74, no.5, p. 669-678 (2013). doi:10.1002/ana.23959.
      http://hdl.handle.net/2078.1/259160
  • Conference paper
    • 2025
      Stölting, Anna ; Vanden Bulcke, Colin ; Serena Borrelli ; Deltombe, Matthieu ; Bayart, Jean-Louis ; Bugli, Céline ; Perdaens, Océane ; Guisset, François ; Van Pesch, Vincent ; María I. Gaitán ; Martina Absinta ; Daniel S. Reich ; Maggi, Pietro. Pathophysiological and clinical implications of PRL heterogeneity in multiple sclerosis. Belgian MS Researcher Day 2025 (Leuven, Belgium).
      http://hdl.handle.net/2078.1/302939
    • Stölting, Anna ; Vanden Bulcke, Colin ; Serena Borrelli ; Deltombe, Matthieu ; Bayart, Jean-Louis ; Guisset, François ; Van Pesch, Vincent ; Maggi, Pietro. Serum GFAP as a Marker of Neurodegeneration in Deep Gray Matter Areas in Multiple Sclerosis. Americas Committee for Treatment and Research in Multiple Sclerosis (West Palm Beach, Florida, USA, du 27/02/2025 au 01/03/2025). In: Multiple Sclerosis Journal - ACTRIMS Forum 2025, Vol. 31, no.2, p. 24-244 (2025). doi:10.1177/13524585251333228.
      http://hdl.handle.net/2078.1/302936
    • Stölting, Anna ; Vanden Bulcke, Colin ; Serena Borrelli ; Deltombe, Matthieu ; Bayart, Jean-Louis ; Bugli, Céline ; Perdaens, Océane ; Guisset, François ; Van Pesch, Vincent ; Maggi, Pietro. The evolution of tissue damage in paramagnetic rim lesions . ARSEP 2025 (Paris, France).
      http://hdl.handle.net/2078.1/302938
    • 2024
      Wynen, Maxence ; Istasse, Maxime ; Pedro Macias Gordaliza ; Stölting, Anna ; Maggi, Pietro ; Macq, Benoît ; Meritxell Bach Cuadra. ConfLUNet: Improving Confluent Lesion Identification in Multiple Sclerosis using Instance Segmentation. International Symposium on Biomedical Imaging (ISBI) (Athens, Greece, du 27/05/2024 au 30/05/2024).
      http://hdl.handle.net/2078.1/286241
    • El Khoury, Karim ; Wynen, Maxence ; Maggi, Pietro ; Meritxell Bach Cuadra ; Macq, Benoît. IMPROVING 3D LESION SEGMENTATION ROBUSTNESS AGAINST IMAGE COMPRESSION IN MULTIPLE SCLEROSIS. 21st IEEE International Symposium on Biomedical Imaging (ISBI 2024) (Athens, Greece, du 27/05/24 au 30/05/24).
      http://hdl.handle.net/2078.1/286141
    • Wynen, Maxence ; Gordaliza, Pedro M. ; Stölting, Anna ; Maggi, Pietro ; Bach Cuadra, Meritxell ; Macq, Benoît. Lesion Instance Segmentation in Multiple Sclerosis: Assessing the Efficacy of Statistical Lesion Splitting. ISMRM & ISMRT Annual Meeting & Exhibition (Singapore, Singapore, du 04/05/2024 au 09/05/2024) (Accepté/Sous presse).
      http://hdl.handle.net/2078.1/285623
    • Wynen, Maxence ; Gordaliza, Pedro M. ; Stölting, Anna ; Maggi, Pietro ; Bach Cuadra, Meritxell ; Macq, Benoit. Multi-modal segmentation for paramagnetic rim lesion detection in multiple sclerosis. Imaging Informatics for Healthcare, Research, and Applications (San Diego, United States, du 18/2/2024 au 23/2/2024). In: SPIE Medical Imaging 2024: Imaging Informatics for Healthcare, Research, and Applications, (2024). doi:10.1117/12.3005951.
      http://hdl.handle.net/2078.1/300350
    • Stölting, Anna ; Vanden Bulcke, Colin ; Serena Borrelli ; Bugli, Céline ; Du Pasquier, Renaud ; Absinta, Martina ; Van Pesch, Vincent ; Maggi, Pietro. Physiopathological and clinical implications of Paramagnetic Rim Lesions. ECTRIMS (Copenhagen, Denmark, du 18/09/2024 au 20/09/2024).
      http://hdl.handle.net/2078.1/290722
    • 2023
      Stölting, Anna ; Vanden Bulcke, Colin ; Macq, Benoît ; Maggi, Pietro. ADVANCED DIFFUSION IMAGING METHODS TO ASSESS THE MICROSTRUCTURE OF MULTIPLE SCLEROSIS LESIONS. International Society for Magnetic Resonance in Medicine (ISMRM) (Toronto, du 03/06/2023 au 08/06/2023). In: Proc. Intl. Soc. Mag. Reson. Med. 31 (2023), (19 May 2023).
      http://hdl.handle.net/2078.1/276351
    • Vanden Bulcke, Colin ; Stölting, Anna ; Macq, Benoît ; Maggi, Pietro. ADVANCED DIFFUSION IMAGING METHODS TO ASSESS THE MICROSTRUCTURE OF MULTIPLE SCLEROSIS LESIONS. International Symposium on Biomedical Imaging (ISBI) (Cartagena de Indias, Colombia, du 18/04/2023 au 21/04/2023).
      http://hdl.handle.net/2078.1/276362
    • Stölting, Anna ; Maggi, Pietro. MS Chronic Active Lesions. Belgian MS Symposium 2023 (Brussels, Belgium, du 28/10/2023 au 28/10/2023).
      http://hdl.handle.net/2078.1/277355
    • Vanden Bulcke, Colin ; Stölting, Anna ; Absinta, Martina ; Maggi, Pietro. Microstructural assessment of multiple sclerosis lesions and peri-plaques using advanced multishell diffusion MRI. European Committee for Treatment and Research in Multiple Sclerosis (Milan, du 11/10/2023 au 13/10/2023). In: Multiple Sclerosis Journal, Vol. Volume 29, no.Issue 3_suppl, p. 394 - 649 (2023). doi:10.1177/13524585231196194.
      http://hdl.handle.net/2078.1/276361
    • Stölting, Anna ; Vanden Bulcke, Colin ; Jelinkova, Dominika ; Gaëtan Duchêne ; Dricot, Laurence ; Macq, Benoît ; Maggi, Pietro. Multishell diffusion-weighted MRI characterization of chronic active lesions in Multiple Sclerosis. European Acadamy of Neurology (Budapest, Hungary, du 01/07/2023 au 04/07/2023). In: EUROPEAN JOURNAL OF NEUROLOGY - Abstracts of the 9th Congress of the European Academy of Neurology, Vol. 30, p. 706 (2023).
      http://hdl.handle.net/2078.1/277318
    • Stölting, Anna ; Vanden Bulcke, Colin ; Jelinkova, Dominika ; Gaëtan Duchêne ; Dricot, Laurence ; Macq, Benoît ; Maggi, Pietro. Multishell diffusion-weighted MRI characterization of chronic active lesions in Multiple Sclerosis. ARSEP - MRI Workshop (Paris, France, 03/02/2023).
      http://hdl.handle.net/2078.1/277284
    • Stölting, Anna ; Maggi, Pietro. Nouveaux Biomarqueurs en IRM pour les pathologies Neuro-inflammatoires. Club de Neuro-Ophtalmologie Francophone (CNOF) 2023 (Brussels, Belgium, du 26/01/2023 au 26/01/2023).
      http://hdl.handle.net/2078.1/277354
    • Stölting, Anna ; Vanden Bulcke, Colin ; Borrelli, Serena ; Bugli, Céline ; Van Pesch, Vincent ; Maggi, Pietro. The Clinical Significance of Heterogeneous Paramagnetic Rim Lesions in MS. European Committee for Treatment and Research in Multiple Sclerosis (Milano, Italy, du 11/10/2023 au 13/10/2023). In: Multiple Sclerosis Journal, Vol. 29, no. 3, p. 394-649 (2023).
      http://hdl.handle.net/2078.1/277319
    • 2021
      Wynen, Maxence. Longitudinal automated assessment of paramagnetic rim lesions in multiple sclerosis using RimNet. ISMRM (En ligne, du 15/05/2021 au 19/05/2021).
      http://hdl.handle.net/2078.1/245824