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Anticipation and its troubles

ions | Bruxelles Woluwe, Louvain-la-Neuve

In a dynamic environment, human subjects often make anticipatory eye movements to shift the visual axis towards the position where a stimulus of interest is likely to appear next. However, anticipation has to adapt to the inherently stochastic nature of physical events that can impact cognitive control and be psychologically distressing. Moreover, anticipatory actions require to keep track of elapsed time and inhibitory control. These cognitive functions could be impacted in neuropsychiatric diseases like Parkinson's.  

Principal investigator

  • Dr Pierre Pouget, Institut du Cerveau et de la Moëlle Epinière 

Crédit de Recherche (CDR) - Exercice 2024 
J.0152.24 (Référence e-space : 40020734) 
"Uncertainty and anticipation"  

  • Degos B, Pouget P, Missal M (2022) From anticipation to impulsivity in Parkinson's disease. Nature Parkinson Journal (npj) Parkinson’s Dis. 8(1):125. 
  • Missal M, Heinen SJ (2017) Stopping smooth pursuit. Philos Trans R Soc Lond B Biol Sci. 372(1718). Review. 
  • Nozaradan S, Peretz I, Missal M, Mouraux A (2011) Tagging the neuronal entrainment to beat and meter. J Neurosci. 31:10234-40. 
  • Badler J, Lefèvre P, Missal M (2010) Causality attribution biases oculomotor responses. J Neurosci. 30:10517-25. 
  • de Hemptinne C, Lefèvre P, Missal M (2008) Neuronal bases of directional expectation and anticipatory pursuit. J Neurosci. 28:4298-310. 
  • de Hemptinne C, Nozaradan S, Duvivier Q, Lefèvre P, Missal M (2007) How do primates anticipate uncertain future events? J Neurosci. 27:4334-41. 
     

Publications

  • 2025
    • Article de journal
      Drążyk, D., Rida, A., & Missal, M. (2025). What is the difference between an impulsive and a timed anticipatory movement ? Scientific Reports, 0322-25.2025(0322-25.2025), 0322-0325. https://doi.org/10.1523/ENEURO.0322-25.2025 (Original work published 2025)
  • 2024
    • Article de journal
      Boutachkourt, A., Drazyk, D., & Missal, M. (2024). Gazing into spatiotemporal ‘known unknowns’: the influence of uncertainty on pupil size and saccadic eye movements. Scientific Reports, 14(1), 17509 [1-11]. https://doi.org/10.1038/s41598-024-68233-w (Original work published 2024)
  • 2023
  • 2022
  • 2021
    • Article de journal
      Brulé, S., Herlin, B., Pouget, P., & Missal, M. (2021). Ketamine reduces temporal expectation in the rhesus monkey. Psychopharmacology, 238(2), 559-567. https://doi.org/10.1007/s00213-020-05706-6 (Original work published 2021)
  • 2019
    • Article de journal
      Hsu, T., Lee, H., Lane, T., Missal, M., & et al. (2019). Temporal Preparation, Impulsivity and Short-Term Memory in Depression. Frontiers in Behavioral Neuroscience, 13(258), 1-12. https://doi.org/10.3389/fnbeh.2019.00258 (Original work published 2019)
  • 2018
    • Article de journal
      Degos, B., Ameqrane, I., Rivaud-Péchoux, S., Pouget, P., & Missal, M. (2018). Short-term temporal memory in idiopathic and Parkin-associated Parkinson’s disease. Scientific Reports, 8(1), 7637. https://doi.org/10.1038/s41598-018-25751-8 (Original work published 2018)
  • 2017
    • Article de journal
      Missal, M., & Heinen, S. J. (2017). Stopping smooth pursuit. Philosophical transactions. Biological sciences / Royal Society of London, 372(1718), 20160200. https://doi.org/10.1098/rstb.2016.0200 (Original work published 2017)
  • 2016
    • Article de journal
      Wende, K. C., Theunissen, L., & Missal, M. (2016). Anticipation of physical causality guides eye movements. Journal of Eye Movement Research, 9(2), 1-9. https://doi.org/10.16910/jemr.9.2.1 (Original work published 2016)
  • 2015
    • Article de journal
      Ameqrane, I., Wattiez, N., Pouget, P., Missal, M., & et al. (2015). A subanesthetic dose of ketamine in the Rhesus monkey reduces the occurrence of anticipatory saccades. Psychopharmacology, 232(19), 3563-3572. https://doi.org/10.1007/s00213-015-4005-z (Original work published 2015)
    • Ameqrane, I., Wattiez, N., Pouget, P., & Missal, M. (2015). Erratum to: a subanesthetic dose of ketamine in the Rhesus monkey reduces the occurrence of anticipatory saccades. Psychopharmacology, 232(19), 3681. https://doi.org/10.1007/s00213-015-4039-2 (Original work published 2015)
    • Papier de conférence
      de Timary, P., Cirilli, L., Luminet, O., Heinz, A., Lefèvre, P., Maurage, P., & Missal, M. (2015). Reduced anticipation and procedural learning during an oculomotor task in alcohol-dependent subjects. Alcohol and Alcoholism, 50(Suppl. 1), i21-i22. https://doi.org/10.1093/alcalc/agv076.78 (Original work published 2015)
    • de Timary, P., Cirilli, L., Luminet, O., Heinz, A., Lefèvre, N., Maurage, P., & Missal, M. (2015). Reduced anticipation and procedural learning during an oculomotor task in alcohol-dependent subjects. Alcohol and Alcoholism, 50(1), S1. (Original work published 2015)
  • 2014
    • Article de journal
      Ameqrane, I., Pouget, P., Wattiez, N., Carpenter, R., & Missal, M. (2014). Implicit and explicit timing in oculomotor control. PLoS One, 9(4), e93958. https://doi.org/10.1371/journal.pone.0093958 (Original work published 2014)
  • 2013
    • Article de journal
      de Hemptinne, C., Ivanoiu, A., Lefèvre, P., & Missal, M. (2013). How does Parkinson’s disease and aging affect temporal expectation and the implicit timing of eye movements? Neuropsychologia, 51(2), 340-348. https://doi.org/10.1016/j.neuropsychologia.2012.10.001 (Original work published 2013)
  • 2012
  • 2011
    • Article de journal
      Nozaradan, S., Peretz, I., Missal, M., & Mouraux, A. (2011). Tagging the neuronal entrainment to beat and meter. The Journal of Neuroscience, 31(28), 10234-10240. https://doi.org/10.1523/JNEUROSCI.0411-11.2011 (Original work published 2011)
    • Cirilli, L., de Timary, P., Lefèvre, P., & Missal, M. (2011). Individual differences in impulsivity predict anticipatory eye movements. PLoS One, 6(10), e26699. https://doi.org/10.1371/journal.pone.0026699 (Original work published 2011)
  • 2010
    • Article de journal
      de Hemptinne, C., Barnes, G. R., & Missal, M. (2010). Influence of previous target motion on anticipatory pursuit deceleration. Experimental Brain Research, 207(3-4), 173-184. https://doi.org/10.1007/s00221-010-2437-6 (Original work published 2010)
    • Coppe, S., Orban de Xivry, J.-J., Missal, M., & Lefèvre, P. (2010). Biological motion influences the visuomotor transformation for smooth pursuit eye movements. Vision Research, 50(24), 2721-2728. https://doi.org/10.1016/j.visres.2010.08.009 (Original work published 2010)
    • Orban de Xivry, J.-J., Coppe, S., Lefèvre, P., & Missal, M. (2010). Biological motion drives perception and action. Journal of Vision, 10(2), 6. https://doi.org/10.1167/10.2.6 (Original work published 2010)
    • Badler, J., Lefèvre, P., & Missal, M. (2010). Causality attribution biases oculomotor responses. The Journal of Neuroscience, 30(31), 10517-10525. https://doi.org/10.1523/JNEUROSCI.1733-10.2010 (Original work published 2010)
  • 2009
    • Article de journal
      Orban de Xivry, J.-J., Missal, M., & Lefèvre, P. (2009). Smooth pursuit performance during target blanking does not influence the triggering of predictive saccades. Journal of Vision, 9(11), 7. https://doi.org/10.1167/9.11.7 (Original work published 2009)
  • 2008
    • Article de journal
      Yang, S.-n., Heinen, S. J., & Missal, M. (2008). The effects of microstimulation of the dorsomedial frontal cortex on saccade latency. Journal of Neurophysiology, 99(4), 1857-1870. https://doi.org/10.1152/jn.00119.2007 (Original work published 2008)
    • Orban de Xivry, J.-J., Missal, M., & Lefèvre, P. (2008). A dynamic representation of target motion drives predictive smooth pursuit during target blanking. Journal of Vision, 8(15), 6. https://doi.org/10.1167/8.15.6 (Original work published 2008)
    • Badler, J., Lefèvre, P., & Missal, M. (2008). Anticipatory pursuit is influenced by a concurrent timing task. Journal of Vision, 8(16), 5. https://doi.org/10.1167/8.16.5 (Original work published 2008)
    • de Hemptinne, C., Lefèvre, P., & Missal, M. (2008). Neuronal bases of directional expectation and anticipatory pursuit. The Journal of Neuroscience, 28(17), 4298-4310. https://doi.org/10.1523/JNEUROSCI.5678-07.2008 (Original work published 2008)
    • Papier de conférence
      Coppe, S., Orban de Xivry, J.-J., Missal, M., & Lefèvre, P. (2008). Biological motion input to the oculomotor system. In Vander Sloten, J.; Nyssen, M.; Verdonck, P.; Haueisen, J.; (ed.), 4th European Conference of the International Federation for Medical and Biological Engineering - ECIFMBE 2008 (p. p. 2142-2145). Springer verlag.
  • 2007
    • Article de journal
      de Hemptinne, C., Nozaradan, S., Duvivier, Q., Lefèvre, P., & Missal, M. (2007). How do primates anticipate uncertain future events? The Journal of Neuroscience, 27(16), 4334-4341. https://doi.org/10.1523/JNEUROSCI.0388-07.2007 (Original work published 2007)
  • 2006
    • Article de journal
      Schreiber, C., Missal, M., & Lefèvre, P. (2006). Asynchrony between position and motion signals in the saccadic system. Journal of Neurophysiology, 95(2), 960-969. https://doi.org/10.1152/jn.00315.2005 (Original work published 2006)
    • de Hemptinne, C., Lefèvre, P., & Missal, M. (2006). Influence of cognitive expectation on the initiation of anticipatory and visual pursuit eye movements in the rhesus monkey. Journal of Neurophysiology, 95(6), 3770-3782. https://doi.org/10.1152/jn.00007.2006 (Original work published 2006)
  • 2005
    • Article de journal
      Blohm, G., Missal, M., & Lefèvre, P. (2005). Direct evidence for a position input to the smooth pursuit system. Journal of Neurophysiology, 94(1), 712-721. https://doi.org/10.1152/jn.00093.2005 (Original work published 2005)
    • Blohm, G., Missal, M., & Lefèvre, P. (2005). Processing of retinal and extraretinal signals for memory-guided saccades during smooth pursuit. Journal of Neurophysiology, 93(3), 1510-1522. https://doi.org/10.1152/jn.00543.2004 (Original work published 2005)
  • 2004
    • Article de journal
      Missal, M., & Heinen, S. (2004). Supplementary eye fields stimulation facilitates anticipatory pursuit. Journal of Neurophysiology, 92(2), 1257-1262. https://doi.org/10.1152/jn.01255.2003 (Original work published 2004)
  • 2003
    • Article de journal
      Keller, E., & Missal, M. (2003). Shared brainstem pathways for saccades and smooth-pursuit eye movements. New York Academy of Sciences. Annals, 1004, 29-39. https://doi.org/10.1196/annals.1303.004 (Original work published 2003)
    • Blohm, G., Missal, M., & Lefèvre, P. (2003). Interaction between smooth anticipation and saccades during ocular orientation in darkness. Journal of Neurophysiology, 89(3), 1423-1433. https://doi.org/10.1152/jn.00675.2002 (Original work published 2003)
    • Blohm, G., Missal, M., & Lefèvre, P. (2003). Smooth anticipatory eye movements alter the memorized position of flashed targets. Journal of Vision, 3(11), 761-770. https://doi.org/10.1167/3.11.10 (Original work published 2003)
  • 2002
    • Article de journal
      Missal, M., & Keller, E. L. (2002). Common inhibitory mechanism for saccades and smooth-pursuit eye movements. Journal of Neurophysiology, 88(4), 1880-1892. (Original work published 2002)
    • de Brouwer, S., Yüksel, D., Blohm, G., Missal, M., & Lefèvre, P. (2002). What triggers catch-up saccades during visual tracking? Journal of Neurophysiology, 87(3), 1646-1650. https://doi.org/10.1152/jn.00432.2001. (Original work published 2002)
    • Missal, M., Coimbra, A., Lefèvre, P., & Olivier, E. (2002). A quantitative analysis of the correlations between eye movements and neural activity in the pretectum. Experimental Brain Research, 143(3), 373-382. https://doi.org/10.1007/s00221-002-0999-7 (Original work published 2002)
    • de Brouwer, S., Missal, M., Barnes, G., & Lefèvre, P. (2002). Quantitative analysis of catch-up saccades during sustained pursuit. Journal of Neurophysiology, 87(4), 1772-1780. https://doi.org/10.1152/jn.00621.2001 (Original work published 2002)
    • Missal, M., Coimbra, A., Lefèvre, P., & Olivier, E. (2002). Further evidence that a shared efferent collicular pathway drives separate circuits for smooth eye movements and saccades. Experimental Brain Research, 147(3), 344-352. https://doi.org/10.1007/s00221-002-1274-7 (Original work published 2002)
  • 2001
    • Article de journal
      de Brouwer, S., Missal, M., & Lefèvre, P. (2001). Role of retinal slip in the prediction of target motion during smooth and saccadic pursuit. Journal of Neurophysiology, 86(2), 550-558. (Original work published 2001)
    • Missal, M., & Heinen, S. (2001). Facilitation of smooth pursuit initiation by electrical stimulation in the supplementary eye fields. Journal of Clinical Neurophysiology, 86(5), 2413-25 (Nov). (Original work published 2001)
  • 2000
    • Article de journal
      Coimbra, A. J., Lefèvre, P., Missal, M., & Olivier, E. (2000). Difference between visually and electrically evoked gaze saccades disclosed by altering the head moment of inertia. Journal of Neurophysiology, 83(2), 1103-1107. (Original work published 2000)
    • Missal, M., de Brouwer, S., Lefèvre, P., & Olivier, E. (2000). Activity of mesencephalic vertical burst neurons during saccades and smooth pursuit. Journal of Neurophysiology, 83(4), 2080-2092. (Original work published 2000)
  • 1999
  • 1997
    • Article de journal
      Missal, M., Vogels, R., & Guy, A. O. (1997). Responses of macaque inferior temporal neurons to overlapping shapes. Cerebral Cortex, 7(8), 758-767. https://doi.org/10.1093/cercor/7.8.758 (Original work published 1997)
  • 1996
    • Article de journal
      Missal, M., Lefèvre, P., Delinte, A., Crommelinck, M., & Roucoux, A. (1996). Smooth eye movements evoked by electrical stimulation of the cat’s superior colliculus. Experimental Brain Research, 107(3), 382-390. https://doi.org/10.1007/BF00230420 (Original work published 1996)
  • 1995
    • Article de journal
      Missal, M., Lefèvre, P., Crommelinck, M., & Roucoux, A. (1995). Evidence for high-velocity smooth pursuit in the trained cat. Experimental Brain Research, 106(3), 509-512. https://doi.org/10.1007/BF00231076 (Original work published 1995)
  • 1994
    • Chapitre de livre
      Missal, M., Lefèvre, P., Crommelinck, M., & Roucoux, A. (1994). The role of postsaccadic slow eye movements in the correction of position errors. In A.F. Fuchs, T. Brandt, U. Büttner, and D. Zee (ed.), Contemporary Ocular Motor and Vestibular Research: A Tribute to David A.Robinson (p. p. 197-199). Thieme Publishing Group.
    • Article de journal
      Lefèvre, P., Missal, M., & Galiana, H. L. (1994). Modeling slow correcting gaze movements. Journal of Vestibular Research: Equilibrium and Orientation : an international journal of experimental and clinical vestibular science, 4(5), 371-381. https://doi.org/10.3233/VES-1994-4506 (Original work published 1994)
  • 1993
    • Article de journal
      Missal, M., Crommelinck, M., Roucoux, A., & Decostre, M.-F. (1993). Slow correcting eye movements of head-fixed, trained cats toward stationary targets. Experimental Brain Research, 96(1), 65-76. https://doi.org/10.1007/BF00230439 (Original work published 1993)
    • Chapitre de livre
      Missal, M., Crommelinck, M., & Roucoux, A. (1993). Behavioural aspects of cats’ saccades. In Alain Berthoz (ed.), Multisensory Control of Movement (p. p. 150-166). Oxford University Press. https://doi.org/10.1093/acprof:oso/9780198547853.003.0079
  • 1992
    • Papier de conférence
      Missal, M., Decostre, MF., Crommelinck, M., & Roucoux, A. (1992). Slow Velocity Corrective Eye-movements of Head Fixed Trained Cats Towards Stationary Targets. European Journal of Neuroscience, 277. (Original work published 1992)