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Institute Of NeuroScience

Anticipation and its troubles

ions | Bruxelles Woluwe, Louvain-la-Neuve

In a dynamic environment, human subjects often make anticipatory eye movements to shift the visual axis towards the position where a stimulus of interest is likely to appear next. However, anticipation has to adapt to the inherently stochastic nature of physical events that can impact cognitive control and be psychologically distressing. Moreover, anticipatory actions require to keep track of elapsed time and inhibitory control. These cognitive functions could be impacted in neuropsychiatric diseases like Parkinson's.  

Principal investigator

  • Dr Pierre Pouget, Institut du Cerveau et de la Moëlle Epinière 

Crédit de Recherche (CDR) - Exercice 2024 
J.0152.24 (Référence e-space : 40020734) 
"Uncertainty and anticipation"  

  • Degos B, Pouget P, Missal M (2022) From anticipation to impulsivity in Parkinson's disease. Nature Parkinson Journal (npj) Parkinson’s Dis. 8(1):125. 
  • Missal M, Heinen SJ (2017) Stopping smooth pursuit. Philos Trans R Soc Lond B Biol Sci. 372(1718). Review. 
  • Nozaradan S, Peretz I, Missal M, Mouraux A (2011) Tagging the neuronal entrainment to beat and meter. J Neurosci. 31:10234-40. 
  • Badler J, Lefèvre P, Missal M (2010) Causality attribution biases oculomotor responses. J Neurosci. 30:10517-25. 
  • de Hemptinne C, Lefèvre P, Missal M (2008) Neuronal bases of directional expectation and anticipatory pursuit. J Neurosci. 28:4298-310. 
  • de Hemptinne C, Nozaradan S, Duvivier Q, Lefèvre P, Missal M (2007) How do primates anticipate uncertain future events? J Neurosci. 27:4334-41. 
     

Publications

  • 2025
    • Journal article
      Drążyk, Dominika ; Rida, Anissa ; Missal, Marcus. What is the difference between an impulsive and a timed anticipatory movement ?. In: eNeuro, Vol. 0322-25.2025, no.0322-25.2025, p. 0322-25.2025 (2025). doi:10.1523/ENEURO.0322-25.2025 (Soumis).
      http://hdl.handle.net/2078.1/306674
  • 2024
    • Journal article
      Boutachkourt, Aïcha ; Drazyk, Dominika ; Missal, Marcus. Gazing into spatiotemporal 'known unknowns': the influence of uncertainty on pupil size and saccadic eye movements.. In: Scientific reports, Vol. 14, no.1, p. 17509 [1-11] (2024). doi:10.1038/s41598-024-68233-w.
      http://hdl.handle.net/2078.1/304369
  • 2023
    • Journal article
      Drazyk, Dominika ; Missal, Marcus. How Does Temporal Blurring Alter Movement Timing?. In: eNeuro, Vol. 10, no. 9, p. ENEURO.0496-22.2023 [1–10] (2023). doi:10.1523/ENEURO.0496-22.2023.
      http://hdl.handle.net/2078.1/287990
  • 2022
    • Journal article
      Degos, Bertrand ; Pouget, Pierre ; Missal, Marcus. From anticipation to impulsivity in Parkinson's disease. In: NPJ Parkinson's disease, Vol. 8, no. 125, p. 125 [1-12] (2022). doi:10.1038/s41531-022-00393-w.
      http://hdl.handle.net/2078.1/272652
    • Drazyk, Dominika ; Missal, Marcus. The oculomotor signature of expected surprise. In: Scientific reports, Vol. 15, no. 1, p. 2543 [1-14] (2022). doi:10.1038/s41598-022-06403-4.
      http://hdl.handle.net/2078.1/272648
  • 2021
    • Journal article
      Brulé, Sophie ; Herlin, Bastien ; Pouget, Pierre ; Missal, Marcus. Ketamine reduces temporal expectation in the rhesus monkey.. In: Psychopharmacology, Vol. 238, no.2, p. 559-567 (2021). doi:10.1007/s00213-020-05706-6.
      http://hdl.handle.net/2078.1/242842
  • 2019
    • Journal article
      Hsu, TY ; Lee, HC ; Lane, TJ ; Missal, Marcus. Temporal Preparation, Impulsivity and Short-Term Memory in Depression. In: Frontiers in Behavioral Neuroscience, Vol. 13, no. 258, p. 1-12 (2019). doi:10.3389/fnbeh.2019.00258.
      http://hdl.handle.net/2078.1/231458
  • 2018
    • Journal article
      Degos, Bertrand ; Ameqrane, Ilham ; Rivaud-Péchoux, Sophie ; Pouget, Pierre ; Missal, Marcus. Short-term temporal memory in idiopathic and Parkin-associated Parkinson's disease.. In: Scientific Reports, Vol. 8, no.1, p. 7637 (2018). doi:10.1038/s41598-018-25751-8.
      http://hdl.handle.net/2078.1/199142
  • 2017
    • Journal article
      Missal, Marcus ; Heinen, Stephen J. Stopping smooth pursuit.. In: Philosophical transactions. Biological sciences / Royal Society of London, Vol. 372, no.1718, p. 20160200 (2017). doi:10.1098/rstb.2016.0200.
      http://hdl.handle.net/2078.1/185451
  • 2016
    • Journal article
      Wende, Kim Claire ; Theunissen, Laetitia ; Missal, Marcus. Anticipation of physical causality guides eye movements. In: Journal of Eye Movement Research, Vol. 9, no. 2, p. 1-9 (2016). doi:10.16910/jemr.9.2.1.
      http://hdl.handle.net/2078.1/186093
  • 2015
    • Journal article
      Ameqrane, Ilhame ; Wattiez, Nicolas ; Pouget, Pierre ; Missal, Marcus. A subanesthetic dose of ketamine in the Rhesus monkey reduces the occurrence of anticipatory saccades. In: Psychopharmacology, Vol. 232, no. 19, p. 3563-3572 (2015). doi:10.1007/s00213-015-4005-z.
      http://hdl.handle.net/2078.1/162697
    • Ameqrane, Ilhame ; Wattiez, Nicolas ; Pouget, Pierre ; Missal, Marcus. Erratum to: a subanesthetic dose of ketamine in the Rhesus monkey reduces the occurrence of anticipatory saccades.. In: Psychopharmacology, Vol. 232, no.19, p. 3681 (2015). doi:10.1007/s00213-015-4039-2.
      http://hdl.handle.net/2078.1/222748
    • Conference paper
      de Timary, Philippe ; Cirilli, Laetitia ; Luminet, Olivier ; Heinz, Andreas ; Lefèvre, Nathalie ; Maurage, Pierre ; Missal, Marcus. Reduced anticipation and procedural learning during an oculomotor task in alcohol-dependent subjects. Congress of the International Society for Biomedical Research on Alcoholism (ISBRA). In: Alcohol and Alcoholism, Vol. 50, no.1, p. S1 (2015).
      http://hdl.handle.net/2078.1/201532
    • de Timary, Philippe ; Cirilli , Laetitia ; Luminet, Olivier ; Heinz , Andreas ; Lefèvre, Philippe ; Maurage, Pierre ; Missal, Marcus. Reduced anticipation and procedural learning during an oculomotor task in alcohol-dependent subjects. ESBRA 2015 European Society for Biomedical Research on Alcoholism ((Spain) Valencia, du 12/09/2015 au 15/09/2015). In: Alcohol and Alcoholism, Vol. 50, no.Suppl. 1 , p. i21-i22 (2015). doi:10.1093/alcalc/agv076.78.
      http://hdl.handle.net/2078.1/176206
  • 2014
    • Journal article
      Ameqrane, Ilhame ; Pouget, Pierre ; Wattiez, Nicolas ; Carpenter, Roger ; Missal, Marcus. Implicit and explicit timing in oculomotor control.. In: PLoS One, Vol. 9, no. 4, p. e93958 (2014). doi:10.1371/journal.pone.0093958.
      http://hdl.handle.net/2078.1/145793
  • 2013
    • Journal article
      de Hemptinne, Coralie ; Ivanoiu, Adrian ; Lefèvre, Philippe ; Missal, Marcus. How does Parkinson's disease and aging affect temporal expectation and the implicit timing of eye movements?. In: Neuropsychologia, Vol. 51, no. 2, p. 340-348 (2013). doi:10.1016/j.neuropsychologia.2012.10.001.
      http://hdl.handle.net/2078.1/115917
  • 2012
    • Journal article
      Badler, Jeremy ; Lefèvre, Philippe ; Missal, Marcus. Divergence between oculomotor and perceptual causality. In: Journal of Vision, Vol. 12, no. 5, p. 1-15 (May 15, 2012). doi:10.1167/12.5.3.
      http://hdl.handle.net/2078.1/109444
  • 2011
    • Journal article
      Cirilli, Laetitia ; de Timary, Philippe ; Lefèvre, Philippe ; Missal, Marcus. Individual differences in impulsivity predict anticipatory eye movements.. In: PLoS One, Vol. 6, no. 10, p. e26699 (2011). doi:10.1371/journal.pone.0026699.
      http://hdl.handle.net/2078.1/105662
    • Nozaradan, Sylvie ; Peretz, Isabelle ; Missal, Marcus ; Mouraux, André. Tagging the neuronal entrainment to beat and meter.. In: The Journal of Neuroscience, Vol. 31, no. 28, p. 10234-10240 (2011). doi:10.1523/JNEUROSCI.0411-11.2011.
      http://hdl.handle.net/2078.1/97554
  • 2010
    • Journal article
      Orban de Xivry, Jean-Jacques ; Coppe, Sébastien ; Lefèvre, Philippe ; Missal, Marcus. Biological motion drives perception and action.. In: Journal of vision, Vol. 10, no. 2, p. 6.1-11 (2010). doi:10.1167/10.2.6.
      http://hdl.handle.net/2078.1/32219
    • Coppe, Sébastien ; Orban de Xivry, Jean-Jacques ; Missal, Marcus ; Lefèvre, Philippe. Biological motion influences the visuomotor transformation for smooth pursuit eye movements.. In: Vision research, Vol. 50, no. 24, p. 2721-8 (2010). doi:10.1016/j.visres.2010.08.009.
      http://hdl.handle.net/2078.1/33230
    • Badler, Jeremy ; Lefèvre, Philippe ; Missal, Marcus. Causality attribution biases oculomotor responses. In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, no. 31, p. 10517-25 (2010). doi:10.1523/JNEUROSCI.1733-10.2010.
      http://hdl.handle.net/2078.1/33149
    • de Hemptinne, Coralie ; Barnes, G R ; Missal, Marcus. Influence of previous target motion on anticipatory pursuit deceleration.. In: Experimental brain research. Experimentelle Hirnforschung. Experimentation cerebrale, Vol. 207, no. 3-4, p. 173-84 (2010). doi:10.1007/s00221-010-2437-6.
      http://hdl.handle.net/2078.1/33431
    • Conference paper
      Nozaradan, Sylvie ; Missal, Marcus ; Peretz, Isabelle ; Mouraux, André. Feeling the beat from ears and eyes: using EEG frequency-tagging to measure audiovisual interaction in beat perception. Annual Conference of the Society for Neuroscience (San Diego, USA, du 13/11/2010 au 18/11/2010).
      http://hdl.handle.net/2078/121036
  • 2009
    • Journal article
      Orban de Xivry, Jean-Jacques ; Missal, Marcus ; Lefèvre, Philippe. Smooth pursuit performance during target blanking does not influence the triggering of predictive saccades. In: Journal Of Vision, Vol. 9, no. 11, p. 7.1-16 (2009). doi:10.1167/9.11.7.
      http://hdl.handle.net/2078.1/34265
  • 2008
    • Journal article
      Orban de Xivry, Jean-Jacques ; Missal, Marcus ; Lefèvre, Philippe. A dynamic representation of target motion drives predictive smooth pursuit during target blanking.. In: Journal of vision, Vol. 8, no. 15, p. 6.1-13 (2008). doi:10.1167/8.15.6.
      http://hdl.handle.net/2078.1/20909
    • Badler, Jeremy ; Lefèvre, Philippe ; Missal, Marcus. Anticipatory pursuit is influenced by a concurrent timing task.. In: Journal of vision, Vol. 8, no. 16, p. 5.1-9 (2008). doi:10.1167/8.16.5.
      http://hdl.handle.net/2078.1/20968
    • de Hemptinne, Coralie ; Lefèvre, Philippe ; Missal, Marcus. Neuronal bases of directional expectation and anticipatory pursuit. In: The Journal of Neuroscience, Vol. 28, no. 17, p. 4298-4310 (2008). doi:10.1523/JNEUROSCI.5678-07.2008.
      http://hdl.handle.net/2078.1/12551
    • Yang, Shun-nan ; Heinen, Stephen J. ; Missal, Marcus. The effects of microstimulation of the dorsomedial frontal cortex on saccade latency. In: Journal of Neurophysiology, Vol. 99, no. 4, p. 1857-1870 (2008). doi:10.1152/jn.00119.2007.
      http://hdl.handle.net/2078.1/36694
    • Conference paper
      Coppe, Sébastien ; Orban de Xivry, Jean-Jacques ; Missal, Marcus ; Lefèvre, Philippe. Biological motion input to the oculomotor system. 4th European Conference of the International Federation for Medical and Biological Engineering - ECIFMBE 2008 (Antwerp, Belgium, 23-27 November 2008). In: 4th European Conference of the International Federation for Medical and Biological Engineering - ECIFMBE 2008, Springer verlag, 2008. 978-3-540-89207-6, p. 2142-2145.
      http://hdl.handle.net/2078.1/67451
  • 2007
    • Journal article
      de Hemptinne, Coralie ; Nozaradan, Sylvie ; Duvivier, Quentin ; Lefèvre, Philippe ; Missal, Marcus. How do primates anticipate uncertain future events?. In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, no. 16, p. 4334-41 (2007). doi:10.1523/JNEUROSCI.0388-07.2007.
      http://hdl.handle.net/2078.1/10932
  • 2006
    • Journal article
      Schreiber, Céline ; Missal, Marcus ; Lefèvre, Philippe. Asynchrony between position and motion signals in the saccadic system.. In: Journal of neurophysiology, Vol. 95, no. 2, p. 960-9 (2006). doi:10.1152/jn.00315.2005.
      http://hdl.handle.net/2078.1/10321
    • de Hemptinne, Coralie ; Lefèvre, Philippe ; Missal, Marcus. Influence of cognitive expectation on the initiation of anticipatory and visual pursuit eye movements in the rhesus monkey.. In: Journal of neurophysiology, Vol. 95, no. 6, p. 3770-82 (2006). doi:10.1152/jn.00007.2006.
      http://hdl.handle.net/2078.1/10524
  • 2005
    • Journal article
      Blohm, Gunnar ; Missal, Marcus ; Lefèvre, Philippe. Direct evidence for a position input to the smooth pursuit system.. In: Journal of neurophysiology, Vol. 94, no. 1, p. 712-21 (2005). doi:10.1152/jn.00093.2005.
      http://hdl.handle.net/2078.1/10109
    • Blohm, Gunnar ; Missal, Marcus ; Lefèvre, Philippe. Processing of retinal and extraretinal signals for memory-guided saccades during smooth pursuit.. In: Journal of neurophysiology, Vol. 93, no. 3, p. 1510-22 (2005). doi:10.1152/jn.00543.2004.
      http://hdl.handle.net/2078.1/9993
  • 2004
    • Journal article
      Missal, Marcus ; Heinen, SJ. Supplementary eye fields stimulation facilitates anticipatory pursuit. In: Journal of Neurophysiology, Vol. 92, no. 2, p. 1257-62 (2004). doi:10.1152/jn.01255.2003.
      http://hdl.handle.net/2078.1/40052
  • 2003
    • Journal article
      Blohm, Gunnar ; Missal, Marcus ; Lefèvre, Philippe. Interaction between smooth anticipation and saccades during ocular orientation in darkness.. In: Journal of neurophysiology, Vol. 89, no. 3, p. 1423-33 (2003). doi:10.1152/jn.00675.2002.
      http://hdl.handle.net/2078.1/9388
    • Keller, EL ; Missal, Marcus. Shared brainstem pathways for saccades and smooth-pursuit eye movements. In: New York Academy of Sciences. Annals, Vol. 1004, p. 29-39 (2003). doi:10.1196/annals.1303.004.
      http://hdl.handle.net/2078.1/61379
    • Blohm, Gunnar ; Missal, Marcus ; Lefèvre, Philippe. Smooth anticipatory eye movements alter the memorized position of flashed targets.. In: Journal of vision, Vol. 3, no. 11, p. 761-70 (2003). doi:10.1167/3.11.10.
      http://hdl.handle.net/2078.1/9734
  • 2002
    • Journal article
      Missal, Marcus ; Coimbra, A ; Lefèvre, Philippe ; Olivier, Etienne. A quantitative analysis of the correlations between eye movements and neural activity in the pretectum.. In: Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale, Vol. 143, no. 3, p. 373-82 (2002). doi:10.1007/s00221-002-0999-7.
      http://hdl.handle.net/2078.1/9093
    • Missal, Marcus ; Keller, E L. Common inhibitory mechanism for saccades and smooth-pursuit eye movements.. In: Journal of Neurophysiology, Vol. 88, no.4, p. 1880-92 (2002).
      http://hdl.handle.net/2078.1/131894
    • Missal, Marcus ; Coimbra, A ; Lefèvre, Philippe ; Olivier, Etienne. Further evidence that a shared efferent collicular pathway drives separate circuits for smooth eye movements and saccades.. In: Experimental Brain Research, Vol. 147, no. 3, p. 344-352 (2002). doi:10.1007/s00221-002-1274-7.
      http://hdl.handle.net/2078.1/9303
    • de Brouwer, Sophie ; Missal, Marcus ; Barnes, Graham ; Lefèvre, Philippe. Quantitative analysis of catch-up saccades during sustained pursuit.. In: Journal of Neurophysiology, Vol. 87, no. 4, p. 1772-1780 (2002). doi:10.1152/jn.00621.2001.
      http://hdl.handle.net/2078.1/9119
    • de Brouwer, Sophie ; Yüksel, Demet ; Blohm, Gunnar ; Missal, Marcus ; Lefèvre, Philippe. What triggers catch-up saccades during visual tracking?. In: Journal of neurophysiology, Vol. 87, no. 3, p. 1646-1650 (2002). doi:10.1152/jn.00432.2001..
      http://hdl.handle.net/2078.1/9084
  • 2001
    • Journal article
      Missal, Marcus ; Heinen, SJ. Facilitation of smooth pursuit initiation by electrical stimulation in the supplementary eye fields. In: Journal of Neurophysiology, Vol. 86, no. 5, p. 2413-25 (Nov).
      http://hdl.handle.net/2078.1/131836
    • de Brouwer, S ; Missal, Marcus ; Lefèvre, Philippe. Role of retinal slip in the prediction of target motion during smooth and saccadic pursuit.. In: Journal of neurophysiology, Vol. 86, no. 2, p. 550-8 (2001).
      http://hdl.handle.net/2078.1/8911
  • 2000
    • Journal article
      Missal, Marcus ; de Brouwer, S ; Lefèvre, Philippe ; Olivier, Etienne. Activity of mesencephalic vertical burst neurons during saccades and smooth pursuit.. In: Journal of neurophysiology, Vol. 83, no. 4, p. 2080-92 (2000).
      http://hdl.handle.net/2078.1/8497
    • Coimbra, A J ; Lefèvre, Philippe ; Missal, Marcus ; Olivier, Etienne. Difference between visually and electrically evoked gaze saccades disclosed by altering the head moment of inertia.. In: Journal of neurophysiology, Vol. 83, no. 2, p. 1103-7 (2000).
      http://hdl.handle.net/2078.1/8446
  • 1999
    • Journal article
      Missal, Marcus ; Vogels, Ruffin ; Li, Chao-Yi ; Orban, Guy A.. Shape interactions in macaque inferior temporal neurons.. In: Journal of Neurophysiology, Vol. 82, no.1, p. 131-42 (Juillet 1999).
      http://hdl.handle.net/2078.1/131654
  • 1997
    • Journal article
      Missal, Marcus ; Vogels, Ruffin ; Guy, A. Orban. Responses of macaque inferior temporal neurons to overlapping shapes. In: Cerebral Cortex, Vol. 7, no. 8, p. 758-767 (1997). doi:10.1093/cercor/7.8.758.
      http://hdl.handle.net/2078.1/131647
  • 1996
    • Journal article
      Missal, Marcus ; Lefèvre, Philippe ; Delinte, A. ; Crommelinck, Marc ; Roucoux, André. Smooth eye movements evoked by electrical stimulation of the cat's superior colliculus. In: Experimental Brain Research, Vol. 107, no. 3, p. 382-390 (1996). doi:10.1007/BF00230420.
      http://hdl.handle.net/2078.1/24363
  • 1995
    • Journal article
      Missal, Marcus ; Lefèvre, Philippe ; Crommelinck, Marc ; Roucoux, André. Evidence for high-velocity smooth pursuit in the trained cat. In: Experimental Brain Research, Vol. 106, no. 3, p. 509-512 (1995). doi:10.1007/BF00231076.
      http://hdl.handle.net/2078.1/24442
  • 1994
    • Journal article
      Lefèvre, Philippe ; Missal, Marcus ; Galiana, H. L.. Modeling slow correcting gaze movements. In: Journal of Vestibular Research: Equilibrium and Orientation, Vol. 4, no. 5, p. 371-381 (1994). doi:10.3233/VES-1994-4506.
      http://hdl.handle.net/2078.1/11973
    • Book chapter
      Missal, Marcus ; Lefèvre, Philippe ; Crommelinck, Marc ; Roucoux, André. The role of postsaccadic slow eye movements in the correction of position errors. In: A.F. Fuchs, T. Brandt, U. Büttner, and D. Zee, Contemporary Ocular Motor and Vestibular Research: A Tribute to David A.Robinson, Thieme Publishing Group: New York, 1994, p. 197-199. 9783131004215.
      http://hdl.handle.net/2078.1/245204
  • 1993
    • Journal article
      Missal, Marcus ; Crommelinck, Marc ; Roucoux, André ; Decostre, M.-F.. Slow correcting eye movements of head-fixed, trained cats toward stationary targets. In: Experimental Brain Research, Vol. 96, no. 1, p. 65-76 (1993). doi:10.1007/BF00230439.
      http://hdl.handle.net/2078.1/28161
    • Book chapter
      Missal, Marcus ; Crommelinck, Marc ; Roucoux, André. Behavioural aspects of cats’ saccades. In: Alain Berthoz, Multisensory Control of Movement, Oxford University Press: Oxford, 1993, p. 150-166. 9780198547853. doi:10.1093/acprof:oso/9780198547853.003.0079.
      http://hdl.handle.net/2078.1/248351
  • 1992
    • Conference paper
      Missal, Marcus ; Decostre, MF. ; Crommelinck, Marc ; Roucoux, André. Slow Velocity Corrective Eye-movements of Head Fixed Trained Cats Towards Stationary Targets. In: European Journal of Neuroscience, , p. 277-277 (1992).
      http://hdl.handle.net/2078.1/63530