Laboratory of Nutritional Psychiatry (NUPS)

Research

The gut microbiota is now considered a key factor in the development of psychiatric disorders, and nutrition is a main modulator shaping the gut microbiota. In the lab, we are using preclinical and clinical approaches to decipher the mechanisms underlying the gut-brain communication, particularly in the context of alcohol use disorder and major depression disorder. We are mainly interested in assessing gut microbiota composition (metagenomics) and function (metabolomics), inflammation (measurement of inflammatory cytokines), behaviour (emotion, cognition, sociability) and brain activity (MRI). We are conducting randomized, double blind, placebo controlled clinical studies to investigate the impact of nutritional interventions on the psychological symptoms developed by psychiatric patients.

Sophie Leclercq, Principal Investigator
Marie Mornard, PhD Student
Simon Van Haverbeke, PhD student
Anaëlle Soille, PhD student
Isabelle Lambermont, Technician

UCLouvain collaborations :

Prof. Philippe de Timary (UCLouvain/IONS/NEUR)
Prof. Peter Stärkel (UCLouvain/IREC/GAEN)
Prof. André Mouraux (UCLouvain/IONS/COSY)
Prof. Julie Duqué (UCLouvain/IONS/COSY)
Prof. Pierre Maurage (UCLouvain/IPSY/LEP)

Prof. Dana Samson (UCLouvain/SSH/IPSY)

Prof. Vincent Lorant (UCLouvain/SSS/FSP)

Prof. Cathy Debier (UCLouvain/SST/AGRO)
Dr. Laurence Dricot (UClouvain/IONS/NIMA)

Dr. Carina.Carbia

International collaborations:

Prof. Olli Kärkkäinen (University of Eastern Finland)
Prof. Sophie Layé (Université de Bordeaux, France)
Prof. Santiago Canals (Instituto de Neurociencias de Alicante, Spain)

Prof. Ina Bergheim (University of Vienna, Austria)

MGBA: Depression phenotypes, dietary habits, and biological pathways: An overall assessment of the Gut-Brain-Axis

W3-AUD: Impact of Omega 3 polyunsaturated fatty acids on biological, emotional, cognitive and social dimensions in alcohol use disorders patients

Pain-Sleep-Microbiota: The objective of this study in healthy volunteers is to evaluate whether the composition of the gut microbiota and sleep quality influence the susceptibility to develop peripheral and central sensitization of pain pathways

S-URGE: Negative affect implications in cognitive and emotional processes in young binge drinkers: from brain to gut

Amadieu C., Coste V., Neyrinck AM., Thijssen V., Leyrolle Q., Bindels LB., Piessevaux H., Stärkel P., de Timary P., Delzenne NM. & Leclercq S. (2022) Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients, Gut Microbes (IF: 10.2), 14:1
Leclercq S. Le Roy T., Furgiuele S., Coste V., Bindels L., Leyrolle Q, Neyrinck A., Quoilin C., Amadieu C., Petit G, Dricot L, Tagliatti V., Cani P., Verbeke K., Colet J-M., Stärkel P., de Timary P., Delzenne N. (2020) Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder. Cell Reports (IF: 8.1). Vol. 33, no.2, p. 108238 [1-24] (2020).
S. Leclercq, F. Mian, A. Stanisz, L. Bindels, E.Cambier, H. Ben-Amram O. Koren , P. Forsythe and J. Bienenstock (2017). Early life exposure to clinical dose penicillin induces long-term changes in gut microbiota, brain cytokines and behavior. Nature Communications (IF: 12.1) 2017 Apr 4;8:15062
S. Leclercq, S. Matamoros, P. D Cani, A. Neyrinck, F. Jamar, P.Stärkel, K. Windey, V. Tremaroli, F. Bäckhed, K. Verbeke, P. de Timary and N. M Delzenne (2014). Intestinal permeability, gut bacterial dysbiosis and behavioral markers of alcohol dependence severity. Proceedings of the National Academy of Sciences (PNAS) (IF: 9.8). Oct 21;111(42):E4485-93
S. Leclercq, C. Desaeger, N. Delzenne, P. de Timary, P. Stärkel (2014). Role of inflammatory pathways, blood mononuclear cells, and gut-derived bacterial products in alcohol dependence. Biological Psychiatry (IF: 10.5) . Nov 1;76(9):725-33

Publications

2025
- Journal article
  
  Amadieu, Camille ; Ahmed, Hany ; Leclercq, Sophie ; Koistinen, Ville ; Leyrolle, Quentin ; Starkel, Peter ; Bindels, Laure B. ; Layé, Sophie ; Neyrinck, Audrey M. ; Kärkkäinen, Olli ; de Timary, Philippe ; Hanhineva, Kati ; Delzenne, Nathalie M.. Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.. In: Clinical nutrition ESPEN, Vol. 66, p. 361-371 (2025). doi:10.1016/j.clnesp.2025.01.046.
  
  http://hdl.handle.net/2078.1/299297
- Neyrinck, Audrey M. ; Ahmed, Hany ; Leyrolle, Quentin (co-first author) ; Leclercq, Sophie ; Amadieu, Camille ; Meuronen, Topi ; Layé, Sophie ; Cani, Patrice D. ; Kärkkäinen, Olli ; Bindels, Laure B. ; Hanhineva, Kati ; Delzenne, Nathalie M.. Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health.. In: Scientific reports, Vol. 15, no.1, p. 15455 [1-13] (2025). doi:10.1038/s41598-025-99047-z.
  
  http://hdl.handle.net/2078.1/302419
- Leclercq, Sophie. Nieuwe therapeutische doelen in de behandeling van alcoholverslaving : wat onthult het metaboloom in het bloed ?. In: Medi-Sfeer, Vol. 774, p. 30-33 (2025).
  
  http://hdl.handle.net/2078.1/299429
- Leclercq, Sophie. Nouvelles cibles thérapeutiques dans la prise en charge de la dépendance à l'alcool : que révèle le métabolome sanguin ?. In: Medi-Sphère, Vol. 774, p. 30-33 (2025).
  
  http://hdl.handle.net/2078.1/299428
- Puhakka, Eemeli ; Ahmed, Hany ; Haikonen, Retu ; Leclercq, Sophie ; Hanhineva, Kati ; Maccioni, Luca ; Amadieu, Camille ; Lehtonen, Marko ; Männistö, Ville ; Rysä, Jaana ; Starkel, Peter ; Kärkkäinen, Olli. Serum Metabolite Profile in Progressive Versus Nonprogressive Alcohol-Related Liver Disease: A Cross-Sectional Metabolomics Study.. In: Liver international : official journal of the International Association for the Study of the Liver, Vol. 45, no.6, p. e70128 (2025). doi:10.1111/liv.70128.
  
  http://hdl.handle.net/2078.1/302219
2024
- Journal article
  
  Leclercq, Sophie. 2023 ESBRA Nordmann Award Lecture: Involvement of the gut microbiome-brain axis in alcohol use disorder. In: Alcohol and Alcoholism, Vol. 59, no.5, p. 050 (2024). doi:10.1093/alcalc/agae050.
  
  http://hdl.handle.net/2078.1/291469
- Leclercq, Sophie ; Ahmed, Hany (co-first author) ; Amadieu, Camille ; Petit, Géraldine ; Koistinen, Ville ; Leyrolle, Quentin ; Poncin, Marie ; Starkel, Peter ; Kok, Eloise ; Karhunen, Pekka J ; de Timary, Philippe ; Laye, Sophie ; Neyrinck, Audrey M. ; Kärkkäinen, Olli K ; Hanhineva, Kati ; Delzenne, Nathalie M.. Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder.. In: eLife, Vol. 13, p. RP96937 [1-19] (2024). doi:10.7554/eLife.96937.
  
  http://hdl.handle.net/2078.1/294988
- Borrelli, Serena ; Leclercq, Sophie ; Pasi, Marco ; Maggi, Pietro. Cerebral small vessel disease and glymphatic system dysfunction in multiple sclerosis: A narrative review. In: Multiple Sclerosis and Related Disorders, Vol. 91, no.10, p. 105878 (2024). doi:10.1016/j.msard.2024.105878.
  
  http://hdl.handle.net/2078.1/291471
- Mornard, Marie ; de Timary, Philippe ; Leclercq, Sophie. What role does the gut microbiota play in alcohol use disorder?. In: Médecine des Maladies Métaboliques, (2024). doi:10.1016/j.mmm.2024.08.004 (Accepté/Sous presse).
  
  http://hdl.handle.net/2078.1/291473
- Book chapter
  
  Leclercq, Sophie ; de Timary, Philippe. Role of the Microbiome and the Gut-Brain Axis in Alcohol Use Disorder: Potential Implication for Treatment Development. In: Collectif, Current Topics in Behavioral Neurosciences, Springer Nature, 2024, p.1-18. 978-3-642-28719-0. doi:10.1007/7854_2024_478.
  
  http://hdl.handle.net/2078.1/302793
2023
- Journal article
  
  Quoilin, Caroline ; Amadieu, Camille ; Fievez, Fanny ; Delzenne, Nathalie M. ; de Timary, Philippe ; Duque, Julie ; Leclercq, Sophie. Exploring the links between gut microbiota and excitatory and inhibitory brain processes in alcohol use disorder: A TMS study.. In: Neuropharmacology, Vol. 225, p. 109384 [1-12] (2023). doi:10.1016/j.neuropharm.2022.109384.
  
  http://hdl.handle.net/2078.1/269128
- Biémar, Valérianne ; Leclercq, Sophie. Les psychobiotiques, futur traitement de la dépression ?. In: Pratiques en nutrition, Vol. 19, no.75, p. 21-23 (2023). doi:10.1016/j.pranut.2023.05.006.
  
  http://hdl.handle.net/2078.1/290315
- Petit, Géraldine ; Leclercq, Sophie ; Quoilin, Caroline ; Poncin, Marie ; Starkel, Peter ; Maurage, Pierre ; Benjamin, Rolland ; Dricot, Laurence ; de Timary, Philippe. Links between psychopathological symptoms and cortical thickness in men with severe alcohol use disorder: A Magnetic Resonance Imaging study. In: Neuropsychopharmacology reports, Vol. 43, no. 4, p. 513-520 (2023). doi:10.1002/npr2.12331.
  
  http://hdl.handle.net/2078.1/275276
- Maccioni, Luca ; Kasavuli, Joyce ; Leclercq, Sophie ; Pirlot, Boris ; Laloux, Géraldine ; Horsmans, Yves ; Leclercq, Isabelle ; Schnabl, Bernd ; Starkel, Peter. Toll-like receptor 2 activation in monocytes contributes to systemic inflammation and alcohol-associated liver disease in humans.. In: Hepatology communications, Vol. 7, no. 5, p. e0107 [1-17] (2023). doi:10.1097/HC9.0000000000000107.
  
  http://hdl.handle.net/2078.1/276369
- Conference paper
  
  Bukowski, Henryk ; Bigot, Alix ; Leclercq, Sophie ; Tiberi, Luca ; Amadieu, Camille ; Peeters, Jean-Charles ; Saloppé, Xavier ; Nandrino, Jean-Louis ; Pham, Thierry ; de Timary, Philippe. Self-other distinction performance in alcohol use disorder and antisocial personality disorder. North American Society for the Study of Personality Disorders (NASSPD) Conference 2023 (Waltham, Massachusetts, USA, du 21/04/2023 au 22/04/2023).
  
  http://hdl.handle.net/2078.1/297233
2022
- Journal article
  
  Amadieu, Camille ; Maccioni, Luca ; Leclercq, Sophie ; Neyrinck, Audrey M. ; Delzenne, Nathalie M. ; de Timary, Philippe ; Starkel, Peter. Liver alterations are not improved by inulin supplementation in alcohol use disorder patients during alcohol withdrawal: A pilot randomized, double-blind, placebo-controlled study.. In: EBioMedicine, Vol. 80, no. 1, p. 104033 [1-15] (2022). doi:10.1016/j.ebiom.2022.104033.
  
  http://hdl.handle.net/2078.1/263690
- Amadieu, Camille ; Coste, Valentin ; Neyrinck, Audrey M. ; Thijssen, Victoria ; Leyrolle, Quentin ; Bindels, Laure B. ; Piessevaux, Hubert ; Starkel, Peter ; de Timary, Philippe ; Delzenne, Nathalie M. ; Leclercq, Sophie. Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients. In: Gut Microbes, Vol. 14, no. 1, p. 2007042 [1-20] (2022). doi:10.1080/19490976.2021.2007042.
  
  http://hdl.handle.net/2078.1/255344
- Conference paper
  
  Bukowski, Henryk ; Amadieu, Camille ; Leclercq, Sophie ; de Timary, Philippe. L’empathie cognitive chez les alcoolodépendants et impact du microbiote. Forum Addiction et Société 2022 (Bruxelles, du 28/09/2022 au 29/09/2022).
  
  http://hdl.handle.net/2078.1/297237
- de Timary, Philippe ; Amadieu, Camille ; Starkel, Peter ; Delzenne, N. ; Mikolajczak, Moïra ; Maurage, Pierre ; Bukowski, Henryk ; Samson, Dana ; Leclercq, Sophie. The gut microbiota, IL8, craving and sociability in AUD. 2nd World Congress on Alcohol and Alcoholism (Cracow, Poland, du 17/09/2022 au 20/09/2022). doi:10.1111/acer.14905.
  
  http://hdl.handle.net/2078.1/267000
- Bukowski, Henryk ; Bigot, Alix ; Amadieu, Camille ; Leclercq, Sophie ; Pham, Thierry ; Saloppé, Xavier ; Tiberi, Luca ; Nandrino, Jean-Louis ; Peeters, Jean-Charles ; de Timary, Philippe. Uncovering transdiagnostic socio-cognitive profiles by measuring the building blocks of mentalizing performance across mental disorders. 22nd meeting of the European Society for Cognitive Psychology (ESCoP) (Lille, du 29/08/2022 au 01/09/2022).
  
  http://hdl.handle.net/2078.1/297234
2021
- Journal article
  
  Leclercq, Sophie ; Schwarz, Markus ; Delzenne, Nathalie M. ; Starkel, Peter ; de Timary, Philippe. Alterations of kynurenine pathway in alcohol use disorder and abstinence: a link with gut microbiota, peripheral inflammation and psychological symptoms. In: Translational Psychiatry, Vol. 11, no. 1, p. 503 [1-9] (2021). doi:10.1038/s41398-021-01610-5.
  
  http://hdl.handle.net/2078.1/251815
- Amadieu, Camille ; Leclercq, Sophie ; Coste, Valentin ; Thijssen, Victoria ; Neyrinck, Audrey M. ; Bindels, Laure B. ; Cani, Patrice D. ; Piessevaux, Hubert ; Starkel, Peter ; De Timary, Philippe ; Delzenne, Nathalie M.. Dietary fiber deficiency as a component of malnutrition associated with psychological alterations in alcohol use disorder.. In: Clinical nutrition, Vol. 40, no. 5, p. 2673-2682 (2021). doi:10.1016/j.clnu.2021.03.029.
  
  http://hdl.handle.net/2078.1/246101
- Knudsen, Christelle ; Neyrinck, Audrey M. ; Leyrolle, Quentin ; Baldin, Paméla ; Leclercq, Sophie ; Rodriguez, Julie ; Beaumont, Martin ; Cani, Patrice D. ; Bindels, Laure B. ; Lanthier, Nicolas ; Delzenne, Nathalie M.. Hepatoprotective Effects of Indole, a Gut Microbial Metabolite, in Leptin-Deficient Obese Mice.. In: The Journal of nutrition, Vol. 151, no. 6, p. 1507-1516 (2021). doi:10.1093/jn/nxab032.
  
  http://hdl.handle.net/2078.1/244683
- Salavrakos, Mélissa ; Leclercq, Sophie ; de Timary, Philippe ; Dom, Geert. Microbiome and substances of abuse.. In: Progress in neuro-psychopharmacology & biological psychiatry, Vol. 105, p. 110113 [1-10] (2021). doi:10.1016/j.pnpbp.2020.110113.
  
  http://hdl.handle.net/2078.1/236423
- Leyrolle, Quentin ; Cserjesi, Renata ; D.G.H. Mulders, Maria ; Zamariola, Giorgia ; Hiel, Sophie ; Gianfrancesco, Marco A. ; Portheault, Daphné ; Amadieu, Camille ; Bindels, Laure B. ; Leclercq, Sophie ; Rodriguez, Julie ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Lanthier, Nicolas ; Trefois, Pierre ; Bindelle, Jérome ; Paquot, Nicolas ; Cnop, Miriam ; Thissen, Jean-Paul ; Klein, Olivier ; Luminet, Olivier ; Delzenne, Nathalie M.. Prebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: a randomized, controlled trial. In: Brain, Behavior, and Immunity, Vol. 94, no. May, p. 289-298 (2021). doi:10.1016/j.bbi.2021.01.014.
  
  http://hdl.handle.net/2078.1/242870
- Leyrolle, Quentin ; Cserjesi, Renata ; Mulders, Maria D G H ; Zamariola, Giorgia ; Hiel, Sophie ; Gianfrancesco, Marco A ; Rodriguez, Julie ; Portheault, Daphnée ; Amadieu, Camille ; Leclercq, Sophie ; Bindels, Laure B. ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Karkkainen, Olli ; Haninheva, Kati ; Lanthier, Nicolas ; Trefois, Pierre ; Paquot, Nicolas ; Cnop, Miriam ; Thissen, Jean-Paul ; Klein, Olivier ; Luminet, Olivier ; Delzenne, Nathalie M.. Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients.. In: Clinical nutrition (Edinburgh, Scotland), Vol. 40, p. 2035-2044 (2021). doi:10.1016/j.clnu.2020.09.025.
  
  http://hdl.handle.net/2078.1/237338
- Book chapter
  
  Leclercq, Sophie ; Sophie Layé. Rôle du microbiote intestinal dans les pathologies psychiatriques. In: Jean-Michel Lecerf et Nathalie Delzenne, Microbiote intestinal et santé humaine, Elsevier Masson, 2021. 2294769309.
  
  http://hdl.handle.net/2078.1/255348
- Conference paper
  
  Amadieu, Camille ; Leclercq, Sophie ; Neyrinck, Audrey M. ; Starkel, Peter ; de Timary, Philippe ; Delzenne, Nathalie M.. Effect of a nutritional modulation of the gut-brain axis in alcohol-dependent patients. 43rd ESPEN Congress (Virtual Congress, du 09/09/2021 au 14/09/2021). In: Clinical Nutrition ESPEN, Vol. 46, p. S665-S666 (2021). doi:10.1016/j.clnesp.2021.09.347.
  
  http://hdl.handle.net/2078.1/295107
2020
- Journal article
  
  Leclercq, Sophie ; Le Roy, Tiphaine ; Furgiuele, Sonia ; Coste, Valentin ; Bindels, Laure B. ; Leyrolle, Quentin ; Neyrinck, Audrey M. ; Quoilin, Caroline ; Amadieu, Camille ; Petit, Géraldine ; Dricot, Laurence ; Tagliatti, Vanessa ; Cani, Patrice D. ; Verbeke, Kristin ; Colet, Jean-Marie ; Starkel, Peter ; de Timary, Philippe ; Delzenne, Nathalie M.. Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder.. In: Cell reports, Vol. 33, no.2, p. 108238 [1-24] (2020). doi:10.1016/j.celrep.2020.108238.
  
  http://hdl.handle.net/2078.1/237323
- Wieërs, Grégoire ; Belkhir, Leïla ; Enaud, Raphaël ; Leclercq, Sophie ; Philippart de Foy, Jean-Michel ; Dequenne, Isabelle ; de Timary, Philippe ; Cani, Patrice D.. How Probiotics Affect the Microbiota.. In: Frontiers in cellular and infection microbiology, Vol. 9, p. 454 [1-9] (2019). doi:10.3389/fcimb.2019.00454.
  
  http://hdl.handle.net/2078.1/228091
- Maccioni, Luca ; Gao, Bei ; Leclercq, Sophie ; Pirlot, Boris ; Horsmans, Yves ; de Timary, Philippe ; Leclercq, Isabelle ; Fouts, Derrick ; Schnabl, Bernd ; Starkel, Peter. Intestinal permeability, microbial translocation, changes in duodenal and fecal microbiota, and their associations with alcoholic liver disease progression in humans.. In: Gut microbes, Vol. 12, no. 1, p. 1782157 [1-23] (2020). doi:10.1080/19490976.2020.1782157.
  
  http://hdl.handle.net/2078.1/230965
- Leclercq, Sophie ; de Timary, Philippe ; Starkel, Peter. Targeting the gut microbiota to treat alcoholic liver diseases: evidence and promises. In: Acta Gastro-Enterologica Belgica, Vol. 83, no.4, p. 616-621 (2020).
  
  http://hdl.handle.net/2078.1/255517
- Conference paper
  
  Amadieu, Camille ; Leclercq, Sophie ; Thijssen, Victoria ; Neyrinck, Audrey M. ; Starkel, Peter ; de Timary, Philippe ; Delzenne, Nathalie M.. Nutritional intake in alcohol-dependent patients: effect of prebiotic fiber supplementation during alcohol withdrawal. 42nd ESPEN Congress (Virtual Congress, du 19/09/2020 au 21/09/2020). In: Clinical Nutrition ESPEN, Vol. 40, p. 523 (2020). doi:10.1016/j.clnesp.2020.09.350.
  
  http://hdl.handle.net/2078.1/295105
2019
- Journal article
  
  Stärkel, Peter ; Schnabl, Bernd ; Leclercq, Sophie ; Komuta, Mina ; Bataller, Ramon ; Argemi, Josepmaria ; Palma, Elena ; Chokshi, Shilpa ; Hellerbrand, Claus ; Maccioni, Luca ; Lanthier, Nicolas ; Leclercq, Isabelle. Deficient IL-6/Stat3 Signaling, High TLR7, and Type I Interferons in Early Human Alcoholic Liver Disease: A Triad for Liver Damage and Fibrosis.. In: Hepatology communications, Vol. 3, no.7, p. 867-882 (2019). doi:10.1002/hep4.1364.
  
  http://hdl.handle.net/2078.1/230935
- Leclercq, Sophie ; Starkel, Peter ; Delzenne, Nathalie M. ; de Timary, Philippe. The gut microbiota: A new target in the management of alcohol dependence?. In: Alcohol, Vol. 74, p. 105-111 (2019). doi:10.1016/j.alcohol.2018.03.005.
  
  http://hdl.handle.net/2078.1/204353
- Leclercq, Sophie ; Amadieu, Camille ; Starkel, Peter ; de Timary, Philippe ; Delzenne, Nathalie M.. Troubles liés à l’usage d’alcool : et si l’addiction trouvait son origine dans l’intestin ?. In: Revue médicale de Liège, Vol. 74, no.5-6, p. 281-286 (2019).
  
  http://hdl.handle.net/2078.1/275982
- Conference paper
  
  Rodriguez, Julie ; Van Kerckhoven, Maxime ; Hiel, Sophie ; Leyrolle, Quentin ; Leclercq, Sophie ; Cani, Patrice D. ; Thissen, Jean-Paul ; Neyrinck, Audrey M. ; Delzenne, Nathalie M.. PT04.1: Evaluation of Synergic Potential Effects Between Inulin and Voluntary Exercise During Obesity. 41st ESPEN Congress ((Poland) Warsaw, du 31/08/2019 au 03/09/2019). In: Clinical Nutrition, Vol. 38, no.Suppl 1, p. S40 (2019). doi:10.1016/s0261-5614(19)32559-2.
  
  http://hdl.handle.net/2078.1/295061
2018
- Journal article
  
  Bindels, Laure B. ; Neyrinck, Audrey M. ; Loumaye, Audrey ; Catry, Emilie ; Walgrave, Hannah ; Cherbuy, Claire ; Leclercq, Sophie ; Van Hul, Matthias ; Plovier, Hubert ; Pachikian, Barbara D. ; Bermúdez-Humarán, Luis G ; Langella, Philippe ; Cani, Patrice D. ; Thissen, Jean-Paul ; Delzenne, Nathalie M.. Increased gut permeability in cancer cachexia: mechanisms and clinical relevance.. In: OncoTarget, Vol. 9, no.26, p. 18224-18238 (2018). doi:10.18632/oncotarget.24804.
  
  http://hdl.handle.net/2078.1/197796
- Starkel, Peter ; Leclercq, Sophie ; de Timary, Philippe ; Schnabl, Bernd. Intestinal dysbiosis and permeability: the yin and yang in alcohol dependence and alcoholic liver disease.. In: Clinical Science, Vol. 132, no. 2, p. 199-212 (2018). doi:10.1042/CS20171055.
  
  http://hdl.handle.net/2078.1/194249
- Molitor, Catherine ; Maurage, Pierre ; Petit, Géraldine ; Poncin, Marie ; Leclercq, Sophie ; Rolland, Benjamin ; de Timary, Philippe. Les symptômes thymiques liés à l’usage d’alcool. In: Annales Médico-psychologiques, revue psychiatrique, Vol. 176, no.8, p. 813-818 (2018). doi:10.1016/j.amp.2018.08.009.
  
  http://hdl.handle.net/2078.1/217972
- Suriano, Francesco ; Neyrinck, Audrey M. ; Verspreet, Joran ; Olivares Sevilla, Marta ; Leclercq, Sophie ; Van de Wiele, Tom ; Courtin, Christophe M. ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Particle size determines the anti-inflammatory effect of wheat bran in a model of fructose over-consumption: Implication of the gut microbiota. In: Journal of Functional Foods, Vol. 41, p. 155-162 (2018). doi:10.1016/j.jff.2017.12.035.
  
  http://hdl.handle.net/2078.1/191993
- Conference paper
  
  Rodriguez, Julie ; Neyrinck, Audrey M. ; Le Roy, Tiphaine ; Leclercq, Sophie ; Hiel, Sophie ; Cani, Patrice D. ; Lanthier, Nicolas ; Thissen, Jean-Paul ; Bindels, Laure B. ; Delzenne, Nathalie M.. Implication of the gut microbiota in personalized metabolic response to dietary inulin in obese patients. 40th ESPEN Congress ((Spain) Madrid, du 01/09/2018 au 04/09/2018). In: Clinical Nutrition, Vol. 37, no.Suppl 1, p. S148 (2018). doi:10.1016/j.clnu.2018.06.1548.
  
  http://hdl.handle.net/2078.1/295080
- Leclercq, Sophie. Implication of the gut microbiota in the behavioral alterations linked to alcohol dependence: mechanistic approaches and therapeutic perspectives. Gordon Research Conference. Alcohol and the nervous system: new perspectives in alcohol neuroscience research (Galveston, Texas, USA).
  
  http://hdl.handle.net/2078.1/213020
- Leclercq, Sophie. Implication of the gut microbiota in the behavioral alterations linked to alcohol dependence: mechanistic approaches and therapeutic perspectives. National Institute of Health (NIH), Section on clinical psychoneuroendocrinology and neuropsycopharmacology (Washington, USA).
  
  http://hdl.handle.net/2078.1/213024
2017
- Journal article
  
  de Timary, Philippe ; Starkel, Peter ; Delzenne, Nathalie M. ; Leclercq, Sophie. A role for the peripheral immune system in the development of alcohol use disorders?. In: Neuropharmacology, Vol. 122, p. 148-160 (2017). doi:10.1016/j.neuropharm.2017.04.013.
  
  http://hdl.handle.net/2078.1/184463
- Petit, Géraldine ; Luminet, Olivier ; Cordovil de Sousa Uva, Mariana ; Monhonval, Pauline ; Leclercq, Sophie ; Spilliaert, Quentin ; Zammit, François ; Maurage, Pierre ; de Timary, Philippe. Gender Differences in Affects and Craving in Alcohol-Dependence: A Study During Alcohol Detoxification. In: Alcoholism: Clinical and Experimental Research, Vol. 41, no. 2, p. 421-431 (2017). doi:10.1111/acer.13292.
  
  http://hdl.handle.net/2078.1/186204
- Leclercq, Sophie ; Mian, Firoz M ; Stanisz, Andrew M ; Bindels, Laure B. ; Cambier, Emmanuel ; Ben-Amram, Hila ; Koren, Omry ; Forsythe, Paul ; Bienenstock, John. Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior. In: Nature Communications, Vol. 8, p. 15062 ^1-12] (2017). doi:10.1038/ncomms15062.
  
  http://hdl.handle.net/2078.1/184100
- Leclercq, Sophie ; de Timary, Philippe ; Delzenne, Nathalie M. ; Starkel, Peter. The link between inflammation, bugs, the intestine and the brain in alcohol dependence. In: Translational Psychiatry, Vol. 7, no.2, p. e1048 [1-12] (2017). doi:10.1038/tp.2017.15.
  
  http://hdl.handle.net/2078.1/183334
- Conference paper
  
  Leclercq, Sophie. Effects of early life antibiotics exposure on brain functions and behavior. 6th Beneficial Microbes Conference (Amsterdam, The Netherlands).
  
  http://hdl.handle.net/2078.1/213028
- Leclercq, Sophie. Implication of the gut microbiota in the behavioral alterations linked to alcohol dependence: mechanistic approaches and therapeutic perspectives. 3rd Annual European Microbiome Congress (London, UK).
  
  http://hdl.handle.net/2078.1/213027
2016
- Journal article
  
  de Timary, Philippe ; Leclercq, Sophie ; Starkel, Peter ; Delzenne, Nathalie M.. A dysbiotic subpopulation of alcohol-dependent subjects. In: Gut Microbes, Vol. 6, no.6, p. 388-391 (2016). doi:10.1080/19490976.2015.1107696.
  
  http://hdl.handle.net/2078.1/169550
- Leclercq, Sophie ; Forsythe, Paul ; Bienenstock, John. Posttraumatic Stress Disorder: Does the Gut Microbiome Hold the Key?. In: The Canadian Journal of Psychiatry, Vol. 61, no.4, p. 204-213 (2016). doi:10.1177/0706743716635535.
  
  http://hdl.handle.net/2078.1/174306
- Book chapter
  
  Starkel, Peter ; Leclercq, Sophie ; Delzenne, Nathalie M. ; de Timary, Philippe. Alcohol-Dependence and the Microbiota-Gut-Brain Axis. In: Niall Hyland, Catherine Stanton (eds.), The Gut-Brain Axis. Dietary, Probiotic, and Prebiotic Interventions on the Microbiota, ELSEVIER, 2016, p. 363-390. 9780128023044. doi:10.1016/B978-0-12-802304-4.00017-7.
  
  http://hdl.handle.net/2078.1/174305
- Conference paper
  
  Leclercq, Sophie. Effect of early life antibiotics exposure on brain functions and behavior. Joint Meeting of the American Physiological Society and The Physiological Society (Dublin, Ireland).
  
  http://hdl.handle.net/2078.1/213031
- Petit, Géraldine ; Luminet, Olivier ; Cordovil de Sousa Uva, Marianna ; Monhonval, Pauline ; Leclercq, Sophie ; Maurage, Pierre ; de Timary, Philippe. Gender difference in affects and craving in alcohol dependence: A study during protracted alcohol withdrawal.. Congress ISBRA International Society For Biomedical Research on Alcoholism (Berlin, Germany).
  
  http://hdl.handle.net/2078.1/180906
- Leclercq, Sophie. Role of the gut microbiota in alcohol dependence. Mind, Mood & Microbes. 1st international congress on gut microbiota-brain axis (Amsterdam, The Netherlands).
  
  http://hdl.handle.net/2078.1/213029
2014
- Journal article
  
  Leclercq, Sophie ; Matamoros, Sébastien ; Cani, Patrice D. ; Neyrinck, Audrey M. ; Jamar, François ; Starkel, Peter ; Windey, Karen ; Tremaroli, Valentina ; Backhed, Fredrik ; Verbeke, Kristin ; de Timary, Philippe ; Delzenne, Nathalie M.. Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. In: Proceedings of the National academy of sciences of the United States of America, Vol. 111, no. 42, p. E4485-E4493 (2014). doi:10.1073/pnas.1415174111.
  
  http://hdl.handle.net/2078.1/151988
- Leclercq, Sophie ; De Saeger, Christine ; Delzenne, Nathalie M. ; de Timary, Philippe ; Starkel, Peter. Role of inflammatory pathways, blood mononuclear cells, and gut-derived bacterial products in alcohol dependence. In: Biological Psychiatry, Vol. 76, no. 9, p. 725-733 (2014). doi:10.1016/j.biopsych.2014.02.003.
  
  http://hdl.handle.net/2078.1/140298
- Conference paper
  
  Leclercq, Sophie ; Matamoros, Sébastien ; Cani, Patrice D. ; Starkel, Peter ; Delzenne, Nathalie M. ; de Timary, Philippe. A possible role of gut microbiota in the behavioral control of alcohol-dependent subjects. International Society for Biomedical Research on Alcoholism and Research Society on Alcoholism (Bellevue, Washington, du 21/06/2014 au 25/06/2014).
  
  http://hdl.handle.net/2078.1/151997
- Leclercq, Sophie ; Matamoros, Sébastien ; Cani, Patrice D. ; Jamar, François ; Starkel, Peter ; de Timary, Philippe ; Delzenne, Nathalie M.. Increased intestinal permeability is related to gut bacterial dysbiosis and behavioral markers of addiction severity in alcohol-dependent subjects. International Society of Addiction Medecine (Yokohama, Japan, du 02/10/2014 au 06/10/2014). In: Alcohol and Alcoholism, Vol. 49, no. 1, p. i33 (September 2014). doi:10.1093/alcalc/agu052.161.
  
  http://hdl.handle.net/2078.1/151993
2013
- Conference paper
  
  Leclercq, Sophie ; De Saeger, Christine ; Delzenne, Nathalie M. ; de Timary, Philippe ; Starkel, Peter. Etude des voies inflammatoires dans les cellules sanguines mononucléés et relation avec les symptômes psychologiques et cognitifs développés par les sujets alcoolo-dépendants. Journée de printemps de la Société de Neurophysiologie de Langue Française (SNLF) (Caen, France).
  
  http://hdl.handle.net/2078.1/140315
- Leclercq, Sophie ; de Timary, Philippe ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Delzenne, Nathalie M.. Role of gut microbiota in the behavioral control of alcohol-dependent subjects. 14th Congress of the European Society for Biomedical Research on Alcoholism (Warsaw, Poland, du 08/09/2013 au 11/09/2013). In: Alcohol and Alcoholism, Vol. 48, no.1, p. i36 (09/2013).
  
  http://hdl.handle.net/2078.1/140304
- Leclercq, Sophie ; de Timary, Philippe ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Delzenne, Nathalie M.. Role of gut microbiota in the biological and behavioral control of alcohol-dependence. Joint conference in sustainable diet and food security (Lille, France).
  
  http://hdl.handle.net/2078.1/140314
2012
- Journal article
  
  Leclercq, Sophie ; Cani, Patrice D. ; Neyrinck, Audrey M. ; Starkel, Peter ; Jamar, François ; Mikolajczak, Moïra ; Delzenne, Nathalie M. ; de Timary, Philippe. Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects. In: Brain, Behavior, and Immunity, Vol. 26, no. 6, p. 911-918 (2012). doi:10.1016/j.bbi.2012.04.001.
  
  http://hdl.handle.net/2078.1/117088
- de Timary, Philippe ; Cani, Patrice D. ; Duchemin, Julie ; Neyrinck, Audrey M. ; Gihousse, Dominique ; Laterre, Pierre-François ; Badaoui, Abdenor ; Leclercq, Sophie ; Delzenne, Nathalie M. ; Starkel, Peter. The loss of metabolic control on alcohol drinking in heavy drinking alcohol-dependent subjects. In: PLoS One, Vol. 7, no. 7, p. e38682 [1-10] (2012). doi:10.1371/journal.pone.0038682.
  
  http://hdl.handle.net/2078.1/118973
- Conference paper
  
  Leclercq, Sophie ; De Saeger, Christine ; Delzenne, Nathalie M. ; de Timary, Philippe ; Starkel, Peter. Stimulation of specific pathways for systemic inflammation in alcohol dependent subjects and relation with psychological symptoms. 14th International Society of Addictive Medecine Annual Meeting (Geneva, Switzerland).
  
  http://hdl.handle.net/2078.1/140307
2011
- Conference paper
  
  Leclercq, Sophie ; Cani, Patrice D. ; Neyrinck, Audrey M. ; de Timary, Philippe ; Delzenne, Nathalie M.. Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects. Belgian Nutrition Society (Brussels, Belgium).
  
  http://hdl.handle.net/2078.1/140319
- Leclercq, Sophie ; de Timary, Philippe ; Cani, Patrice D. ; Delzenne, Nathalie M.. Role of intestinal permeability and inflammation on the biological and behavioral control of alcohol-dependent subjects. 13th Congress of the European Society for Biomedical Research on Alcoholism (Vienna, Austria). In: Alcohol and Alcoholism, Vol. 46, no.Suppl 1, p. i26-28 (September October 2011). doi:10.1093/alcalc/agr094.
  
  http://hdl.handle.net/2078.1/140310

Menu

Laboratory of Nutritional Psychiatry (NUPS)

ions | Bruxelles Woluwe, Louvain-la-Neuve

Research

Publications