Mammalian Development & Cell Biology (MACE Lab)

Research

The mammalian cerebral cortex plays key roles in learning and memory, the control of sensory and motor functions or of our emotions. The proper execution of these tasks depends on a long process of embryonic and postnatal development which relies on the production by neural stem cells of the appropriate number of neurons with proper identities that migrate to their specific location and make connections with each other. Defective signaling pathways during development are the causes of human brain disorders such as lissencephalies and heterotopias, mental retardation, dyslexia, schizophrenia, autism, epilepsy and many others. The goal of our laboratory is to better define the mechanisms of neural cell proliferation, migration, differentiation and synaptogenesis.

A better understanding of how the brain develops in normal conditions and in disease will provide new concepts for therapeutic approaches to improve diagnosis and to treat and prevent neurodevelopmental disorders.

video MACE

Yves JOSSIN, PhD, Head of the research group
Kirsten STAM, PhD Student
Angélique JOSSI, Technician

Mechanisms regulating neuronal cell polarity, migration and differentiation.
Mechanisms regulating embryonic neural stem cell adhesion, proliferation and neurogenesis.

Calvo-Jiménez, Elisa, Stam, Kirsten, Jossi, Angélique & Jossin, Yves (2025). GRASPs link Reelin to the Golgi during neocortical development to control neuronal migration and dendritogenesis. Communications Biology. 2025 Apr 6;8(1):572. doi: 10.1038/s42003-025-08014-x.
Cossard, Alexia; Stam, Kirsten; Smets, Aurore & Jossin, Yves (2023). MKL/SRF and Bcl6 mutual transcriptional repression safeguards the fate and positioning of neocortical progenitor cells mediated by RhoA. Science Advances, 9, 1-20. doi :10.1126/sciadv.add0676
Na, Youn ; Calvo Jimenez, Elisa ; Kon, Elif ; Cao, Hong ; Jossin, Yves ; Cooper, Jonathan A. Fbxo45 binds SPRY motifs in the extracellular domain of N-cadherin and regulates neuron migration during brain development.. In: Molecular and cellular biology, Vol. 40, no. 14, p. e00539-19. (2020). doi:10.1128/MCB.00539-19.
Kon, Elif ; Calvo Jimenez, Elisa ; Cossard, Alexia ; Na, Youn ; Cooper, Jonathan A ; Jossin, Yves. N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration.. In: eLife, Vol. 8 (2019). doi:10.7554/eLife.47673.
Jossin, Yves ; Lee, Minhui ; Klezovitch, Olga ; Kon, Elif ; Cossard, Alexia ; Lien, Wen-Hui ; Fernandez, Tania E ; Cooper, Jonathan A ; Vasioukhin, Valera. Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells.. In: Developmental Cell, Vol. 41, no.5, p. 481-495.e5 (2017). doi:10.1016/j.devcel.2017.05.002.
Jossin, Yves ; Cooper, Jonathan A. Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex.. In: Nature neuroscience, Vol. 14, no.6, p. 697-703 (2011 juin). doi:10.1038/nn.2816.

Publications

2025
- Journal article
  
  Calvo-Jiménez, Elisa ; Stam, Kirsten ; Jossi, Angélique ; Jossin, Yves. GRASPs link Reelin to the Golgi during neocortical development to control neuronal migration and dendritogenesis. In: Communications Biology, Vol. 8, no.1, p. 1-14 (2025). doi:10.1038/s42003-025-08014-x.
  
  http://hdl.handle.net/2078.1/300519
2024
- Journal article
  
  Boucherie, Cédric ; Alkailani, Maisa ; Jossin, Yves ; Ruiz Reig, Nuria ; Mahdi, Asma ; Aldaalis, Arwa ; Aittaleb, Mohamed ; Tissir, Fadel. Auts2 enhances neurogenesis and promotes expansion of the cerebral cortex. In: Journal of Advanced Research, (2024). doi:10.1016/j.jare.2024.07.012 (Accepté/Sous presse).
  
  http://hdl.handle.net/2078.1/293333
2023
- Journal article
  
  Cossard, Alexia ; Stam, Kirsten ; Smets, Aurore ; Jossin, Yves. MKL/SRF and Bcl6 mutual transcriptional repression safeguards the fate and positioning of neocortical progenitor cells mediated by RhoA. In: Science Advances, Vol. 9, no. 46, p. eadd0676 [1-20] (2023). doi:10.1126/sciadv.add0676.
  
  http://hdl.handle.net/2078.1/280014
2021
- Journal article
  
  Lau, Eva On-Chai ; Damiani, Devid ; Chehade, Georges ; Ruiz-Reig, Nuria ; Saade, Rana ; Jossin, Yves ; Aittaleb, Mohamed ; Schakman, Olivier ; Tajeddine, Nicolas ; Gailly, Philippe ; Tissir, Fadel. DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction.. In: eLife, Vol. 10, no.10, p. 61974 (2021). doi:10.7554/eLife.61974.
  
  http://hdl.handle.net/2078.1/246636
2020
- Journal article
  
  Na, Youn ; Calvo Jimenez, Elisa ; Kon, Elif ; Cao, Hong ; Jossin, Yves ; Cooper, Jonathan A. Fbxo45 binds SPRY motifs in the extracellular domain of N-cadherin and regulates neuron migration during brain development.. In: Molecular and cellular biology, Vol. 40, no. 14, p. e00539-19. (2020). doi:10.1128/MCB.00539-19.
  
  http://hdl.handle.net/2078.1/230097
- Jossin, Yves. Molecular mechanisms of cell polarity in a range of model systems and in migrating neurons.. In: Molecular and Cellular Neuroscience, Vol. 106, p. 103503 [1-23] (2020). doi:10.1016/j.mcn.2020.103503 (Accepté/Sous presse).
  
  http://hdl.handle.net/2078.1/230098
- Jossin, Yves. Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation. In: Biomolecules, Vol. 10, no.6, p. 964 (2020).
  
  http://hdl.handle.net/2078.1/230849
2019
- Journal article
  
  Kon, Elif ; Calvo Jimenez, Elisa ; Cossard, Alexia ; Na, Youn ; Cooper, Jonathan A ; Jossin, Yves. N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration.. In: eLife, Vol. 8 (2019). doi:10.7554/eLife.47673.
  
  http://hdl.handle.net/2078.1/221769
2018
- Journal article
  
  Boucherie, Cédric ; Boutin, Camille ; Jossin, Yves ; Schakman, Olivier ; Goffinet, André ; Ris, Laurence ; Gailly, Philippe ; Tissir, Fadel. Neural progenitor fate decision defects, cortical hypoplasia and behavioral impairment in Celsr1-deficient mice. In: Molecular Psychiatry, Vol. 23, no. 3, p. 723-734 (2018). doi:10.1038/mp.2017.236.
  
  http://hdl.handle.net/2078.1/199403
2017
- Journal article
  
  Jossin, Yves ; Lee, Minhui ; Klezovitch, Olga ; Kon, Elif ; Cossard, Alexia ; Lien, Wen-Hui ; Fernandez, Tania E ; Cooper, Jonathan A ; Vasioukhin, Valera. Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells.. In: Developmental Cell, Vol. 41, no.5, p. 481-495.e5 (2017). doi:10.1016/j.devcel.2017.05.002.
  
  http://hdl.handle.net/2078.1/185450
- Kon, Elif ; Cossard, Alexia ; Jossin, Yves. Neuronal Polarity in the Embryonic Mammalian Cerebral Cortex. In: Frontiers in Cellular Neuroscience, Vol. 11 (2017). doi:10.3389/fncel.2017.00163.
  
  http://hdl.handle.net/2078.1/185611
2016
- Journal article
  
  Wang, Wei ; Jossin, Yves ; Chai, Guoliang ; Lien, Wen-Hui ; Tissir, Fadel ; Goffinet, André. Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling.. In: Nature Communications, Vol. 7, p. 10936 (2016). doi:10.1038/ncomms10936.
  
  http://hdl.handle.net/2078.1/172409
2013
- Journal article
  
  Dimidschstein, Jordane ; Passante, Lara ; Dufour, Audrey ; van den Ameele, Jelle ; Tiberi, Luca ; Hrechdakian, Tatyana ; Adams, Ralf ; Klein, Rüdiger ; Lie, Dieter Chichung ; Jossin, Yves ; Vanderhaeghen, Pierre. Ephrin-B1 Controls the Columnar Distribution of Cortical Pyramidal Neurons by Restricting Their Tangential Migration. In: Neuron, Vol. 79, no.6, p. 1123-1135 (2013). doi:10.1016/j.neuron.2013.07.015.
  
  http://hdl.handle.net/2078.1/133851
2011
- Journal article
  
  Jossin, Yves. Polarization of migrating cortical neurons by Rap1 and N-cadherin: Revisiting the model for the Reelin signaling pathway.. In: Small GTPases, Vol. 2, no.6, p. 322-328 (novembre 2011). doi:10.4161/sgtp.18283.
  
  http://hdl.handle.net/2078.1/122113
- Jossin, Yves ; Cooper, Jonathan A. Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex.. In: Nature neuroscience, Vol. 14, no.6, p. 697-703 (2011 juin). doi:10.1038/nn.2816.
  
  http://hdl.handle.net/2078.1/122107
2010
- Journal article
  
  Simo, S ; Jossin, Yves ; Cooper, JA. Cullin 5 regulates cortical layering by modulating the speed and duration of Dab1-dependent neuronal migration.. In: The journal of neuroscience, Vol. 30, no.16, p. 5668-76 (21 avril 2010). doi:10.1523/JNEUROSCI.0035-10.2010.
  
  http://hdl.handle.net/2078.1/122105
2008
- Book chapter
  
  Jossin, Yves. Chemistry of Reelin. In: S.H. Fatemi, Reelin glycoprotein: structure, biology and roles in health and disease, Springer: New-York, 2008. 978-3-540-44328-5.
  
  http://hdl.handle.net/2078.1/130305
2007
- Journal article
  
  Andrade, Nuno ; Komnenovic, Vukoslav ; Blake, Sophia M. ; Jossin, Yves ; Howell, Brian ; Goffinet, André ; Schneider, Wolfgang J. ; Nimpf, Johannes. ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin. In: Proceedings of the National academy of sciences of the United States of America, Vol. 104, no. 20, p. 8508-8513 (2007). doi:10.1073/pnas.0611391104.
  
  http://hdl.handle.net/2078.1/25777
- Zhou, Libing ; Jossin, Yves ; Goffinet, André. Identification of small molecules that interfere with radial neuronal migration and early cortical plate development.. In: Cerebral cortex, Vol. 17, no. 1, p. 211-220 (2007). doi:10.1093/cercor/bhj139.
  
  http://hdl.handle.net/2078.1/25783
- Jossin, Yves ; Gui, Lanrun ; Goffinet, André. Processing of Reelin by embryonic neurons is important for function in tissue but not in dissociated cultured neurons. In: The Journal of Neuroscience, Vol. 27, no. 16, p. 4243-4252 (2007). doi:10.1523/JNEUROSCI.0023-07.2007.
  
  http://hdl.handle.net/2078.1/10931
- Jossin, Yves ; Goffinet, André. Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth. In: Molecular and Cellular Biology, Vol. 27, no. 20, p. 7113-7124 (2007). doi:10.1128/MCB.00928-07.
  
  http://hdl.handle.net/2078.1/11071
2006
- Journal article
  
  Servais, Hélène ; Jossin, Yves ; Van Bambeke, Françoise ; Tulkens, Paul M. ; Mingeot-Leclercq, Marie-Paule. Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation. In: Antimicrobial Agents and Chemotherapy, Vol. 50, no. 4, p. 1213-1221 (2006). doi:10.1128/AAC.50.4.1213-1221.2006.
  
  http://hdl.handle.net/2078.1/10535
- Förster, Eckart ; Jossin, Yves ; Zhao, Shanting ; Chai, Xuejun ; Frotscher, Michael ; Goffinet, André. Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus.. In: The European journal of neuroscience, Vol. 23, no. 4, p. 901-909 (2006). doi:10.1111/j.1460-9568.2006.04612.x.
  
  http://hdl.handle.net/2078.1/25781
- Price, David J ; Kennedy, Henry ; Dehay, Colette ; Zhou, Libing ; Mercier, Marjorie ; Jossin, Yves ; Goffinet, André ; Tissir, Fadel ; Blakey, Daniel ; Molnár, Zoltán. The development of cortical connections.. In: The European journal of neuroscience, Vol. 23, no. 4, p. 910-920 (2006). doi:10.1111/j.1460-9568.2006.04620.x.
  
  http://hdl.handle.net/2078.1/25780
2005
- Journal article
  
  Tissir, Fadel ; Bar, Isabelle ; Jossin, Yves ; Goffinet, André. Protocadherin Celsr3 is crucial in axonal tract development.. In: Nature neuroscience, Vol. 8, no. 4, p. 451-7 (2005). doi:10.1038/nn1428.
  
  http://hdl.handle.net/2078.1/12810
2004
- Journal article
  
  Bock, HH ; Jossin, Yves ; May, P J ; Bergner, O ; Herz, J. Apolipoprotein E receptors are required for Reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1. In: Journal of Biological Chemistry, Vol. 279, no. 32, p. 33471-9 (2004). doi:10.1074/jbc.M401770200.
  
  http://hdl.handle.net/2078.1/40057
- Jossin, Yves. Neuronal migration and the role of reelin during early development of the cerebral cortex.. In: Molecular neurobiology, Vol. 30, no. 3, p. 225-51 (2004). doi:10.1385/MN:30:3:225.
  
  http://hdl.handle.net/2078.1/12814
- Jossin, Yves ; Ignatova, Nina ; Hiesberger, Thomas ; Herz, Joachim ; Lambert de Rouvroit, Catherine ; Goffinet, André. The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development.. In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, no. 2, p. 514-521 (2004). doi:10.1523/JNEUROSCI.3408-03.2004.
  
  http://hdl.handle.net/2078.1/12845
2003
- Journal article
  
  Jossin, Yves ; Ogawa, Masuhara ; Metin, Christine ; Tissir, Fadel ; Goffinet, André. Inhibition of SRC family kinases and non-classical protein kinases C induce a reeler-like malformation of cortical plate development.. In: The Journal of Neuroscience, Vol. 23, no. 30, p. 9953-9959 (2003).
  
  http://hdl.handle.net/2078.1/12851
- Bock, Hans H ; Jossin, Yves ; Liu, Pingsheng ; Förster, Eckart ; May, Petra ; Goffinet, André ; Herz, Joachim. Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination.. In: The Journal of biological chemistry, Vol. 278, no. 40, p. 38772-9 (2003). doi:10.1074/jbc.M306416200.
  
  http://hdl.handle.net/2078.1/25791
- Jossin, Yves ; Bar, Isabelle ; Ignatova, Nina ; Tissir, Fadel ; De Rouvroit, Catherine Lambert ; Goffinet, André. The reelin signaling pathway: some recent developments.. In: Cerebral cortex (New York, N.Y. : 1991), Vol. 13, no. 6, p. 627-33 (2003). doi:10.1093/cercor/13.6.627.
  
  http://hdl.handle.net/2078.1/25792
2001
- Journal article
  
  Jossin, Yves ; Goffinet, André. Reelin does not directly influence axonal growth.. In: The journal of neuroscience, Vol. 21, no.23, p. RC183 (1 décembre 2001).
  
  http://hdl.handle.net/2078.1/122098
2000
- Journal article
  
  Gilot, Philippe ; Jossin, Yves ; Content, Jean. Cloning, sequencing and characterisation of a Listeria monocytogenes gene encoding a fibronectin-binding protein.. In: Journal of Medical Microbiology, Vol. 49, no. 10, p. 887-896 (2000).
  
  http://hdl.handle.net/2078.1/122043

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Mammalian Development & Cell Biology (MACE Lab)

ions | Bruxelles Woluwe, Louvain-la-Neuve

Research

video MACE

Publications